{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:56:02Z","timestamp":1787313362714,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Dhaka","award":["2021-22"],"award-info":[{"award-number":["2021-22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Glycosmis cyanocarpa (Blume) Spreng is a plant in the Rutaceae family and a species in the Glycosmis genus that has received little attention. Therefore, this research aimed to report the chemical and biological analysis of Glycosmis cyanocarpa (Blume) Spreng. The chemical analysis involved the isolation and characterization of secondary metabolites through an extensive chromatographic study, and the structures of these metabolites were elucidated on the basis of a detailed analysis of NMR and HRESIMS spectroscopic data and by comparison with those of related compounds reported in the literature. Different partitions of the crude ethyl acetate (EtOAc) extract were evaluated for antioxidant, cytotoxic, and thrombolytic potentials. In chemical analysis, one new phenyl acetate derivative, namely 3,7,11,15-tetramethylhexadec-2-en-1-yl 2-phenylacetate (1), along with four known compounds N-methyl-3-(methylthio)-N-(2-phenylacetyl) acrylamide (2), penangin (3), \u03b2-Caryophyllene oxide (4), and acyclic diterpene-phytol (5) were isolated for the first time from the stem and leaf of the plant. The ethyl acetate fraction showed significant free radical scavenging activity with an IC50 value of 11.536 \u00b5g\/mL compared to standard ascorbic acid (4.816 \u00b5g\/mL). In the thrombolytic assay, the dichloromethane fraction showed the maximum thrombolytic activity of 16.42% but was still insignificant compared to the standard streptokinase (65.98%). Finally, in a brine shrimp lethality bioassay, the LC50 values of dichloromethane, ethyl acetate, and aqueous fractions were found to be 0.687 \u00b5g\/mL, 0.805 \u00b5g\/mL, and 0.982 \u00b5g\/mL which are significant compared to the standard vincristine sulfate of 0.272 \u00b5g\/mL.<\/jats:p>","DOI":"10.3390\/molecules28052207","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T02:01:51Z","timestamp":1677549711000},"page":"2207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isolation and Characterization of One New Natural Compound with Other Potential Bioactive Secondary Metabolites from Glycosmis cyanocarpa (Blume) Spreng. (Family: Rutaceae)"],"prefix":"10.3390","volume":"28","author":[{"given":"Md. Ariful","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-8500","authenticated-orcid":false,"given":"Sania","family":"Ashrafi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-8648","authenticated-orcid":false,"given":"Khondaker Miraz","family":"Rahman","sequence":"additional","affiliation":[{"name":"School of Cancer and Pharmaceutical Science, King\u2019s College London, 150 Stamford Street, London SE1 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamim","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Institute of National Analytical Research and Service (INARS), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H. M. Shofiul Islam","family":"Molla Jamal","sequence":"additional","affiliation":[{"name":"Institute of National Analytical Research and Service (INARS), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monira","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","article-title":"Natural Products in Drug Discovery","volume":"13","author":"Harvey","year":"2008","journal-title":"Drug Discov. 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