{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:25:50Z","timestamp":1788557150752,"version":"build-2803163510"},"reference-count":63,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education and Science of the Russian Federation","award":["075-15-2022-1143"],"award-info":[{"award-number":["075-15-2022-1143"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Three types of extraction were used to obtain biologically active substances from the heartwood of M. amurensis: supercritical CO2 extraction, maceration with EtOH, and maceration with MeOH. The supercritical extraction method proved to be the most effective type of extraction, giving the highest yield of biologically active substances. Several experimental conditions were investigated in the pressure range of 50\u2013400 bar, with 2% of ethanol as co-solvent in the liquid phase at a temperature in the range of 31\u201370 \u00b0C. The most effective extraction conditions are: pressure of 100 bar and a temperature of 55 \u00b0C for M. amurensis heartwood. The heartwood of M. amurensis contains various polyphenolic compounds and compounds of other chemical groups with valuable biological activity. Tandem mass spectrometry (HPLC-ESI\u2014ion trap) was applied to detect target analytes. High-accuracy mass spectrometric data were recorded on an ion trap equipped with an ESI source in the modes of negative and positive ions. The four-stage ion separation mode was implemented. Sixty-six different biologically active components have been identified in M. amurensis extracts. Twenty-two polyphenols were identified for the first time in the genus Maackia.<\/jats:p>","DOI":"10.3390\/molecules28052026","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T02:08:34Z","timestamp":1677031714000},"page":"2026","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Maackia amurensis Rupr. et Maxim.: Supercritical CO2 Extraction and Mass Spectrometric Characterization of Chemical Constituents"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9732-1649","authenticated-orcid":false,"given":"Mayya P.","family":"Razgonova","sequence":"first","affiliation":[{"name":"N.I. Vavilov All-Russian Institute of Plant Genetic Resources, B. Morskaya 42-44, 190000 Saint Petersburg, Russia"},{"name":"Department of Pharmacy and Pharmacology, School of Biomedicine, Far Eastern Federal University, Sukhanova 8, 690950 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena I.","family":"Cherevach","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, School of Biomedicine, Far Eastern Federal University, Sukhanova 8, 690950 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila A.","family":"Tekutyeva","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, School of Biomedicine, Far Eastern Federal University, Sukhanova 8, 690950 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-2099","authenticated-orcid":false,"given":"Sergey A.","family":"Fedoreyev","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, School of Biomedicine, Far Eastern Federal University, Sukhanova 8, 690950 Vladivostok, Russia"},{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100 let Vladivostoku 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-574X","authenticated-orcid":false,"given":"Natalia P.","family":"Mishchenko","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100 let Vladivostoku 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1769-3627","authenticated-orcid":false,"given":"Darya V.","family":"Tarbeeva","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100 let Vladivostoku 159, 690022 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina N.","family":"Demidova","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, School of Biomedicine, Far Eastern Federal University, Sukhanova 8, 690950 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita S.","family":"Kirilenko","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, School of Biomedicine, Far Eastern Federal University, Sukhanova 8, 690950 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-2281","authenticated-orcid":false,"given":"Kirill","family":"Golokhvast","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology, School of Biomedicine, Far Eastern Federal University, Sukhanova 8, 690950 Vladivostok, Russia"},{"name":"Laboratory of Supercritical Fluid Research and Application in Agrobiotechnology, The National Research Tomsk State University, Lenin Str. 36, 634050 Tomsk, Russia"},{"name":"Siberian Federal Scientific Centre of Agrobiotechnology, Centralnaya, Presidium, 633501 Krasnoobsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0031-9422(95)00270-H","article-title":"Stilbenolignan from Maackia amurensis","volume":"40","author":"Kulesh","year":"1995","journal-title":"Phytochemistry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10600-020-03051-w","article-title":"Isoflavone glycosides from root bark of Maackia amurensis","volume":"56","author":"Kulesh","year":"2020","journal-title":"Chem. 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