{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:47:56Z","timestamp":1783522076812,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB20159029"],"award-info":[{"award-number":["AB20159029"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AD18126013"],"award-info":[{"award-number":["AD18126013"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["2019001"],"award-info":[{"award-number":["2019001"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["ZY21195044"],"award-info":[{"award-number":["ZY21195044"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific and Technology Development Program of Guangxi","award":["AB20159029"],"award-info":[{"award-number":["AB20159029"]}]},{"name":"Scientific and Technology Development Program of Guangxi","award":["AD18126013"],"award-info":[{"award-number":["AD18126013"]}]},{"name":"Scientific and Technology Development Program of Guangxi","award":["2019001"],"award-info":[{"award-number":["2019001"]}]},{"name":"Scientific and Technology Development Program of Guangxi","award":["ZY21195044"],"award-info":[{"award-number":["ZY21195044"]}]},{"name":"Science and Technology Innovation Team Project of Guangxi Botanical Garden of Medicinal Plants","award":["AB20159029"],"award-info":[{"award-number":["AB20159029"]}]},{"name":"Science and Technology Innovation Team Project of Guangxi Botanical Garden of Medicinal Plants","award":["AD18126013"],"award-info":[{"award-number":["AD18126013"]}]},{"name":"Science and Technology Innovation Team Project of Guangxi Botanical Garden of Medicinal Plants","award":["2019001"],"award-info":[{"award-number":["2019001"]}]},{"name":"Science and Technology Innovation Team Project of Guangxi Botanical Garden of Medicinal Plants","award":["ZY21195044"],"award-info":[{"award-number":["ZY21195044"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["AB20159029"],"award-info":[{"award-number":["AB20159029"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["AD18126013"],"award-info":[{"award-number":["AD18126013"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["2019001"],"award-info":[{"award-number":["2019001"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["ZY21195044"],"award-info":[{"award-number":["ZY21195044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Jigucao capsules (JGCC) have the effects of soothing the liver and gallbladder and clearing heat and detoxification. It is a good medicine for treating acute and chronic hepatitis cholecystitis with damp heat of the liver and gallbladder. However, the existing quality standard of JGCC does not have content determination items, which is not conducive to quality control. In this study, serum pharmacochemistry technology and UNIFI data processing software were used to identify the blood prototype components and metabolites under the condition of the obvious drug effects of JGCC, and the referenced literature reports and the results from in vitro analysis of JGCC in the early stage revealed a total of 43 prototype blood components and 33 metabolites in JGCC. Quality markers (Q-markers) were discovered, such as abrine, trigonelline, hypaphorine and isoschaftoside. In addition, ultra-high-performance liquid chromatography\u2013triple quadrupole mass spectrometry (UPLC-QQQ-MS) was used to determine the active ingredients in JGCC. The components of quantitative analysis have good correlation in the linear range with R2 \u2265 0.9993. The recovery rate is 93.15%~108.92% and the relative standard deviation (RSD) is less than 9.48%. The established UPLC-MS\/MS quantitative analysis method has high sensitivity and accuracy, and can be used for the quality evaluation of JGCC.<\/jats:p>","DOI":"10.3390\/molecules28062494","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T01:35:37Z","timestamp":1678325737000},"page":"2494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quality Markers\u2019 Discovery and Quality Evaluation of Jigucao Capsule Using UPLC-MS\/MS Method"],"prefix":"10.3390","volume":"28","author":[{"given":"Yanmei","family":"He","sequence":"first","affiliation":[{"name":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150036, China"},{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Wu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhien","family":"Tan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-6266","authenticated-orcid":false,"given":"Mengli","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Li","sequence":"additional","affiliation":[{"name":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-4472","authenticated-orcid":false,"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Miao","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ou","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihuo","family":"Long","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijun","family":"Wang","sequence":"additional","affiliation":[{"name":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Chinmedomics Research Center of State Administration of TCM, Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150036, China"},{"name":"National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning 500023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref_1","unstructured":"Xiao, B.D. (1970). Lingnan Herbs Collection, Guangdong Science and Technology Press."},{"key":"ref_2","first-page":"829","article-title":"Preliminary observation on the treatment of infectious hepatitis with Abrus cantoniensis","volume":"11","author":"Wang","year":"1958","journal-title":"Peoples Mil. Surg."},{"key":"ref_3","first-page":"715","article-title":"A preliminary report on curativeeffect of Jigucao powder on 57 cases of infectious hepatitis","volume":"9","author":"Bai","year":"1959","journal-title":"Peoples Mil. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jchromb.2018.02.035","article-title":"UPLC-G2Si-HDMS untargeted metabolomics for identification of metabolic targets of Yin-Chen-Hao-Tang used as a therapeutic agent of dampness-heat jaundice syndrome","volume":"1081\u20131082","author":"Sun","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"857361","DOI":"10.3389\/fphar.2022.857361","article-title":"Targets and Effective Constituents of ZhiziBaipi Decoction for Treating Damp-Heat Jaundice Syndrome Based on Chinmedomics Coupled with UPLC-MS\/MS","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Pharm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"822193","DOI":"10.3389\/fphar.2022.822193","article-title":"Metabolomics Analysis Coupled With UPLC\/MS on Therapeutic Effect of Jigucao Capsule Against Dampness-Heat Jaundice Syndrome","volume":"13","author":"He","year":"2022","journal-title":"Front. Pharm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123185","DOI":"10.1016\/j.jchromb.2022.123185","article-title":"High throughput metabolomics explores the mechanism of Jigucao capsules in treating Yanghuang syndrome rats using ultra-performance liquid chromatography quadrupole time of flight coupled with mass spectrometry","volume":"1194","author":"Li","year":"2022","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_8","first-page":"2036","article-title":"Discuss the efficacy of Jigucao capsule combined with antiviral treatment of chronic hepatitis B and its effect on liver function, serum TGF-\u03b21 and ECM levels","volume":"29","author":"Lei","year":"2018","journal-title":"Mod. Diagn. Treat."},{"key":"ref_9","first-page":"116","article-title":"Jigucao capsule combined with entecavir in the treatment of 24 cases of chronic hepatitis B","volume":"19","author":"Qin","year":"2013","journal-title":"Guid. J. Tradit. Chin. Med. Pharm."},{"key":"ref_10","first-page":"37","article-title":"The effect of Jigucao capsule adjuvant therapy on liver fibrosis in patients with non-alcoholic fatty liver disease","volume":"28","author":"Lei","year":"2018","journal-title":"Shenzhen J. Integr. Med."},{"key":"ref_11","first-page":"24","article-title":"Jigucao Capsule in the treatment of 30 cases of chronic cholecystitis","volume":"28","author":"Lin","year":"2007","journal-title":"Shanxi J. Tradit. Chin. Med."},{"key":"ref_12","first-page":"247","article-title":"Clinical observation of Jigucao capsule in the treatment of acute hepatitis","volume":"30","author":"Sui","year":"2002","journal-title":"Chin. Youjiang Med. J."},{"key":"ref_13","first-page":"46","article-title":"Therapeutic effect of Jigucao capsule on immune hepatic fibrosis in rats","volume":"8","author":"Wu","year":"2010","journal-title":"Guide Chin. Med."},{"key":"ref_14","first-page":"99","article-title":"Study on the protective effect of Jigucao capsule on liver fibrosis in rats","volume":"15","author":"Zhao","year":"2009","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_15","first-page":"1","article-title":"Study on Serum Medicinal Chemistry of Traditional Chinese Medicine and Chinese Medicine Compounds","volume":"4","author":"Wang","year":"2002","journal-title":"World Sci. Technol."},{"key":"ref_16","first-page":"13","article-title":"A systematic methodology for basic research on pharmacodynamics of traditional Chinese medicine\u2014Chinmedomics","volume":"40","author":"Wang","year":"2015","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_17","first-page":"1443","article-title":"Traditional Chinese medicine quality marker (Q-marker): A new concept for quality control of traditional Chinese medicine Products","volume":"47","author":"Liu","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"153165","DOI":"10.1016\/j.phymed.2019.153165","article-title":"Analytical strategies for the discovery and validation of quality-markers of traditional Chinese medicine","volume":"67","author":"Ren","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"153690","DOI":"10.1016\/j.phymed.2021.153690","article-title":"Deciphering the Q-markers of nourishing kidney-yin of Cortex Phellodendri amurense from ZhibaiDihuang pill based on Chinmedomics strategy","volume":"91","author":"Liu","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.phymed.2018.01.023","article-title":"Q-marker based strategy for CMC research of Chinese medicine: A case study of Panax Notoginseng saponins","volume":"44","author":"Zhong","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"152928","DOI":"10.1016\/j.phymed.2019.152928","article-title":"Discovery of quality-marker ingredients of Panax quinquefolius driven by high-throughput chinmedomics approach","volume":"74","author":"Xiong","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.phymed.2018.02.003","article-title":"A quality marker study on salvianolic acids for injection","volume":"44","author":"Li","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_23","unstructured":"(1998). Formulated Preparation of Traditional Chinese Medicine (Standard No. WS3-B-3420-98)."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jssc.202100664","article-title":"Rapid characterization of the constituents in Jigucao capsule using ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry","volume":"45","author":"Li","year":"2022","journal-title":"J. Sep. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/pca.2598","article-title":"Simultaneous Detection of Flavonoids, Phenolic Acids and Alkaloids in Abri Herba and Abri Mollis Herba using Liquid Chromatography Tandem Mass Spectrometry","volume":"27","author":"Yan","year":"2016","journal-title":"Phytochem. Anal. PCA"},{"key":"ref_26","first-page":"406","article-title":"Determination of the concentrations and excretion kinetics of the main components in the urine and bile of rats by HPLC-MS\/MS","volume":"38","author":"Liu","year":"2018","journal-title":"Chin. J. Pharm. Anal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0021-9673(01)82148-8","article-title":"Determination of geniposide, gardenoside, geniposidic acid and genipin-1-beta- gentiobioside in Gardenia jasminoides by high-performance liquid chromatography","volume":"455","author":"Oshima","year":"1988","journal-title":"J. Chromatogr."},{"key":"ref_28","first-page":"484","article-title":"Simultaneous Determination of 15 Components in Medicinal and Ornamental Peony by UPLC-MS\/MS","volume":"42","author":"Zhang","year":"2022","journal-title":"Chin. J. Pharm. Anal."},{"key":"ref_29","first-page":"220","article-title":"Determination of taurocholic acid, taurochenodeoxycholic acid and taurodeoxycholic acid in artificial snake bile by reversed-phase high performance liquid chromatography","volume":"29","author":"Xiang","year":"2000","journal-title":"Univ. Sci. Technol. Huazhong"},{"key":"ref_30","first-page":"4291","article-title":"Simultaneous determination of five components including tauroursodeoxycholic acid in biotransformation samples by HPLC-ELSD","volume":"25","author":"Zhao","year":"2014","journal-title":"China Pharm."},{"key":"ref_31","first-page":"667","article-title":"Quantitative study of 6, 7-dimethoxy-coumarin and capillarisin and its compound preparation","volume":"19","author":"Wang","year":"1994","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_32","first-page":"1702","article-title":"RP-HPLC method was used for simultaneous determination of abrine and hypaphorine","volume":"29","author":"Huang","year":"2009","journal-title":"Chin. J. Pharm. Anal."},{"key":"ref_33","first-page":"7609676","article-title":"Abrine Elicits Liver Carcinoma Immunity and Enhances Antitumor Efficacy of Immune Checkpoint Blockade by Modulating PD-L1 Signaling","volume":"2022","author":"Zhang","year":"2022","journal-title":"J. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fct.2018.09.011","article-title":"Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL\/6J mice, via restoration of hepatic autophagy","volume":"121","author":"Sharma","year":"2018","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2122563","DOI":"10.1155\/2022\/2122563","article-title":"Isoschaftoside Reverses Nonalcoholic Fatty Liver Disease via Activating Autophagy In Vivo and In Vitro","volume":"2022","author":"Su","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"862006","DOI":"10.3389\/fvets.2022.862006","article-title":"Protective Effects of Abrus cantoniensis Hance on the Fatty Liver Hemorrhagic Syndrome in Laying Hens Based on Liver Metabolomics and Gut Microbiota","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115394","DOI":"10.1016\/j.jep.2022.115394","article-title":"Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor","volume":"294","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3892\/mmr.2022.12694","article-title":"Ginsenoside Rg1 exerts anti-apoptotic effects on non-alcoholic fatty liver cells by downregulating the expression of SGPL1","volume":"25","author":"Li","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_39","first-page":"8","article-title":"The protective effect of ginsenoside Rb1 on cantharidin-induced hepatotoxicity in SD rats","volume":"18","author":"Hu","year":"2022","journal-title":"Asia-Pac. Tradit. Med."},{"key":"ref_40","first-page":"4028","article-title":"Study on the mechanism of ginsenoside Rb1 in improving restraint stress and lipopolysaccharide-induced immune liver injury in mice","volume":"53","author":"Wang","year":"2022","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"175096","DOI":"10.1016\/j.ejphar.2022.175096","article-title":"Ameliorative effects of chlorogenic acid on alcoholic liver injury in mice via gut microbiota informatics","volume":"928","author":"Zhu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109020","DOI":"10.1016\/j.jnutbio.2022.109020","article-title":"Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism","volume":"106","author":"Miao","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"108760","DOI":"10.18632\/oncotarget.21897","article-title":"Dissect new mechanistic insights for geniposide efficacy on the hepatoprotection using multiomics approach","volume":"8","author":"Qiu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1039\/C6MB00742B","article-title":"High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chromatography coupled to high resolution mass spectrometry","volume":"13","author":"Zhang","year":"2016","journal-title":"Mol. Biosyst."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Lee, H.I., Seo, K.O., Yun, K.W., Kim, M.J., and Lee, M.K. (2011). Comparative study of the hepatoprotective efficacy of Artemisia iwayomogi\u2002and Artemisia capillaris on ethanol-administered mice. J. Food Sci., 76.","DOI":"10.1111\/j.1750-3841.2011.02385.x"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"37519","DOI":"10.1038\/srep37519","article-title":"Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndrome","volume":"6","author":"Fang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.fct.2013.03.016","article-title":"Scoparone attenuates D-galactosamine\/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice","volume":"57","author":"Kang","year":"2013","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jceh.2021.08.017","article-title":"Current Understanding of Bile Acids in Chronic Liver Disease","volume":"12","author":"Farooqui","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s41374-021-00628-z","article-title":"Bile acid-induced tissue factor activity in hepatocytes correlates with activation of farnesoid X receptor","volume":"101","author":"Greimel","year":"2021","journal-title":"Lab. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1388-1981(01)00184-6","article-title":"Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line","volume":"1580","author":"Carubbi","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/hep.510250601","article-title":"Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans","volume":"25","author":"Loria","year":"1997","journal-title":"Hepatology"},{"key":"ref_52","first-page":"1","article-title":"Research path of compound traditional Chinese medicine quality marker (Q-marker) based on \u201cfive principles\u201d","volume":"49","author":"Zhang","year":"2018","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_53","first-page":"41","article-title":"Determination of geniposide in Jigucao Capsules","volume":"14","author":"Wang","year":"2007","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"key":"ref_54","first-page":"271","article-title":"Determination of abrine in Jigucao Capsules by High Performance Liquid Chromatography","volume":"27","author":"Li","year":"2011","journal-title":"J. Guangdong Pharm. Univ."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/6\/2494\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:51:23Z","timestamp":1760122283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/6\/2494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":54,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["molecules28062494"],"URL":"https:\/\/doi.org\/10.3390\/molecules28062494","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]}}}