{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:39:45Z","timestamp":1769265585418,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province","award":["HLJTSXK-2022-03"],"award-info":[{"award-number":["HLJTSXK-2022-03"]}]},{"name":"North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province","award":["LH2022H095"],"award-info":[{"award-number":["LH2022H095"]}]},{"name":"North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province","award":["LBH-Z21214"],"award-info":[{"award-number":["LBH-Z21214"]}]},{"name":"North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province","award":["2019-KYYWF-1342"],"award-info":[{"award-number":["2019-KYYWF-1342"]}]},{"name":"North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province","award":["JMSUBZ2019-14"],"award-info":[{"award-number":["JMSUBZ2019-14"]}]},{"name":"North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province","award":["KFKT2021-04"],"award-info":[{"award-number":["KFKT2021-04"]}]},{"name":"North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province","award":["202110222166"],"award-info":[{"award-number":["202110222166"]}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["HLJTSXK-2022-03"],"award-info":[{"award-number":["HLJTSXK-2022-03"]}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["LH2022H095"],"award-info":[{"award-number":["LH2022H095"]}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["LBH-Z21214"],"award-info":[{"award-number":["LBH-Z21214"]}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["2019-KYYWF-1342"],"award-info":[{"award-number":["2019-KYYWF-1342"]}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["JMSUBZ2019-14"],"award-info":[{"award-number":["JMSUBZ2019-14"]}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["KFKT2021-04"],"award-info":[{"award-number":["KFKT2021-04"]}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["202110222166"],"award-info":[{"award-number":["202110222166"]}]},{"name":"Heilongjiang Postdoctoral Foundation","award":["HLJTSXK-2022-03"],"award-info":[{"award-number":["HLJTSXK-2022-03"]}]},{"name":"Heilongjiang Postdoctoral Foundation","award":["LH2022H095"],"award-info":[{"award-number":["LH2022H095"]}]},{"name":"Heilongjiang Postdoctoral Foundation","award":["LBH-Z21214"],"award-info":[{"award-number":["LBH-Z21214"]}]},{"name":"Heilongjiang Postdoctoral Foundation","award":["2019-KYYWF-1342"],"award-info":[{"award-number":["2019-KYYWF-1342"]}]},{"name":"Heilongjiang Postdoctoral Foundation","award":["JMSUBZ2019-14"],"award-info":[{"award-number":["JMSUBZ2019-14"]}]},{"name":"Heilongjiang Postdoctoral Foundation","award":["KFKT2021-04"],"award-info":[{"award-number":["KFKT2021-04"]}]},{"name":"Heilongjiang Postdoctoral Foundation","award":["202110222166"],"award-info":[{"award-number":["202110222166"]}]},{"name":"Provincial Undergraduate Colleges Basal Research Foundation","award":["HLJTSXK-2022-03"],"award-info":[{"award-number":["HLJTSXK-2022-03"]}]},{"name":"Provincial Undergraduate Colleges Basal Research Foundation","award":["LH2022H095"],"award-info":[{"award-number":["LH2022H095"]}]},{"name":"Provincial Undergraduate Colleges Basal Research Foundation","award":["LBH-Z21214"],"award-info":[{"award-number":["LBH-Z21214"]}]},{"name":"Provincial Undergraduate Colleges Basal Research Foundation","award":["2019-KYYWF-1342"],"award-info":[{"award-number":["2019-KYYWF-1342"]}]},{"name":"Provincial Undergraduate Colleges Basal Research Foundation","award":["JMSUBZ2019-14"],"award-info":[{"award-number":["JMSUBZ2019-14"]}]},{"name":"Provincial Undergraduate Colleges Basal Research Foundation","award":["KFKT2021-04"],"award-info":[{"award-number":["KFKT2021-04"]}]},{"name":"Provincial Undergraduate Colleges Basal Research Foundation","award":["202110222166"],"award-info":[{"award-number":["202110222166"]}]},{"name":"Doctoral Scientific Research Startup Fund","award":["HLJTSXK-2022-03"],"award-info":[{"award-number":["HLJTSXK-2022-03"]}]},{"name":"Doctoral Scientific Research Startup Fund","award":["LH2022H095"],"award-info":[{"award-number":["LH2022H095"]}]},{"name":"Doctoral Scientific Research Startup Fund","award":["LBH-Z21214"],"award-info":[{"award-number":["LBH-Z21214"]}]},{"name":"Doctoral Scientific Research Startup Fund","award":["2019-KYYWF-1342"],"award-info":[{"award-number":["2019-KYYWF-1342"]}]},{"name":"Doctoral Scientific Research Startup Fund","award":["JMSUBZ2019-14"],"award-info":[{"award-number":["JMSUBZ2019-14"]}]},{"name":"Doctoral Scientific Research Startup Fund","award":["KFKT2021-04"],"award-info":[{"award-number":["KFKT2021-04"]}]},{"name":"Doctoral Scientific Research Startup Fund","award":["202110222166"],"award-info":[{"award-number":["202110222166"]}]},{"name":"Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation","award":["HLJTSXK-2022-03"],"award-info":[{"award-number":["HLJTSXK-2022-03"]}]},{"name":"Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation","award":["LH2022H095"],"award-info":[{"award-number":["LH2022H095"]}]},{"name":"Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation","award":["LBH-Z21214"],"award-info":[{"award-number":["LBH-Z21214"]}]},{"name":"Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation","award":["2019-KYYWF-1342"],"award-info":[{"award-number":["2019-KYYWF-1342"]}]},{"name":"Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation","award":["JMSUBZ2019-14"],"award-info":[{"award-number":["JMSUBZ2019-14"]}]},{"name":"Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation","award":["KFKT2021-04"],"award-info":[{"award-number":["KFKT2021-04"]}]},{"name":"Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation","award":["202110222166"],"award-info":[{"award-number":["202110222166"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["HLJTSXK-2022-03"],"award-info":[{"award-number":["HLJTSXK-2022-03"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["LH2022H095"],"award-info":[{"award-number":["LH2022H095"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["LBH-Z21214"],"award-info":[{"award-number":["LBH-Z21214"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["2019-KYYWF-1342"],"award-info":[{"award-number":["2019-KYYWF-1342"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["JMSUBZ2019-14"],"award-info":[{"award-number":["JMSUBZ2019-14"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["KFKT2021-04"],"award-info":[{"award-number":["KFKT2021-04"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["202110222166"],"award-info":[{"award-number":["202110222166"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this work, glucose transporter-1 (GLUT-1) and glutathione (GSH) over-expression in liver cancer was utilized to design a reduction-responsive and active targeting drug delivery system AG-PEG-SS-PCL (APSP) for the delivery of sorafenib (SF). The SF-APSP micelles were prepared using the thin film hydration method and characterized by various techniques. In vitro release experiments showed that the cumulative release of SF-APSP micelles in the simulated tumor microenvironment (pH 7.4 with GSH) reached 94.76 \u00b1 1.78% at 48 h, while it was only 20.32 \u00b1 1.67% in the normal physiological environment (pH 7.4 without GSH). The in vitro study revealed that glucosamine (AG) enhanced the antitumor effects of SF, and SF-APSP micelles inhibited proliferation by targeting HepG2 cells and suppressing cyclin D1 expression. The in vivo antitumor efficacy study further confirmed that the SF-APSP micelles had excellent antitumor effects and better tolerance against nude mouse with HepG2 cells than other treatment groups. All in all, these results indicated that SF-APSP micelles could be a promising drug delivery system for anti-hepatoma treatment.<\/jats:p>","DOI":"10.3390\/molecules28093824","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T12:12:11Z","timestamp":1682943131000},"page":"3824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy"],"prefix":"10.3390","volume":"28","author":[{"given":"Lei","family":"Meng","sequence":"first","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangshu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenchen","family":"Du","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xiong","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9462-8509","authenticated-orcid":false,"given":"Weitong","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1084\/jem.20181288","article-title":"Adiponectin accounts for gender differences in hepatocellular carcinoma incidence","volume":"216","author":"Manieri","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jhep.2012.06.014","article-title":"Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial","volume":"57","author":"Bruix","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15384047.2022.2135960","article-title":"DDX24 regulates the chemosensitivity of hepatocellular carcinoma to sorafenib via mediating the expression of SNORA18","volume":"23","author":"Gan","year":"2022","journal-title":"Cancer Biol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Randrup Hansen, C., Grimm, D., Bauer, J., Wehland, M., and Magnusson, N.E. (2017). Effects and Side Effects of Using Sorafenib and Sunitinib in the Treatment of Metastatic Renal Cell Carcinoma. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020461"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/17474124.2017.1264874","article-title":"Development of sorafenib-related side effects in patients diagnosed with advanced hepatocellular carcinoma treated with sorafenib: A systematic-review and meta-analysis of the impact on survival","volume":"11","author":"Lamarca","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2019.08.034","article-title":"Current strategies for different paclitaxel-loaded Nano-delivery Systems towards therapeutic applications for ovarian carcinoma: A review article","volume":"311\u2013312","author":"Khalifa","year":"2019","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijpharm.2017.09.005","article-title":"Polymeric micelles: Basic research to clinical practice","volume":"532","author":"Deshmukh","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1517\/17425240903380446","article-title":"Overcoming the barriers in micellar drug delivery: Loading efficiency, in vivo stability, and micelle-cell interaction","volume":"7","author":"Kim","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/mp800049w","article-title":"Pharmacokinetics and biodistribution of nanoparticles","volume":"5","author":"Li","year":"2008","journal-title":"Mol. Pharm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1080\/10717544.2018.1526227","article-title":"Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice","volume":"25","author":"Chang","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/bjc.2011.6","article-title":"A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours","volume":"104","author":"Plummer","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.colsurfb.2018.11.082","article-title":"Glycyrrhetinic acid-conjugated polymeric prodrug micelles co-delivered with doxorubicin as combination therapy treatment for liver cancer","volume":"175","author":"Yang","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.addr.2004.02.014","article-title":"Nanoparticle and targeted systems for cancer therapy","volume":"56","author":"Blanchette","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_15","first-page":"171","article-title":"Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI","volume":"82","author":"Liu","year":"2016","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1517\/14728220903307509","article-title":"GLUT1 as a therapeutic target in hepatocellular carcinoma","volume":"13","author":"Amann","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.aanat.2010.03.001","article-title":"Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays","volume":"192","author":"Airley","year":"2010","journal-title":"Ann. Anat. Anat. Anz. Off. Organ Anat. Ges."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/09687688.2011.554447","article-title":"Analysis of a promoter polymorphism of the GLUT1 gene in patients with hepatocellular carcinoma","volume":"28","author":"Amann","year":"2011","journal-title":"Mol. Membr. Biol."},{"key":"ref_19","first-page":"36","article-title":"Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate","volume":"22","author":"Christgau","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.lfs.2016.03.028","article-title":"Molecular mechanisms and biomedical applications of glucosamine as a potential multifunctional therapeutic agent","volume":"152","author":"Dalirfardouei","year":"2016","journal-title":"Life Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbrc.2009.02.129","article-title":"D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells","volume":"382","author":"Park","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3109\/1061186X.2015.1055572","article-title":"Glucosamine anchored cancer targeted nano-vesicular drug delivery system of doxorubicin","volume":"24","author":"Pawar","year":"2016","journal-title":"J. Drug Target."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bbrc.2007.06.137","article-title":"D-glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K","volume":"360","author":"Oh","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.biomaterials.2009.01.026","article-title":"Reduction-sensitive polymers and bioconjugates for biomedical applications","volume":"30","author":"Meng","year":"2009","journal-title":"Biomaterials"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.actbio.2013.12.033","article-title":"Thermo- and pH-responsive copolymers based on PLGA-PEG-PLGA and poly(L-histidine): Synthesis and in vitro characterization of copolymer micelles","volume":"10","author":"Hong","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_26","first-page":"2845","article-title":"Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs","volume":"46","author":"Russo","year":"1986","journal-title":"Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0169-409X(02)00179-5","article-title":"Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities","volume":"55","author":"Saito","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jinorgbio.2014.09.012","article-title":"Design, synthesis and SAR studies of novel 1,2-bis(aminomethyl)cyclohexane platinum (II) complexes with cytotoxic activity. Studies of interaction with DNA of iodinated seven-membered 1,4-diaminoplatinocycles","volume":"142","author":"Gay","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/ptr.2836","article-title":"Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells","volume":"23","author":"Lee","year":"2009","journal-title":"Phytother. Res. PTR"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2014.06.046","article-title":"PEG\u2014A versatile conjugating ligand for drugs and drug delivery systems","volume":"192","author":"Kolate","year":"2014","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejpb.2016.10.003","article-title":"Pharmacokinetics and in vivo delivery of curcumin by copolymeric mPEG-PCL micelles","volume":"116","author":"Ghasemi","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.colsurfb.2019.01.044","article-title":"Tumor-targeting micelles based on folic acid and \u03b1-tocopherol succinate conjugated hyaluronic acid for paclitaxel delivery","volume":"177","author":"Zhang","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.biopha.2017.08.122","article-title":"Molecular mechanisms of anticancer effects of Glucosamine","volume":"95","author":"Zahedipour","year":"2017","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jcp.21791","article-title":"Nuclear cyclin D1: An oncogenic driver in human cancer","volume":"220","author":"Kim","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.ijbiomac.2018.01.093","article-title":"pH-responsive nanoreservoirs based on hyaluronic acid end-capped mesoporous silica nanoparticles for targeted drug delivery","volume":"111","author":"Chen","year":"2018","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/9\/3824\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:27:02Z","timestamp":1760124422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/9\/3824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,30]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["molecules28093824"],"URL":"https:\/\/doi.org\/10.3390\/molecules28093824","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,30]]}}}