{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:36:24Z","timestamp":1787985384603,"version":"build-2784847793"},"reference-count":64,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University for funding this work through Research Group","award":["RG-21-09-92"],"award-info":[{"award-number":["RG-21-09-92"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Centaurea parviflora (C.\u00a0parviflora), belonging to the family Asteraceae, is an Algerian medicinal plant used in folk medicine to treat different diseases related to hyperglycemic and inflammatory disorders, as well as in food. The present study aimed to assess the total phenolic content, in vitro antioxidant and antimicrobial activity and phytochemical profile of the extracts of C. parviflora. The extraction of phenolic compounds from aerial parts was conducted using solvents of increasing polarity starting from methanol, resulting in crude extract (CE), to chloroform extract (CHE), ethyl acetate extract (EAE) and butanol extract (BUE). The total phenolic, flavonoid and flavonol contents of the extracts were determined using the Folin\u2013Ciocalteu and AlCl3 methods, respectively. The antioxidant activity was measured with seven methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, galvinoxyl free-radical-scavenging test, 2,2\u2032-Azino-Bis(3-Ethylbenzothiazoline-6-Sulfonic Acid) (ABTS) assay, cupric reducing antioxidant capacity (CUPRAC), reducing power, Fe+2-phenanthroline reduction assay and superoxide-scavenging test. The disc-diffusion method aimed at testing the sensitivity of bacterial strains toward our extracts. A qualitative analysis with thin-layer chromatography of the methanolic extract was performed. Moreover, HPLC-DAD-MS was used to establish the phytochemical profile of the BUE. The BUE was found to contain high amounts of total phenolics (175.27 \u00b1 2.79 \u00b5g GAE\/mg E), flavonoids (59.89 \u00b1 0.91 \u00b5g QE\/mg E) and flavonols (47.30 \u00b1 0.51 \u00b5g RE\/mg E). Using TLC, different components such as flavonoids and polyphenols were noted. The highest radical-scavenging ability was recorded for the BUE against DPPH (IC50 = 59.38 \u00b1 0.72 \u00b5g\/mL), galvinoxyl (IC50 = 36.25 \u00b1 0.42 \u00b5g\/mL), ABTS (IC50 = 49.52 \u00b1 1.54 \u00b5g\/mL) and superoxide (IC50 = 13.61 \u00b1 0.38 \u00b5g\/mL). The BUE had the best reducing power according to the CUPRAC (A0.5 = 71.80 \u00b1 1.22 \u03bcg\/mL), phenanthroline test (A0.5 = 20.29 \u00b1 1.16 \u03bcg\/mL) and FRAP (A0.5 = 119.17 \u00b1 0.29 \u03bcg\/mL). The LC-MS analysis of BUE allowed us to identify eight compounds including six phenolic acids and two flavonoids: quinic acid, five chlorogenic acid derivatives, rutin and quercetin 3-o-glucoside. This preliminary investigation revealed that the extracts of C. parviflora have a good biopharmaceutical activity. The BUE possesses an interesting potential for pharmaceutical\/nutraceutical applications.<\/jats:p>","DOI":"10.3390\/molecules28052263","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T01:36:09Z","timestamp":1677634569000},"page":"2263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Phytochemicals, Antioxidant and Antimicrobial Potentials and LC-MS Analysis of Centaurea parviflora Desf. Extracts"],"prefix":"10.3390","volume":"28","author":[{"given":"Fatima Zohra","family":"Hechaichi","sequence":"first","affiliation":[{"name":"Biodiversity and Biotechnological Techniques for Plant Resources Valorization Laboratory, Department of Natural and Life Sciences, Faculty of Sciences, University of Msila, Msila 28000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-8618","authenticated-orcid":false,"given":"Hamdi","family":"Bendif","sequence":"additional","affiliation":[{"name":"Biodiversity and Biotechnological Techniques for Plant Resources Valorization Laboratory, Department of Natural and Life Sciences, Faculty of Sciences, University of Msila, Msila 28000, Algeria"},{"name":"Laboratory of Ethnobotany and Natural Substances, Department of Natural Sciences, Ecole Normale Sup\u00e9rieure (ENS), Alger 16308, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawki","family":"Bensouici","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, UV 03, BP E7, Ali Mendjeli, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman A.","family":"Alsalamah","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boutheina","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Faculty of Nature and Life Sciences, University of Constantine, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha Mounir","family":"Bouhenna","sequence":"additional","affiliation":[{"name":"Scientific and Technical Research Center in Physico-Chemical Analysis, Algiers 16000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Souilah","sequence":"additional","affiliation":[{"name":"Laboratory for the Optimization of Agricultural Production in Sub-Humid Zones (LOPAZS), Department of Agricultural Sciences, Faculty of Sciences, University of Skikda, Skikda 21000, Algeria"},{"name":"Laboratory for Valorization of Natural Resources, Bioactive Molecules and Physico-Chemical and Biological Analysis, Department of Chemistry, University of Constantine, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed I.","family":"Alghonaim","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-6269","authenticated-orcid":false,"given":"Abderrahim","family":"Benslama","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry, University of Msila, Msila 28000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-4579","authenticated-orcid":false,"given":"Samir","family":"Medjekal","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry, University of Msila, Msila 28000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf A.","family":"Qurtam","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Djamel","family":"Miara","sequence":"additional","affiliation":[{"name":"Department and Faculty of Nature and Life Sciences, University of Tiaret, Tiaret 14000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fehmi","family":"Boufahja","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ympev.2019.03.012","article-title":"Spatio-temporal evolution of climbing habit in the Dahlia-Hidalgoa group (Coreopsidae, Asteraceae)","volume":"135","author":"Sosa","year":"2019","journal-title":"Mol. 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