{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:34:46Z","timestamp":1792154086720,"version":"4.4.0"},"reference-count":95,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University, Riyadh, Saudi Arabia","doi-asserted-by":"publisher","award":["RSP2023R504"],"award-info":[{"award-number":["RSP2023R504"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Exposure to food contaminants continues to be a substantial source of human health risks all over the world, particularly in developing countries. Carbendazim (CBZ) is a chemical fungicide used to control the spread of various fungi and other pathogens in the agriculture and veterinary sectors. The hazardous effects of CBZ on human health occur due to the accumulation of its residues in agricultural food products. In this study, the possible hepatoprotective effects of Adiantum capillus-veneris L. (ACVL) extract were evaluated in CBZ-treated rats. A GC-MS analysis revealed that ACVL extract contained several bioactive hydrocarbon components and fatty acids, and that the components exerted hepatic protection by mitigating oxidative stress via upregulating antioxidant agents and neutralizing nitrogen and oxygen free radicals. Moreover, ACVL extracts relieved hepatic inflammation via decreasing NO, NF-\u03baB, and pro-inflammatory cytokines (TNF-a, IL-6) in the liver of CBZ-treated rats, both at protein and mRNA levels. In addition, the protective effect of ACVL has appeared in the histopathological figures and function markers in the livers of CBZ-treated rats. According to the present results, ACVL extract can protect the hepatic tissue and restore its functions to a control level in CBZ-treated rats; this effect may be attributed to its antioxidant and anti-inflammatory activities.<\/jats:p>","DOI":"10.3390\/molecules28124720","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T02:00:45Z","timestamp":1686621645000},"page":"4720","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mitigation of Hepatotoxicity via Boosting Antioxidants and Reducing Oxidative Stress and Inflammation in Carbendazim-Treated Rats Using Adiantum Capillus-Veneris L. Extract"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-0030","authenticated-orcid":false,"given":"Mohamed","family":"Seif","sequence":"first","affiliation":[{"name":"Toxicology and Food Contaminants Department, Food Industries and Nutrition Research Institute, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1598-2273","authenticated-orcid":false,"given":"Hanan","family":"Aati","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Amer","sequence":"additional","affiliation":[{"name":"Toxicology and Food Contaminants Department, Food Industries and Nutrition Research Institute, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3536-554X","authenticated-orcid":false,"given":"Arthur J.","family":"Ragauskas","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996-2200, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Seif","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Assuit University, Asyut 71516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed H.","family":"El-Sappah","sequence":"additional","affiliation":[{"name":"Genetics Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Aati","sequence":"additional","affiliation":[{"name":"Rokn Al-Madaein Pharmaceutical Warehouse Co., P.O. Box 2990, Riyadh 11495, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd El-Nasser A.","family":"Madboli","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Artificial Insemination Department, Veterinary Research Institute, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7741-7435","authenticated-orcid":false,"given":"Mahmoud","family":"Emam","sequence":"additional","affiliation":[{"name":"Phytochemistry and Plant Systematics Department, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-3059.2006.01440.x","article-title":"The development of commercial disease control","volume":"55","author":"Russell","year":"2006","journal-title":"Plant Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"62943","DOI":"10.1007\/s11356-021-15142-4","article-title":"Ephedra sinica mitigates hepatic oxidative stress and inflammation via suppressing the TLR4\/MyD88\/NF-\u03baB pathway in fipronil-treated rats","volume":"28","author":"Seif","year":"2021","journal-title":"Environ. 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