{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:11:51Z","timestamp":1790626311917,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In toxicology, screenings are routinely performed using chromatographic methods coupled to detection systems such as high-resolution mass spectrometry (HR\/MS). The increase in specificity and sensitivity of HRMS is responsible for the development of methods for alternative samples such as Volumetric Adsorptive Micro-Sampling. Whole blood overloaded with 90 drugs was sampled with 20 \u00b5L MitraTM to optimize the pre-analytical step as well as to determine the identification limits of drugs. Elution of chemicals was carried out in a solvent mixture through agitation and sonication. After dissolution, 10 \u03bcL was injected into the chromatographic system coupled to the OrbitrapTM HR\/MS. Compounds were confirmed against the laboratory library. The clinical feasibility was assessed in fifteen poisoned patients using the simultaneous sampling of plasma, whole blood and MitraTM. The optimized extraction procedure allowed us to confirm 87 compounds out of the 90 present in the spiked whole blood. Cannabis derivatives were not detected. For 82.2% of the investigated drugs, the identification limits were below 12.5 ng\u00b7mL\u22121, with the extraction yields ranging from 80.6 to 108.7%. Regarding the patients\u2019 analysis, 98% of the compounds in plasma were detected in MitraTM compared to whole blood, with a satisfying concordance (R2 = 0.827). Our novel screening approach opens new insights into different toxicologic fields appropriate for pediatrics, forensics or to perform mass screening.<\/jats:p>","DOI":"10.3390\/molecules28083466","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:03:38Z","timestamp":1681437818000},"page":"3466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["New Trend in Toxicological Screening Using Volumetric Absorptive Microsampling (VAMS) and High-Resolution Mass Spectrometry (HR\/MS) Combination"],"prefix":"10.3390","volume":"28","author":[{"given":"Pascal","family":"Houz\u00e9","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"},{"name":"Chemical and Biological Health Technologies Unit (UTCBS), CNRS UMR8258-U1022, University of Paris, 4 Avenue de l\u2019Observatoire, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Borowski","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e9nie","family":"Bito","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Magny","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"},{"name":"INSERM UMRS-1144, University of Paris, 4 Avenue de l\u2019Observatoire, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Morcos","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Voicu","sequence":"additional","affiliation":[{"name":"INSERM UMRS-1144, University of Paris, 4 Avenue de l\u2019Observatoire, 75006 Paris, France"},{"name":"Department of Medical and Toxicological Critical Care, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-2764","authenticated-orcid":false,"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"INSERM UMRS-1144, University of Paris, 4 Avenue de l\u2019Observatoire, 75006 Paris, France"},{"name":"Department of Medical and Toxicological Critical Care, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-3054","authenticated-orcid":false,"given":"Laurence","family":"Labat","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"},{"name":"Department of Medical and Toxicological Critical Care, Federation of Toxicology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 10 rue Ambroise Par\u00e9, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00007691-200204000-00008","article-title":"Progress of liquid chromatography-mass spectrometry in clinical and forensic toxicology","volume":"24","author":"Marquet","year":"2002","journal-title":"Ther. Drug Monit."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/jms.1112","article-title":"Hyphenated mass spectrometric techniques-indispensable tools in clinical and forensic toxicology and in doping control","volume":"41","author":"Maurer","year":"2006","journal-title":"J. Mass Spectrom."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13613-020-00762-9","article-title":"Management of pharmaceutical and recreational drug poisoning","volume":"10","author":"Oberlin","year":"2020","journal-title":"Ann. Intensive Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1373\/49.3.357","article-title":"National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Recommendations for the Use of Laboratory Tests to Support Poisoned Patients Who Present to the Emergency Department","volume":"49","author":"Wu","year":"2003","journal-title":"Clin. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0378-4347(92)80526-V","article-title":"Systematic toxicological analysis of drugs and their metabolites by gas chromatography-mass spectrometry","volume":"580","author":"Maurer","year":"1992","journal-title":"J. Chromatogr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/rcm.1942","article-title":"Rapid screening of drugs of abuse and their metabolites by gas chromatography\/mass spectrometry: Application to urinalysis","volume":"19","author":"Molaioni","year":"2005","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1002\/rcm.3326","article-title":"Application of fast gas chromatography\/mass spectrometry for the rapid screening of synthetic anabolic steroids and other drugs in anti-doping analysis","volume":"21","author":"Mazzarino","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/jms.846","article-title":"Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fluid by long column fast gas chromatography\/electron impact mass spectrometry","volume":"40","author":"Gunnar","year":"2005","journal-title":"J. Mass Spectrom."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4236\/ojapps.2019.99055","article-title":"Pharmaceutical Applications of Gas Chromatography","volume":"9","author":"Jwaili","year":"2019","journal-title":"Open J. Appl. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jchromb.2004.04.005","article-title":"Validated semiquantitative\/quantitative screening of 51 drugs in whole blood as silylated derivatives by gas chromatography-selected ion monitoring mass spectrometry and gas chromatography electron capture detection","volume":"806","author":"Gunnar","year":"2004","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1520\/JFS15353J","article-title":"Systematic toxicological analysis using HPLC\/DAD","volume":"40","author":"Tracqui","year":"1995","journal-title":"J. Forensic Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1515\/CCLM.2004.251","article-title":"Systematic toxicological analysis by high-performance liquid chromatography with diode array detection (HPLC-DAD)","volume":"42","author":"Pragst","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/bmc.3377","article-title":"Toxicological screening of human plasma by on-line SPE-HPLC-DAD: Identification and quantification of basic drugs and metabolites","volume":"29","author":"Mut","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/FTD.0b013e3181676186","article-title":"The role of liquid chromatography-tandem mass spectrometry (LC-MS\/MS) to test blood and urine samples for the toxicological investigation of drug-facilitated crimes","volume":"30","author":"Deveaux","year":"2008","journal-title":"Ther. Drug Monit."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2533\/chimia.2012.339","article-title":"LC-MS (\/MS) in clinical toxicology screening methods","volume":"66","author":"Viette","year":"2012","journal-title":"Chimia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115082","DOI":"10.1016\/j.jpba.2022.115082","article-title":"A multi-analyte LC-MS\/MS method for the determination of 57 pharmaceuticals and illicit drugs in plasma, and its application to poisoning cases","volume":"222","author":"Eller","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3109\/15563650.2012.713108","article-title":"Role of liquid chromatography-high-resolution mass spectrometry (LC-HR\/MS) in clinical toxicology","volume":"50","author":"Wu","year":"2012","journal-title":"Clin. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00216-022-04432-6","article-title":"Establishment and application of a screening method for 354 organic toxicants in blood and urine with high-performance liquid chromatography-high-resolution orbitrap mass spectrometry","volume":"415","author":"Li","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.forsciint.2018.03.039","article-title":"Systematic forensic toxicological analysis by liquid-chromatography-quadrupole-time-of-flight mass spectrometry in serum and comparison to gas chromatography-mass spectrometry","volume":"287","author":"Grapp","year":"2018","journal-title":"Forensic Sci. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-3252-8_17","article-title":"High-Resolution Mass Spectrometry for Untargeted Drug Screening","volume":"1383","author":"Wu","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/FTD.0b013e3181dca295","article-title":"Perspectives of liquid chromatography coupled to low- and high-resolution mass spectrometry for screening, identification, and quantification of drugs in clinical and forensic toxicology","volume":"32","author":"Maurer","year":"2010","journal-title":"Ther. Drug Monit."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3109\/10408444.2011.650790","article-title":"Dried blood spots in toxicology: From the cradle to the grave?","volume":"42","author":"Stove","year":"2012","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1007\/s00216-012-6043-2","article-title":"Development and validation of a mass spectrometric detection method of peginesatide in dried blood spots for sports drug testing","volume":"403","author":"Thomas","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.4155\/bio-2020-0044","article-title":"Microsampling and LC-MS\/MS for antidoping testing of glucocorticoids in urine","volume":"12","author":"Protti","year":"2020","journal-title":"Bioanalysis"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ververi, C., Vincenti, M., and Salomone, A. (2022). Recent advances in the detection of drugs of abuse by dried blood spots. Biomed. Chromatogr., e5555.","DOI":"10.1002\/bmc.5555"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jchromb.2016.12.038","article-title":"Dried haematic microsamples and LC-MS\/MS for the analysis of natural and synthetic cannabinoids","volume":"1044\u20131045","author":"Protti","year":"2017","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/dta.2418","article-title":"Detection of erythropoiesis-stimulating agents in a single dried blood spot","volume":"10","author":"Ventura","year":"2018","journal-title":"Drug Test. Anal."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.4155\/bio.13.197","article-title":"Microsample analyses via DBS: Challenges and opportunities","volume":"5","author":"Henion","year":"2013","journal-title":"Bioanalysis"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jpba.2017.07.029","article-title":"Volumetric absorptive microsampling: Current advances and applications","volume":"147","author":"Kok","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1515\/cclm-2019-1260","article-title":"Volumetric absorptive microsampling and dried blood spot microsampling vs. conventional venous sampling for tacrolimus trough concentration monitoring","volume":"58","author":"Veenhof","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1007\/s00216-018-0866-4","article-title":"Volumetric absorptive microsampling as an alternative tool for therapeutic drug monitoring of first-generation anti-epileptic drugs","volume":"410","author":"Velghe","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00216-020-03143-0","article-title":"Development, validation, and application of a quantitative volumetric absorptive microsampling-based method in finger prick blood by means of LC-HRMS\/MS applicable for adherence monitoring of antipsychotics","volume":"413","author":"Jacobs","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mandrioli, R., Mercolini, L., and Protti, M. (2020). Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS\/MS for the Forensic Assessment of Cocaine Consumption. Molecules, 25.","DOI":"10.3390\/molecules25051046"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jpba.2016.02.015","article-title":"LC-MS\/MS and volumetric absorptive microsampling for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples","volume":"123","author":"Mercolini","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"100517","DOI":"10.1016\/j.scp.2021.100517","article-title":"Green and sustainable drug analysis\u2014Combining microsampling and microextraction of drugs of abuse","volume":"24","author":"Mestad","year":"2021","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1586\/14789450.2014.904204","article-title":"Emerging liquid chromatography-mass spectrometry technologies improving dried blood spot analysis","volume":"11","author":"Rao","year":"2014","journal-title":"Expert Rev. Proteom."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.4155\/bio.14.156","article-title":"Spot them in the spot: Analysis of abused substances using dried blood spots","volume":"6","author":"Sadones","year":"2014","journal-title":"Bioanalysis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chroma.2012.11.030","article-title":"Dried blood spots: Liquid chromatography-mass spectrometry analysis of delta (9)-tetrahydrocannabinol and its main metabolites","volume":"1271","author":"Mercolini","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2011.11.035","article-title":"On-line liquid chromatography\/tandem mass spectrometry simultaneous determination of opiates, cocainics and amphetamines in dried blood spots","volume":"885","author":"Saussereau","year":"2012","journal-title":"J. Chromatogr. B"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/anatox\/35.5.269","article-title":"Analysis of 3,4-methylenedioxymetamphetamine: Whole blood versus dried blood spots","volume":"35","author":"Jantos","year":"2011","journal-title":"J. Anal. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s00216-010-4183-9","article-title":"Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC\u2013MS method with direct \u201con spot\u201d derivatization","volume":"398","author":"Ingels","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.4155\/bio.15.127","article-title":"Cocaine and metabolite concentrations in DBS and venous blood after controlled intravenous cocaine administration","volume":"7","author":"Ellefsen","year":"2015","journal-title":"Bioanalysis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/bmc.1367","article-title":"Dried blood spot sampling in combination with LC-MS\/MS for quantitative analysis of small molecules","volume":"24","author":"Li","year":"2010","journal-title":"Biomed. Chromatogr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aca.2019.02.011","article-title":"Liquid chromatography-high resolution mass spectrometry for broad-spectrum drug screening of dried blood spot as microsampling procedure","volume":"1063","author":"Joye","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jpba.2011.12.018","article-title":"Development of an UPLC-MS\/MS method for the determination of antibiotic ertapenem on dried blood spots","volume":"61","author":"Giocaliere","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_46","first-page":"288","article-title":"Advantages and Challenges of Dried Blood Spot Analysis by Mass Spectrometry Across the Total Testing Process","volume":"27","author":"Zakaria","year":"2016","journal-title":"eJIFCC"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cca.2016.01.017","article-title":"Fully automated semi-quantitative toxicological screening in three biological matrices using turbulent flow chromatography\/high resolution mass spectrometry","volume":"455","author":"Roche","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/jat\/bkt071","article-title":"Drug screening in medical examiner casework by high-resolution mass spectrometry (UPLC-MSE-TOF)","volume":"37","author":"Rosano","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Joye, T., D\u00e9glon, J., Donz\u00e9, N., Gilardi, F., Sidib\u00e9, J., Favrat, B., Augsburger, M., and Thomas, A. (2022). Randomly controlled drivers using minimally invasive sampling: Assessment of drug prevalence in Western Switzerland over two time periods. BMC Public Health, 22.","DOI":"10.1186\/s12889-022-14883-2"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3389\/fchem.2020.00695","article-title":"High-Throughput Qualitative and Quantitative Drug Checking by MALDI HRMS","volume":"8","author":"Joye","year":"2020","journal-title":"Front. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/jat\/bky001","article-title":"Toxicological Drug Screening using Paper Spray High-Resolution Tandem Mass Spectrometry (HR-MS\/MS)","volume":"42","author":"McKenna","year":"2018","journal-title":"J. Anal. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00001813-200111000-00011","article-title":"Quantification of doxorubicin in plasma--a comparative study of capillary and venous blood sampling","volume":"12","author":"Palm","year":"2001","journal-title":"Anticancer Drugs"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/cpdd.290","article-title":"Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole","volume":"5","author":"Remmerie","year":"2016","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Goh, E.M.L., Xue, Q.N., Ching, Y.Y., Hamzah, A., and Yan, H.M. (2023). Qualitative Confirmation of 94 New Psychoactive Substances and Metabolites in Urine using Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-QTOF-MS). J. Anal. Toxicol., bkad006.","DOI":"10.1093\/jat\/bkad006"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chroma.2005.08.064","article-title":"Determination of the limits of identification and quantitation of selected organochlorine and organophosphorous pesticide residues in surface water by full-scan gas chromatography\/mass spectrometry","volume":"1098","author":"Tahboub","year":"2005","journal-title":"J. Chromatogr. A"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/8\/3466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:15:38Z","timestamp":1760123738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/8\/3466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["molecules28083466"],"URL":"https:\/\/doi.org\/10.3390\/molecules28083466","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]}}}