{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:52:28Z","timestamp":1792623148934,"version":"4.5.0"},"reference-count":93,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T00:00:00Z","timestamp":1688256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Development Plan Project of Jilin Province, China","award":["YDZJ202301ZYTS171"],"award-info":[{"award-number":["YDZJ202301ZYTS171"]}]},{"name":"Science and Technology Development Plan Project of Jilin Province, China","award":["YDZJ202201ZYTS186"],"award-info":[{"award-number":["YDZJ202201ZYTS186"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Euphorbia fischeriana has a long-standing history of use in traditional medicine for the treatment of tuberculosis diseases. However, the plant\u2019s therapeutic potential extends beyond this specific ailment. The present study aimed to investigate the antioxidant properties of Euphorbia fischeriana and lay the groundwork for further research on its potential therapeutic applications. Phytochemical tests were performed on the plant, and 11 types of phytochemicals were identified. Ultraviolet\u2013visible spectrophotometry was used to evaluate the active components and antioxidant properties of eight different solvent extracts, ultimately selecting acetone extract for further research. UHPLC-ESI-Q-TOF-MS identified 43 compounds in the acetone extract, and chemical calculations were used to isolate those with high content and antioxidant activity. Three stability experiments confirmed the extract\u2019s stability, while cell viability and oral acute toxicity studies demonstrated its relatively low toxicity. In rats, the acetone extract showed significant protective effects against D-galactosamine-induced liver damage through histopathological examination and biochemical analysis. These results suggest that Euphorbia fischeriana\u2019s acetone extract has potential in treating diseases related to oxidative imbalances. Therefore, this study highlights the plant\u2019s potential therapeutic applications while providing insight into its antioxidant properties.<\/jats:p>","DOI":"10.3390\/molecules28135172","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:53:16Z","timestamp":1688345596000},"page":"5172","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Phytochemical Analysis, Antioxidant Activities In Vitro and In Vivo, and Theoretical Calculation of Different Extracts of Euphorbia fischeriana"],"prefix":"10.3390","volume":"28","author":[{"given":"Yue","family":"Sun","sequence":"first","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"},{"name":"Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xin","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"},{"name":"Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Bao","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Scientific and Technical Information of Jilin, Changchun 130033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"},{"name":"Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Qing","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"},{"name":"Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-2888","authenticated-orcid":false,"given":"Hao","family":"Zang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"},{"name":"Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,2]]},"reference":[{"key":"ref_1","unstructured":"Flora of China editorial Committee of Chinese Academy of Sciences (1997). 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