{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:37:30Z","timestamp":1782945450513,"version":"3.54.5"},"reference-count":106,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Life Sciences","award":["SD\/54\/T\u017b\/2022"],"award-info":[{"award-number":["SD\/54\/T\u017b\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Medicinal mushrooms, e.g., Lion\u2019s Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst.), Chaga (Inonotus obliquus (Ach. ex Pers.) Pil\u00e1t), Cordyceps (Ophiocordyceps sinensis (Berk.) G.H. Sung, J.M. Sung, Hywel-Jones and Spatafora), Shiitake (Lentinula edodes (Berk.) Pegler), and Turkey Tail (Trametes versicolor (L.) Lloyd), are considered new-generation foods and are of growing interest to consumers. They are characterised by a high content of biologically active compounds, including (1,3)(1,6)-\u03b2-d-glucans, which are classified as dietary fibre, triterpenes, phenolic compounds, and sterols. Thanks to their low-fat content, they are a low-calorie product and are classified as a functional food. They have a beneficial effect on the organism through the improvement of its overall health and nutritional level. The biologically active constituents contained in medicinal mushrooms exhibit anticancer, antioxidant, antidiabetic, and immunomodulatory effects. In addition, these mushrooms accelerate metabolism, help fight obesity, and slow down the ageing processes thanks to their high antioxidant activity. The vast therapeutic properties of mushrooms are still not fully understood. Detailed mechanisms of the effects of medicinal mushrooms on the human organism still require long-term clinical studies to confirm their nutraceutical effects, their safety of use, and their dosage. Medicinal mushrooms have great potential to be used in the design of innovative functional foods. There is a need for further research on the possibility of incorporating mushrooms into food products to assess the interactions of their bioactive substances with ingredients in the food matrix. This review focuses on the properties of selected medicinal mushrooms and their effects on the human organism and presents current knowledge on the possibilities of their use in the production of functional foods.<\/jats:p>","DOI":"10.3390\/molecules28145393","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:49:30Z","timestamp":1689295770000},"page":"5393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":226,"title":["Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production\u2014A Review"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-2986","authenticated-orcid":false,"given":"Paulina","family":"\u0141ysakowska","sequence":"first","affiliation":[{"name":"Department of Plant Food Technology and Gastronomy, University of Life Sciences in Lublin, Skromna 8 Street, 20-704 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-6764","authenticated-orcid":false,"given":"Aldona","family":"Sobota","sequence":"additional","affiliation":[{"name":"Department of Plant Food Technology and Gastronomy, University of Life Sciences in Lublin, Skromna 8 Street, 20-704 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1647-2921","authenticated-orcid":false,"given":"Anna","family":"Wirkijowska","sequence":"additional","affiliation":[{"name":"Department of Plant Food Technology and Gastronomy, University of Life Sciences in Lublin, Skromna 8 Street, 20-704 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.5897\/JMPR09.565","article-title":"Nutritional and medicinal importance of mushrooms","volume":"4","author":"Wani","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/NT.0000000000000063","article-title":"Mushrooms-Biologically Distinct and Nutritionally Unique: Exploring a \u201dThird Food Kingdom\u201d","volume":"49","author":"Feeney","year":"2014","journal-title":"Nutr. Today"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.46505\/IJBI.2020.2211","article-title":"Status of Animal Phyla in Different Kingdom Systems of Biological Classification","volume":"2","author":"Verma","year":"2020","journal-title":"Int. J. Biol. Innov."},{"key":"ref_4","first-page":"611","article-title":"Marvelous Medicinal Mushrooms","volume":"3","author":"Beulah","year":"2013","journal-title":"Int. J. Pharma Bio Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13225-022-00507-y","article-title":"The numbers of fungi","volume":"114","author":"Hyde","year":"2022","journal-title":"Fungal Divers."},{"key":"ref_6","first-page":"145","article-title":"Medicinal Mushrooms as a Source of Natural Therapeutic Bioactive Compounds","volume":"18","author":"Elkhateeb","year":"2019","journal-title":"Egypt. Pharm. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3945\/an.112.003566","article-title":"White vegetables: A forgotten source of nutrients: Purdue roundtable executive summary","volume":"4","author":"Weaver","year":"2013","journal-title":"Adv. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1615\/IntJMedMushrooms.2020037133","article-title":"Effect of Cultured Substrates on the Chemical Composition and Biological Activities of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes)","volume":"22","author":"Song","year":"2020","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18231\/j.ijpca.2022.001","article-title":"Medicinal mushroom: What should we know?","volume":"9","author":"Elkhateeb","year":"2022","journal-title":"Int. J. Pharm. Chem. Anal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11101-021-09748-2","article-title":"Mycochemicals in wild and cultivated mushrooms: Nutrition and health","volume":"21","author":"Cateni","year":"2022","journal-title":"Phytochem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1021\/jf071435+","article-title":"Effect of Fruiting Body Maturity Stage on Chemical Composition and Antimicrobial Activity of Lactarius sp. Mushrooms","volume":"55","author":"Barros","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"042007","DOI":"10.1088\/1742-6596\/2373\/4\/042007","article-title":"Methods for evaluating chaga extraction effectiveness based on its porosity change","volume":"2373","author":"Safin","year":"2022","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1024\/0300-9831\/a000294","article-title":"Vitamin D2, Ergosterol, and Vitamin B2 Content in Commercially Dried Mushrooms Marketed in China and Increased Vitamin D2 Content Following UV-C Irradiation","volume":"87","author":"Huang","year":"2017","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jep.2014.12.069","article-title":"Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal \u201cmushroom\u201d","volume":"162","author":"Fernandes","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1177\/1534735418757912","article-title":"Chaga (Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B)","volume":"17","author":"Dubreule","year":"2018","journal-title":"Integr Cancer Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1016\/j.chroma.2010.06.062","article-title":"Determination of nucleotides, nucleosides and their transformation products in Cordyceps by ion-pairing reversed-phase liquid chromatography-mass spectrometry","volume":"1217","author":"Yang","year":"2010","journal-title":"J. Chromatogr. A."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.31665\/JFB.2022.17304","article-title":"Qualitative Analysis of Secondary Metabolites of Chaga Mushroom (Inonotus obliquus): Phenolics, Fatty Acids, and Terpenoids","volume":"17","author":"Peng","year":"2022","journal-title":"J. Food Bioact."},{"key":"ref_18","first-page":"513","article-title":"Mushrooms in the human diet\u2014Nutritional and pro-health value","volume":"65","author":"Golianek","year":"2016","journal-title":"Kosmos"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Dimopoulou, M., Kolonas, A., Mourtakos, S., Androutsos, O., and Gortzi, O. (2022). Nutritional Composition and Biological Properties of Sixteen Edible Mushroom Species. Appl. Sci., 12.","DOI":"10.3390\/app12168074"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lu, Y., Jia, Y., Xue, Z., Li, N., Liu, J., and Chen, H. (2021). Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application. Polymers, 13.","DOI":"10.3390\/polym13091441"},{"key":"ref_21","first-page":"48","article-title":"\u03b2-Glucan Content and Hydration Properties of Filamentous Fungi","volume":"49","author":"Kyanko","year":"2013","journal-title":"Prikl Biokhim Mikrobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3923\/ijp.2021.243.250","article-title":"Evaluation of Some Active Nutrients, Biological Compounds and Health Benefits of Reishi Mushroom (Ganoderma lucidum)","volume":"17","author":"Parepalli","year":"2021","journal-title":"Int. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s13205-018-1358-0","article-title":"Medicinal Mushroom: Boon for Therapeutic Applications","volume":"8","author":"Chaturvedi","year":"2018","journal-title":"3 Biotech"},{"key":"ref_24","first-page":"7","article-title":"Chemical composition and physicochemical properties of shiitake mushroom and high fiber products","volume":"7","year":"2009","journal-title":"J. Food"},{"key":"ref_25","unstructured":"Riaz, S., Ahmad, A., Farooq, R., Ahmed, M., Shaheryar, M., and Hussain, M. (2022). Current Topics in Functional Food, IntechOpen."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1590\/s0102-0536-20210412","article-title":"Firmness and biochemical composition of Shitake and Shimeji commercialized in natura and consumers\u2019 opinion survey","volume":"39","author":"Antunes","year":"2021","journal-title":"Hortic. Bras."},{"key":"ref_27","first-page":"135","article-title":"Dried Shiitake (Lentinula edodes) and Oyster (Pleurotus ostreatus) Mushrooms as a Good Source of Nutrient","volume":"6","author":"Siwulski","year":"2007","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1615\/IntJMedMushrooms.2020035027","article-title":"Assessment of Bioactive Compounds and Antioxidant Activity of Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes)","volume":"22","author":"Kivrak","year":"2020","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Vetter, J. (2023). The Mushroom Glucans: Molecules of High Biological and Medicinal Importance. Foods, 12.","DOI":"10.3390\/foods12051009"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"376387","DOI":"10.1155\/2015\/376387","article-title":"Edible mushroom: Improving human health and promoting quality life","volume":"2015","author":"Valverde","year":"2015","journal-title":"Int. J. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3390\/agriculture2040452","article-title":"Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms","volume":"2","author":"Villares","year":"2012","journal-title":"Agriculture"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cerletti, C., Esposito, S., and Iacoviello, L. (2021). Edible Mushrooms and Beta-Glucans: Impact on Human Health. Nutrients, 13.","DOI":"10.3390\/nu13072195"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1021\/acs.biomac.9b01644","article-title":"Recent advances in chain conformation and bioactivities of triple-helix polysaccharides","volume":"21","author":"Meng","year":"2020","journal-title":"Biomacromolecules"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1753-4887.2009.00230.x","article-title":"Beta-glucans in higher fungi and their health effects","volume":"67","author":"Rop","year":"2009","journal-title":"Nutr. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0008-6215(00)00222-6","article-title":"The cytokine stimulating activity of (1\u21923)-beta-D-glucans is dependent on the triple helix conformation","volume":"329","author":"Falch","year":"2000","journal-title":"Carbohydr. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/bip.20920","article-title":"Higher order structure of (1,3)-beta-D-glucans and its influence on their biological activities and complexation abilities","volume":"89","author":"Sletmoen","year":"2008","journal-title":"Biopolymers"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1074-7613(03)00233-4","article-title":"Fungal beta-glucans and mammalian immunity","volume":"19","author":"Brown","year":"2003","journal-title":"Immunity"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.foodchem.2010.12.149","article-title":"A New Colorimetric Method to Quantify \u03b2-1,3\u20131,6-Glucans in Comparison with Total \u03b2-1,3-Glucans in Edible Mushrooms","volume":"127","author":"Nitschke","year":"2011","journal-title":"Food Chem."},{"key":"ref_39","first-page":"5717","article-title":"Preparation of Glucan from Lentinula edodes Edible Mushroom and Elucidation of Its Medicinal Value","volume":"4","author":"Rasmy","year":"2010","journal-title":"Aust. J. Basic Appl. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Miro\u0144czuk-Chodakowska, I., and Witkowska, A.M. (2020). Evaluation of Polish Wild Mushrooms as Beta-Glucan Sources. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17197299"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100045","DOI":"10.1016\/j.prmcm.2022.100045","article-title":"Functional polysaccharide lentinan: Role in anti-cancer therapies and management of carcinomas","volume":"2","author":"Trivedi","year":"2022","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wu, J.-Y., Siu, K.-C., and Geng, P. (2021). Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake). Foods, 10.","DOI":"10.3390\/foods10010095"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Del Corn\u00f2, M., Gessani, S., and Conti, L. (2020). Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?. Cancers, 12.","DOI":"10.3390\/cancers12010155"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3746\/pnf.2020.25.2.184","article-title":"Functional Cordyceps Coffee Containing Cordycepin and \u03b2-Glucan Hyo-Nam Song","volume":"25","author":"Song","year":"2020","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.foodchem.2016.08.010","article-title":"Screening of beta-glucan contents in commercially cultivated and wild growing mushrooms","volume":"216","author":"Sari","year":"2017","journal-title":"Food Chem."},{"key":"ref_46","first-page":"47758","article-title":"Effect of lentinan on proliferation and apoptosis of human astrocytoma U251 cells","volume":"3","author":"Yuan","year":"2023","journal-title":"Pol J Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/pat.5614","article-title":"Fabrication and investigation potential effect of lentinan and docetaxel nanofibers for synergistic treatment of breast cancer in vitro","volume":"33","author":"Ataollahi","year":"2022","journal-title":"Polym. Adv. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbrc.2021.08.030","article-title":"Apaf1 NanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells","volume":"577","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1089\/act.2007.13410","article-title":"A turkey tail polysaccharide as an immunochemotherapy agent in cancer","volume":"13","author":"Abascal","year":"2007","journal-title":"Altern. Complement. Ther."},{"key":"ref_50","first-page":"420","article-title":"Simple and Efficient Method for the Detection and Quantification of Cordycepin Content in Cordyceps","volume":"48","author":"Thuy","year":"2021","journal-title":"Chiang Mai J. Sci."},{"key":"ref_51","first-page":"1923","article-title":"Potential Secondary Bioactive Compounds of Ganoderma lucidum (Reishi Mushroom) against Various Pathogenic Activity","volume":"3","author":"Karishma","year":"2021","journal-title":"Pharmacologyonline"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.biopha.2018.08.036","article-title":"Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement","volume":"107","author":"Ahmad","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_53","first-page":"138","article-title":"Large-flowered mushrooms\u2014An underestimated source of medicinal substances","volume":"17","year":"2015","journal-title":"Stud. I Mater. CEPL"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11557-015-1105-4","article-title":"Hericium erinaceus, an Amazing Medicinal Mushroom","volume":"14","author":"Thongbai","year":"2015","journal-title":"Mycol. Prog."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3136\/fstr.FSTR-D-22-00120","article-title":"Anti-glycation and antioxidant effects of Chaga mushroom decoction extracted with a fermentation medium","volume":"29","author":"Doi","year":"2023","journal-title":"Food Sci. Technol. Res."},{"key":"ref_56","first-page":"575063","article-title":"The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evid. Based Complement","volume":"2015","author":"Liu","year":"2015","journal-title":"Altern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.carbpol.2012.03.029","article-title":"Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice","volume":"89","author":"Wang","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/10755530260127998","article-title":"CordyMax Cs-4 improves glucose metabolism and increases insulin sensitivity in normal rats","volume":"8","author":"Zhao","year":"2002","journal-title":"J. Altern. Complement. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/ptr.4899","article-title":"Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors","volume":"27","author":"Yan","year":"2013","journal-title":"Phytother. Res."},{"key":"ref_60","first-page":"14","article-title":"Immune-Enhancing Effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) Extracts","volume":"2","author":"Vetvicka","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1615\/IntJMedMushrooms.2020035877","article-title":"Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Crude Exopolysaccharides with Antioxidative Activity","volume":"22","author":"Podsadni","year":"2020","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Benson, K.F., Stamets, P., Davis, R., Nally, R., Taylor, A., Slater, S., and Jensen, G.S. (2019). The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro. BMC Complement. Altern. Med., 19.","DOI":"10.1186\/s12906-019-2681-7"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Landi, N., Clemente, A., Pedone, P.V., Ragucci, S., and Di Maro, A. (2022). An Updated Review of Bioactive Peptides from Mushrooms in a Well-Defined Molecular Weight Range. Toxins, 14.","DOI":"10.3390\/toxins14020084"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"804","DOI":"10.2174\/1381612829666221223103756","article-title":"The health-promoting potential of edible mushroom proteins","volume":"29","author":"Sousa","year":"2023","journal-title":"Current Pharm. Des."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijbiomac.2021.03.015","article-title":"Lectins purified from medicinal and edible mushrooms: Insights into their antiviral activity against pathogenic viruses","volume":"179","author":"Hashish","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2174\/1389203717666160226144741","article-title":"Mushroom lectins as promising anticancer substances","volume":"17","author":"Singh","year":"2016","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11427-011-4153-2","article-title":"Purification and characterization of a novel immunomodulatory protein from the medicinal mushroom Trametes versicolor","volume":"54","author":"Li","year":"2011","journal-title":"Sci. China Life Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"985636","DOI":"10.1155\/2013\/985636","article-title":"The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats","volume":"2013","author":"Qi","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"523","DOI":"10.5897\/AJB2013.13446","article-title":"Diversity, Nutritional Composition and Medicinal Potential of Indian Mushrooms: A Review","volume":"13","author":"Thatoi","year":"2014","journal-title":"Afr. J. Biotechnol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"343","DOI":"10.15835\/nbha46211132","article-title":"Characterization of Trametes versicolor: Medicinal Mushroom with Important Health Benefits","volume":"46","author":"Pop","year":"2018","journal-title":"Not. Bot. Horti Agrobo."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Tagkouli, D., Kaliora, A., Bekiaris, G., Koutrotsios, G., Christea, M., Zervakis, G.I., and Kalogeropoulos, N. (2020). Free Amino Acids in Three Pleurotus Species Cultivated on Agricultural and Agro-Industrial By-Products. Molecules, 25.","DOI":"10.3390\/molecules25174015"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bionut.2011.07.002","article-title":"Fatty acid composition of lipids in wild Cordyceps sinensis from major habitats in China","volume":"2","author":"Guo","year":"2012","journal-title":"Biomed. Prev. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbalip.2004.11.007","article-title":"Erickson. Conjugated Linoleic Acid Reduction of Murine Mammary Tumor Cell Growth through 5-Hydroxyeicosatetraenoic","volume":"1687","author":"Kim","year":"2005","journal-title":"Acid. Biochim. Biophys. Acta"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/ejcn.2011.53","article-title":"Bioavailability of vitamin D2 from UV-B-irradiated button mushrooms in healthy adults deficient in serum 25-hydroxyvitamin D: A randomized controlled trial","volume":"65","author":"Urbain","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00792-013-0578-9","article-title":"Antimicrobial Ergosteroids and Pyrrole Derivatives from Halotolerant Aspergillus flocculosus PT05-1 Cultured in a Hypersaline Medium","volume":"17","author":"Zheng","year":"2013","journal-title":"Extremophiles"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1067\/mlc.2003.6","article-title":"H1-A Extracted from Cordyceps sinensis, Suppresses the Proliferation of Human Mesangial Cells and Promotes Apoptosis, Probably by Inhibiting the Tyrosine Phosphorylation of Bcl-2 and Bcl-XL","volume":"141","author":"Yang","year":"2003","journal-title":"J. Lab. Clin. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jfutfo.2022.09.002","article-title":"Overview on the edible mushrooms in Egypt","volume":"3","author":"Ahmed","year":"2023","journal-title":"J. Future Foods"},{"key":"ref_78","first-page":"100130","article-title":"Comparison of Antioxidant Activity and Extraction Techniques for Commercially and Laboratory Prepared Extracts from Six Mushroom Species","volume":"4","author":"Sharpe","year":"2021","journal-title":"J. Agric. Food Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Das, A.K., Nanda, P.K., Dandapat, P., Bandyopadhyay, S., Gull\u00f3n, P., Sivaraman, G.K., McClements, D.J., Gull\u00f3n, B., and Lorenzo, J.M. (2021). Edible Mushrooms as Functional Ingredients for Development of Healthier and More Sustainable Muscle Foods: A Flexitarian Approach. Molecules, 26.","DOI":"10.3390\/molecules26092463"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00217-020-03646-1","article-title":"Culinary\u2013Medicinal Mushrooms: A Review of Organic Compounds and Bioelements with Antioxidant Activity","volume":"247","author":"Podkowa","year":"2021","journal-title":"Eur. Food Res. Technol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.fshw.2018.05.002","article-title":"A critical review on the health promoting effects of mushrooms nutraceuticals","volume":"7","author":"Ma","year":"2018","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s13197-020-04583-3","article-title":"Total Phenolics, Antioxidant Activities and Fatty Acid Profiles of Six Morchella Species","volume":"58","author":"Attar","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jep.2018.11.041","article-title":"Phytochemical Composition, Antioxidant and Antiproliferative Activities and Effects on Nuclear DNA of Ethanolic Extract from an Italian Mycelial Isolate of Ganoderma lucidum","volume":"231","author":"Saltarelli","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jep.2009.06.026","article-title":"Anti-inflammatory effect of Inonotus obliquus, Polygala senega L.; and Viburnum trilobum in a cell screening assay","volume":"125","author":"Van","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/cbdv.200790027","article-title":"Anti-Inflammatory and Anti-Tumor-Promoting Effects of Triterpene Acids and Sterols from the Fungus Ganoderma lucidum","volume":"4","author":"Akihisa","year":"2007","journal-title":"Chem. Biodivers."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1021\/jf401612t","article-title":"Isolation, Identification, and Bioactivity of Monoterpenoids and Sesquiterpenoids from the Mycelia of Edible Mushroom Pleurotus cornucopiae","volume":"61","author":"Wang","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s13205-019-1906-2","article-title":"Mushrooms: An Emerging Resource for Therapeutic Terpenoids","volume":"9","author":"Dasgupta","year":"2019","journal-title":"3 Biotech."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.phytochem.2019.01.017","article-title":"Natural barrigenol-like triterpenoids: A comprehensive review of their contributions to medicinal chemistry","volume":"161","author":"Zhang","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.lwt.2006.04.003","article-title":"Sterol and vitamin D2 concentrations in cultivated and wild grown mushrooms: Effects of UV irradiation","volume":"40","author":"Teichmann","year":"2007","journal-title":"LWT Food Sci. Technol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1128S","DOI":"10.3945\/jn.114.190728","article-title":"Mushrooms and Health Summit Proceedings","volume":"144","author":"Feeney","year":"2014","journal-title":"J. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"153131","DOI":"10.1016\/j.phymed.2019.153131","article-title":"European medicinal mushrooms: Do they have potential for modern medicine?\u2013An update","volume":"66","author":"Reinhardt","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_92","first-page":"555817","article-title":"Application of Mushroom as Food and Medicine","volume":"11","author":"Waktola","year":"2018","journal-title":"Adv. Biotechnol. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2174\/1389201021666200130113441","article-title":"Current Prospects of Nutraceuticals: A Review","volume":"21","author":"Sachdeva","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Benkeblia, N. (2014). Polysaccharides Natural Fibres in Food and Nutrition, CRC Press.","DOI":"10.1201\/b17121"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phanu.2017.02.001","article-title":"Mushroom Nutraceuticals for Improved Nutrition and Better Human Health: A Review","volume":"5","author":"Rathore","year":"2017","journal-title":"PharmaNutrition"},{"key":"ref_96","unstructured":"Krzystyniak, K.L., and Klonowska, J. (2019). New Trends in Dietetics, University of Engineering and Health."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/cche.10043","article-title":"Incorporation of Mushroom Powder into Bread Dough\u2014Effects on Dough Rheology and Bread Properties","volume":"95","author":"Lu","year":"2018","journal-title":"Cereal Chem."},{"key":"ref_98","first-page":"505","article-title":"Effect of Adding Ling-zhi (Ganoderma lucidum) on Oxidative Stability, Textural and Sensory Properties of Smoked Fish Sausage","volume":"44","author":"Wannasupchue","year":"2011","journal-title":"Thai J. Agric. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.foodres.2010.07.014","article-title":"Ganoderma lucidum\u2014Medical Mushroom as a Raw Material for Beer with Enhanced Functional Properties","volume":"43","author":"Despotovic","year":"2010","journal-title":"Food Res. Int."},{"key":"ref_100","first-page":"135","article-title":"Effect of Ganoderma lucidum Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage","volume":"7","author":"Ghobadi","year":"2018","journal-title":"Adv. Biomed. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3746\/jkfn.2004.33.7.1201","article-title":"Bread Properties Utilizing Extracts of Ganoderma lucidum (GL)","volume":"33","author":"Chung","year":"2004","journal-title":"J. Korean Soc. Food Sci. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"456","DOI":"10.17221\/164\/2022-CJFS","article-title":"Yogurt Fortified with GABA-Producing Strain and Ganoderma lucidum Industrial Waste","volume":"40","year":"2022","journal-title":"Czech J. Food Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Szyd\u0142owska-Tutaj, M., Szymanowska, U., Tutaj, K., Domaga\u0142a, D., and Z\u0142otek, U. (2023). The Addition of Reishi and Lion\u2019s Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta. Antioxidants, 12.","DOI":"10.20944\/preprints202305.2143.v1"},{"key":"ref_104","first-page":"27155","article-title":"Development and Evaluation of Value Added Biscuits from Dehydrated Shiitake (Lentinus edodes) Mushroom","volume":"8","author":"Singh","year":"2016","journal-title":"Int. J. Curr. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1745-459X.2005.00016.x","article-title":"Perception of Pork Patties with Shiitake (Lentinus edodes) Mushroom Powder and Sodium Tripolyphosphate as Measured by Korean and United States Consumers","volume":"20","author":"Chun","year":"2005","journal-title":"J. Sens. Stud."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1111\/ijfs.13246","article-title":"How the Inclusion of Mushroom Powder Can Affect the Physicochemical Characteristics of Pasta","volume":"51","author":"Lu","year":"2016","journal-title":"Int. J. Food Sci. Technol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/14\/5393\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:11:43Z","timestamp":1760127103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/14\/5393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":106,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["molecules28145393"],"URL":"https:\/\/doi.org\/10.3390\/molecules28145393","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]}}}