{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:53:33Z","timestamp":1787619213496,"version":"build-2736575974"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Asian Office of Aerospace Research and Development (AOARD)","award":["FA2386-17-1-4051"],"award-info":[{"award-number":["FA2386-17-1-4051"]}]},{"name":"The AOARD and the region Grand Est","award":["FA2386-17-1-4051"],"award-info":[{"award-number":["FA2386-17-1-4051"]}]},{"name":"IDEX\u2013Prix Espoirs from University of Strasbourg","award":["FA2386-17-1-4051"],"award-info":[{"award-number":["FA2386-17-1-4051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Regulation of the sodium cations level in the case of renal failure diseases is a very challenging task for clinicians, and new pollutant extractors based on nanomaterials are emerging as potential treatments. In this work, we report different strategies for the chemical functionalization of biocompatible large pore mesoporous silica, denoted stellate mesoporous silica (STMS), with chelating ligands able to selectively capture sodium. We address efficient methods to covalently graft highly chelating macrocycles onto STMS NPs such as crown ethers (CE) and cryptands (C221) through complementary carbodiimidation reactions. Regarding sodium capture in water, C221 cryptand-grafted STMS showed better capture efficiency than CE-STMS due to higher sodium atom chelation in the cryptand cage (Na+ coverage of 15.5% vs. 3.7%). The sodium selectivity was hence tested with C221 cryptand-grafted STMS in a multi-element aqueous solution (metallic cations with the same concentration) and in a solution mimicking peritoneal dialysis solution. Results obtained indicate that C221 cryptand-grafted STMS are relevant nanomaterials to extract sodium cations in such media and allow us to regulate their levels.<\/jats:p>","DOI":"10.3390\/molecules28124622","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:02:28Z","timestamp":1686189748000},"page":"4622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Grafting of Crown Ether and Cryptand Macrocycles on Large Pore Stellate Mesoporous Silica for Sodium Cation Extraction"],"prefix":"10.3390","volume":"28","author":[{"given":"Paula","family":"Duenas-Ramirez","sequence":"first","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg (IPCMS), UMR-7504 CNRS-Universit\u00e9 de Strasbourg, 23 Rue du Loess, 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-1737","authenticated-orcid":false,"given":"Caroline","family":"Bertagnolli","sequence":"additional","affiliation":[{"name":"Institut Pluridisciplinaire Hubert Curien (IPHC), UMR 7178 CNRS-Universit\u00e9 de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1291-230X","authenticated-orcid":false,"given":"Robin","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institut Charles Sadron (ICS) CNRS UPR 22, 23 Rue du Loess, 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-0525","authenticated-orcid":false,"given":"Jo\u00eblle","family":"Bizeau","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg (IPCMS), UMR-7504 CNRS-Universit\u00e9 de Strasbourg, 23 Rue du Loess, 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Jierry","sequence":"additional","affiliation":[{"name":"Institut Charles Sadron (ICS) CNRS UPR 22, 23 Rue du Loess, 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-0726","authenticated-orcid":false,"given":"Philippe","family":"Choquet","sequence":"additional","affiliation":[{"name":"UF6237 Imagerie Pr\u00e9clinique, P\u00f4le d\u2019Imagerie, H\u00f4pitaux Universitaires de Strasbourg, 1 Avenue Moli\u00e8re, 67098 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Zaloszyc","sequence":"additional","affiliation":[{"name":"UF6237 Imagerie Pr\u00e9clinique, P\u00f4le d\u2019Imagerie, H\u00f4pitaux Universitaires de Strasbourg, 1 Avenue Moli\u00e8re, 67098 Strasbourg, France"},{"name":"Institut de Chimie et Proc\u00e9d\u00e9s pour l\u2019Energie, l\u2019Environnement et la Sant\u00e9 (ICPEES), UMR-7515 CNRS-Universit\u00e9 de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"B\u00e9gin-Colin","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg (IPCMS), UMR-7504 CNRS-Universit\u00e9 de Strasbourg, 23 Rue du Loess, 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6745-8978","authenticated-orcid":false,"given":"Damien","family":"Mertz","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg (IPCMS), UMR-7504 CNRS-Universit\u00e9 de Strasbourg, 23 Rue du Loess, 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00005792-196948060-00002","article-title":"Hypernatremia","volume":"48","author":"Ross","year":"1969","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1056\/NEJM200005183422006","article-title":"Hypernatremia","volume":"342","author":"Madias","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/j.ajkd.2019.07.014","article-title":"Diagnosis and Management of Disorders of Body Tonicity\u2014Hyponatremia and Hypernatremia: Core Curriculum 2020","volume":"75","author":"Seay","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"769287","DOI":"10.3389\/fmed.2021.769287","article-title":"Dysnatremias in Chronic Kidney Disease: Pathophysiology, Manifestations, and Treatment","volume":"8","author":"Arzhan","year":"2021","journal-title":"Front. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/ndt\/gfn542","article-title":"Characteristics and survival of young adults who started renal replacement therapy during childhood","volume":"24","author":"Kramer","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.kint.2016.02.016","article-title":"Mortality risk in European children with end-stage renal disease on dialysis","volume":"89","author":"Chesnaye","year":"2016","journal-title":"Kidney Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1093\/ndt\/gfm220","article-title":"Associations of a facility level decrease in dialysate sodium concentration with blood pressure and interdialytic weight gain","volume":"22","author":"Thein","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/hdi.12384","article-title":"Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysis","volume":"20","author":"Marsenic","year":"2015","journal-title":"Hemodial. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1053\/ajkd.2002.34507","article-title":"Time-averaged concentration of dialysate sodium relates with sodium load and interdialytic weight gain during sodium-profiling hemodialysis","volume":"40","author":"Song","year":"2002","journal-title":"Am. J. Kidney Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/ckj\/sfac021","article-title":"Outcomes and predictors of skin sodium concentration in dialysis patients","volume":"15","author":"Salerno","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1525-139X.2003.16070.x","article-title":"Editorials: Sodium Balance in Hemodialysis Therapy","volume":"16","author":"Kooman","year":"2003","journal-title":"Semin. Dial."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.desal.2016.06.024","article-title":"Membrane distillation and membrane electrolysis of coal seam gas reverse osmosis brine for clean water extraction and NaOH production","volume":"397","author":"Duong","year":"2016","journal-title":"Desalination"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.desal.2016.08.018","article-title":"Selective removal of sodium from alkali-metal solutions with tetraoctylammonium monensin","volume":"399","author":"Parmentier","year":"2016","journal-title":"Desalination"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1021\/bk-1994-0561.ch027","article-title":"Fluorescent Chemosensors of Ion and Molecule Recognition","volume":"561","author":"Czarnik","year":"1994","journal-title":"ACS Symp. Ser."},{"key":"ref_15","unstructured":"Atwood, J.L., and Lehn, J.-M. (1996). Comprehensive Supramolecular Chemistry, Pergamon."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10527-018-9801-4","article-title":"A Wearable Device for Low-Flow Detoxification of Human Body by Peritoneal Dialysis","volume":"52","author":"Bazaev","year":"2018","journal-title":"Biomed. Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1177\/089686089301302S09","article-title":"A three-pore model of peritoneal transport","volume":"13","author":"Rippe","year":"1993","journal-title":"Perit. Dial. Int. J. Int. Soc. Perit. Dial."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.memsci.2005.11.038","article-title":"Mathematical modeling of fluid and solute transport in hemodialysis and peritoneal dialysis","volume":"274","author":"Waniewski","year":"2006","journal-title":"J. Membr. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jmmm.2018.06.064","article-title":"A study on magnetic removal of sodium, calcium and potassium ions from seawater using magnetite\/clinoptilolite\u2013Na composite nanoparticles","volume":"465","author":"Kouli","year":"2018","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41545-022-00156-3","article-title":"Selective removal of Na+ by NaTi2(PO4)3-MWCNT composite hollow-fiber membrane electrode in capacitive deionization","volume":"5","author":"Park","year":"2022","journal-title":"NPJ Clean Water"},{"key":"ref_21","first-page":"277","article-title":"Effective heavy metal removal from aqueous systems by thiol functionalized magnetic mesoporous silica","volume":"192","author":"Li","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cej.2011.04.051","article-title":"Synthesis and characterization of thiol-functionalized silica nano hollow sphere as a novel adsorbent for removal of poisonous heavy metal ions from water: Kinetics, isotherms and error analysis","volume":"171","author":"Rostamian","year":"2011","journal-title":"Chem. Eng. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jiec.2017.01.019","article-title":"Polyethylenimine-modified mesoporous silica adsorbent for simultaneous removal of Cd(II) and Ni(II) from aqueous solution","volume":"49","author":"Thakur","year":"2017","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jece.2015.03.006","article-title":"Potential of functionalized SBA-15 mesoporous materials for decontamination of water solutions from Cr(VI), As(V) and Hg(II) ions","volume":"3","author":"Dindar","year":"2015","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cej.2009.06.016","article-title":"Removal of Ni(II), Cd(II), and Pb(II) from a ternary aqueous solution by amino functionalized mesoporous and nano mesoporous silica","volume":"153","author":"Heidari","year":"2009","journal-title":"Chem. Eng. J."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Adam, A., Parkhomenko, K., Duenas-Ramirez, P., Nadal, C., Cotin, G., Zorn, P.-E., Choquet, P., B\u00e9gin-Colin, S., and Mertz, D. (2021). Orienting the Pore Morphology of Core-Shell Magnetic Mesoporous Silica with the Sol-Gel Temperature. Influence on MRI and Magnetic Hyperthermia Properties. Molecules, 26.","DOI":"10.3390\/molecules26040971"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1021\/ja3116873","article-title":"Facile Large-Scale Synthesis of Monodisperse Mesoporous Silica Nanospheres with Tunable Pore Structure","volume":"135","author":"Zhang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jcis.2020.06.013","article-title":"Highly chelating stellate mesoporous silica nanoparticles for specific iron removal from biological media","volume":"579","author":"Bertagnolli","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1002\/ejic.202100678","article-title":"Serum Albumin Antifouling Effects of Hydroxypropyl-Cellulose and Pluronic F127 Adsorbed on Isobutyramide-Grafted Stellate Silica Nanoparticles","volume":"2021","author":"Bizeau","year":"2021","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_30","first-page":"100130","article-title":"Protein sustained release from isobutyramide-grafted stellate mesoporous silica nanoparticles","volume":"4","author":"Bizeau","year":"2022","journal-title":"Int. J. Pharm. X"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jcis.2019.01.098","article-title":"Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo","volume":"542","author":"Perton","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.apmt.2019.06.006","article-title":"Fluorescent and magnetic stellate mesoporous silica for bimodal imaging and magnetic hyperthermia","volume":"16","author":"Perton","year":"2019","journal-title":"Appl. Mater. Today"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"128407","DOI":"10.1016\/j.colsurfa.2022.128407","article-title":"Core-shell iron oxide@stellate mesoporous silica for combined near-infrared photothermia and drug delivery: Influence of pH and surface chemistry","volume":"640","author":"Adam","year":"2022","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/anie.197200161","article-title":"Macrocyclic Polyethers and Their Complexes","volume":"11","author":"Pedersen","year":"1972","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1021\/ja00856a018","article-title":"Cryptates. XVI. [2]-Cryptates. Stability and selectivity of alkali and alkaline-earth macrobicyclic complexes","volume":"97","author":"Lehn","year":"1975","journal-title":"J. Am. Chem. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s11172-011-0075-1","article-title":"Synthesis of azacrown ethers and benzocryptands by macrocyclization of podands at high concentrations of reactants","volume":"60","author":"Oshchepkov","year":"2011","journal-title":"Russ. Chem. Bull."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/acsanm.1c03959","article-title":"Peptide Hydrogels Assembled from Enzyme-Adsorbed Mesoporous Silica Nanostructures for Thermoresponsive Doxorubicin Release","volume":"5","author":"Li","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_38","unstructured":"(2022, November 16). Carbodiimide Crosslinker Chemistry\u2014FR. Available online: https:\/\/www.thermofisher.com\/fr\/fr\/home\/life-science\/protein-biology\/protein-biology-learning-center\/protein-biology-resource-library\/pierce-protein-methods\/carbodiimide-crosslinker-chemistry.html."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e4271","DOI":"10.1002\/aoc.4271","article-title":"An efficient and new protocol for the Heck reaction using palladium nanoparticle-engineered dibenzo-18-crown-6-ether\/MCM-41 nanocomposite in water","volume":"32","author":"Azaroon","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1021\/ja00403a026","article-title":"Nuclear magnetic resonance studies of some sodium ion complexes with crown ethers and [2]-cryptands in various solvents","volume":"103","author":"Lin","year":"1981","journal-title":"J. Am. Chem. Soc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00646180","article-title":"The influence of acetonitrile on complex formation of crown ethers containing different donor atoms","volume":"17","author":"Buschmann","year":"1988","journal-title":"J. Solut. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/jo00340a033","article-title":"Crown cation complex effects. 16. Solvent dependence of the 15-crown-5 and 18-crown-6 equilibriums with sodium cation","volume":"47","author":"Dishong","year":"1982","journal-title":"J. Org. Chem."},{"key":"ref_43","unstructured":"Hamilton, A.D. (2023, June 01). 5. 21\u2014Crown Ethers and Cryptands. Available online: https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/B9780080965192001272?via%3Dihub."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0024-3205(91)90504-5","article-title":"The toxicity of methanol","volume":"48","author":"Tephly","year":"1991","journal-title":"Life Sci."},{"key":"ref_45","unstructured":"Knerr, T. (2001). Solution for Peritoneal Dialysis. (US6277815B1)."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.kint.2015.12.032","article-title":"Increasing sodium removal on peritoneal dialysis: Applying dialysis mechanics to the peritoneal dialysis prescription","volume":"89","author":"Fischbach","year":"2016","journal-title":"Kidney Int."},{"key":"ref_47","unstructured":"Katritzky, A.R., and Rees, C.W. (1985). Handbook of Heterocyclic Chemistry, Elsevier."},{"key":"ref_48","first-page":"16","article-title":"Determinants of sodium removal with tidal automated peritoneal dialysis","volume":"28","author":"Domenici","year":"2012","journal-title":"Adv. Perit. Dial. Conf. Perit. Dial."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/12\/4622\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:50:22Z","timestamp":1760125822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/12\/4622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["molecules28124622"],"URL":"https:\/\/doi.org\/10.3390\/molecules28124622","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]}}}