{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:30:49Z","timestamp":1789439449514,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Umm Al-Qura University","award":["22UQU4331128DSR61"],"award-info":[{"award-number":["22UQU4331128DSR61"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Retama monosperma L. (Boiss.) or Genista monosperma L. (Lam.), known locally as \u201cR\u2019tam\u201d, is a spontaneous and annual herb that belongs to the Fabaceae family. It is native to the Mediterranean regions, specifically in the desert areas and across the Middle Atlas in Morocco. This plant has been extensively used in folk medicine and it is rich in bioactive compounds, including polyphenols, flavonoids, and alkaloids. Current research efforts are focusing on the development of novel natural drugs as alternatives to various organic and non-organic chemical products from Retama monosperma. In addition, extract, and isolated compounds obtained from different parts of the chosen plant have been described to exhibit multiple biological and pharmacological properties such as antioxidant, anti-aging, anti-inflammatory, antihypertensive, anti-helminthic, disinfectant, diuretic, and hypoglycemic effects. The plant-derived extract also acts as an antimicrobial agent, which is highly efficient in the treatment of bacterial, viral, and fungal infections. Its antiproliferative effects are associated with some mechanisms, such as the inhibition of cell cycle arrest and apoptosis. In light of these assessments, we critically highlight the beneficial effects of the flowers, stems, seeds extracts, and isolated compounds from R. monosperma (L.) Boiss in human health care, industrial, and other applications, as well as the possible ways to be employed as a potential natural source for future drug discovery.<\/jats:p>","DOI":"10.3390\/molecules28041708","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T01:48:56Z","timestamp":1676252936000},"page":"1708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Comprehensive Review of the Pharmacological Properties and Bioactive Components of Retama monosperma"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-3588","authenticated-orcid":false,"given":"Adil","family":"El Yadini","sequence":"first","affiliation":[{"name":"Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat BP 1014, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0441-2913","authenticated-orcid":false,"given":"Youssef","family":"Elouafy","sequence":"additional","affiliation":[{"name":"Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat BP 1014, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8948-9153","authenticated-orcid":false,"given":"Ehsan","family":"Amiri-Ardekani","sequence":"additional","affiliation":[{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran"},{"name":"Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Shafiee","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-3710","authenticated-orcid":false,"given":"Amirhosein","family":"Firouzi","sequence":"additional","affiliation":[{"name":"Essential Oils Research Institute, University of Kashan, Kashan P.O. Box 87516-51998, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh","family":"Sasani","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran"},{"name":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-2588","authenticated-orcid":false,"given":"Asaad","family":"Khalid","sequence":"additional","affiliation":[{"name":"Substance Abuse and Toxicology Research Center, Jazan University, Jazan 45142, Saudi Arabia"},{"name":"Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, Khartoum P.O. Box 2404, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4770-9319","authenticated-orcid":false,"given":"Ashraf N.","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-3515","authenticated-orcid":false,"given":"Saad","family":"Bakrim","sequence":"additional","affiliation":[{"name":"Geo-Bio-Environment Engineering and Innovation Laboratory, Molecular Engineering, Biotechnologies, and Innovation Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir 80000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5069-3314","authenticated-orcid":false,"given":"Ching Siang","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, KPJ Healthcare University College, Nilai 71800, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-7019","authenticated-orcid":false,"given":"Khang Wen","family":"Goh","sequence":"additional","affiliation":[{"name":"Faculty of Data Science and Information Technology, INTI International University, Nilai 71800, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-1383","authenticated-orcid":false,"given":"Long Chiau","family":"Ming","sequence":"additional","affiliation":[{"name":"School of Medical and Life Sciences, Sunway University, Sunway City 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhakim","family":"Bouyahya","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ptr.1627","article-title":"Hypoglycaemic Activity of Retama Raetam in Rats","volume":"19","author":"Maghrani","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100349","DOI":"10.1016\/j.phyplu.2022.100349","article-title":"Retama Monosperma (L.) Boiss.: A Review of Its Uses in Traditional Medicine, Chemical Constituents, and Pharmacologic Activities","volume":"2","author":"Benkhouili","year":"2022","journal-title":"Phytomed. Plus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"114451","DOI":"10.1016\/j.jep.2021.114451","article-title":"Effect of Extracts and Isolated Compounds Derived from Retama Monosperma (L.) Boiss. on Anti-Aging Gene Expression in Human Keratinocytes and Antioxidant Activity","volume":"280","author":"Zefzoufi","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Belayachi, L., Aceves-Luquero, C., Merghoub, N., Bakri, Y., Fern\u00e1ndez de Mattos, S., Amzazi, S., and Villalonga, P. (2014). Retama Monosperma N-Hexane Extract Induces Cell Cycle Arrest and Extrinsic Pathway-Dependent Apoptosis in Jurkat Cells. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-38"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.eujim.2017.06.004","article-title":"Indigenous Knowledge of the Use of Medicinal Plants in the North-West of Morocco and Their Biological Activities","volume":"13","author":"Bouyahya","year":"2017","journal-title":"Eur. J. Integr. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bourais, I., Elmarrkechy, S., Taha, D., Mourabit, Y., Bouyahya, A., el Yadini, M., Machich, O., el Hajjaji, S., el Boury, H., and Dakka, N. (2022). A Review on Medicinal Uses, Nutritional Value, and Antimicrobial, Antioxidant, Anti-Inflammatory, Antidiabetic, and Anticancer Potential Related to Bioactive Compounds of J. Regia. Food Rev. Int., 1\u201351.","DOI":"10.1080\/87559129.2022.2094401"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Elouafy, Y., el Idrissi, Z.L., el Yadini, A., Harhar, H., Alshahrani, M.M., al Awadh, A.A., Goh, K.W., Ming, L.C., Bouyahya, A., and Tabyaoui, M. (2022). Variations in Antioxidant Capacity, Oxidative Stability, and Physicochemical Quality Parameters of Walnut (Juglans regia) Oil with Roasting and Accelerated Storage Conditions. Molecules, 27.","DOI":"10.3390\/molecules27227693"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Elouafy, Y., el Yadini, A., el Moudden, H., Harhar, H., Alshahrani, M.M., Awadh, A.A.A., Goh, K.W., Ming, L.C., Bouyahya, A., and Tabyaoui, M. (2022). Influence of the Extraction Method on the Quality and Chemical Composition of Walnut (Juglans regia L.) Oil. Molecules, 27.","DOI":"10.3390\/molecules27227681"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112198","DOI":"10.1016\/j.indcrop.2020.112198","article-title":"Pharmacological Properties and Mechanism Insights of Moroccan Anticancer Medicinal Plants: What Are the next Steps?","volume":"147","author":"Bouyahya","year":"2020","journal-title":"Ind. Crop. Prod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.21448\/ijsm.1031208","article-title":"Acute Toxicity, Phenol Content, Antioxidant and Postprandial Anti-Diabetic Activity of Echinops Spinosus Extracts","volume":"9","author":"Benrahou","year":"2022","journal-title":"Int. J. Second. Metab."},{"key":"ref_11","unstructured":"Rajkumar, R. (2012). Topics On Cervical Cancer With An Advocacy For Prevention, IntechOpen."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tifs.2021.03.032","article-title":"Moroccan Antidiabetic Medicinal Plants: Ethnobotanical Studies, Phytochemical Bioactive Compounds, Preclinical Investigations, Toxicological Validations and Clinical Evidences; Challenges, Guidance and Perspectives for Future Management of Diabetes Worldwide","volume":"115","author":"Bouyahya","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1080\/14786419.2014.934237","article-title":"In Vitro Antioxidant Activity of Retama monosperma (L.) Boiss","volume":"28","author":"Belmokhtar","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_14","first-page":"1889","article-title":"Preliminary Phytochemical Analysis and Antibacterial Potential of Organic Extracts from Aerial Parts of Retama monosperma","volume":"2508","author":"Zefzoufi","year":"2018","journal-title":"J. Mater. Environ. Sci."},{"key":"ref_15","first-page":"701","article-title":"An Overeview on Phytochemical Composition and Biological Activities of Retama monosperma L Boiss. (Fabaceae)","volume":"10","author":"Belmokhtar","year":"2016","journal-title":"PhytoChem. BioSub. J."},{"key":"ref_16","first-page":"163","article-title":"Anti-Inflammatory Effects of Retama monosperma in Acute Ulcerative Colitis in Rats","volume":"70","author":"Rosillo","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"ref_17","first-page":"965","article-title":"Antifungal Activity of the Alkaloids Extracts from Aerial Parts of Retama monosperma","volume":"7","author":"Fdil","year":"2016","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"ref_18","first-page":"358","article-title":"Evaluation of Alkaloids Extract of Retama monosperma (L.) Boiss. Stems as a Green Corrosion Inhibitor for Carbon Steel in Pickling Acidic Medium by Means of Gravimetric, AC Impedance and Surface Studies","volume":"9","author":"Fdil","year":"2018","journal-title":"J. Mater. Environ. Sci."},{"key":"ref_19","first-page":"301","article-title":"Quinolizidine Alkaloid Profiles of Retama raetam, R. sphaerocarpa and R. monosperma","volume":"21\u201330","author":"Ateya","year":"1996","journal-title":"Zeitschrift f\u00fcr Naturforschung C"},{"key":"ref_20","first-page":"42","article-title":"Phytochemical Study, Antioxidant and Antimicrobial Activities of Flavonoids and Diethyl Ether Extracts from Leaves and Seeds of Medicinal Plant of Algeria Flora: Retama monosperma (L.) Boiss","volume":"76","author":"Abdelmadjide","year":"2020","journal-title":"PONTE Int. Sci. Res. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s11101-018-9555-3","article-title":"Genus Retama: A Review on Traditional Uses, Phytochemistry, and Pharmacological Activities","volume":"17","author":"Navarro","year":"2018","journal-title":"Phytochem. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0305-1978(80)90006-X","article-title":"Quinolizidine Alkaloids as Systematic Markers of the Papilionoideae","volume":"8","author":"Salatino","year":"1980","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_23","first-page":"538","article-title":"Evaluation of Fatty Acids Profile and Mineral Content of Retama monosperma (L.) Boiss. of Morocco","volume":"6","author":"Fdil","year":"2015","journal-title":"J. Mater. Environ. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/10408690490911800","article-title":"Role of the Conjugated Linoleic Acid in the Prevention of Cancer","volume":"45","author":"Lee","year":"2005","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1051\/ata\/2012016","article-title":"Distribution of Alkaloids in the Aerial Parts of Retama monosperma (L.) Boiss. in Morocco|Distribution Des Alcalo\u00efdes Dans Les Parties A\u00e9riennes de Retama monosperma (L.) Boiss. Du Maroc","volume":"24","author":"Fdil","year":"2012","journal-title":"Ann. De Toxicol. Anal."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.apsusc.2015.09.159","article-title":"Alkaloids Extract of Retama Monosperma (L.) Boiss. Seeds Used as Novel Eco-Friendly Inhibitor for Carbon Steel Corrosion in 1 M HCl Solution: Electrochemical and Surface Studies","volume":"357","author":"Fdil","year":"2015","journal-title":"Appl. Surf. Sci."},{"key":"ref_27","first-page":"263695","article-title":"Antioxidant Activity and Total Phenolic and Flavonoid Contents of 30 Medicinal and Aromatic Plants Located in the South of Morocco","volume":"1","author":"Tahrouch","year":"2015","journal-title":"Int. J. New Technol. Res. IJNTR"},{"key":"ref_28","first-page":"2102","article-title":"Chemical Composition of Essential Oils of Retama monosperma (L.) Boiss. from Morocco","volume":"7","author":"Derhali","year":"2016","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"ref_29","first-page":"250","article-title":"Qualitative and Quantitative Identification by GC\/MS of the Main Compounds of Extracts Using Solvents of Retama monosperma from the Flora of Algeria","volume":"15","author":"Abdelmadjide","year":"2021","journal-title":"PhytoChem. BioSub. J."},{"key":"ref_30","first-page":"1581","article-title":"In Vitro Antiproliferative Effect and Induction of Apoptosis by Retama monosperma L. Extract in Human Cervical Cancer Cells","volume":"57","author":"Merghoub","year":"2011","journal-title":"Cell. Mol. Biol."},{"key":"ref_31","first-page":"214","article-title":"Extraction and Analysis of Polysaccharides from Tissues of Retama monosperma Branches Extraction and Analysis of Polysaccharides from Tissues of Retama monosperma Branches","volume":"9","author":"Aizi","year":"2019","journal-title":"S. Asian J. Exp. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.9734\/EJMP\/2013\/3403","article-title":"Screening of North African Medicinal Plant Extracts for Cytotoxic Activity Against Tumor Cell Lines","volume":"3","author":"Belayachi","year":"2013","journal-title":"Eur. J. Med. Plant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.aninu.2020.01.001","article-title":"Antioxidant Mechanism of Tea Polyphenols and Its Impact on Health Benefits","volume":"6","author":"Yan","year":"2020","journal-title":"Anim. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","article-title":"Antioxidants and Antioxidant Methods: An Updated Overview","volume":"94","author":"Gulcin","year":"2020","journal-title":"Arch. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e00536","DOI":"10.1016\/j.btre.2020.e00536","article-title":"Phytochemical Screening and Antioxidant Activity of Some Medicinal Plants\u2019 Crude Juices","volume":"28","author":"Farag","year":"2020","journal-title":"Biotechnol. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Elisha, I.L., Botha, F.S., McGaw, L.J., and Eloff, J.N. (2017). The Antibacterial Activity of Extracts of Nine Plant Species with Good Activity against Escherichia coli against Five Other Bacteria and Cytotoxicity of Extracts. BMC Complement. Altern. Med., 17.","DOI":"10.1186\/s12906-017-1645-z"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/np068054v","article-title":"Natural Products as Sources of New Drugs over the Last 25 Years","volume":"70","author":"Newman","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1470-2045(03)01277-4","article-title":"Anticancer Therapy Targeting the Apoptotic Pathway","volume":"4","author":"Hu","year":"2003","journal-title":"Lancet Oncol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/4\/1708\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:30:34Z","timestamp":1760121034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/4\/1708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["molecules28041708"],"URL":"https:\/\/doi.org\/10.3390\/molecules28041708","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}