{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:43:23Z","timestamp":1790347403376,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Apium graveolens is an indigenous plant in the family Apiaceae, or Umbelliferae, that contains many active compounds. It has been used traditionally to treat arthritic conditions, gout, and urinary infections. The authors conducted a scoping review to assess the quality of available evidence on the overall effects of celery when treating neurological disorders. A systematic search was performed using predetermined keywords in selected electronic databases. The 26 articles included upon screening consisted of 19 in vivo studies, 1 published clinical trial, 4 in vitro studies and 2 studies comprising both in vivo and in vitro methods. A. graveolens and its bioactive phytoconstituent, 3-n-butylphthalide (NBP), have demonstrated their effect on neurological disorders such as Alzheimer\u2019s disease, Parkinson\u2019s disease, stroke-related neurological complications, depression, diabetes-related neurological complications, and epilepsy. The safety findings were minimal, showing that NBP is safe for up to 18 weeks at 15 mg\/kg in animal studies, while there were adverse effects (7%) reported when consuming NBP for 24 weeks at 600 mg daily in human trials. In conclusion, the safety of A. graveolens extract and NBP can be further investigated clinically on different neurological disorders based on their potential role in different targeted pathways.<\/jats:p>","DOI":"10.3390\/molecules28155824","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T11:17:17Z","timestamp":1690975037000},"page":"5824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neurological Applications of Celery (Apium graveolens): A Scoping Review"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7178-7435","authenticated-orcid":false,"given":"Terence Yew Chin","family":"Tan","sequence":"first","affiliation":[{"name":"Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-3166","authenticated-orcid":false,"given":"Xin Yi","family":"Lim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-1094","authenticated-orcid":false,"given":"Nor Azrina","family":"Norahmad","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-3920","authenticated-orcid":false,"given":"Hemahwathy","family":"Chanthira Kumar","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0789-170X","authenticated-orcid":false,"given":"Bee Ping","family":"Teh","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4204-3098","authenticated-orcid":false,"given":"Nai Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Monash University Malaysia, Subang Jaya 47500, Malaysia"},{"name":"School of Medicine, Taylor\u2019s University, Subang Jaya 47100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-951X","authenticated-orcid":false,"given":"Ami Fazlin","family":"Syed Mohamed","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"ref_1","unstructured":"U.S. Department of Health and Human Services, National Institute of Environmental Health Sciences (2022, September 05). 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