{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:04:23Z","timestamp":1787313863504,"version":"build-2736575974"},"reference-count":88,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Recently, the study of the protective powers of medicinal plants has become the focus of several studies. Attention has been focused on the identification of new molecules with antioxidant and chelating properties to counter reactive oxygen species (ROS) involved as key elements in several pathologies. Considerable attention is given to argan oil (AO) and olive oil (OO) due to their particular composition and preventive properties. Our study aimed to determine the content of AO and OO on phenolic compounds, chlorophylls, and carotenoid pigments and their antioxidant potential by FRAP and DPPH tests. Thus, several metallic elements can induce oxidative stress, as a consequence of the formation of ROS. Iron is one of these metal ions, which participates in the generation of free radicals, especially OH from H2O2 via the Fenton reaction, initiating oxidative stress. To study the antioxidant potential of AO and OO, we evaluated their preventives effects against oxidative stress induced by ferrous sulfate (FeSO4) in the protozoan Tetrahymena pyriformis and mice. Then, we evaluated the activities of the enzymatic (superoxide dismutase (SOD), glutathione peroxidase (GPx)) and metabolite markers (lipid peroxidation (MDA) and glutathione (GSH)) of the antioxidant balance. The results of the antioxidant compounds show that both oils contain phenolic compounds and pigments. Moreover, AO and OO exhibit antioxidant potential across FRAP and DPPH assays. On the other hand, the results in Tetrahymena pyriformis and mice show a variation in the level of iron-changed SOD and GPx activities and MDA and GSH levels. By contrast, treating Tetrahymena pyriformis and mice with argan and olive oils shows significant prevention in the SOD and GPx activities. These results reveal that the iron-changed ROS imbalance can be counteracted by AO and OO, which is probably related to their composition, especially their high content of polyphenols, sterols, and tocopherols, which is underlined by their antioxidant activities.<\/jats:p>","DOI":"10.3390\/molecules28155924","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T06:38:48Z","timestamp":1691390328000},"page":"5924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antioxidant Effects of Argan Oil and Olive Oil against Iron-Induced Oxidative Stress: In Vivo and In Vitro Approaches"],"prefix":"10.3390","volume":"28","author":[{"given":"Habiba","family":"Bouchab","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco"},{"name":"Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soukaina","family":"Essadek","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco"},{"name":"Bio-PeroxIL Laboratory, EA7270, Universit\u00e9 de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soufiane","family":"El Kamouni","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Moustaid","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Chemistry and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkhalid","family":"Essamadi","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2118-7858","authenticated-orcid":false,"given":"Pierre","family":"Andreoletti","sequence":"additional","affiliation":[{"name":"Bio-PeroxIL Laboratory, EA7270, Universit\u00e9 de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Cherkaoui-Malki","sequence":"additional","affiliation":[{"name":"Bio-PeroxIL Laboratory, EA7270, Universit\u00e9 de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-2168","authenticated-orcid":false,"given":"Riad","family":"El Kebbaj","sequence":"additional","affiliation":[{"name":"Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubker","family":"Nasser","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.neuroscience.2006.08.061","article-title":"DNA Repair, Mitochondria, and Neurodegeneration","volume":"145","author":"Weissman","year":"2007","journal-title":"Neuroscience"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Irazabal, M.V., and Torres, V.E. 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