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screening of antihypertensive drugs, but the nonspecific adsorption is a serious problem in separation processes involving complex biological products. In this study, triblock copolymers with dopamine (DA) block as anchors and PEG block as the main body (DA-PEGx-DA) were attached to an immobilized ACE (ACE@mZIF-8\/PDA, AmZP) surface via the \u201cgrafting to\u201d strategy which endowed them with anti-nonspecific adsorption. The influence of DA-PEGx-DA chain length on nonspecific adsorption was confirmed. The excellent specificity and reusability of the obtained ACE@mZIF-8\/PDA\/DA-PEG5000-DA (AmZPP5000) was validated by screening two known ACE inhibitory peptides Val-Pro-Pro (VPP, competitive inhibitory peptides of ACE) and Gly-Met-Lys-Cys-Ala-Phe (GF-6, noncompetitive inhibitory peptides of ACE) from a mixture containing active and inactive compounds. These results demonstrate that anchored polymer loops are effective for high-recognition selectivity and AmZPP5000 is a promising compound for the efficient separation of ACE inhibitors in biological samples.<\/jats:p>","DOI":"10.3390\/molecules28073117","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T02:08:01Z","timestamp":1680228481000},"page":"3117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anchoring of Polymer Loops on Enzyme-Immobilized Mesoporous ZIF-8 Enhances the Recognition Selectivity of Angiotensin-Converting Enzyme Inhibitory Peptides"],"prefix":"10.3390","volume":"28","author":[{"given":"Zefen","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China"},{"name":"Institute of Biological Manufacturing Technology Co., Ltd., Guangxi Institute of Industrial Technology, Nanning 530002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dankui","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengru","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China"},{"name":"Key Laboratory of New Technology for Chemical and Biological Transformation Process of Guangxi Higher Education Institutes, Guangxi Minzu University, Nanning 530006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongdiao","family":"Lan","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China"},{"name":"Key Laboratory of New Technology for Chemical and Biological Transformation Process of Guangxi Higher Education Institutes, Guangxi Minzu University, Nanning 530006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1039\/D1FO03570C","article-title":"The effects of angiotensin I-converting enzyme inhibitory peptide vginyw and the hydrolysate of \u03b1-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats","volume":"13","author":"Xie","year":"2022","journal-title":"Food Funct."},{"key":"ref_2","first-page":"e202103336","article-title":"Design and synthesis of angiotensin converting enzyme(ace)inhibitors: Analysis of the role of tetrazole ring appended to biphenyl moiety","volume":"7","author":"Bayannavar","year":"2022","journal-title":"Chem. 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