{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:51:19Z","timestamp":1793076679506,"version":"4.5.0"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of China","award":["22271027"],"award-info":[{"award-number":["22271027"]}]},{"name":"Natural Science Foundation of China","award":["22171029"],"award-info":[{"award-number":["22171029"]}]},{"name":"Natural Science Foundation of China","award":["21901024"],"award-info":[{"award-number":["21901024"]}]},{"name":"Natural Science Foundation of China","award":["21871252"],"award-info":[{"award-number":["21871252"]}]},{"name":"Natural Science Foundation of China","award":["2021YFS0315"],"award-info":[{"award-number":["2021YFS0315"]}]},{"name":"Natural Science Foundation of China","award":["2081919035"],"award-info":[{"award-number":["2081919035"]}]},{"name":"Natural Science Foundation of China","award":["2081921038"],"award-info":[{"award-number":["2081921038"]}]},{"name":"Sichuan Science and Technology Program","award":["22271027"],"award-info":[{"award-number":["22271027"]}]},{"name":"Sichuan Science and Technology Program","award":["22171029"],"award-info":[{"award-number":["22171029"]}]},{"name":"Sichuan Science and Technology Program","award":["21901024"],"award-info":[{"award-number":["21901024"]}]},{"name":"Sichuan Science and Technology Program","award":["21871252"],"award-info":[{"award-number":["21871252"]}]},{"name":"Sichuan Science and Technology Program","award":["2021YFS0315"],"award-info":[{"award-number":["2021YFS0315"]}]},{"name":"Sichuan Science and Technology Program","award":["2081919035"],"award-info":[{"award-number":["2081919035"]}]},{"name":"Sichuan Science and Technology Program","award":["2081921038"],"award-info":[{"award-number":["2081921038"]}]},{"name":"Talent Program of Chengdu University","award":["22271027"],"award-info":[{"award-number":["22271027"]}]},{"name":"Talent Program of Chengdu University","award":["22171029"],"award-info":[{"award-number":["22171029"]}]},{"name":"Talent Program of Chengdu University","award":["21901024"],"award-info":[{"award-number":["21901024"]}]},{"name":"Talent Program of Chengdu University","award":["21871252"],"award-info":[{"award-number":["21871252"]}]},{"name":"Talent Program of Chengdu University","award":["2021YFS0315"],"award-info":[{"award-number":["2021YFS0315"]}]},{"name":"Talent Program of Chengdu University","award":["2081919035"],"award-info":[{"award-number":["2081919035"]}]},{"name":"Talent Program of Chengdu University","award":["2081921038"],"award-info":[{"award-number":["2081921038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Catalytic asymmetric dearomative [3+2] cycloaddition of \u03b1-imino \u03b3-lactones with either 3-nitroindoles or 2-nitrobenzofurans by using a chiral copper complex as the catalyst was developed. A wide range of structurally diverse polyheterocyclic compounds containing spirocyclic-fused butyrolactone-pyrrolidine-indoline and butyrolactone\u2013pyrrolidine\u2013dihydrobenzofuran skeletons could be smoothly obtained with excellent results (&gt;99:1 dr and 98% ee). The potential synthetic applications of this methodology were also demonstrated by the scale-up experiment and by the diverse transformations of one product. This method is characterized by high asymmetric induction, wide functional group tolerance and scalability, and attractive product diversification.<\/jats:p>","DOI":"10.3390\/molecules28062765","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T03:30:31Z","timestamp":1679283031000},"page":"2765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Copper-Catalyzed Asymmetric Dearomative [3+2] Cycloaddition of Nitroheteroarenes with Azomethines"],"prefix":"10.3390","volume":"28","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China"},{"name":"Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-9630","authenticated-orcid":false,"given":"Jian-Qiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Qiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China"},{"name":"Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China"},{"name":"Department of Chemistry, Xihua University, Chengdu 610039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Cheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China"},{"name":"Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1055\/s-2006-960860","article-title":"Bioactive Indole Alkaloids from the Bark of Uncaria guianensis","volume":"65","author":"Lee","year":"1999","journal-title":"Planta Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-2999(02)01608-4","article-title":"Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte","volume":"444","author":"Kang","year":"2002","journal-title":"Eur. 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These data can be obtained free of charge from The Cambridge Crystallographic Data Center via www.ccdc.cam.ac.uk\/data_request\/cif, or by emailing data_request@ccdc.cam.ac.uk."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/6\/2765\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:58:38Z","timestamp":1760122718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/6\/2765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,19]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["molecules28062765"],"URL":"https:\/\/doi.org\/10.3390\/molecules28062765","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,19]]}}}