{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T08:01:54Z","timestamp":1782633714296,"version":"3.54.5"},"reference-count":24,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82073718"],"award-info":[{"award-number":["82073718"]}]},{"name":"National Natural Science Foundation of China","award":["82160668"],"award-info":[{"award-number":["82160668"]}]},{"name":"National Natural Science Foundation of China","award":["3332022050"],"award-info":[{"award-number":["3332022050"]}]},{"name":"National Natural Science Foundation of China","award":["2022-I2M-1-017"],"award-info":[{"award-number":["2022-I2M-1-017"]}]},{"name":"National Natural Science Foundation of China","award":["JCYJ20190806162001763"],"award-info":[{"award-number":["JCYJ20190806162001763"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["82073718"],"award-info":[{"award-number":["82073718"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["82160668"],"award-info":[{"award-number":["82160668"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["3332022050"],"award-info":[{"award-number":["3332022050"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["2022-I2M-1-017"],"award-info":[{"award-number":["2022-I2M-1-017"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["JCYJ20190806162001763"],"award-info":[{"award-number":["JCYJ20190806162001763"]}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["82073718"],"award-info":[{"award-number":["82073718"]}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["82160668"],"award-info":[{"award-number":["82160668"]}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["3332022050"],"award-info":[{"award-number":["3332022050"]}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["2022-I2M-1-017"],"award-info":[{"award-number":["2022-I2M-1-017"]}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["JCYJ20190806162001763"],"award-info":[{"award-number":["JCYJ20190806162001763"]}]},{"name":"Basic research projects of Shenzhen Science and Technology Program","award":["82073718"],"award-info":[{"award-number":["82073718"]}]},{"name":"Basic research projects of Shenzhen Science and Technology Program","award":["82160668"],"award-info":[{"award-number":["82160668"]}]},{"name":"Basic research projects of Shenzhen Science and Technology Program","award":["3332022050"],"award-info":[{"award-number":["3332022050"]}]},{"name":"Basic research projects of Shenzhen Science and Technology Program","award":["2022-I2M-1-017"],"award-info":[{"award-number":["2022-I2M-1-017"]}]},{"name":"Basic research projects of Shenzhen Science and Technology Program","award":["JCYJ20190806162001763"],"award-info":[{"award-number":["JCYJ20190806162001763"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (1\u20134) and a 10-membered carbocycle fused with an \u03b1,\u03b2-epoxy-\u03b3-lactone, were isolated from Clitocybe clavipes, a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their spectroscopic data, and the ECD method. All the isolated compounds (1\u20134) were evaluated for their antitumor activity against three human cancer cell lines using the MTT assay. Compound 1 and 2 exhibited a significant suppression of cell viability in the Hela (IC50 = 22.8 and 19.7 \u03bcM) cell line.<\/jats:p>","DOI":"10.3390\/molecules28145456","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:46:02Z","timestamp":1689644762000},"page":"5456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity"],"prefix":"10.3390","volume":"28","author":[{"given":"Zhonghao","family":"Sun","sequence":"first","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongben","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Hebei University of Chinese Medicine, Shijiazhuang 050091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxu","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-9114","authenticated-orcid":false,"given":"Haifeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiling","family":"Shi","sequence":"additional","affiliation":[{"name":"Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaocui","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1039\/C5NP00090D","article-title":"Biosynthesis of fungal meroterpenoids","volume":"33","author":"Matsuda","year":"2016","journal-title":"Nat. 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