{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:38:51Z","timestamp":1791689931141,"version":"4.3.4"},"reference-count":110,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Najran University","award":["NU\/RG\/MRC\/12\/13"],"award-info":[{"award-number":["NU\/RG\/MRC\/12\/13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this review, we describe and discuss the phytoconstituents present in Hedychium species and emphasize their potential as drug candidates. Though they are widely validated in vitro and in vivo models, to date, no efforts have been made to compile in a single review all the pharmacologically active phytoconstituents from Hedychium species, and their pharmacological and toxicity profile. In this study, we present a reinvestigation of the chemical constituents present in Hedychium species obtained from the essential oil and solvent extraction of the flowers, leaves and rhizomes under consideration. Key databases such as PubMed, Science Direct, Scopus, and Google Scholar amongst others were probed for a systematic search using keywords to retrieve relevant publications on this plant. An exhaustive electronic survey of the related literature on Hedychium species resulted in around 200 articles. Articles published between the years 1975\u20132021 were included. The studies conducted on either crude extracts, solvent fractions or isolated pure compounds from Hedychium species reported with a varied range of biological effects such as anti-inflammatory, analgesic, antidiabetic, potentially anti-asthmatic, and cytotoxic, among other related activities of the chemical constituents present in its essential oil and solvent extract deployed in this review. Traditional and herbal medication around the world that uses different parts of Hedychium species were considered for anti-inflammatory, skincare, analgesic, anti-asthmatic, anti-diabetic, antidotal uses, among others. These uses support the idea that chemical constituents obtained from solvent extraction may also exert the same action individually or in a synergistic manner. The review concluded that there is scope for computation and biological study to find out possible new targets for strengthening the potency and selectivity of the relevant compounds, and to find a commercial method for extraction of active pharmaceutical ingredients.<\/jats:p>","DOI":"10.3390\/molecules28073278","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T04:04:16Z","timestamp":1680840256000},"page":"3278","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6387-0930","authenticated-orcid":false,"given":"Alok Pratap","family":"Singh","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, DIT University, Dehradun 248009, Uttarakhand, India"},{"name":"Department of Research and Development, India Glycols Ltd., Pharma City, Selaqui, Dehradun 248009, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-9634","authenticated-orcid":false,"given":"Havagiray","family":"Chitme","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, DIT University, Dehradun 248009, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-9049","authenticated-orcid":false,"given":"Rajeev Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, DIT University, Dehradun 248009, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JB","family":"Kandpal","sequence":"additional","affiliation":[{"name":"Department of Research and Development, India Glycols Ltd., Pharma City, Selaqui, Dehradun 248009, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-5722","authenticated-orcid":false,"given":"Ashok","family":"Behera","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, DIT University, Dehradun 248009, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5545-6422","authenticated-orcid":false,"given":"Basel A.","family":"Abdel-Wahab","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Najran University, Najran P.O. Box 1988, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-6829","authenticated-orcid":false,"given":"Mohammed Abdelmalek","family":"Orabi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, Najran University, Najran P.O. Box 1988, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-5210","authenticated-orcid":false,"given":"Masood Medleri","family":"Khateeb","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Najran University, Najran P.O. Box 1988, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Habeeb","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Najran University, Najran P.O. Box 1988, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa B.","family":"Bakir","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine Najran University, Najran P.O. Box 1988, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Prakash, O., Chandra, M., Punetha, H., Pant, A.K., and Rawat, D.S. (2016). Spiked Ginger Lily (Hedychium Spp.) Oils, Elsevier Inc.","DOI":"10.1016\/B978-0-12-416641-7.00084-5"},{"key":"ref_2","unstructured":"World Flora Online (2020, August 05). Demonstartion Portal World Flora Online. 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