{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:42:46Z","timestamp":1768729366920,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Science, Research and Sport of the Slovak Republic within the Research and Development Operational Programe for the project \u201cUniversity Science Park of STU Bratislava\u201d","award":["ITMS 26240220084"],"award-info":[{"award-number":["ITMS 26240220084"]}]},{"name":"Ministry of Education, Science, Research and Sport of the Slovak Republic within the Research and Development Operational Programe for the project \u201cUniversity Science Park of STU Bratislava\u201d","award":["APVV-19-0087"],"award-info":[{"award-number":["APVV-19-0087"]}]},{"name":"Ministry of Education, Science, Research and Sport of the Slovak Republic within the Research and Development Operational Programe for the project \u201cUniversity Science Park of STU Bratislava\u201d","award":["1\/0686\/23"],"award-info":[{"award-number":["1\/0686\/23"]}]},{"name":"Ministry of Education, Science, Research and Sport of the Slovak Republic within the Research and Development Operational Programe for the project \u201cUniversity Science Park of STU Bratislava\u201d","award":["1\/0145\/20"],"award-info":[{"award-number":["1\/0145\/20"]}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["ITMS 26240220084"],"award-info":[{"award-number":["ITMS 26240220084"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-19-0087"],"award-info":[{"award-number":["APVV-19-0087"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["1\/0686\/23"],"award-info":[{"award-number":["1\/0686\/23"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["1\/0145\/20"],"award-info":[{"award-number":["1\/0145\/20"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Grant Agency of the Slovak Republic","award":["ITMS 26240220084"],"award-info":[{"award-number":["ITMS 26240220084"]}]},{"name":"Scientific Grant Agency of the Slovak Republic","award":["APVV-19-0087"],"award-info":[{"award-number":["APVV-19-0087"]}]},{"name":"Scientific Grant Agency of the Slovak Republic","award":["1\/0686\/23"],"award-info":[{"award-number":["1\/0686\/23"]}]},{"name":"Scientific Grant Agency of the Slovak Republic","award":["1\/0145\/20"],"award-info":[{"award-number":["1\/0145\/20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ruthenium complexes currently represent a perspective subject of investigation in terms of potential anticancer therapeutics. Eight novel octahedral ruthenium(II) complexes are the subject of this article. Complexes contain 2,2\u2032-bipyridine molecules and salicylates as ligands, differing in position and type of halogen substituent. The structure of the complexes was determined via X-ray structural analysis and NMR spectroscopy. All complexes were characterized by spectral methods\u2014FTIR, UV\u2013Vis, ESI-MS. Complexes show sufficient stability in solutions. Therefore, their biological properties were studied. Binding ability to BSA, interaction with DNA, as well as in vitro antiproliferative effects against MCF-7 and U-118MG cell lines were investigated. Several complexes showed anticancer effects against these cell lines.<\/jats:p>","DOI":"10.3390\/molecules28124609","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:02:28Z","timestamp":1686189748000},"page":"4609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity"],"prefix":"10.3390","volume":"28","author":[{"given":"Martin","family":"Schoeller","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry, Slovak University of Technology, Radlinsk\u00e9ho 9, 812 37 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Piro\u0161","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Slovak University of Technology, Radlinsk\u00e9ho 9, 812 37 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-9819","authenticated-orcid":false,"given":"Miroslava","family":"Liteck\u00e1","sequence":"additional","affiliation":[{"name":"Department of Materials Chemistry, Institute of Inorganic Chemistry of the CAS, Husinec-\u0158e\u017e \u010d.p. 1001, 250 68 \u0158e\u017e, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katar\u00edna","family":"Ko\u0148arikov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-5265","authenticated-orcid":false,"given":"Fl\u00f3ra","family":"Jozef\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Slovak University of Technology, Radlinsk\u00e9ho 9, 812 37 Bratislava, Slovakia"},{"name":"Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalin\u010diakova 8, 832 32 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"\u0160ag\u00e1tov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Slovak University of Technology, Radlinsk\u00e9ho 9, 812 37 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Zahradn\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, Palack\u00fd University, 17. Listopadu 12, 771 46 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindra","family":"Valentov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalin\u010diakova 8, 832 32 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-9753","authenticated-orcid":false,"given":"J\u00e1n","family":"Moncol","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Slovak University of Technology, Radlinsk\u00e9ho 9, 812 37 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00003495-199600525-00004","article-title":"The Mechanisms of Action of NSAIDs in Analgesia","volume":"52","author":"Cashman","year":"1996","journal-title":"Drugs"},{"key":"ref_2","first-page":"225","article-title":"The mechanism of action of aspirin","volume":"5\u20136","author":"Vane","year":"2003","journal-title":"Tromb. 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