{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:58:27Z","timestamp":1789239507749,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union","award":["778051"],"award-info":[{"award-number":["778051"]}]},{"name":"European Union","award":["3899\/ H2020\/2018\/2"],"award-info":[{"award-number":["3899\/ H2020\/2018\/2"]}]},{"name":"Ministry of Science and Higher Education of Poland","award":["778051"],"award-info":[{"award-number":["778051"]}]},{"name":"Ministry of Science and Higher Education of Poland","award":["3899\/ H2020\/2018\/2"],"award-info":[{"award-number":["3899\/ H2020\/2018\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The influence of ionizing radiation on the physicochemical properties of quercetin and rutin in the solid state was studied. Quercetin and rutin were irradiated with the standard recommended radiation dose (25 kGy) according to EN 522 standard. The samples were irradiated by electron beam radiation. EPR studies indicate the formation of a small number of free radicals due to irradiation. Moreover, some radicals recombined with the mean lifetime of 1200 and 93 h, and a stable radical concentration reached only 0.29 and 0.90 ppm for quercetin and rutin, respectively. The performed spectroscopic study (FT-IR) confirmed the radiostability of the flavonoids tested. Chromatographic tests (HPLC, HPLC-MS) showed that irradiation of quercetin and rutin with a 25 kGy dose did not change the physicochemical properties of the tested compounds. Degradation products were not observed. The antioxidant activities were determined by the 2,2-diphenyl-1-pycrylhydrazyl (DPPH) free radical scavenging activity assay, ABTS Radical Scavenging Assay (ABTS), Ferric Reducing Antioxidant Power Assay (FRAP), Cupric Ion Reducing Antioxidant Capacity Assay (CUPRAC). The conducted research confirmed that exposure to ionizing radiation does not change the chemical structure of tested flavonoids and their antioxidant properties.<\/jats:p>","DOI":"10.3390\/molecules28062713","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T03:33:57Z","timestamp":1679024037000},"page":"2713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Do Rutin and Quercetin Retain Their Structure and Radical Scavenging Activity after Exposure to Radiation?"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-6413","authenticated-orcid":false,"given":"Natalia","family":"Rosiak","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-5419","authenticated-orcid":false,"given":"Judyta","family":"Cielecka-Piontek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8429-7515","authenticated-orcid":false,"given":"Robert","family":"Skibi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2063-7805","authenticated-orcid":false,"given":"Kornelia","family":"Lewandowska","sequence":"additional","affiliation":[{"name":"Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-7501","authenticated-orcid":false,"given":"Waldemar","family":"Bednarski","sequence":"additional","affiliation":[{"name":"Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-9426","authenticated-orcid":false,"given":"Przemys\u0142aw","family":"Zalewski","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ajcn\/88.1.38","article-title":"Flavonoids, flavonoid-rich foods, and cardiovascular risk: A meta-analysis of randomized controlled trials","volume":"88","author":"Hooper","year":"2008","journal-title":"Am. 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