{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:50:23Z","timestamp":1769151023002,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"Deputyship for Research and Innovation, \u201dMinistry of Education\u201d in Saudi Arabia","doi-asserted-by":"publisher","award":["IFKSURG-2-350"],"award-info":[{"award-number":["IFKSURG-2-350"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Background: The remarkable properties of nickel oxide (NiO) and cerium oxide (CeO2) nanostructures have attracted considerable interest in these nanocomposites as potential electroactive materials for sensor construction. Methods: The mebeverine hydrochloride (MBHCl) content of commercial formulations was determined in this study using a unique factionalized CeO2\/NiO-nanocomposite-coated membrane sensor. Results: Mebeverine-phosphotungstate (MB-PT) was prepared by adding phosphotungstic acid to mebeverine hydrochloride and mixing with a polymeric matrix (polyvinyl chloride, PVC) and plasticizing agent o-nitrophenyl octyl ether. The new suggested sensor showed an excellent linear detection range of the selected analyte at 1.0 \u00d7 10\u22128\u20131.0 \u00d7 10\u22122 mol L\u22121 with regression equation EmV = (\u221229.429 \u00b1 0.2) log [MB] + 347.86. However, the unfunctionalized sensor MB\u2013PT displayed less linearity at 1.0 \u00d7 10\u22125\u20131.0 \u00d7 10\u22122 mol L\u22121 drug solution with regression equation EmV = (\u221226.603 \u00b1 0.5) log [MB] + 256.81. By considering a number of factors, the applicability and validity of the suggested potentiometric system were improved following the rules of analytical methodological requirements. Conclusion: The created potentiometric technique worked well for determining MB in bulk substance and in medical commercial samples.<\/jats:p>","DOI":"10.3390\/molecules28052095","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T01:37:52Z","timestamp":1677202672000},"page":"2095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prospective of Agro-Waste Husks for Biogenic Synthesis of Polymeric-Based CeO2\/NiO Nanocomposite Sensor for Determination of Mebeverine Hydrochloride"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-3173","authenticated-orcid":false,"given":"Gamal A. E.","family":"Mostafa","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha F.","family":"El-Tohamy","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitham","family":"Alrabiah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/smll.200400130","article-title":"Nanoscience, nanotechnology, and chemistry","volume":"1","author":"Whitesides","year":"2005","journal-title":"Small"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"116806","DOI":"10.1016\/j.trac.2022.116806","article-title":"Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis","volume":"29","author":"Tavakoli","year":"2022","journal-title":"TrAC Trends Anal. 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