{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:04:29Z","timestamp":1791950669641,"version":"4.3.4"},"reference-count":191,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["APQ-00995-21"],"award-info":[{"award-number":["APQ-00995-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Bismuth-based drugs have been used primarily to treat ulcers caused by Helicobacter pylori and other gastrointestinal ailments. Combined with antibiotics, these drugs also possess synergistic activity, making them ideal for multiple therapy regimens and overcoming bacterial resistance. Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments. As a result, there is a growing interest in developing new bismuth compounds and approaches to overcome this challenge. Considering the beneficial properties of bismuth and the importance of discovering new drugs, this review focused on the last decade\u2019s updates involving bismuth compounds, especially those with potent activity and low toxicity, desirable characteristics for developing new drugs. In addition, bismuth-based compounds with dual activity were also highlighted, as well as their modes of action and structure\u2013activity relationship, among other relevant discoveries. In this way, we hope this review provides a fertile ground for rationalizing new bismuth-based drugs.<\/jats:p>","DOI":"10.3390\/molecules28155921","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T06:38:48Z","timestamp":1691390328000},"page":"5921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome"],"prefix":"10.3390","volume":"28","author":[{"given":"J\u00e2nia dos Santos","family":"Ros\u00e1rio","sequence":"first","affiliation":[{"name":"Department of Chemistry, Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais, Belo Horizonte 30421-169, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Henrique","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais, Belo Horizonte 30421-169, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Hewilin Fernandes","family":"Rosa","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Universidade Federal de Uberl\u00e2ndia, Campus Santa M\u00f4nica, Uberl\u00e2ndia 38400-142, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendell","family":"Guerra","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Universidade Federal de Uberl\u00e2ndia, Campus Santa M\u00f4nica, Uberl\u00e2ndia 38400-142, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-3840","authenticated-orcid":false,"given":"Priscila Pereira","family":"Silva-Caldeira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais, Belo Horizonte 30421-169, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, R., Li, H., Ip, T.K.Y., and Sun, H. 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