{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:07:07Z","timestamp":1760148427570,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Fund of the State Key Laboratory Coal Resources and Safe Mining","award":["SKLCRSM21KFA11","81960752","2020Q047"],"award-info":[{"award-number":["SKLCRSM21KFA11","81960752","2020Q047"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SKLCRSM21KFA11","81960752","2020Q047"],"award-info":[{"award-number":["SKLCRSM21KFA11","81960752","2020Q047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianshan Youth Project","award":["SKLCRSM21KFA11","81960752","2020Q047"],"award-info":[{"award-number":["SKLCRSM21KFA11","81960752","2020Q047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Background and objective: Asthma is a common chronic inflammatory disease of the airways with no known cure. Lipid mediators (LMs) are a kind of inflammatory signaling molecules which are believed to be involved in the development of asthma. Hyssopus cuspidatus Boriss. is a traditional Uyghur medicine, which is widely used in the treatment of asthma and other respiratory diseases. Extraction of Hyssopus cuspidatus Boriss. was reported to neutralize asthma symptoms. The purpose of the study was to investigate both the anti-inflammatory and immunoregulation properties of the Hyssopus cuspidatus Boriss. extract (SXCF) and its main active constituent, rosmarinic acid (RosA), in vivo. The effect of RosA, a major constituent of SXCF, was evaluated on an asthmatic model, with both anti-inflammatory and immunoregulation properties. Materials and methods: Anti-inflammatory effect of SXCF and RosA was assessed using OVA-induced asthma model mice by UPLC-MS\/MS method. Results: Overall, RosA played a critical role in anti-asthma treatment. In total, 90% of LMs species that were significantly regulated by SXCF were covered. On the most important LMs associated with asthma, RosA equivalent induced similar effects as SXCF did. It is believed that some constituents in SXCF could neutralize RosA excessive impacts on LMs.<\/jats:p>","DOI":"10.3390\/molecules28093827","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T12:12:11Z","timestamp":1682943131000},"page":"3827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lipid Mediators Metabolic Chaos of Asthmatic Mice Reversed by Rosmarinic Acid"],"prefix":"10.3390","volume":"28","author":[{"given":"Tuo","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory Coal Resources and Safe Mining, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China"},{"name":"School of Chemical and Environmental Engineering, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Rong","sequence":"additional","affiliation":[{"name":"Xinjiang Institute of Material Medica, South Xinhua Road 140, Urumqi 830004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingfei","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory Coal Resources and Safe Mining, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China"},{"name":"School of Chemical and Environmental Engineering, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutong","family":"Kang","sequence":"additional","affiliation":[{"name":"Xinjiang Institute of Material Medica, South Xinhua Road 140, Urumqi 830004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanlin","family":"Liu","sequence":"additional","affiliation":[{"name":"Xinjiang Institute of Material Medica, South Xinhua Road 140, Urumqi 830004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Hu","sequence":"additional","affiliation":[{"name":"Xinjiang Institute of Material Medica, South Xinhua Road 140, Urumqi 830004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handong","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Coal Resources and Safe Mining, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai","family":"Tie","sequence":"additional","affiliation":[{"name":"State Key Laboratory Coal Resources and Safe Mining, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China"},{"name":"School of Chemical and Environmental Engineering, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1172\/JCI84144","article-title":"Current concepts of severe asthma","volume":"126","author":"Ray","year":"2016","journal-title":"J. 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