{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:47:00Z","timestamp":1764874020565,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico-CNPq","doi-asserted-by":"publisher","award":["408369\/2016-7","AUXPE-CIMAR-1956\/2014"],"award-info":[{"award-number":["408369\/2016-7","AUXPE-CIMAR-1956\/2014"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento Pessoal de N\u00edvel Superior (CAPES)","doi-asserted-by":"publisher","award":["408369\/2016-7","AUXPE-CIMAR-1956\/2014"],"award-info":[{"award-number":["408369\/2016-7","AUXPE-CIMAR-1956\/2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Oreochromis niloticus (tilapia) is one of the most cultivated fish species worldwide. Tilapia farming generates organic waste from fish removal processes in nurseries. Visceral waste can damage natural ecosystems. Therefore, the use of this material as a source of biomolecules helps reduce environmental impacts and improve pharmacological studies. Tilapia viscera were subjected to proteolysis and complexation with an ion-exchange resin. The obtained glycosaminoglycans were purified using ion exchange chromatography (DEAE-Sephacel). The electrophoretic profile and analysis of 1H\/13C nuclear magnetic resonance (NMR) spectra allowed for the characterization of the compound as chondroitin sulfate and its sulfation position. This chondroitin was named CST. We tested the ability of CST to reduce leukocyte influx in acute peritonitis models induced by sodium thioglycolate and found a significant reduction in leukocyte migration to the peritoneal cavity, similar to the polymorphonuclear population of the three tested doses of CST. This study shows, for the first time, the potential of CST obtained from O. niloticus waste as an anti-inflammatory drug, thereby contributing to the expansion of the study of molecules with pharmacological functions.<\/jats:p>","DOI":"10.3390\/molecules28073082","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T04:45:35Z","timestamp":1680151535000},"page":"3082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chondroitin Sulfate from Oreochromis niloticus Waste Reduces Leukocyte Influx in an Acute Peritonitis Model"],"prefix":"10.3390","volume":"28","author":[{"given":"Marianna Barros","family":"Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia de Lourdes de Sousa","family":"Pinto","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Henrique","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Airton Ara\u00fajo","family":"Souza","sequence":"additional","affiliation":[{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Rio Grande do Norte, Campus de Parnamirim, Parnamirim 59143-455, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suely Ferreira","family":"Chavante","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Guimar\u00e3es Alves","family":"Filgueira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5109-1991","authenticated-orcid":false,"given":"Rafael Barros Gomes","family":"Camara","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-168X","authenticated-orcid":false,"given":"Guilherme Lanzi","family":"Sassaki","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular, Setor de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Parana (UFPR), Curitiba 81531-980, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-1221","authenticated-orcid":false,"given":"Hugo Alexandre Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulianna Paiva Viana","family":"Andrade","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","unstructured":"FAO (2022). 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