{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:58:04Z","timestamp":1784879884851,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HerbElixa Ltd.","award":["1409"],"award-info":[{"award-number":["1409"]}]},{"name":"HerbElixa Ltd.","award":["ST01-2021\/00016"],"award-info":[{"award-number":["ST01-2021\/00016"]}]},{"name":"The Innovation Fund of the Republic of Serbia","award":["1409"],"award-info":[{"award-number":["1409"]}]},{"name":"The Innovation Fund of the Republic of Serbia","award":["ST01-2021\/00016"],"award-info":[{"award-number":["ST01-2021\/00016"]}]},{"name":"NALED (Belgrade, Serbia) in cooperation with Philip Morris Operations A.D. Ni\u0161 (Ni\u0161, Serbia) through the NALED StarTech Program","award":["1409"],"award-info":[{"award-number":["1409"]}]},{"name":"NALED (Belgrade, Serbia) in cooperation with Philip Morris Operations A.D. Ni\u0161 (Ni\u0161, Serbia) through the NALED StarTech Program","award":["ST01-2021\/00016"],"award-info":[{"award-number":["ST01-2021\/00016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Fifty percent of the world\u2019s population is infected with Helicobacter pylori, which can trigger many gastrointestinal disorders. H. pylori eradication therapy consists of two to three antimicrobial medicinal products, but they exhibit limited efficacy and may cause adverse side effects. Alternative therapies are urgent. It was assumed that an essential oil mixture, obtained from species from genera Satureja L., Origanum L. and Thymus L. and called the HerbELICO\u00ae essential oil mixture, could be useful in H. pylori infection treatment. HerbELICO\u00ae was analyzed by GC-MS and assessed in vitro against twenty H. pylori clinical strains isolated from patients of different geographical origins and with different antimicrobial medicinal products resistance profiles, and for its ability to penetrate the artificial mucin barrier. A customer case study included 15 users of HerbELICO\u00ae\u00a0 liquid\/HerbELICO\u00ae\u00a0 solid dietary supplements (capsulated HerbELICO\u00ae mixture in liquid\/solid form). Carvacrol and thymol were the most dominant compounds (47.44% and 11.62%, respectively), together with p-cymene (13.35%) and \u03b3-terpinene (18.20%). The minimum concentration required to inhibit in vitro H. pylori growth by HerbELICO\u00ae was 4\u20135% (v\/v); 10 min exposure to HerbELICO\u00ae was enough to kill off the examined H. pylori strains, while HerbELICO\u00ae was able to penetrate through mucin. A high eradication rate (up to 90%) and acceptance by consumers was observed.<\/jats:p>","DOI":"10.3390\/molecules28052138","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:10:46Z","timestamp":1677463846000},"page":"2138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Savory, Oregano and Thyme Essential Oil Mixture (HerbELICO\u00ae) Counteracts Helicobacter pylori"],"prefix":"10.3390","volume":"28","author":[{"given":"Ivan","family":"Nikoli\u0107","sequence":"first","affiliation":[{"name":"Oncology Institute of Vojvodina, Faculty of Medicine Novi Sad, University of Novi Sad, Put Doktora Goldmana 4, 21204 Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng Guan","family":"Chua","sequence":"additional","affiliation":[{"name":"Helicobacter Research Laboratory, The Marshall Centre for Infectious Diseases Research and Training, University of Western Australia, Perth, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-4010","authenticated-orcid":false,"given":"Alfred Chin Yen","family":"Tay","sequence":"additional","affiliation":[{"name":"Helicobacter Research Laboratory, The Marshall Centre for Infectious Diseases Research and Training, University of Western Australia, Perth, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kostre\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Polarislab, Branka Baji\u0107a 78, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Pavlovi\u0107","sequence":"additional","affiliation":[{"name":"Phytonet Ltd., Science Technology Park, Veljka Dugo\u0161evi\u0107a 54, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Jon\u010di\u0107 Savi\u0107","sequence":"additional","affiliation":[{"name":"Phytonet Ltd., Science Technology Park, Veljka Dugo\u0161evi\u0107a 54, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global prevalence of Helicobacter pylori infection: Systematic review and meta-analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/1319-3767.54743","article-title":"Helicobacter pylori infection in developing countries: The burden for how long?","volume":"15","author":"Salih","year":"2009","journal-title":"Saudi J. 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