{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:28:35Z","timestamp":1783733315803,"version":"3.55.0"},"reference-count":84,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Slovak Research &amp; Development Agency","doi-asserted-by":"publisher","award":["APVV-19-0154"],"award-info":[{"award-number":["APVV-19-0154"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research &amp; Development Agency","doi-asserted-by":"publisher","award":["SK-BY-RD-19-0019"],"award-info":[{"award-number":["SK-BY-RD-19-0019"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research &amp; Development Agency","doi-asserted-by":"publisher","award":["2\/0091\/21"],"award-info":[{"award-number":["2\/0091\/21"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research &amp; Development Agency","doi-asserted-by":"publisher","award":["2\/0153\/21"],"award-info":[{"award-number":["2\/0153\/21"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VEGA Grant Agency of the Slovak Republic","award":["APVV-19-0154"],"award-info":[{"award-number":["APVV-19-0154"]}]},{"name":"VEGA Grant Agency of the Slovak Republic","award":["SK-BY-RD-19-0019"],"award-info":[{"award-number":["SK-BY-RD-19-0019"]}]},{"name":"VEGA Grant Agency of the Slovak Republic","award":["2\/0091\/21"],"award-info":[{"award-number":["2\/0091\/21"]}]},{"name":"VEGA Grant Agency of the Slovak Republic","award":["2\/0153\/21"],"award-info":[{"award-number":["2\/0153\/21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H2Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aimed to study how R-Se affects rat hemodynamic parameters and vasoactive properties in isolated arteries. The right jugular vein of anesthetized Wistar male rats was cannulated for IV administration of R-Se. The arterial pulse waveform (APW) was detected by cannulation of the left carotid artery, enabling the evaluation of 35 parameters. R-Se (1\u20132 \u00b5mol kg\u22121), but not phthalic anhydride or phthalic thioanhydride, transiently modulated most of the APW parameters including a decrease in systolic and diastolic blood pressure, heart rate, dP\/dtmax relative level, or anacrotic\/dicrotic notches, whereas systolic area, dP\/dtmin delay, dP\/dtd delay, anacrotic notch relative level or its delay increased. R-Se (~10\u2013100 \u00b5mol L\u22121) significantly decreased the tension of precontracted mesenteric, femoral, and renal arteries, whereas it showed a moderate vasorelaxation effect on thoracic aorta isolated from normotensive Wistar rats. The results imply that R-Se acts on vascular smooth muscle cells, which might underlie the effects of R-Se on the rat hemodynamic parameters.<\/jats:p>","DOI":"10.3390\/molecules28124826","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T02:29:19Z","timestamp":1687141759000},"page":"4826","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-2941","authenticated-orcid":false,"given":"Peter","family":"Balis","sequence":"first","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-238X","authenticated-orcid":false,"given":"Andrea","family":"Berenyiova","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6331-1004","authenticated-orcid":false,"given":"Anton","family":"Misak","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-7924","authenticated-orcid":false,"given":"Marian","family":"Grman","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0192-9626","authenticated-orcid":false,"given":"Zuzana","family":"Rostakova","sequence":"additional","affiliation":[{"name":"Institute of Measurement Science, Slovak Academy of Sciences, Dubravska Cesta 9, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-2780","authenticated-orcid":false,"given":"Iveta","family":"Waczulikova","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynska Dolina F1, 842 48 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-7468","authenticated-orcid":false,"given":"Sona","family":"Cacanyiova","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-1575","authenticated-orcid":false,"given":"Enrique","family":"Dom\u00ednguez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG), Consejo Superior de Investigaciones Cient\u00edficas CSIC, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3563","authenticated-orcid":false,"given":"Karol","family":"Ondrias","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scitotenv.2011.02.040","article-title":"Medical geology of arsenic, selenium and thallium in China","volume":"421\u2013422","author":"Li","year":"2012","journal-title":"Sci. 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