{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:09:20Z","timestamp":1789585760236,"version":"build-2803163510"},"reference-count":263,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82151224,"],"award-info":[{"award-number":["82151224,"]}]},{"name":"National Natural Science Foundation of China","award":["82202492"],"award-info":[{"award-number":["82202492"]}]},{"name":"National Natural Science Foundation of China","award":["2020YFA0712102"],"award-info":[{"award-number":["2020YFA0712102"]}]},{"name":"National Natural Science Foundation of China","award":["BWS21J025"],"award-info":[{"award-number":["BWS21J025"]}]},{"name":"National Natural Science Foundation of China","award":["20SWAQK22"],"award-info":[{"award-number":["20SWAQK22"]}]},{"name":"National Natural Science Foundation of China","award":["QNTD2023-01"],"award-info":[{"award-number":["QNTD2023-01"]}]},{"name":"National Natural Science Foundation of China","award":["H2021028"],"award-info":[{"award-number":["H2021028"]}]},{"name":"National Key Research and Development Program of China","award":["82151224,"],"award-info":[{"award-number":["82151224,"]}]},{"name":"National Key Research and Development Program of China","award":["82202492"],"award-info":[{"award-number":["82202492"]}]},{"name":"National Key Research and Development Program of China","award":["2020YFA0712102"],"award-info":[{"award-number":["2020YFA0712102"]}]},{"name":"National Key Research and Development Program of China","award":["BWS21J025"],"award-info":[{"award-number":["BWS21J025"]}]},{"name":"National Key Research and Development Program of China","award":["20SWAQK22"],"award-info":[{"award-number":["20SWAQK22"]}]},{"name":"National Key Research and Development Program of China","award":["QNTD2023-01"],"award-info":[{"award-number":["QNTD2023-01"]}]},{"name":"National Key Research and Development Program of China","award":["H2021028"],"award-info":[{"award-number":["H2021028"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["82151224,"],"award-info":[{"award-number":["82151224,"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["82202492"],"award-info":[{"award-number":["82202492"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["2020YFA0712102"],"award-info":[{"award-number":["2020YFA0712102"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["BWS21J025"],"award-info":[{"award-number":["BWS21J025"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["20SWAQK22"],"award-info":[{"award-number":["20SWAQK22"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["QNTD2023-01"],"award-info":[{"award-number":["QNTD2023-01"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["H2021028"],"award-info":[{"award-number":["H2021028"]}]},{"name":"H&amp;H Global Research and Technology Center","award":["82151224,"],"award-info":[{"award-number":["82151224,"]}]},{"name":"H&amp;H Global Research and Technology Center","award":["82202492"],"award-info":[{"award-number":["82202492"]}]},{"name":"H&amp;H Global Research and Technology Center","award":["2020YFA0712102"],"award-info":[{"award-number":["2020YFA0712102"]}]},{"name":"H&amp;H Global Research and Technology Center","award":["BWS21J025"],"award-info":[{"award-number":["BWS21J025"]}]},{"name":"H&amp;H Global Research and Technology Center","award":["20SWAQK22"],"award-info":[{"award-number":["20SWAQK22"]}]},{"name":"H&amp;H Global Research and Technology Center","award":["QNTD2023-01"],"award-info":[{"award-number":["QNTD2023-01"]}]},{"name":"H&amp;H Global Research and Technology Center","award":["H2021028"],"award-info":[{"award-number":["H2021028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for human use and has been used in the clinic for more than 70 years. Cepharanthine has a variety of medicinal properties, including signaling pathway inhibitory activities, immunomodulatory activities, and antiviral activities. Recently, cepharanthine has been confirmed to greatly inhibit SARS-CoV-2 infection. Therefore, we aimed to describe the pharmacological properties and mechanisms of cepharanthine, mainly including antitumor, anti-inflammatory, anti-pathogen activities, inhibition of bone resorption, treatment of alopecia, treatment of snake bite, and other activities. At the same time, we analyzed and summarized the potential antiviral mechanism of cepharanthine and concluded that one of the most important anti-viral mechanisms of cepharanthine may be the stability of plasma membrane fluidity. Additionally, we explained its safety and bioavailability, which provides evidence for cepharanthine as a potential drug for the treatment of a variety of diseases. Finally, we further discuss the potential new clinical applications of cepharanthine and provide direction for its future development.<\/jats:p>","DOI":"10.3390\/molecules28135019","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:45:11Z","timestamp":1687913111000},"page":"5019","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Pharmacological Activity of Cepharanthine"],"prefix":"10.3390","volume":"28","author":[{"given":"Ke","family":"Liu","sequence":"first","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixia","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxing","family":"Lou","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-9540","authenticated-orcid":false,"given":"Yecheng","family":"You","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolan","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Shafqat","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-2158","authenticated-orcid":false,"given":"Huahao","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-8045","authenticated-orcid":false,"given":"Yigang","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"},{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/0968-0896(95)00136-5","article-title":"The biological activity of cyclic bis(bibenzyls): A rational approach","volume":"3","author":"Keseru","year":"1995","journal-title":"Bioorg. 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