{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:12:14Z","timestamp":1790871134104,"version":"4.1.0"},"reference-count":354,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center","doi-asserted-by":"publisher","award":["OPUS 22 2021\/43\/B\/NZ7\/00230"],"award-info":[{"award-number":["OPUS 22 2021\/43\/B\/NZ7\/00230"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maj Institute of Pharmacology Polish Academy of Sciences","award":["OPUS 22 2021\/43\/B\/NZ7\/00230"],"award-info":[{"award-number":["OPUS 22 2021\/43\/B\/NZ7\/00230"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients\u2019 quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and maintenance of neuropathy but also in the effectiveness of analgesic drugs. Currently, approximately 50 chemokines are known to act through 20 different seven-transmembrane G-protein-coupled receptors located on the surface of neuronal, glial, and immune cells. Data from recent years clearly indicate that more chemokines than initially thought (CCL1\/2\/3\/5\/7\/8\/9\/11, CXCL3\/9\/10\/12\/13\/14\/17; XCL1, CX3CL1) have pronociceptive properties; therefore, blocking their action by using neutralizing antibodies, inhibiting their synthesis, or blocking their receptors brings neuropathic pain relief. Several of them (CCL1\/2\/3\/7\/9\/XCL1) have been shown to be able to reduce opioid drug effectiveness in neuropathy, and neutralizing antibodies against them can restore morphine and\/or buprenorphine analgesia. The latest research provides irrefutable evidence that chemokine receptors are promising targets for pharmacotherapy; chemokine receptor antagonists can relieve pain of different etiologies, and most of them are able to enhance opioid analgesia, for example, the blockade of CCR1 (J113863), CCR2 (RS504393), CCR3 (SB328437), CCR4 (C021), CCR5 (maraviroc\/AZD5672\/TAK-220), CXCR2 (NVPCXCR220\/SB225002), CXCR3 (NBI-74330\/AMG487), CXCR4 (AMD3100\/AMD3465), and XCR1 (vMIP-II). Recent research has shown that multitarget antagonists of chemokine receptors, such as CCR2\/5 (cenicriviroc), CXCR1\/2 (reparixin), and CCR2\/CCR5\/CCR8 (RAP-103), are also very effective painkillers. A multidirectional strategy based on the modulation of neuronal\u2013glial\u2013immune interactions by changing the activity of the chemokine family can significantly improve the quality of life of patients suffering from neuropathic pain. However, members of the chemokine family are still underestimated pharmacological targets for pain treatment. In this article, we review the literature and provide new insights into the role of chemokines and their receptors in neuropathic pain.<\/jats:p>","DOI":"10.3390\/molecules28155766","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T02:13:32Z","timestamp":1690769612000},"page":"5766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain"],"prefix":"10.3390","volume":"28","author":[{"given":"Katarzyna","family":"Pawlik","sequence":"first","affiliation":[{"name":"Department of Pain Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Str., 31-343 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-7205","authenticated-orcid":false,"given":"Joanna","family":"Mika","sequence":"additional","affiliation":[{"name":"Department of Pain Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Str., 31-343 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic Pain in the General Population: A Systematic Review of Epidemiological Studies","volume":"155","author":"Austin","year":"2014","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP Classification of Chronic Pain for ICD-11: Chronic Neuropathic Pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"key":"ref_3","first-page":"e22419","article-title":"Neuropathic Pain in Neurologic Disorders: A Narrative Review","volume":"14","author":"Mitsikostas","year":"2022","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7408508","DOI":"10.1155\/2020\/7408508","article-title":"Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life","volume":"2020","author":"Cherif","year":"2020","journal-title":"Pain Res. Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1157790","DOI":"10.3389\/fpsyt.2023.1157790","article-title":"Sleep Disorders in Chronic Pain and Its Neurochemical Mechanisms: A Narrative Review","volume":"14","author":"Duo","year":"2023","journal-title":"Front. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bja.2023.04.021","article-title":"Advances and Challenges in Neuropathic Pain: A Narrative Review and Future Directions","volume":"131","author":"Attal","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for Neuropathic Pain in Adults: A Systematic Review and Meta-Analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.pharep.2018.01.006","article-title":"The Importance of Chemokines in Neuropathic Pain Development and Opioid Analgesic Potency","volume":"70","author":"Kwiatkowski","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","article-title":"Chemokines, Neuronal-Glial Interactions, and Central Processing of Neuropathic Pain","volume":"126","author":"Gao","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The Many Roles of Chemokines and Chemokine Receptors in Inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.dci.2003.09.006","article-title":"Chemokines","volume":"28","author":"Laing","year":"2004","journal-title":"Dev. Comp. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.immuni.2009.09.010","article-title":"Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology","volume":"31","author":"Ransohoff","year":"2009","journal-title":"Immunity"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.intimp.2017.09.021","article-title":"Spinal CCL1\/CCR8 Signaling Interplay as a Potential Therapeutic Target\u2014Evidence from a Mouse Diabetic Neuropathy Model","volume":"52","author":"Zychowska","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e679","DOI":"10.1038\/cddis.2013.198","article-title":"CCL-1 in the Spinal Cord Contributes to Neuropathic Pain Induced by Nerve Injury","volume":"4","author":"Akimoto","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cyto.2019.03.007","article-title":"Chemokines CCL2 and CCL7, but Not CCL12, Play a Significant Role in the Development of Pain-Related Behavior and Opioid-Induced Analgesia","volume":"119","author":"Kwiatkowski","year":"2019","journal-title":"Cytokine"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pawlik, K., Ciapa\u0142a, K., Ciechanowska, A., Kwiatkowski, K., and Mika, J. (2023). Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2\/7\/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain. Cells, 12.","DOI":"10.3390\/cells12010098"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1523\/JNEUROSCI.3623-08.2009","article-title":"JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain","volume":"29","author":"Gao","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1097\/j.pain.0000000000001212","article-title":"Chemokine CCL2 and Its Receptor CCR2 in the Dorsal Root Ganglion Contribute to Oxaliplatin-Induced Mechanical Hypersensitivity","volume":"159","author":"Illias","year":"2018","journal-title":"Pain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fimmu.2018.00494","article-title":"Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine","volume":"9","author":"Rojewska","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/ALN.0000000000000190","article-title":"Chemokine (C-C Motif) Receptor 5 Is an Important Pathological Regulator in the Development and Maintenance of Neuropathic Pain","volume":"120","author":"Matsushita","year":"2014","journal-title":"Anesthesiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2010.07.085","article-title":"CC-Chemokine MIP-1\u03b1 in the Spinal Cord Contributes to Nerve Injury-Induced Neuropathic Pain","volume":"484","author":"Kiguchi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_22","first-page":"53","article-title":"Involvement of the Chemokine CCL3 and the Purinoceptor P2\u00d77 in the Spinal Cord in Paclitaxel-Induced Mechanical Allodynia","volume":"10","author":"Nagata","year":"2014","journal-title":"Mol. Pain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2021.781310","article-title":"Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain","volume":"12","author":"Pawlik","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/j.1532-2149.2012.00146.x","article-title":"CC-Chemokine Ligand 4\/Macrophage Inflammatory Protein-1beta Participates in the Induction of Neuropathic Pain after Peripheral Nerve Injury","volume":"16","author":"Saika","year":"2012","journal-title":"Eur. J. Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jneuroim.2016.05.003","article-title":"Calcitonin Gene-Related Peptide Contributes to Peripheral Nerve Injury-Induced Mechanical Hypersensitivity through CCL5 and P38 Pathways","volume":"297","author":"Malon","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yin, Q., Fan, Q., Zhao, Y., Cheng, M.-Y., Liu, H., Li, J., Lu, F.-F., Jia, J.-T., Cheng, W., and Yan, C.-D. (2015). Spinal NF-\u039aB and Chemokine Ligand 5 Expression during Spinal Glial Cell Activation in a Neuropathic Pain Model. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0115120"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"173166","DOI":"10.1016\/j.ejphar.2020.173166","article-title":"CCR4 Antagonist (C021) Influences the Level of Nociceptive Factors and Enhances the Analgesic Potency of Morphine in a Rat Model of Neuropathic Pain","volume":"880","author":"Bogacka","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1016\/j.bbadis.2018.07.032","article-title":"Pharmacological Blockade of CXCR3 by (\u00b1)-NBI-74330 Reduces Neuropathic Pain and Enhances Opioid Effectiveness\u2014Evidence from in Vivo and in Vitro Studies","volume":"1864","author":"Piotrowska","year":"2018","journal-title":"BBA-Mol. Basis Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1744806919863292","DOI":"10.1177\/1744806919863292","article-title":"GATA3-Dependent Epigenetic Upregulation of CCL21 Is Involved in the Development of Neuropathic Pain Induced by Bortezomib","volume":"15","author":"Zheng","year":"2019","journal-title":"Mol. Pain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/emboj.2011.89","article-title":"Neuronal CCL21 Up-Regulates Microglia P2X4 Expression and Initiates Neuropathic Pain Development","volume":"30","author":"Biber","year":"2011","journal-title":"EMBO J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.3389\/fimmu.2019.02198","article-title":"Pharmacological Blockade of Spinal CXCL3\/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury","volume":"10","author":"Piotrowska","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.pain.2013.07.002","article-title":"Chemokine Contribution to Neuropathic Pain: Respective Induction of CXCL1 and CXCR2 in Spinal Cord Astrocytes and Neurons","volume":"154","author":"Zhang","year":"2013","journal-title":"Pain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1124\/jpet.111.187724","article-title":"Epigenetic Augmentation of the Macrophage Inflammatory Protein 2\/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain","volume":"340","author":"Kiguchi","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neulet.2016.10.004","article-title":"Spinal CXCL5 Contributes to Nerve Injury-Induced Neuropathic Pain via Modulating GSK-3\u03b2 Phosphorylation and Activity in Rats","volume":"634","author":"Xu","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fimmu.2020.00477","article-title":"C-X-C Motif Chemokine 10 Contributes to the Development of Neuropathic Pain by Increasing the Permeability of the Blood\u2013Spinal Cord Barrier","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10549-013-2807-4","article-title":"Spinal IFN-\u03b3-Induced Protein-10 (CXCL10) Mediates Metastatic Breast Cancer-Induced Bone Pain by Activation of Microglia in Rat Models","volume":"143","author":"Bu","year":"2014","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1744806916636385","DOI":"10.1177\/1744806916636385","article-title":"Crosstalk between Astrocytic CXCL12 and Microglial CXCR4 Contributes to the Development of Neuropathic Pain","volume":"12","author":"Luo","year":"2016","journal-title":"Mol. Pain"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12264-015-0007-4","article-title":"Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats","volume":"32","author":"Bai","year":"2016","journal-title":"Neurosci. Bull."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/cns.13128","article-title":"CXCL12\/CXCR4 Signaling Contributes to Neuropathic Pain via Central Sensitization Mechanisms in a Rat Spinal Nerve Ligation Model","volume":"25","author":"Liu","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI81950","article-title":"CXCL13 Drives Spinal Astrocyte Activation and Neuropathic Pain via CXCR5","volume":"126","author":"Jiang","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12974-023-02778-x","article-title":"CXCL13 Contributes to Chronic Pain of a Mouse Model of CRPS-I via CXCR5-Mediated NF-\u039aB Activation and pro-Inflammatory Cytokine Production in Spinal Cord Dorsal Horn","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.pharep.2018.10.002","article-title":"Kynurenic Acid and Zaprinast Diminished CXCL17-Evoked Pain-Related Behaviour and Enhanced Morphine Analgesia in a Mouse Neuropathic Pain Model","volume":"71","author":"Rojewska","year":"2019","journal-title":"Pharmacol Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1058204","DOI":"10.3389\/fimmu.2022.1058204","article-title":"New Insights into the Analgesic Properties of the XCL1\/XCR1 and XCL1\/ITGA9 Axes Modulation under Neuropathic Pain Conditions\u2014Evidence from Animal Studies","volume":"13","author":"Ciechanowska","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/ALN.0000000000001219","article-title":"Microglial Inhibition Influences XCL1\/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy","volume":"125","author":"Zychowska","year":"2016","journal-title":"Anesthesiology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1111\/j.1460-9568.2004.03709.x","article-title":"Evidence That Exogenous and Endogenous Fractalkine Can Induce Spinal Nociceptive Facilitation in Rats","volume":"20","author":"Milligan","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1744806917726256","DOI":"10.1177\/1744806917726256","article-title":"Upregulation of CX3CL1 Mediated by NF-\u039aB Activation in Dorsal Root Ganglion Contributes to Peripheral Sensitization and Chronic Pain Induced by Oxaliplatin Administration","volume":"13","author":"Wang","year":"2017","journal-title":"Mol. Pain"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: A New Classification System and Their Role in Immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.it.2003.12.005","article-title":"Chemokines: Multiple Levels of Leukocyte Migration Control","volume":"25","author":"Moser","year":"2004","journal-title":"Trends Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainresrev.2004.07.021","article-title":"Chemokine Receptors in the Central Nervous System: Role in Brain Inflammation and Neurodegenerative Diseases","volume":"48","author":"Cartier","year":"2005","journal-title":"Brain Res. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1007\/s43440-020-00137-8","article-title":"Metamizole Relieves Pain by Influencing Cytokine Levels in Dorsal Root Ganglia in a Rat Model of Neuropathic Pain","volume":"72","author":"Zajaczkowska","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejpain.2008.04.017","article-title":"CCL2 Is a Key Mediator of Microglia Activation in Neuropathic Pain States","volume":"13","author":"Michael","year":"2009","journal-title":"Eur. J. Pain"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s11481-017-9729-6","article-title":"The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats","volume":"12","author":"Kwiatkowski","year":"2017","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/imm.13172","article-title":"The Blockade of CC Chemokine Receptor Type 1 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in a Rat Model of Neuropathic Pain","volume":"159","author":"Pawlik","year":"2020","journal-title":"Immunology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/jnr.22820","article-title":"Expression of Inflammatory Cytokines Following Acute Spinal Cord Injury in a Rodent Model","volume":"90","author":"Stammers","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"615327","DOI":"10.3389\/fimmu.2020.615327","article-title":"Bidirectional Action of Cenicriviroc, a CCR2\/CCR5 Antagonist, Results in Alleviation of Pain-Related Behaviors and Potentiation of Opioid Analgesia in Rats With Peripheral Neuropathy","volume":"11","author":"Kwiatkowski","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pnpbp.2015.07.005","article-title":"Beneficial Properties of Maraviroc on Neuropathic Pain Development and Opioid Effectiveness in Rats","volume":"64","author":"Kwiatkowski","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ciechanowska, A., Pawlik, K., Ciapa\u0142a, K., and Mika, J. (2023). Pharmacological Modulation of the MIP-1 Family and Their Receptors Reduces Neuropathic Pain Symptoms and Influences Morphine Analgesia: Evidence from a Mouse Model. Brain Sci., 13.","DOI":"10.3390\/brainsci13040579"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Piotrowska, A., Ciapa\u0142a, K., Pawlik, K., Kwiatkowski, K., Rojewska, E., and Mika, J. (2021). Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model\u2014In Vivo and In Vitro Study. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011074"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/brain\/aws330","article-title":"Epigenetic Transcriptional Activation of Monocyte Chemotactic Protein 3 Contributes to Long-Lasting Neuropathic Pain","volume":"136","author":"Imai","year":"2013","journal-title":"Brain"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"106540","DOI":"10.1016\/j.intimp.2020.106540","article-title":"Comparison of the Beneficial Effects of RS504393, Maraviroc and Cenicriviroc on Neuropathic Pain-Related Symptoms in Rodents: Behavioral and Biochemical Analyses","volume":"84","author":"Kwiatkowski","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_61","first-page":"3572","article-title":"Expression Levels of CX3CL1 and CCL21 in the Spinal Cords of Rats with Neuropathic Pain and Correlation Levels with JNK\/MCP-1 Signaling Pathways","volume":"13","author":"Zhao","year":"2020","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"750182","DOI":"10.1155\/2015\/750182","article-title":"The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy","volume":"2015","author":"Zychowska","year":"2015","journal-title":"J. Diabetes Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1248\/bpb.b22-00680","article-title":"Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation","volume":"46","author":"Zhang","year":"2023","journal-title":"Biol. Pharm. Bull."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5114\/fn.2023.126016","article-title":"Effects of Intrathecally Administered Interferon \u03b1 on Chronic Constriction Injury Model Rats\u2019 Mechanical Pain Threshold and G Protein Expression in the Spinal Cord","volume":"61","author":"Guo","year":"2023","journal-title":"Folia Neuropathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1097\/BRS.0b013e31821945a3","article-title":"Changes in Expression of MRNA for Interleukin-8 and Effects of Interleukin-8 Receptor Inhibitor in the Spinal Dorsal Horn in a Rat Model of Lumbar Disc Herniation","volume":"36","author":"Kim","year":"2011","journal-title":"Spine"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neulet.2017.07.049","article-title":"Interleukin-8 Levels in Rat Models of Nerve Damage and Neuropathic Pain","volume":"657","author":"Khan","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12264-020-00608-1","article-title":"CXCL10\/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice","volume":"37","author":"Kong","year":"2021","journal-title":"Neurosci. Bull."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Strong, J.A., Xie, W., Coyle, D.E., and Zhang, J.M. (2012). Microarray Analysis of Rat Sensory Ganglia after Local Inflammation Implicates Novel Cytokines in Pain. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040779"},{"key":"ref_69","first-page":"570","article-title":"Effect of CXCL12\/CXCR4 Signaling on Neuropathic Pain after Chronic Compression of Dorsal Root Ganglion","volume":"7","author":"Yu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/s41401-022-01046-7","article-title":"Up-Regulation of Microglial Chemokine CXCL12 in Anterior Cingulate Cortex Mediates Neuropathic Pain in Diabetic Mice","volume":"44","author":"Song","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.bbi.2019.05.020","article-title":"CXCL13\/CXCR5 Signaling Contributes to Diabetes-Induced Tactile Allodynia via Activating PERK, PSTAT3, PAKT Pathways and pro-Inflammatory Cytokines Production in the Spinal Cord of Male Mice","volume":"80","author":"Liu","year":"2019","journal-title":"Brain. Behav. Immun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e20210920","DOI":"10.1084\/jem.20210920","article-title":"Znf382 Controls Mouse Neuropathic Pain via Silencer-Based Epigenetic Inhibition of Cxcl13 in Drg Neurons","volume":"218","author":"Ma","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3389\/fnins.2020.00488","article-title":"Identification of the Hub Genes Related to Nerve Injury-Induced Neuropathic Pain","volume":"14","author":"Wang","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Zhang, T., Liang, W., Zhang, M., Cui, S., Huang, X., Ou, W., Huang, R., Gao, J., Jia, Z., and Zhang, S. (2023). Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020243"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3344\/kjp.2022.35.4.391","article-title":"The Role of Botulinum Toxin Type A Related Axon Transport in Neuropathic Pain Induced by Chronic Constriction Injury","volume":"35","author":"Bu","year":"2022","journal-title":"Korean J. Pain"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12974-020-01992-1","article-title":"NFATc2-Dependent Epigenetic Upregulation of CXCL14 Is Involved in the Development of Neuropathic Pain Induced by Paclitaxel","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2020027","DOI":"10.21037\/apm-20-1078","article-title":"MMP-9 Regulates CX3CL1\/CX3CR1 in the Early Phase of Neuropathic Pain in Chronic Sciatic Nerve Constriction Injury (CCI) Rats","volume":"9","author":"Zhao","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.nurt.2007.07.004","article-title":"Chemokines and Chemokine Receptors in Neurological Disease: Raise, Retain, or Reduce?","volume":"4","author":"Ransohoff","year":"2007","journal-title":"Neurotherapeutics"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroscience.2020.06.025","article-title":"Blockade of CCR4 Diminishes Hypersensitivity and Enhances Opioid Analgesia\u2014Evidence from a Mouse Model of Diabetic Neuropathy","volume":"441","author":"Bogacka","year":"2020","journal-title":"Neuroscience"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3389\/fimmu.2020.01241","article-title":"CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain","volume":"11","author":"Bogacka","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"15934","DOI":"10.1523\/JNEUROSCI.1924-15.2015","article-title":"CCL2 Mediates Neuron\u2013Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury","volume":"35","author":"Kwon","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cyto.2013.09.019","article-title":"Epigenetic Upregulation of CCL2 and CCL3 via Histone Modifications in Infiltrating Macrophages after Peripheral Nerve Injury","volume":"64","author":"Kiguchi","year":"2013","journal-title":"Cytokine"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1523\/JNEUROSCI.3016-07.2007","article-title":"Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain","volume":"27","author":"Zhang","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jneuroim.2008.05.011","article-title":"The Chemokine CCL2 Activates P38 Mitogen-Activated Protein Kinase Pathway in Cultured Rat Hippocampal Cells","volume":"199","author":"Cho","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1744-8069-3-33","article-title":"P38 MAPK, Microglial Signaling, and Neuropathic Pain","volume":"3","author":"Ji","year":"2007","journal-title":"Mol. Pain"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1093\/rheumatology\/keab064","article-title":"CCL2 Produced by CD68+\/CD163+ Macrophages as a Promising Clinical Biomarker of Microscopic Polyangiitis-Interstitial Lung Disease","volume":"60","author":"Matsuda","year":"2021","journal-title":"Rheumatology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.smim.2016.04.003","article-title":"Neutrophil-Derived Chemokines on the Road to Immunity","volume":"28","author":"Tecchio","year":"2016","journal-title":"Semin. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12987-022-00365-5","article-title":"Microglia-Derived CCL2 Has a Prime Role in Neocortex Neuroinflammation","volume":"19","author":"Errede","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"E106","DOI":"10.1097\/j.pain.0000000000002321","article-title":"Sympathectomy Decreases Pain Behaviors and Nerve Regeneration by Downregulating Monocyte Chemokine CCL2 in Dorsal Root Ganglia in the Rat Tibial Nerve Crush Model","volume":"163","author":"Zhu","year":"2022","journal-title":"Pain"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1007\/s12035-022-03184-9","article-title":"Spinal MCP-1 Contributes to Central Post-Stroke Pain by Inducing Central Sensitization in Rats","volume":"60","author":"Yang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12035-007-0036-8","article-title":"Neuronal Chemokines: Versatile Messengers in Central Nervous System Cell Interaction","volume":"36","author":"Boddeke","year":"2007","journal-title":"Mol. Neurobiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a Source and Target of Cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1167\/iovs.12-10602","article-title":"Regulation of T-Lymphocyte CCL3 and CCL4 Production by Retinal Pigment Epithelial Cells","volume":"54","author":"Wallace","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1753425911423270","article-title":"Chemokine Release by Neutrophils in Chronic Obstructive Pulmonary Disease","volume":"18","author":"Blidberg","year":"2012","journal-title":"Innate Immun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s43440-020-00109-y","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Part 1\u2014Current State of Knowledge and Perspectives for Pharmacotherapy","volume":"72","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"8104","DOI":"10.4049\/jimmunol.0803348","article-title":"Selective Autoantibody Production against CCL3 Is Associated with Human Type 1 Diabetes Mellitus and Serves As a Novel Biomarker for Its Diagnosis","volume":"182","author":"Shehadeh","year":"2009","journal-title":"J. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Makker, P.G.S., Duffy, S.S., Lees, J.G., Perera, C.J., Tonkin, R.S., Butovsky, O., Park, S.B., Goldstein, D., and Moalem-Taylor, G. (2017). Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170814"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4049\/jimmunol.166.1.552","article-title":"The Chemokine RANTES Is a Crucial Mediator of the Progression from Acute to Chronic Colitis in the Rat","volume":"166","author":"Ajuebor","year":"2001","journal-title":"J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/347669a0","article-title":"Selective Attraction of Monocytes and T Lymphocytes of the Memory Phenotype by Cytokine RANTES","volume":"347","author":"Schall","year":"1990","journal-title":"Nature"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/bcpt.12099","article-title":"Involvement of Spinal CC Chemokine Ligand 5 in the Development of Bone Cancer Pain in Rats","volume":"113","author":"Hang","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.pain.2012.03.008","article-title":"Absence of C-C Motif Chemokine Ligand 5 in Mice Leads to Decreased Local Macrophage Recruitment and Behavioral Hypersensitivity in a Murine Neuropathic Pain Model","volume":"153","author":"Liou","year":"2012","journal-title":"Pain"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpain.2012.09.015","article-title":"Peritoneal Administration of Met-RANTES Attenuates Inflammatory and Nociceptive Responses in a Murine Neuropathic Pain Model","volume":"14","author":"Liou","year":"2013","journal-title":"J. Pain"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1523\/JNEUROSCI.21-14-05027.2001","article-title":"Chemokines and Glycoprotein120 Produce Pain Hypersensitivity by Directly Exciting Primary Nociceptive Neurons","volume":"21","author":"Oh","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1126\/sciadv.abb5943","article-title":"Eosinophilic Inflammation Promotes CCL6-Dependent Metastatic Tumor Growth","volume":"7","author":"Li","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jneuroim.2005.06.028","article-title":"Functional Expression of CCL6 by Rat Microglia: A Possible Role of CCL6 in Cell\u2013cell Communication","volume":"167","author":"Kanno","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-021-00482-x","article-title":"Eosinophil-Derived Chemokine (HCCL15\/23, MCCL6) Interacts with CCR1 to Promote Eosinophilic Airway Inflammation","volume":"6","author":"Du","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1097\/j.pain.0000000000001061","article-title":"High Levels of Cerebrospinal Fluid Chemokines Point to the Presence of Neuroinflammation in Peripheral Neuropathic Pain: A Cross-Sectional Study of 2 Cohorts of Patients Compared with Healthy Controls","volume":"158","author":"Lind","year":"2017","journal-title":"Pain"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/WNR.0000000000000625","article-title":"Neuronal-Derived Ccl7 Drives Neuropathic Pain by Promoting Astrocyte Proliferation","volume":"27","author":"Ke","year":"2016","journal-title":"Neuroreport"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/bbrc.1994.1729","article-title":"Mouse Macrophage Derived Monocyte Chemotactic Protein-3: CDNA Cloning and Identification as MARC\/FIC","volume":"201","author":"Thirion","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"107975","DOI":"10.1016\/j.intimp.2021.107975","article-title":"Astrocyte-Derived CCL7 Promotes Microglia-Mediated Inflammation Following Traumatic Brain Injury","volume":"99","author":"Xue","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4049\/jimmunol.175.2.1257","article-title":"A Non-Glycosaminoglycan-Binding Variant of CC Chemokine Ligand 7 (Monocyte Chemoattractant Protein-3) Antagonizes Chemokine-Mediated Inflammation","volume":"175","author":"Ali","year":"2005","journal-title":"J. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1189\/jlb.1A0314-170R","article-title":"The Chemotaxis of M1 and M2 Macrophages Is Regulated by Different Chemokines","volume":"97","author":"Xuan","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"42260","DOI":"10.1038\/srep42260","article-title":"Interleukin-1\u03b2 Pre-Treated Bone Marrow Stromal Cells Alleviate Neuropathic Pain through CCL7-Mediated Inhibition of Microglial Activation in the Spinal Cord","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.brainresbull.2017.10.009","article-title":"Chemokine CCL8 and Its Receptor CCR5 in the Spinal Cord Are Involved in Visceral Pain Induced by Experimental Colitis in Mice","volume":"135","author":"Lu","year":"2017","journal-title":"Brain Res. Bull."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s12935-021-02350-8","article-title":"Correlation of CCL8 Expression with Immune Cell Infiltration of Skin Cutaneous Melanoma: Potential as a Prognostic Indicator and Therapeutic Pathway","volume":"21","author":"Yang","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.celrep.2016.04.063","article-title":"Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain","volume":"15","author":"Denk","year":"2016","journal-title":"Cell Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.joca.2016.11.004","article-title":"Role of the C-C Chemokine Receptor-2 in a Murine Model of Injury-Induced Osteoarthritis","volume":"25","author":"Longobardi","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0212074","article-title":"CCL26\/Eotaxin-3 Is More Effective to Induce the Migration of Eosinophils of Asthmatics than CCL11\/Eotaxin-1 and CCL24\/Eotaxin-2","volume":"94","author":"Provost","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.4049\/jimmunol.169.5.2712","article-title":"Eotaxin (CCL11) and Eotaxin-2 (CCL24) Induce Recruitment of Eosinophils, Basophils, Neutrophils, and Macrophages as Well as Features of Early- and Late-Phase Allergic Reactions Following Cutaneous Injection in Human Atopic and Nonatopic Volunteers","volume":"169","author":"Ying","year":"2002","journal-title":"J. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clim.2016.09.010","article-title":"An Emerging Role for Eotaxins in Neurodegenerative Disease","volume":"189","author":"Huber","year":"2018","journal-title":"Clin. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s13760-022-01984-3","article-title":"Eotaxin-1 (CCL11) in Neuroinflammatory Disorders and Possible Role in COVID-19 Neurologic Complications","volume":"122","author":"Nazarinia","year":"2022","journal-title":"Acta Neurol. Belg."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0004563213506413","article-title":"Altered Profile of Chemokines in Fibromyalgia Patients","volume":"51","author":"Cidoncha","year":"2014","journal-title":"Ann. Clin. Biochem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/1947603518764280","article-title":"Synovial Fluid Eotaxin-1 Levels May Reflect Disease Progression in Primary Knee Osteoarthritis Among Elderly Han Chinese: A Cross-Sectional Study","volume":"10","author":"Li","year":"2019","journal-title":"Cartilage"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fimmu.2019.00978","article-title":"Current Clinical Trials in Pemphigus and Pemphigoid","volume":"10","author":"Izumi","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_125","unstructured":"Pelletier, J.P.R., and Mukhtar, F. (2020). Immunologic Concepts in Transfusion Medicine, Elsevier."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7257681","DOI":"10.1155\/2018\/7257681","article-title":"Elevated Levels of Eotaxin-2 in Serum of Fibromyalgia Patients","volume":"2018","author":"Furer","year":"2018","journal-title":"Pain Res. Manag."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/intimm\/dxu079","article-title":"CCR4 and Its Ligands: From Bench to Bedside","volume":"27","author":"Yoshie","year":"2015","journal-title":"Int. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Scheu, S., Ali, S., Ruland, C., Arolt, V., and Alferink, J. (2017). The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112306"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Bogacka, J., Pawlik, K., Ciapa\u0142a, K., Ciechanowska, A., and Mika, J. (2022). CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415638"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1084\/jem.20170277","article-title":"CCL22 Controls Immunity by Promoting Regulatory T Cell Communication with Dendritic Cells in Lymph Nodes","volume":"216","author":"Rapp","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"486386","DOI":"10.1155\/2014\/486386","article-title":"Identification of Chemokines and Growth Factors in Proliferative Diabetic Retinopathy Vitreous","volume":"2014","author":"Dai","year":"2014","journal-title":"Biomed Res. Int."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jid.2018.10.039","article-title":"Role of Chemokine Receptor CCR4 and Regulatory T Cells in Wound Healing of Diabetic Mice","volume":"139","author":"Barros","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lin, Z., Wang, Y., Lin, S., Liu, D., Mo, G., Zhang, H., and Dou, Y. (2021). Identification of Potential Biomarkers for Abdominal Pain in IBS Patients by Bioinformatics Approach. BMC Gastroenterol., 21.","DOI":"10.1186\/s12876-021-01626-7"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1002\/jor.24398","article-title":"Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery","volume":"37","author":"Paish","year":"2019","journal-title":"J. Orthop. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3389\/fimmu.2017.01871","article-title":"Expression of Membrane-Bound CC Chemokine Ligand 20 on Follicular T Helper Cells in T-B-Cell Conjugates","volume":"8","author":"Lee","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"L\u00f6tsch, J., Mustonen, L., Harno, H., and Kalso, E. (2022). Machine-Learning Analysis of Serum Proteomics in Neuropathic Pain after Nerve Injury in Breast Cancer Surgery Points at Chemokine Signaling via SIRT2 Regulation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073488"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1515\/sjpain-2021-0195","article-title":"Association between Systemic Inflammation and Experimental Pain Sensitivity in Subjects with Pain and Painless Neuropathy after Traumatic Nerve Injuries","volume":"23","author":"Miclescu","year":"2023","journal-title":"Scand. J. Pain"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fcell.2019.00212","article-title":"CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention","volume":"7","author":"Yan","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"J\u00f6nsson, M., Gerdle, B., Ghafouri, B., and B\u00e4ckryd, E. (2021). The Inflammatory Profile of Cerebrospinal Fluid, Plasma, and Saliva from Patients with Severe Neuropathic Pain and Healthy Controls-a Pilot Study. BMC Neurosci., 22.","DOI":"10.1186\/s12868-021-00608-5"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3389\/fneur.2021.540660","article-title":"Nerve Growth Factor Enhances Tooth Mechanical Hyperalgesia Through C-C Chemokine Ligand 19 in Rats","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.4049\/jimmunol.168.7.3221","article-title":"Secondary Lymphoid Tissue Chemokine (CCL21) Activates CXCR3 to Trigger a Cl\u2212 Current and Chemotaxis in Murine Microglia","volume":"168","author":"Rappert","year":"2002","journal-title":"J. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"8893","DOI":"10.1523\/JNEUROSCI.2209-07.2007","article-title":"Modulation of Thalamic Nociceptive Processing after Spinal Cord Injury through Remote Activation of Thalamic Microglia by Cysteine\u2013Cysteine Chemokine Ligand 21","volume":"27","author":"Zhao","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2013.04.011","article-title":"Dichotomy of CCL21 and CXCR3 in Nerve Injury-Evoked and Autoimmunity-Evoked Hyperalgesia","volume":"32","author":"Schmitz","year":"2013","journal-title":"Brain. Behav. Immun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4110\/in.2011.11.4.203","article-title":"Identification of CCL1 as a Gene Differentially Expressed in CD4+ T Cells Expressing TIM-3","volume":"11","author":"Jun","year":"2011","journal-title":"Immune Netw."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"16614","DOI":"10.1002\/jcb.28920","article-title":"MiR-21-5p Inhibits Neuropathic Pain Development via Directly Targeting C-C Motif Ligand 1 and Tissue Inhibitor of Metalloproteinase-3","volume":"120","author":"Zhong","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_146","unstructured":"(2023, June 01). The Effects of Bindarit in Diabetic Nephropathy, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01109212."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1742-2094-9-171","article-title":"The CCL2 Synthesis Inhibitor Bindarit Targets Cells of the Neurovascular Unit, and Suppresses Experimental Autoimmune Encephalomyelitis","volume":"9","author":"Ge","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"17448069221135743","DOI":"10.1177\/17448069221135743","article-title":"CXCR1 Participates in Bone Cancer Pain Induced by Walker 256 Breast Cancer Cells in Female Rats","volume":"18","author":"Xu","year":"2022","journal-title":"Mol. Pain"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8023460","DOI":"10.1155\/2019\/8023460","article-title":"The Crucial Role of CXCL8 and Its Receptors in Colorectal Liver Metastasis","volume":"2019","author":"Bie","year":"2019","journal-title":"Dis. Markers"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s00415-018-8748-4","article-title":"Increased Pro-Inflammatory Cytokine Gene Expression in Peripheral Blood Mononuclear Cells of Patients with Polyneuropathies","volume":"265","author":"Langjahr","year":"2018","journal-title":"J. Neurol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3389\/fnins.2020.00890","article-title":"Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain","volume":"14","author":"Heng","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ijbiomac.2017.09.032","article-title":"Molecular Cloning and Biophysical Characterization of CXCL3 Chemokine","volume":"107","author":"Gulati","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1248\/yakushi.122.263","article-title":"The Role of Rat Cytokine-Induced Neutrophil Chemoattractants (CINCs) in Inflammation","volume":"122","author":"Shibata","year":"2002","journal-title":"Yakugaku Zasshi"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1080\/21655979.2021.1952772","article-title":"Expression Levels of Chemokine (C-X-C Motif) Ligands CXCL1 and CXCL3 as Prognostic Biomarkers in Rectal Adenocarcinoma: Evidence from Gene Expression Omnibus (GEO) Analyses","volume":"12","author":"Lv","year":"2021","journal-title":"Bioengineered"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/01.anes.0000278907.37774.8d","article-title":"Systemic Antiinflammatory Corticosteroid Reduces Mechanical Pain Behavior, Sympathetic Sprouting, and Elevation of Proinflammatory Cytokines in a Rat Model of Neuropathic Pain","volume":"107","author":"Li","year":"2007","journal-title":"Anesthesiology"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Pang, J., Xin, P., Kong, Y., Wang, Z., and Wang, X. (2023). Resolvin D2 Reduces Chronic Neuropathic Pain and Bone Cancer Pain via Spinal Inhibition of IL-17 Secretion, CXCL1 Release and Astrocyte Activation in Mice. Brain Sci., 13.","DOI":"10.3390\/brainsci13010152"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.1203421","article-title":"Differential Roles of CXCL2 and CXCL3 and Their Receptors in Regulating Normal and Asthmatic Airway Smooth Muscle Cell Migration","volume":"191","author":"Chang","year":"2013","journal-title":"J. Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"27426","DOI":"10.1038\/srep27426","article-title":"CXCL3 Contributes to CD133+CSCs Maintenance and Forms a Positive Feedback Regulation Loop with CD133 in HCC via Erk1\/2 Phosphorylation","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.2174\/0929867323666160607120124","article-title":"Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain","volume":"23","author":"Mika","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1358\/dnp.2002.15.8.840067","article-title":"ichi Role of Cytokines and Chemokines in Renal Ischemia-Reperfusion Injury","volume":"15","author":"Furuichi","year":"2002","journal-title":"Drug News Perspect."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/j.1471-4159.2008.05267.x","article-title":"Expression of CXCL4 in Microglia in Vitro and in Vivo and Its Possible Signaling through CXCR3","volume":"105","author":"Brouwer","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Turbic, A., Leong, S.Y., and Turnley, A.M. (2011). Chemokines and Inflammatory Mediators Interact to Regulate Adult Murine Neural Precursor Cell Proliferation, Survival and Differentiation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025406"},{"key":"ref_163","first-page":"685","article-title":"Promoted Interaction of C\/EBP\u03b1 with Demethylated Cxcr3 Gene Promoter Contributes to Neuropathic Pain in Mice","volume":"37","author":"Jiang","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2013.05.003","article-title":"Diabetic Neuropathic Pain Development in Type 2 Diabetic Mouse Model and the Prophylactic and Therapeutic Effects of Coenzyme Q10","volume":"58","author":"Zhang","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/JPR.S288292","article-title":"CXCL10 and CXCR3 in the Trigeminal Ganglion Contribute to Trigeminal Neuropathic Pain in Mice","volume":"14","author":"Ju","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e14302","DOI":"10.1111\/ijcp.14302","article-title":"Peripheral Blood Levels of CXCL10 Are a Useful Marker for Diabetic Polyneuropathy in Subjects with Type 2 Diabetes","volume":"75","author":"Ascaso","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/joor.13262","article-title":"CXCR3 Signalling Partially Contributes to the Pathogenesis of Neuropathic Pain in Male Rodents","volume":"49","author":"Li","year":"2022","journal-title":"J. Oral Rehabil."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12974-016-0644-1","article-title":"Transcriptome Sequencing Reveals That LPS-Triggered Transcriptional Responses in Established Microglia BV2 Cell Lines Are Poorly Representative of Primary Microglia","volume":"13","author":"Das","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fncel.2014.00210","article-title":"Neuronal CC Chemokines: The Distinct Roles of CCL21 and CCL2 in Neuropathic Pain","volume":"8","author":"Biber","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/glia.1047","article-title":"Ischemia-Induced Neuronal Expression of the Microglia Attracting Chemokine Secondary Lymphoid-Tissue Chemokine (SLC)","volume":"34","author":"Biber","year":"2001","journal-title":"Glia"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1096\/fj.07-101907","article-title":"Expression, Transport, and Axonal Sorting of Neuronal CCL21 in Large Dense-Core Vesicles","volume":"22","author":"Jong","year":"2008","journal-title":"FASEB J."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1742-2094-11-75","article-title":"CXCL12 in Astrocytes Contributes to Bone Cancer Pain through CXCR4-Mediated Neuronal Sensitization and Glial Activation in Rat Spinal Cord","volume":"11","author":"Shen","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"153734","DOI":"10.1016\/j.phymed.2021.153734","article-title":"Loganin Prevents CXCL12\/CXCR4-Regulated Neuropathic Pain via the NLRP3 Inflammasome Axis in Nerve-Injured Rats","volume":"92","author":"Cheng","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1096\/fj.201700013R","article-title":"Epithelial Chemokine CXCL14 Synergizes with CXCL12 via Allosteric Modulation of CXCR4","volume":"31","author":"Collins","year":"2017","journal-title":"FASEB J."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fncel.2014.00154","article-title":"Chemokines in the Balance: Maintenance of Homeostasis and Protection at CNS Barriers","volume":"8","author":"Williams","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.nbd.2008.11.014","article-title":"The \u03b1-Chemokine CXCL14 Is up-Regulated in the Sciatic Nerve of a Mouse Model of Charcot\u2013Marie\u2013Tooth Disease Type 1A and Alters Myelin Gene Expression in Cultured Schwann Cells","volume":"33","author":"Barbaria","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1267\/ahc.20-00004","article-title":"The Chemokine CXCL14-like Immunoreactivity Co-Exists with Somatostatin, but Not NPY in the Rat Dorsal Horn and Has Intimate Association with GABAergic Neurons in the Lateral Spinal Nucleus","volume":"53","author":"Yamamoto","year":"2020","journal-title":"Acta Histochem. Cytochem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"34836","DOI":"10.1038\/srep34836","article-title":"CXCL13\/CXCR5 Enhances Sodium Channel Nav1.8 Current Density via P38 MAP Kinase in Primary Sensory Neurons Following Inflammatory Pain","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12974-016-0652-1","article-title":"Chemokine CXCL13 Mediates Orofacial Neuropathic Pain via CXCR5\/ERK Pathway in the Trigeminal Ganglion of Mice","volume":"13","author":"Zhang","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/79738","article-title":"A Transmembrane CXC Chemokine Is a Ligand for HIV-Coreceptor Bonzo","volume":"1","author":"Matloubian","year":"2000","journal-title":"Nat. Immunol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.4049\/jimmunol.172.10.6362","article-title":"The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-\u03b3 and TNF-\u03b1 and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10","volume":"172","author":"Abel","year":"2004","journal-title":"J. Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/ner.12465","article-title":"Genomics of the Effect of Spinal Cord Stimulation on an Animal Model of Neuropathic Pain","volume":"19","author":"Vallejo","year":"2016","journal-title":"Neuromodulation"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1080\/21655979.2021.2021710","article-title":"A Transcriptomic Analysis of Neuropathic Pain in the Anterior Cingulate Cortex after Nerve Injury","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4049\/jimmunol.1401704","article-title":"Cutting Edge: GPR35\/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17","volume":"194","author":"Burkhardt","year":"2015","journal-title":"J. Immunol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"714","DOI":"10.4049\/jimmunol.1700884","article-title":"Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35","volume":"201","author":"Mackenzie","year":"2018","journal-title":"J. Immunol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.4049\/jimmunol.176.4.2069","article-title":"Cutting Edge: Novel Human Dendritic Cell- and Monocyte-Attracting Chemokine-Like Protein Identified by Fold Recognition Methods","volume":"176","author":"Pisabarro","year":"2006","journal-title":"J. Immunol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1152\/ajpendo.00083.2012","article-title":"CXCL17, an Orphan Chemokine, Acts as a Novel Angiogenic and Anti-Inflammatory Factor","volume":"304","author":"Lee","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.bbrc.2017.09.113","article-title":"The Role and Clinical Significance of the CXCL17-CXCR8 (GPR35) Axis in Breast Cancer","volume":"493","author":"Guo","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1369\/jhc.6A7121.2007","article-title":"Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital and Endocrine Organs","volume":"55","author":"Schmitz","year":"2007","journal-title":"J. Histochem. Cytochem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cyto.2014.11.010","article-title":"Structural and Agonist Properties of XCL2, the Other Member of the C-Chemokine Subfamily","volume":"71","author":"Fox","year":"2015","journal-title":"Cytokine"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2017.06.010","article-title":"Identification and Expression Analysis of Three XCR1-like Receptors from Epinephelus Coioides after Cryptocaryon Irritans Infection","volume":"67","author":"Ni","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.micinf.2011.10.003","article-title":"XCL1 and XCR1 in the Immune System","volume":"14","author":"Lei","year":"2012","journal-title":"Microbes Infect."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4049\/jimmunol.1601329","article-title":"A Novel A9 Integrin Ligand, XCL1\/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases","volume":"199","author":"Matsumoto","year":"2017","journal-title":"J. Immunol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12017-021-08694-8","article-title":"The Identification of Blood Biomarkers of Chronic Neuropathic Pain by Comparative Transcriptomics","volume":"24","author":"Islam","year":"2021","journal-title":"NeuroMolecular Med."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12974-020-01828-y","article-title":"Two Forms of CX3CL1 Display Differential Activity and Rescue Cognitive Deficits in CX3CL1 Knockout Mice","volume":"17","author":"Winter","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"10655","DOI":"10.1073\/pnas.0610811104","article-title":"Inhibition of Spinal Microglial Cathepsin S for the Reversal of Neuropathic Pain","volume":"104","author":"Clark","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s43094-022-00446-0","article-title":"Implications of Fractalkine on Glial Function, Ablation and Glial Proteins\/Receptors\/Markers\u2014Understanding Its Therapeutic Usefulness in Neurological Settings: A Narrative Review","volume":"8","author":"Paul","year":"2022","journal-title":"Futur. J. Pharm. Sci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10787-023-01216-x","article-title":"Microglia Polarization in Nociplastic Pain: Mechanisms and Perspectives","volume":"31","author":"Atta","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jnr.23168","article-title":"CX3CL1\/CX3CR1 Regulates Nerve Injury-Induced Pain Hypersensitivity through the ERK5 Signaling Pathway","volume":"91","author":"Sun","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fpain.2021.684684","article-title":"Fractalkine\/CX3CR1 Pathway in Neuropathic Pain: An Update","volume":"2","author":"Silva","year":"2021","journal-title":"Front. Pain Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1124\/mi.9.4.7","article-title":"Chemokine Signaling and the Management of Neuropathic Pain","volume":"9","author":"White","year":"2009","journal-title":"Mol. Interv."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2016.04.017","article-title":"Direct and Indirect Pharmacological Modulation of CCL2\/CCR2 Pathway Results in Attenuation of Neuropathic Pain\u2014In Vivo and in Vitro Evidence","volume":"297","author":"Piotrowska","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainresbull.2013.03.005","article-title":"Spinal CCL2 and Microglial Activation Are Involved in Paclitaxel-Evoked Cold Hyperalgesia","volume":"95","author":"Pevida","year":"2013","journal-title":"Brain Res. Bull."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1742-2094-9-136","article-title":"Chemokine CCL2 and Its Receptor CCR2 in the Medullary Dorsal Horn Are Involved in Trigeminal Neuropathic Pain","volume":"9","author":"Zhang","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1186\/1744-8069-6-90","article-title":"Blocking Spinal CCR2 with AZ889 Reversed Hyperalgesia in a Model of Neuropathic Pain","volume":"6","author":"Serrano","year":"2010","journal-title":"Mol. Pain"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuropharm.2016.04.024","article-title":"Maraviroc Reduces Neuropathic Pain through Polarization of Microglia and Astroglia\u2014Evidence from in Vivo and in Vitro Studies","volume":"108","author":"Piotrowska","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuroscience.2013.11.055","article-title":"The Chemokine CCL5 Induces CCR1-Mediated Hyperalgesia in Mice Inoculated with NCTC 2472 Tumoral Cells","volume":"259","author":"Pevida","year":"2014","journal-title":"Neuroscience"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Lewis, N.D., Muthukumarana, A., Fogal, S.E., Corradini, L., Stefanopoulos, D.E., Adusumalli, P., Pelletier, J., Panzenbeck, M., Berg, K., and Canfield, M. (2014). CCR1 Plays a Critical Role in Modulating Pain through Hematopoietic and Non-Hematopoietic Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105883"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1023\/B:NERE.0000021246.96864.89","article-title":"Chemokines and Glial Cells: A Complex Network in the Central Nervous System","volume":"29","author":"Ambrosini","year":"2004","journal-title":"Neurochem. Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/sj.bjp.0706912","article-title":"Pharmacological Blockade of CCR1 Ameliorates Murine Arthritis and Alters Cytokine Networks in Vivo","volume":"149","author":"Amat","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.intimp.2013.06.034","article-title":"Neutrophil Cell Surface Receptors and Their Intracellular Signal Transduction Pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_212","first-page":"251","article-title":"Chemokiny Jako Wa\u017cne Mediatory Stanu Zapalnego","volume":"7","author":"Henc","year":"2013","journal-title":"Forum Med. Rodz."},{"key":"ref_213","first-page":"31","article-title":"Consider the Chemokines: A Review of the Interplay between Chemokines and T Cell Subset Function","volume":"24","author":"Strazza","year":"2017","journal-title":"Discov. Med."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrd1852","article-title":"Chemokines: Integrators of Pain and Inflammation","volume":"4","author":"White","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"94591","DOI":"10.18632\/oncotarget.21813","article-title":"C-C Motif Chemokine Receptor 1 (CCR1) Is a Target of the EGF-AKT-MTOR-STAT3 Signaling Axis in Breast Cancer Cells","volume":"8","author":"Shin","year":"2017","journal-title":"Oncotarget"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5604\/1640324x.1108256","article-title":"Chemokines under Neuropathic Pain","volume":"15","author":"Kwiatkowski","year":"2014","journal-title":"B\u00f3l"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jneuroim.2012.01.012","article-title":"Prolonged Increase in Rat Hippocampal Chemokine Signalling after Status Epilepticus","volume":"245","author":"Kan","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0002-9440(10)63921-1","article-title":"Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas","volume":"162","author":"Lu","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neulet.2012.04.026","article-title":"Involvement of Spinal Monocyte Chemoattractant Protein-1 (MCP-1) in Cancer-Induced Bone Pain in Rats","volume":"517","author":"Hu","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11481-020-09913-y","article-title":"Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1\u03b1\/CCR1 Pathway","volume":"16","author":"Li","year":"2021","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41434-021-00285-3","article-title":"CCR1 Enhances SUMOylation of DGCR8 by Up-Regulating ERK Phosphorylation to Promote Spinal Nerve Ligation-Induced Neuropathic Pain","volume":"29","author":"Shi","year":"2021","journal-title":"Gene Ther."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2013.01.072","article-title":"Importance of Glial Activation in Neuropathic Pain","volume":"716","author":"Mika","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_223","first-page":"297","article-title":"Modulation of Microglia Can Attenuate Neuropathic Pain Symptoms and Enhance Morphine Effectiveness","volume":"60","author":"Mika","year":"2008","journal-title":"Pharmacol Rep."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.mcn.2015.12.013","article-title":"Blockade of IL-18 Signaling Diminished Neuropathic Pain and Enhanced the Efficacy of Morphine and Buprenorphine","volume":"71","author":"Pilat","year":"2016","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejphar.2015.05.058","article-title":"IL-1 Receptor Antagonist Improves Morphine and Buprenorphine Efficacy in a Rat Neuropathic Pain Model","volume":"764","author":"Pilat","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1016\/j.bmc.2016.09.059","article-title":"Exploration of Bivalent Ligands Targeting Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Dimerization","volume":"24","author":"Arnatt","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1160\/TH13-05-0420","article-title":"Exchange of Extracellular Domains of CCR1 and CCR5 Reveals Confined Functions in CCL5-Mediated Cell Recruitment","volume":"110","author":"Kramp","year":"2013","journal-title":"Thromb. Haemost."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1471-4159.2012.07720.x","article-title":"RANTES-Mediated Control of Excitatory Amino Acid Release in Mouse Spinal Cord","volume":"121","author":"Summa","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/156802610791561192","article-title":"CC Chemokine Receptor Small Molecule Antagonists in the Treatment of Rheumatoid Arthritis and Other Diseases: A Current View","volume":"10","author":"Liu","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.spinee.2020.07.001","article-title":"Small Molecule Antagonist of C-C Chemokine Receptor 1 (CCR1) Reduces Disc Inflammation in the Rabbit Model","volume":"20","author":"Chou","year":"2020","journal-title":"Spine J."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"152245","DOI":"10.1016\/j.imbio.2022.152245","article-title":"CCR1 Antagonist J-113863 Corrects the Imbalance of pro- and Anti-Inflammatory Cytokines in a SJL\/J Mouse Model of Relapsing-Remitting Multiple Sclerosis","volume":"227","author":"Ansari","year":"2022","journal-title":"Immunobiology"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.molimm.2022.02.017","article-title":"CCR1 Antagonist Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibition of Th9\/Th22-Related Markers in the Brain and Periphery","volume":"144","author":"Nadeem","year":"2022","journal-title":"Mol. Immunol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2174\/156802610791561237","article-title":"CCR1 Antagonists: What Have We Learned From Clinical Trials","volume":"10","author":"Gladue","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/aogs.13105","article-title":"Efficacy, Safety and Tolerability of the CCR1 Antagonist BAY 86-5047 for the Treatment of Endometriosis-Associated Pelvic Pain: A Randomized Controlled Trial","volume":"96","author":"Trummer","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jpain.2014.01.492","article-title":"Contribution of Chemokine CCL2\/CCR2 Signaling in the Dorsal Root Ganglion and Spinal Cord to the Maintenance of Neuropathic Pain in a Rat Model of Lumbar Disc Herniation","volume":"15","author":"Zhu","year":"2014","journal-title":"J. Pain"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1074\/jbc.271.20.11603","article-title":"Cloning and Functional Expression of MCCR2, a Murine Receptor for the C-C Chemokines JE and FIC","volume":"271","author":"Kurihara","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1523\/JNEUROSCI.0485-09.2009","article-title":"Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic Pain","volume":"29","author":"Jung","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1073\/pnas.1331358100","article-title":"Impaired Neuropathic Pain Responses in Mice Lacking the Chemokine Receptor CCR2","volume":"100","author":"Abbadie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_239","unstructured":"(2023, May 25). BMS-741672 for Diabetic Neuropathic Pain\u2014No Study Results Posted\u2014ClinicalTrials.Gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT00683423."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"175646","DOI":"10.1016\/j.ejphar.2023.175646","article-title":"Targeting the Chemokine Ligand 2\u2013chemokine Receptor 2 Axis Provides the Possibility of Immunotherapy in Chronic Pain","volume":"947","author":"Liu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bj.2018.01.002","article-title":"Complex Role of Chemokine Mediators in Animal Models of Alzheimer\u2019s Disease","volume":"41","author":"Martin","year":"2018","journal-title":"Biomed. J."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1128\/JVI.73.1.205-213.1999","article-title":"Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates","volume":"73","author":"Albright","year":"1999","journal-title":"J. Virol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1398-9995.2006.01253.x","article-title":"T Lymphocytes Expressing CCR3 Are Increased in Allergic Rhinitis Compared with Non-Allergic Controls and Following Allergen Immunotherapy","volume":"62","author":"Francis","year":"2007","journal-title":"Allergy Eur. J. Allergy Clin. Immunol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0165-5728(03)00009-2","article-title":"Regulation of Chemokine Receptor Expression in Human Microglia and Astrocytes","volume":"136","author":"Flynn","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0002-9440(10)61235-7","article-title":"Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis","volume":"167","author":"Huaux","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1073\/pnas.261462598","article-title":"The Murine CCR3 Receptor Regulates Both the Role of Eosinophils and Mast Cells in Allergen-Induced Airway Inflammation and Hyperresponsiveness","volume":"99","author":"Humbles","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1517\/13543784.9.1.43","article-title":"CCR3 Blockade as a New Therapy for Asthma","volume":"9","author":"Bertrand","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"36842","DOI":"10.18632\/oncotarget.9209","article-title":"Crosstalk between CCL7 and CCR3 Promotes Metastasis of Colon Cancer Cells via ERK-JNK Signaling Pathways","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jdermsci.2013.04.011","article-title":"The Chemokine Receptor CCR3 Participates in Tissue Remodeling during Atopic Skin Inflammation","volume":"71","author":"Gaspar","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Toyoda, H., Honda, Y., Tanaka, S., Miyagawa, T., Honda, M., Honda, K., Tokunaga, K., and Kodama, T. (2017). Narcolepsy Susceptibility Gene CCR3 Modulates Sleep-Wake Patterns in Mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187888"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.1038\/s41598-017-05654-w","article-title":"CCL11, a Novel Mediator of Inflammatory Bone Resorption","volume":"7","author":"Kindstedt","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Zhu, L.-P., Xu, M.-L., Yuan, B.-T., Ma, L.-J., and Gao, Y.-J. (2023). Chemokine CCL7 Mediates Trigeminal Neuropathic Pain via CCR2\/CCR3-ERK Pathway in the Trigeminal Ganglion of Mice. Mol. Pain, 174480692311693.","DOI":"10.1177\/17448069231169373"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3389\/fphar.2018.01240","article-title":"Heteromerization Modulates Mu Opioid Receptor Functional Properties in Vivo","volume":"9","author":"Ugur","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fimmu.2020.00094","article-title":"Bidirectional Regulation of Opioid and Chemokine Function","volume":"11","author":"TJ","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuropharm.2012.10.030","article-title":"Decreased Pain Responses of C-C Chemokine Receptor 5 Knockout Mice to Chemical or Inflammatory Stimuli","volume":"67","author":"Lee","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41419-020-2306-6","article-title":"Blocking the Autocrine Regulatory Loop of Gankyrin\/STAT3\/CCL24\/CCR3 Impairs the Progression and Pazopanib Resistance of Clear Cell Renal Cell Carcinoma","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1165\/rcmb.2020-0425OC","article-title":"Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3","volume":"64","author":"Shah","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cyto.2015.09.012","article-title":"Upregulated Expression of CCR3 in Osteoarthritis and CCR3 Mediated Activation of Fibroblast-like Synoviocytes","volume":"77","author":"Chang","year":"2016","journal-title":"Cytokine"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.yexcr.2011.01.004","article-title":"Chemokine Oligomerization and Interactions with Receptors and Glycosaminoglycans: The Role of Structural Dynamics in Function","volume":"317","author":"Salanga","year":"2011","journal-title":"Exp. Cell Res."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"14500","DOI":"10.1073\/pnas.95.24.14500","article-title":"Chemokines Regulate Hippocampal Neuronal Signaling and Gp120 Neurotoxicity","volume":"95","author":"Meucci","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1055\/s-0043-113455","article-title":"Ginger Extract Modulates the Expression of Chemokines CCL20 and CCL22 and Their Receptors (CCR6 and CCR4) in the Central Nervous System of Mice with Experimental Autoimmune Encephalomyelitis","volume":"67","author":"Jafarzadeh","year":"2017","journal-title":"Drug Res."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1046\/j.1471-4159.2002.01091.x","article-title":"Characterization of Chemokines and Their Receptors in the Central Nervous System: Physiopathological Implications","volume":"82","author":"Bajetto","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.2174\/15680266106061335","article-title":"Antagonists of CCR4 as Immunomodulatory Agents","volume":"6","author":"Purandare","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.bmcl.2005.02.084","article-title":"Identification of Chemokine Receptor CCR4 Antagonist","volume":"15","author":"Purandare","year":"2005","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/193229681100500122","article-title":"Evaluation of Dexterity in Insulin-Treated Patients with Type 1 and Type 2 Diabetes Mellitus","volume":"5","author":"Hellhammer","year":"2011","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ptj\/74.4.299","article-title":"Differences in the Gait Characteristics of Patients with Diabetes and Peripheral Neuropathy Compared with Age-Matched Controls","volume":"74","author":"Mueller","year":"1994","journal-title":"Phys. Ther."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2217\/imt.14.94","article-title":"Mogamulizumab and the Treatment of CCR4-Positive T-Cell Lymphomas","volume":"6","author":"Remer","year":"2014","journal-title":"Immunotherapy"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1158\/1078-0432.CCR-19-1090","article-title":"A Phase I Study of the Anti-CC Chemokine Receptor 4 Antibody, Mogamulizumab, in Combination with Nivolumab in Patients with Advanced or Metastatic Solid Tumors","volume":"25","author":"Doi","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/sj.cdd.4402006","article-title":"HIV-1 Coreceptors CCR5 and CXCR4 Both Mediate Neuronal Cell Death but CCR5 Paradoxically Can Also Contribute to Protection","volume":"14","author":"Kaul","year":"2007","journal-title":"Cell Death Differ."},{"key":"ref_270","first-page":"1341","article-title":"Cellular Localization of the Chemokine Receptor CCR5: Correlation to Cellular Targets of HIV-1 Infection","volume":"151","author":"Rottman","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1523\/JNEUROSCI.5171-04.2005","article-title":"Migration of Perilesional Microglia after Focal Brain Injury and Modulation by CC Chemokine Receptor 5: An in Situ Time-Lapse Confocal Imaging Study","volume":"25","author":"Carbonell","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1523\/JNEUROSCI.4303-03.2004","article-title":"Neurons and Astrocytes Respond to Prion Infection by Inducing Microglia Recruitment","volume":"24","author":"Marella","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"31305","DOI":"10.1074\/jbc.M001269200","article-title":"Morphine Induces Gene Expression of CCR5 in Human CEM X174 Lymphocytes","volume":"275","author":"Miyagi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1128\/CDLI.7.5.719-723.2000","article-title":"Detection and Function of Opioid Receptors on Cells from the Immune System","volume":"7","author":"Bidlack","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Mika, J., Popiolek-Barczyk, K., Rojewska, E., Makuch, W., Starowicz, K., and Przewlocka, B. (2014). Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104420"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejphar.2003.10.033","article-title":"Heterodimerization and Cross-Desensitization between the \u03bc-Opioid Receptor and the Chemokine CCR5 Receptor","volume":"483","author":"Chen","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"10276","DOI":"10.1073\/pnas.102327699","article-title":"Heterologous Desensitization of Opioid Receptors by Chemokines Inhibits Chemotaxis and Enhances the Perception of Pain","volume":"99","author":"Szabo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1471-4159.2011.07549.x","article-title":"Modulatory Effects of the CCR5 Antagonist Maraviroc on Microglial Pro-Inflammatory Activation Elicited by Gp120","volume":"120","author":"Lisi","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1517\/13543770802641353","article-title":"Chemokine Receptor Antagonists: Part 2","volume":"19","author":"Pease","year":"2009","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2019.04.014","article-title":"Spinal Blockage of CXCL1 and Its Receptor CXCR2 Inhibits Paclitaxel-Induced Peripheral Neuropathy in Mice","volume":"151","author":"Manjavachi","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/joor.13273","article-title":"C-X-C Motif Chemokine Ligand 1 and Its Receptor C-X-C Motif Chemokine Receptor 2 in Trigeminal Ganglion Contribute to Nerve Injury-Induced Orofacial Mechanical Allodynia","volume":"49","author":"Yang","year":"2022","journal-title":"J. Oral Rehabil."},{"key":"ref_282","first-page":"3803","article-title":"Pharmacological Inhibition of CXCR2 Alleviates Neuropathic Pain by Inactivating Microglia in a Rat L5 Spinal Nerve Ligation Model","volume":"12","author":"Zhou","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbrc.2020.07.104","article-title":"CXCR3 Contributes to Neuropathic Pain via ERK Activation in the Anterior Cingulate Cortex","volume":"531","author":"Qin","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1007\/s11064-016-1943-8","article-title":"Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation","volume":"41","author":"Xie","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"174322","DOI":"10.1016\/j.ejphar.2021.174322","article-title":"Intervertebral Foramen Injection of Plerixafor Attenuates Neuropathic Pain after Chronic Compression of the Dorsal Root Ganglion: Possible Involvement of the down-Regulation of Nav1.8 and Nav1.9","volume":"908","author":"Yang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2018.09.001","article-title":"Zaprinast Diminished Pain and Enhanced Opioid Analgesia in a Rat Neuropathic Pain Model","volume":"839","author":"Rojewska","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.4049\/jimmunol.158.6.2882","article-title":"Expression of Chemokine Receptors by Subsets of Neurons in the Central Nervous System","volume":"158","author":"Horuk","year":"1997","journal-title":"J. Immunol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/ALN.0b013e31829ce340","article-title":"Epigenetic Regulation of Spinal Cxcr2 Signaling in Incisional Hypersensitivity in Mice","volume":"119","author":"Sun","year":"2013","journal-title":"Anesthesiology"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1744806917730212","DOI":"10.1177\/1744806917730212","article-title":"The Chemokine Receptor CXCR2 Supports Nociceptive Sensitization after Traumatic Brain Injury","volume":"13","author":"Liang","year":"2017","journal-title":"Mol. Pain"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"173039","DOI":"10.1016\/j.ejphar.2020.173039","article-title":"Participation of CXCL1 in the Glial Cells during Neuropathic Pain","volume":"875","author":"Moraes","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuropharm.2018.03.004","article-title":"Levo-Corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-Kappa B-Dependent CXCL1\/CXCR2 Signaling Pathway","volume":"135","author":"Zhou","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"110330","DOI":"10.1016\/j.intimp.2023.110330","article-title":"The Role of CXCL1\/CXCR2 Axis in Neurological Diseases","volume":"120","author":"Jiang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.coph.2011.10.015","article-title":"Chemokine Mediated Neuron-Glia Communication and Aberrant Signalling in Neuropathic Pain States","volume":"12","author":"Old","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20021897","article-title":"An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4","volume":"197","author":"Lasagni","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1074\/jbc.M209470200","article-title":"Structure-Function Relationship between the Human Chemokine Receptor CXCR3 and Its Ligands","volume":"278","author":"Mattioli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1182\/blood-2002-12-3945","article-title":"CXCR3-Mediated Chemotaxis of Human T Cells Is Regulated by a G i-and Phospholipase C-Dependent Pathway and Not via Activation of MEK\/P44\/P42 MAPK nor Akt\/PI-3 Kinase","volume":"102","author":"Smit","year":"2003","journal-title":"Blood"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuropharm.2019.02.024","article-title":"HIV Gp120 Upregulates Tonic Inhibition through A5-Containing GABA A Rs","volume":"149","author":"Green","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2015.09.005","article-title":"CXC Chemokine Receptor 3 Promotes Steatohepatitis in Mice through Mediating Inflammatory Cytokines, Macrophages and Autophagy","volume":"64","author":"Zhang","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1124\/mol.116.105502","article-title":"CXC Chemokine Receptor 3 Alternative Splice Variants Selectively Activate Different Signaling Pathways","volume":"90","author":"Berchiche","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bbi.2008.07.008","article-title":"Minocycline Suppresses Morphine-Induced Respiratory Depression, Suppresses Morphine-Induced Reward, and Enhances Systemic Morphine-Induced Analgesia","volume":"22","author":"Hutchinson","year":"2008","journal-title":"Brain. Behav. Immun."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"2040206619829382","DOI":"10.1177\/2040206619829382","article-title":"Mozobil\u00ae (Plerixafor, AMD3100), 10 Years after Its Approval by the US Food and Drug Administration","volume":"27","year":"2019","journal-title":"Chem. Chemother."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"F783","DOI":"10.1152\/ajprenal.00685.2013","article-title":"CXCR4 Antagonism as a Therapeutic Approach to Prevent Acute Kidney Injury","volume":"307","author":"Zuk","year":"2014","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/CIRCULATIONAHA.112.099242","article-title":"CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery after Ischemia\/Reperfusion Injury via Endothelial Nitric Oxide Synthase-Dependent Mechanism","volume":"127","author":"Jujo","year":"2013","journal-title":"Circulation"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1128\/AAC.44.6.1667-1673.2000","article-title":"Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR- 4 Chemokine Receptor, in Human Volunteers","volume":"44","author":"Hendrix","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1744-8069-5-48","article-title":"Increased Chemokine Signaling in a Model of HIV1-Associated Peripheral Neuropathy","volume":"5","author":"Bhangoo","year":"2009","journal-title":"Mol. Pain"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jnc.12985","article-title":"CXCL12\/CXCR4 Chemokine Signaling in Spinal Glia Induces Pain Hypersensitivity through MAPKs-Mediated Neuroinflammation in Bone Cancer Rats","volume":"132","author":"Hu","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1744-8069-10-42","article-title":"CXCR4 Chemokine Receptor Signaling Mediates Pain in Diabetic Neuropathy","volume":"10","author":"Menichella","year":"2014","journal-title":"Mol. Pain"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"e09178","DOI":"10.1016\/j.heliyon.2022.e09178","article-title":"The Axis of Long Non-Coding RNA MALAT1\/MiR-1-3p\/CXCR4 Is Dysregulated in Patients with Diabetic Neuropathy","volume":"8","author":"Ashjari","year":"2022","journal-title":"Heliyon"},{"key":"ref_309","doi-asserted-by":"crossref","unstructured":"Luo, X., Tai, W.L., Sun, L., Qiu, Q., Xia, Z., Chung, S.K., and Cheung, C.W. (2014). Central Administration of C-X-C Chemokine Receptor Type 4 Antagonist Alleviates the Development and Maintenance of Peripheral Neuropathic Pain in Mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104860"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.bbi.2010.12.014","article-title":"CXCR4 Signaling Mediates Morphine-Induced Tactile Hyperalgesia","volume":"25","author":"Wilson","year":"2011","journal-title":"Brain. Behav. Immun."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bcp.2014.12.009","article-title":"Functional G-Protein-Coupled Receptor 35 Is Expressed by Neurons in the CA1 Field of the Hippocampus","volume":"93","author":"Alkondon","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_312","doi-asserted-by":"crossref","unstructured":"Berlinguer-Palmini, R., Masi, A., Narducci, R., Cavone, L., Maratea, D., Cozzi, A., Sili, M., Moroni, F., and Mannaioni, G. (2013). GPR35 Activation Reduces Ca2+ Transients and Contributes to the Kynurenic Acid-Dependent Reduction of Synaptic Activity at CA3-CA1 Synapses. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0082180"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.neuropharm.2010.11.014","article-title":"G-Protein Coupled Receptor 35 (GPR35) Activation and Inflammatory Pain: Studies on the Antinociceptive Effects of Kynurenic Acid and Zaprinast","volume":"60","author":"Cosi","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"22021","DOI":"10.1074\/jbc.M603503200","article-title":"Kynurenic Acid as a Ligand for Orphan G Protein-Coupled Receptor GPR35","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbrc.2007.10.197","article-title":"GPR35 Is a Functional Receptor in Rat Dorsal Root Ganglion Neurons","volume":"365","author":"Ohshiro","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1016\/j.febslet.2006.08.015","article-title":"Zaprinast, a Well-Known Cyclic Guanosine Monophosphate-Specific Phosphodiesterase Inhibitor, Is an Agonist for GPR35","volume":"580","author":"Taniguchi","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neuropharm.2015.07.035","article-title":"The Emerging Pharmacology and Function of GPR35 in the Nervous System","volume":"113","author":"Mackenzie","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1074\/jbc.M113.508382","article-title":"Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor","volume":"289","author":"Zhao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2016.04.038","article-title":"Kynurenic Acid and Zaprinast Induce Analgesia by Modulating HCN Channels through GPR35 Activation","volume":"108","author":"Resta","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/schbul\/sbl033","article-title":"Elevations of Endogenous Kynurenic Acid Produce Spatial Working Memory Deficits","volume":"33","author":"Chess","year":"2007","journal-title":"Schizophr. Bull."},{"key":"ref_321","first-page":"27296","article-title":"Galantamine-Memantine Combination for Cognitive Impairments Due to Electroconvulsive Therapy, Traumatic Brain Injury, and Neurologic and Psychiatric Disorders: Kynurenic Acid and Mismatch Negativity Target Engagement","volume":"20","author":"Koola","year":"2018","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1124\/jpet.111.189860","article-title":"Regulation of GABAergic Inputs to CA1 Pyramidal Neurons by Nicotinic Receptors and Kynurenic Acid","volume":"341","author":"Banerjee","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(85)90685-7","article-title":"Effects of Kynurenate on Root Potentials Evoked by Synaptic Activity and Amino Acids in the Frog Spinal Cord","volume":"330","author":"Elmslie","year":"1985","journal-title":"Brain Res."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(92)90067-E","article-title":"Antinociceptive Actions of Different Classes of Excitatory Amino Acid Receptor Antagonists in Mice","volume":"212","author":"Karlsson","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0006-8993(95)01063-7","article-title":"Time-Related Roles of Excitatory Amino Acid Receptors during Persistent Noxiously Evoked Responses of Rat Dorsal Horn Neurones","volume":"703","author":"Chapman","year":"1995","journal-title":"Brain Res."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neulet.2005.08.006","article-title":"Lack of the Nitric Oxide-Cyclic GMP-Potassium Channel Pathway for the Antinociceptive Effect of Intrathecal Zaprinast in a Rat Formalin Test","volume":"390","author":"Yoon","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1177\/1087057113475480","article-title":"Screening \u03b2-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors","volume":"18","author":"Southern","year":"2013","journal-title":"J. Biomol. Screen."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/bph.14082","article-title":"GPR35 Mediates Lodoxamide-Induced Migration Inhibitory Response but Not CXCL17-Induced Migration Stimulatory Response in THP-1 Cells; Is GPR35 a Receptor for CXCL17?","volume":"175","author":"Park","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_329","doi-asserted-by":"crossref","unstructured":"Zhao, R., Liu, J., Li, Z., Zhang, W., Wang, F., and Zhang, B. (2022). Recent Advances in CXCL12\/CXCR4 Antagonists and Nano-Based Drug Delivery Systems for Cancer Therapy. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081541"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuroscience.2018.03.030","article-title":"A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via Its Receptor XCR1 to Increase Trigeminal Neuronal Excitability","volume":"379","author":"Bird","year":"2018","journal-title":"Neuroscience"},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1006\/bbrc.2001.4363","article-title":"Neutrophils and B Cells Express XCR1 Receptor and Chemotactically Respond to Lymphotactin","volume":"281","author":"Huang","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/ptr.7696","article-title":"Total Saponins of Panax Ginseng via the CX3CL1\/CX3CR1 Axis Attenuates Neuroinflammation and Exerted Antidepressant-like Effects in Chronic Unpredictable Mild Stress in Rats","volume":"37","author":"Qin","year":"2022","journal-title":"Phyther. Res."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1460-9568.2004.03593.x","article-title":"Fractalkine (CX3CL1) and Fractalkine Receptor (CX3CR1) Distribution in Spinal Cord and Dorsal Root Ganglia under Basal and Neuropathic Pain Conditions","volume":"20","author":"Verge","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbi.2006.11.003","article-title":"Role of the CX3CR1\/P38 MAPK Pathway in Spinal Microglia for the Development of Neuropathic Pain Following Nerve Injury-Induced Cleavage of Fractalkine","volume":"21","author":"Zhuang","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1111\/j.1460-9568.2005.04470.x","article-title":"An Initial Investigation of Spinal Mechanisms Underlying Pain Enhancement Induced by Fractalkine, a Neuronally Released Chemokine","volume":"22","author":"Milligan","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1471-4159.2010.06837.x","article-title":"Reduced Inflammatory and Neuropathic Pain and Decreased Spinal Microglial Response in Fractalkine Receptor (CX3CR1) Knockout Mice","volume":"114","author":"Staniland","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1152\/jn.00348.2020","article-title":"Spinal Cord Fractalkine (CX3CL1) Signaling Is Critical for Neuronal Sensitization in Experimental Nonspecific, Myofascial Low Back Pain","volume":"125","author":"Sessler","year":"2021","journal-title":"J. Neurophysiol."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1471-4159.2008.05419.x","article-title":"Intra-Neural Administration of Fractalkine Attenuates Neuropathic Pain-Related Behaviour","volume":"106","author":"Holmes","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_339","doi-asserted-by":"crossref","unstructured":"Noh, C., Shin, H.J., Lee, S., Kim, S.I., Kim, Y.H., Lee, W.H., Kim, D.W., Lee, S.Y., and Ko, Y.K. (2020). CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103469"},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"120788","DOI":"10.1016\/j.lfs.2022.120788","article-title":"Potentiation of Morphine Antinociception and Inhibition of Diabetic Neuropathic Pain by the Multi-Chemokine Receptor Antagonist Peptide RAP-103","volume":"306","author":"Ruff","year":"2022","journal-title":"Life Sci."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pain.2011.09.022","article-title":"Attenuation of Rodent Neuropathic Pain by an Orally Active Peptide, RAP-103, Which Potently Blocks CCR2- and CCR5-Mediated Monocyte Chemotaxis and Inflammation","volume":"153","author":"Padi","year":"2012","journal-title":"Pain"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"23188","DOI":"10.18632\/oncotarget.15533","article-title":"CXCR1\/2 Pathways in Paclitaxel-Induced Neuropathic Pain","volume":"8","author":"Laura","year":"2017","journal-title":"Oncotarget"},{"key":"ref_343","doi-asserted-by":"crossref","unstructured":"Cho, H.S., Choi, Y.I., Park, S.U., Han, Y.S., Kwon, J., and Jung, S.J. (2023). Prevention of Chemotherapy-Induced Peripheral Neuropathy by Inhibiting C-X-C Motif Chemokine Receptor 2. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031855"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"27935","DOI":"10.1074\/jbc.M703255200","article-title":"Small Molecule Receptor Agonists and Antagonists of CCR3 Provide Insight into Mechanisms of Chemokine Receptor Activation","volume":"282","author":"Wise","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/acsmedchemlett.1c00373","article-title":"BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate","volume":"12","author":"Cherney","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.ekir.2018.07.010","article-title":"Effect of PF-04634817, an Oral CCR2\/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy","volume":"3","author":"Gale","year":"2018","journal-title":"Kidney Int. Rep."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1007\/s00018-008-8666-1","article-title":"Modulation of Chemokine Receptor Activity through Dimerization and Crosstalk","volume":"66","author":"Salanga","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fimmu.2018.00557","article-title":"Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines\/Cytokines","volume":"9","author":"Pranzatelli","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.pain.2010.02.025","article-title":"Macrophage Inflammatory Protein-1alpha Mediates the Development of Neuropathic Pain Following Peripheral Nerve Injury through Interleukin-1beta up-Regulation","volume":"149","author":"Kiguchi","year":"2010","journal-title":"Pain"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/QAD.0000000000000988","article-title":"A 48-Week Randomized Phase 2b Study Evaluating Cenicriviroc versus Efavirenz in Treatment-Naive HIV-Infected Adults with C-C Chemokine Receptor Type 5-Tropic Virus","volume":"30","author":"Thompson","year":"2016","journal-title":"AIDS"},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"11791","DOI":"10.1073\/pnas.0402090101","article-title":"Noncompetitive Allosteric Inhibitors of the Inflammatory Chemokine Receptors CXCR1 and CXCR2: Prevention of Reperfusion Injury","volume":"101","author":"Bertini","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12974-020-01997-w","article-title":"Spinal Neuronal Excitability and Neuroinflammation in a Model of Chemotherapeutic Neuropathic Pain: Targeting the Resolution Pathways","volume":"17","author":"Meesawatsom","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuint.2017.12.005","article-title":"Neuropathic Pain Inhibitor, RAP-103, Is a Potent Inhibitor of Microglial CCL1\/CCR8","volume":"119","author":"Noda","year":"2018","journal-title":"Neurochem. Int."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"109556","DOI":"10.1016\/j.drugalcdep.2022.109556","article-title":"Multi-Chemokine Receptor Antagonist RAP-103 Inhibits Opioid-Derived Respiratory Depression, Reduces Opioid Reinforcement and Physical Dependence, and Normalizes Opioid-Induced Dysregulation of Mesolimbic Chemokine Receptors in Rats","volume":"238","author":"Bongiovanni","year":"2022","journal-title":"Drug Alcohol Depend."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/15\/5766\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:22:45Z","timestamp":1760127765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/15\/5766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,30]]},"references-count":354,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["molecules28155766"],"URL":"https:\/\/doi.org\/10.3390\/molecules28155766","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,30]]}}}