{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:52:48Z","timestamp":1775523168641,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902293"],"award-info":[{"award-number":["31902293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The mite Sarcoptes scabiei is responsible for the emerging or re-emerging skin disease called scabies in humans and sarcoptic mange in animals. Essential oils represent an appealing alternative strategy for the control of Sarcoptes infections, but the commercial development of essential oils may be hampered by their inconsistency in efficacy due to their varied chemical compositions. In order to address this issue, we assessed the efficacy of six components (carvacrol, eugenol, geraniol, citral, terpinen-4-ol, and linalool) against S. scabiei. At a concentration of 0.5%, carvacrol presented the best miticidal efficacy, with a median lethal time (LT50) value of 6.7 min, followed by eugenol (56.3 min), geraniol (1.8 h), citral (6.1 h), terpinen-4-ol (22.3 h), and linalool (39.9 h). The LC50 values at 30 min for carvacrol, eugenol, and geraniol were 0.24, 0.79, and 0.91%, respectively. In conclusion, carvacrol, eugenol, and geraniol represent potential complementary or alternative agents for S. scabiei infections in humans or animals. Our study provides a scientific basis for the development of scabicidal products based on essential oils.<\/jats:p>","DOI":"10.3390\/molecules28083361","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T02:08:11Z","timestamp":1681265291000},"page":"3361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In Vitro Efficacy of Terpenes from Essential Oils against Sarcoptes scabiei"],"prefix":"10.3390","volume":"28","author":[{"given":"Meilin","family":"Li","sequence":"first","affiliation":[{"name":"Parasitology Department, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"},{"name":"Department of Pathogenic Biology, Army Medical University (Third Military Medical University), Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenrui","family":"Feng","sequence":"additional","affiliation":[{"name":"Parasitology Department, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Parasitology Department, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Guillot","sequence":"additional","affiliation":[{"name":"Dermatology-Parasitology-Mycology Departement, Oniris, 100 Route de Gachet, 44300 Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Parasitology Department, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"},{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning 530004, China"},{"name":"Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning 530004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13071-017-2234-1","article-title":"A Review of Sarcoptes Scabiei: Past, Present and Future","volume":"10","author":"Arlian","year":"2017","journal-title":"Parasites Vectors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"adv00112","DOI":"10.2340\/00015555-3468","article-title":"The Management of Scabies in the 21st Century: Past, Advances and Potentials","volume":"100","author":"Bernigaud","year":"2020","journal-title":"Acta Dermato Venereologica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1203475420960446","article-title":"Scabies: Diagnostic and Therapeutic Update","volume":"25","author":"Richards","year":"2020","journal-title":"J. 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