{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:49:58Z","timestamp":1790279398777,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977014"],"award-info":[{"award-number":["21977014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), an amyloid-related disease, seriously endangers the health of elderly individuals. According to current research, its main pathogenic factor is the amyloid protein, which is a kind of fibrillar aggregate formed by noncovalent self-assembly of proteins. Based on the characteristics of aggregation-induced emission (AIE), a bislactosyl-decorated tetraphenylethylene (TPE) molecule TMNL (TPE + malononitrile + lactose), bearing two malononitrile substituents, was designed and synthesized in this work. The amphiphilic TMNL could self-assemble into fluorescent organic nanoparticles (FONs) with near-infrared (NIR) fluorescence emission in physiological PBS (phosphate buffered saline), achieving excellent fluorescent enhancement (47-fold) upon its combination with A\u03b21\u201342 fibrils. TMNL was successfully applied to image A\u03b21\u201342 plaques in the brain tissue of AD transgenic mice, and due to the AIE properties of TMNL, no additional rinsing process was necessary. It is believed that the probe reported in this work should be useful for the sensitive detection and accurate localization mapping of A\u03b21\u201342 aggregates related to Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/molecules28135110","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T01:14:12Z","timestamp":1688087652000},"page":"5110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An AIE-Active NIR Fluorescent Probe with Good Water Solubility for the Detection of A\u03b21\u201342 Aggregates in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"28","author":[{"given":"Yan-Ming","family":"Ji","sequence":"first","affiliation":[{"name":"Center of Safety Production and Testing Technology, China Academy of Safety Science and Technology, Beijing 100012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Chemistry, Beijing Normal University, Beijing 100875, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry, Beijing Normal University, Beijing 100875, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang-Wei","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Chemistry, Beijing Normal University, Beijing 100875, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Beijing Normal University, Beijing 100875, China"},{"name":"Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-7569","authenticated-orcid":false,"given":"Guo-Wen","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Chemistry, Beijing Normal University, Beijing 100875, China"},{"name":"Key Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1038\/475S9a","article-title":"Drugs: A tangled web of targets","volume":"475","author":"Gravitz","year":"2011","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nm.2460","article-title":"Resolving controversies on the path to Alzheimer\u2019s therapeutics","volume":"17","author":"Selkoe","year":"2011","journal-title":"Nat. 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