{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:39:14Z","timestamp":1789684754634,"version":"4.0.1"},"reference-count":55,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/27161-0"],"award-info":[{"award-number":["2019\/27161-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["5344"],"award-info":[{"award-number":["5344"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Scientific and Technological Development","doi-asserted-by":"publisher","award":["2019\/27161-0"],"award-info":[{"award-number":["2019\/27161-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Scientific and Technological Development","doi-asserted-by":"publisher","award":["5344"],"award-info":[{"award-number":["5344"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","award":["2019\/27161-0"],"award-info":[{"award-number":["2019\/27161-0"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","award":["5344"],"award-info":[{"award-number":["5344"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Candida spp. cause fungal infection that affects patients\u2019 oral health. This study aimed to evaluate the isolated and synergistic antifungal effect of Rosa centifolia L., Curcuma longa L., Rosmarinus officinalis L., and Punica granatum L. glycolic extracts against Candida albicans, Candida dubliniensis, Candida tropicalis, and Candida krusei planktonic and biofilm forms. The plant extracts were chemically characterized and the main compounds were quantified by high-performance liquid chromatography (HPLC-DAD) analysis. The minimum inhibitory and minimum fungicidal concentrations of the extracts were determined, and antibiofilm activity was evaluated by MTT assay. Data were analyzed by one-way ANOVA and Tukey\u2019s tests, and by Kruskal\u2013Wallis and Dunn\u2019s tests, considering a significance level of 5%. The main compounds identified in each of the extracts were: p-coumaric acid (2153.22 \u03bcg\/100 mL) in the rosemary extract, gallotannins (4318.31 \u03bcg\/100 mL) in the pomegranate extract, quercetin derivatives (3316.50 \u03bcg\/100 mL) in the extract of white roses, and curcumin (135.09 \u03bcg\/100 mL) in the turmeric extract. The combination of R. centifolia and C. longa glycolic extracts was effective against C. albicans, C. dubliniensis, and C. tropicalis biofilms over different periods (p &lt; 0.05). The combination of R. officinalis and P. granatum glycolic extracts was effective against C. albicans and C. krusei biofilms after 30 min, and against C. tropicalis after 24 h, with all combinations showing an average reduction of 50% in cell viability (p &lt; 0.05). In conclusion, the combined plant extracts have antifungal and antibiofilm action against Candida spp. in different concentrations and times of action.<\/jats:p>","DOI":"10.3390\/molecules28062857","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T06:35:28Z","timestamp":1679466928000},"page":"2857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antifungal Action of Herbal Plants\u2019 Glycolic Extracts against Candida Species"],"prefix":"10.3390","volume":"28","author":[{"given":"Vanessa Marques","family":"Meccatti","sequence":"first","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana Ferreira","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Steffany","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Bulh\u00f5es","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio Antonio Talge","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-5618","authenticated-orcid":false,"given":"Maria Cristina","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-985X","authenticated-orcid":false,"given":"Amjad","family":"Abu Hasna","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane Dias","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (ICT-UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"K\u00f6hler, J.R., Hube, B., Puccia, R., Casadevall, A., and Perfect, J.R. 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