{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:32:55Z","timestamp":1778783575703,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Catalyst-free multicomponent reactions of mixed alkylzinc reagents with Michael acceptors and aldehydes, ketones or activated imines are described. Primary, secondary and tertiary alkylzinc reagents, pre-generated in acetonitrile from the corresponding iodoalkanes, were used in the process, leading to the very efficient formation of a variety of \u03b2-hydroxycarbonyl compounds. The imines showed more contrasting results, due to the direct addition of the organozinc compound to the C=N bond. Mechanistic assays involving TEMPO account for a polar instead of a radical character of the reaction.<\/jats:p>","DOI":"10.3390\/molecules28031401","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T01:53:54Z","timestamp":1675302834000},"page":"1401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Catalyst-Free Formal Conjugate Addition\/Aldol or Mannich Multicomponent Reactions of Mixed Aliphatic Organozinc Reagents, \u03c0-Electrophiles and Michael Acceptors"],"prefix":"10.3390","volume":"28","author":[{"given":"Marine","family":"Pinaud","sequence":"first","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, CNRS, ICMPE, UMR 7182, 2 rue Henri Dunant, 94320 Thiais, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-5572","authenticated-orcid":false,"given":"Marc","family":"Presset","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, CNRS, ICMPE, UMR 7182, 2 rue Henri Dunant, 94320 Thiais, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwan","family":"Le Gall","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, CNRS, ICMPE, UMR 7182, 2 rue Henri Dunant, 94320 Thiais, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/anie.200500195","article-title":"Catalytic asymmetric tandem transformations triggered by conjugate additions","volume":"45","author":"Guo","year":"2006","journal-title":"Angew. 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