{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:14:42Z","timestamp":1776942882576,"version":"3.51.4"},"reference-count":66,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Special Research Account of the National and Kapodistrian University of Athens (NKUA)","award":["18638"],"award-info":[{"award-number":["18638"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Metal complexes displaying antiplatelet properties is a promising research area. In our methodology, Platelet-Activating Factor (PAF), the most potent lipid pro-inflammatory mediator, serves as a biological probe. The antiplatelet activity is exerted by the inhibition of the PAF-induced aggregation in washed rabbit platelets (WRPs) and in rabbit plasma rich in platelets (rPRPs). Herein, the synthesis and biological investigation of a series of organometallic tin(II) and tin(IV) complexes, featuring the oxygen tripodal Kl\u00e4ui ligands [(\u03b75-C5R5)Co{P(OEt)2O}3]\u2212, {R = H, (LOEt\u2212); Me (L*OEt\u2212)}, are reported. Reaction of NaLOEt (1a) and NaL*OEt (1b) with SnCl2, yielded the rare four-coordinate LOEtSnCl (2a) and L*OEtSnCl (2b) complexes. Accordingly, LOEtSnPh3 (3a) and L*OEtSnPh3 (3b) were prepared, starting from Ph3SnCl. Characterization includes spectroscopy and X-ray diffraction studies for 2a, 2b and 3b. The antiplatelet activity of the lead complexes 2b and 3a (IC50 = 0.5 \u03bc\u039c) is superior compared to that of 1a and 1b, while both complexes display a pronounced inhibitory activity against thrombin (IC50 = 1.8 \u03bcM and 0.6 \u03bcM). The in vitro cytotoxic activities of 3a and 2b on human Jurkat T lymphoblastic tumor cell line is higher than that of cisplatin.<\/jats:p>","DOI":"10.3390\/molecules28041859","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T02:04:03Z","timestamp":1676513043000},"page":"1859","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tin(II) and Tin(IV) Complexes Incorporating the Oxygen Tripodal Ligands [(\u03b75-C5R5)Co{P(OEt)2O}3]\u2212, (R = H, Me; Et = -C2H5) as Potent Inflammatory Mediator Inhibitors: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin"],"prefix":"10.3390","volume":"28","author":[{"given":"Alexandros","family":"Kalampalidis","sequence":"first","affiliation":[{"name":"Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artemis","family":"Damati","sequence":"additional","affiliation":[{"name":"Department of Environmental Engineering, School of Engineering, University of Patras, 26504 Patras, Greece"},{"name":"Department of Forestry and Environment Natural Management, School of Plant Sciences, Agricultural University of Athens, 11855 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-0125","authenticated-orcid":false,"given":"Demetrios","family":"Matthopoulos","sequence":"additional","affiliation":[{"name":"Department of Environmental Engineering, School of Engineering, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-9778","authenticated-orcid":false,"given":"Alexandros B.","family":"Tsoupras","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland"},{"name":"Health Research Institute, University of Limerick, V94 T9PX Limerick, Ireland"},{"name":"Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland"},{"name":"Department of Chemistry, International Hellenic University, 57001 Kavala, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-4411","authenticated-orcid":false,"given":"Constantinos A.","family":"Demopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-2106","authenticated-orcid":false,"given":"Gregor","family":"Schnakenburg","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Anorganische Chemie, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Gerhard-Domagk-Stra\u00dfe 1, D-53121 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-5654","authenticated-orcid":false,"given":"Athanassios I.","family":"Philippopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref_1","first-page":"349","article-title":"A Review of Organotin Compounds: Chemistry and Applications","volume":"3","author":"Duaa","year":"2018","journal-title":"Arc. 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