{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:50:15Z","timestamp":1790977815698,"version":"4.1.0"},"reference-count":142,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lublin","award":["DS. 730"],"award-info":[{"award-number":["DS. 730"]}]},{"name":"Medical University of Lublin","award":["UPH\/WNSP\/ICH\/zadaniebadawcze\/143\/23\/B"],"award-info":[{"award-number":["UPH\/WNSP\/ICH\/zadaniebadawcze\/143\/23\/B"]}]},{"name":"Siedlce University of Natural Sciences and Humanities","award":["DS. 730"],"award-info":[{"award-number":["DS. 730"]}]},{"name":"Siedlce University of Natural Sciences and Humanities","award":["UPH\/WNSP\/ICH\/zadaniebadawcze\/143\/23\/B"],"award-info":[{"award-number":["UPH\/WNSP\/ICH\/zadaniebadawcze\/143\/23\/B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand. Sharpless introduced this methodology after considering the importance of enantioselectivity in the total synthesis of medicinally important compounds. Vicinal diols, produced as a result of this reaction, act as intermediates in the synthesis of different naturally occurring compounds. Hence, Sharpless asymmetric dihydroxylation plays an important role in synthetic organic chemistry due to its undeniable contribution to the synthesis of biologically active organic compounds. This review emphasizes the significance of Sharpless asymmetric dihydroxylation in the total synthesis of various natural products, published since 2020.<\/jats:p>","DOI":"10.3390\/molecules28062722","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T03:09:37Z","timestamp":1679281777000},"page":"2722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review"],"prefix":"10.3390","volume":"28","author":[{"given":"Aqsa","family":"Mushtaq","sequence":"first","affiliation":[{"name":"Medicinal Chemistry Research Lab, Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-8848","authenticated-orcid":false,"given":"Ameer Fawad","family":"Zahoor","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Lab, Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-6138","authenticated-orcid":false,"given":"Muhammad","family":"Bilal","sequence":"additional","affiliation":[{"name":"College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-3887","authenticated-orcid":false,"given":"Syed Makhdoom","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Zoology, Government College University Faisalabad, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Irfan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Government College University Faisalabad, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Lab, Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan"},{"name":"Department of Chemistry, Superior University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8977-3303","authenticated-orcid":false,"given":"Ali","family":"Irfan","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Lab, Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kotwica-Mojzych","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cytology, Medical University of Lublin, Radziwi\u0142\u0142owska 11, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-6068","authenticated-orcid":false,"given":"Mariusz","family":"Mojzych","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Siedlce University of Natural Sciences and Humanities, 3-Go Maja 54, 08-110 Siedlce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref_1","first-page":"1899","article-title":"Chiral auxiliaries\u2014Principles and recent applications","volume":"12","author":"Gnas","year":"2006","journal-title":"Synthesis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1016\/S0040-4020(01)86657-6","article-title":"A highly efficient kinetic resolution of \u03b3- and \u03b2-trimethylsilyl secondary allylic alcohols by the sharpless asymmetric epoxidation","volume":"44","author":"Kitano","year":"1988","journal-title":"Tetrahedron"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1021\/jo00289a066","article-title":"Osmium tetraoxide catalyzed vicinal hydroxylation of higher olefins by using hexacyanoferrate(III) ion as a cooxidant","volume":"55","author":"Minato","year":"1999","journal-title":"J. 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