{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:20:12Z","timestamp":1790857212619,"version":"4.1.0"},"reference-count":152,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Polit\u00e9cnico Nacional","award":["2021-0392"],"award-info":[{"award-number":["2021-0392"]}]},{"name":"Instituto Polit\u00e9cnico Nacional","award":["2022-0660"],"award-info":[{"award-number":["2022-0660"]}]},{"name":"Instituto Polit\u00e9cnico Nacional","award":["2023-0831"],"award-info":[{"award-number":["2023-0831"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Due to the increase in multidrug-resistant microorganisms, the investigation of novel or more efficient antimicrobial compounds is essential. The World Health Organization issued a list of priority multidrug-resistant bacteria whose eradication will require new antibiotics. Among them, Acinetobacter baumannii, Pseudomonas\u00a0aeruginosa, and Enterobacteriaceae are in the \u201ccritical\u201d (most urgent) category. As a result, major investigations are ongoing worldwide to discover new antimicrobial compounds. Burkholderia, specifically Burkholderia sensu stricto, is recognized as an antimicrobial-producing group of species. Highly dissimilar compounds are among the molecules produced by this genus, such as those that are unique to a particular strain (like compound CF66I produced by Burkholderia cepacia CF-66) or antimicrobials found in a number of species, e.g., phenazines or ornibactins. The compounds produced by Burkholderia include N-containing heterocycles, volatile organic compounds, polyenes, polyynes, siderophores, macrolides, bacteriocins, quinolones, and other not classified antimicrobials. Some of them might be candidates not only for antimicrobials for both bacteria and fungi, but also as anticancer or antitumor agents. Therefore, in this review, the wide range of antimicrobial compounds produced by Burkholderia is explored, focusing especially on those compounds that were tested in vitro for antimicrobial activity. In addition, information was gathered regarding novel compounds discovered by genome-guided approaches.<\/jats:p>","DOI":"10.3390\/molecules28041646","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T01:37:07Z","timestamp":1675906627000},"page":"1646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto"],"prefix":"10.3390","volume":"28","author":[{"given":"Mariana","family":"Rodr\u00edguez-Cisneros","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. de Carpio y Plan de Ayala S\/N Col. Santo Tom\u00e1s Alc. Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Mariana","family":"Morales-Ru\u00edz","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. de Carpio y Plan de Ayala S\/N Col. Santo Tom\u00e1s Alc. Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuar","family":"Salazar-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Escuela Nacional de Estudios Superiores Unidad Le\u00f3n, Universidad Nacional Aut\u00f3noma de M\u00e9xico (ENES-Le\u00f3n UNAM), Blvd. UNAM 2011, Le\u00f3n, Guanajuato 37684, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-1588","authenticated-orcid":false,"given":"Fernando Uriel","family":"Rojas-Rojas","sequence":"additional","affiliation":[{"name":"Laboratorio de Ciencias AgroGen\u00f3micas, Escuela Nacional de Estudios Superiores Unidad Le\u00f3n, Universidad Nacional Aut\u00f3noma de M\u00e9xico (ENES-Le\u00f3n UNAM), Blvd. UNAM 2011, Le\u00f3n, Guanajuato 37684, Mexico"},{"name":"Laboratorio Nacional PlanTECC, Escuela Nacional de Estudios Superiores Unidad Le\u00f3n, Universidad Nacional Aut\u00f3noma de M\u00e9xico (ENES-Le\u00f3n UNAM), Blvd. UNAM 2011, Le\u00f3n, Guanajuato 37684, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2407-0284","authenticated-orcid":false,"given":"Paulina","family":"Estrada-de los Santos","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prol. de Carpio y Plan de Ayala S\/N Col. Santo Tom\u00e1s Alc. Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fgene.2014.00429","article-title":"Molecular signatures and phylogenomic analysis of the genus Burkholderia: Proposal for division of this genus into the emended genus Burkholderia containing pathogenic organisms and a new genus Paraburkholderia gen. nov. harboring environmental species","volume":"5","author":"Sawana","year":"2014","journal-title":"Front. 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