{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:54:50Z","timestamp":1784840090816,"version":"3.55.0"},"reference-count":45,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Community - PNRR \u201cNational Biodiversity Future Center&quot; - Tematica: &quot;Bio-diversit\u00e0\u201d, Missione 4 Istruzione e Ricerca \u2013Componente 2 Dalla ricerca all\u2019impresa \u2013 Investimento 1.4, \u201cPotenziamento strutture di ricerca e creazione di &quot;campioni nazionali","award":["D.D. MUR di concessione Prot. 1034 (17-06-2022)"],"award-info":[{"award-number":["D.D. MUR di concessione Prot. 1034 (17-06-2022)"]}]},{"name":"European Community - PNRR \u201cNational Biodiversity Future Center&quot; - Tematica: &quot;Bio-diversit\u00e0\u201d, Missione 4 Istruzione e Ricerca \u2013Componente 2 Dalla ricerca all\u2019impresa \u2013 Investimento 1.4, \u201cPotenziamento strutture di ricerca e creazione di &quot;campioni nazionali","award":["VPMA-4-2022\/12"],"award-info":[{"award-number":["VPMA-4-2022\/12"]}]},{"name":"European Community - PNRR \u201cNational Biodiversity Future Center&quot; - Tematica: &quot;Bio-diversit\u00e0\u201d, Missione 4 Istruzione e Ricerca \u2013Componente 2 Dalla ricerca all\u2019impresa \u2013 Investimento 1.4, \u201cPotenziamento strutture di ricerca e creazione di &quot;campioni nazionali","award":["Prot.n.0006848 del 21\/01\/2022-[UOR:SI001006-Classif.III\/13]"],"award-info":[{"award-number":["Prot.n.0006848 del 21\/01\/2022-[UOR:SI001006-Classif.III\/13]"]}]},{"name":"Centre National de la Recherche Scientifique et Technique (CNRST)  Agence Nationale des Plantes M\u00e9dicinales et Aromatiques (ANPMA)  Cadi Ayyad University","award":["D.D. MUR di concessione Prot. 1034 (17-06-2022)"],"award-info":[{"award-number":["D.D. MUR di concessione Prot. 1034 (17-06-2022)"]}]},{"name":"Centre National de la Recherche Scientifique et Technique (CNRST)  Agence Nationale des Plantes M\u00e9dicinales et Aromatiques (ANPMA)  Cadi Ayyad University","award":["VPMA-4-2022\/12"],"award-info":[{"award-number":["VPMA-4-2022\/12"]}]},{"name":"Centre National de la Recherche Scientifique et Technique (CNRST)  Agence Nationale des Plantes M\u00e9dicinales et Aromatiques (ANPMA)  Cadi Ayyad University","award":["Prot.n.0006848 del 21\/01\/2022-[UOR:SI001006-Classif.III\/13]"],"award-info":[{"award-number":["Prot.n.0006848 del 21\/01\/2022-[UOR:SI001006-Classif.III\/13]"]}]},{"name":"Erasmus+ KA107 program","award":["D.D. MUR di concessione Prot. 1034 (17-06-2022)"],"award-info":[{"award-number":["D.D. MUR di concessione Prot. 1034 (17-06-2022)"]}]},{"name":"Erasmus+ KA107 program","award":["VPMA-4-2022\/12"],"award-info":[{"award-number":["VPMA-4-2022\/12"]}]},{"name":"Erasmus+ KA107 program","award":["Prot.n.0006848 del 21\/01\/2022-[UOR:SI001006-Classif.III\/13]"],"award-info":[{"award-number":["Prot.n.0006848 del 21\/01\/2022-[UOR:SI001006-Classif.III\/13]"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Background: The genus Cistus L. (Cistaceae) includes several medicinal plants growing wild in the Moroccan area. Acne vulgaris (AV) is a chronic skin disorder treated with topical and systemic therapies that often lead to several side effects in addition to the development of antimicrobial resistance. Our study aimed to investigate the bioactivity of extracts of two Moroccan Cistus species, Cistus laurifolius L. and Cistus salviifolius L., in view of their use as potential coadjuvants in the treatment of mild acne vulgaris. Methods: Targeted phytochemical profiles obtained by HPLC-DAD and HPLC-ESI\/MS analyses and biological activities ascertained by several antioxidants in vitro chemical and cell-based assays of the leaf extracts. Moreover, antimicrobial activity against Gram-positive and Gram-negative bacteria, and Candida albicans was evaluated. Results: Analyses revealed the presence of several polyphenols in the studied extracts, mainly flavonoids and tannins. Cistus laurifolius L. and Cistus salviifolius L. possessed good biological properties and all extracts showed antibacterial activity, particularly against Staphylococcus aureus, S. epidermidis, and Propionibacterium acnes, identified as the main acne-causing bacteria. Conclusion: The results suggest that examined extracts are promising agents worthy of further studies to develop coadjuvants\/natural remedies for mild acne treatment.<\/jats:p>","DOI":"10.3390\/molecules28062797","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:56:37Z","timestamp":1679298997000},"page":"2797","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Two Moroccan Cistus Species Extracts against Acne Vulgaris: Phytochemical Profile, Antioxidant, Anti-Inflammatory and Antimicrobial Activities"],"prefix":"10.3390","volume":"28","author":[{"given":"Maryem","family":"Bouabidi","sequence":"first","affiliation":[{"name":"Laboratory of Sustainable Development and Health Research (LRDDS), Faculty of Sciences and Technology, Cadi Ayyad University, 549 Bd Abdelkrim Al Khattabi, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-2120","authenticated-orcid":false,"given":"Federica Lina","family":"Salamone","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 di Messina, Viale F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-5362","authenticated-orcid":false,"given":"Chemseddoha","family":"Gadhi","sequence":"additional","affiliation":[{"name":"Laboratory of Agri-Food, Biotechnology and Valorization of Plant Bioresources, Faculty of Sciences Semlalia, Cadi Ayyad University, Bd. Prince My Abdellah, B.P. 2390, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2739-5896","authenticated-orcid":false,"given":"Hafida","family":"Bouamama","sequence":"additional","affiliation":[{"name":"Laboratory of Sustainable Development and Health Research (LRDDS), Faculty of Sciences and Technology, Cadi Ayyad University, 549 Bd Abdelkrim Al Khattabi, Marrakesh 40000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6135-3892","authenticated-orcid":false,"given":"Antonio","family":"Speciale","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 di Messina, Viale F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Ginestra","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 di Messina, Viale F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Pulvirenti","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare del Consiglio Nazionale delle Ricerche (ICB-CNR), Via Paolo Gaifami, 18, 95126 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3771-3138","authenticated-orcid":false,"given":"Laura","family":"Siracusa","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare del Consiglio Nazionale delle Ricerche (ICB-CNR), Via Paolo Gaifami, 18, 95126 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4280-7895","authenticated-orcid":false,"given":"Antonia","family":"Nostro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 di Messina, Viale F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-9616","authenticated-orcid":false,"given":"Mariateresa","family":"Cristani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 di Messina, Viale F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/bjd.12149","article-title":"Epidemiology of acne vulgaris","volume":"168","author":"Bhate","year":"2013","journal-title":"Br. J. 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