{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:55:53Z","timestamp":1790614553981,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Chicago (UChicago) Joint Task Force Initiative (JTFI)","award":["P30 CA14599"],"award-info":[{"award-number":["P30 CA14599"]}]},{"name":"University of Chicago (UChicago) Joint Task Force Initiative (JTFI)","award":["S10 OD025265"],"award-info":[{"award-number":["S10 OD025265"]}]},{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI)","award":["P30 CA14599"],"award-info":[{"award-number":["P30 CA14599"]}]},{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI)","award":["S10 OD025265"],"award-info":[{"award-number":["S10 OD025265"]}]},{"name":"UChicago High-Risk and Advanced Prostate Cancer (UCHAP) Team Science Research Award","award":["P30 CA14599"],"award-info":[{"award-number":["P30 CA14599"]}]},{"name":"UChicago High-Risk and Advanced Prostate Cancer (UCHAP) Team Science Research Award","award":["S10 OD025265"],"award-info":[{"award-number":["S10 OD025265"]}]},{"name":"UChicago Comprehensive Cancer Center (UCCCC)","award":["P30 CA14599"],"award-info":[{"award-number":["P30 CA14599"]}]},{"name":"UChicago Comprehensive Cancer Center (UCCCC)","award":["S10 OD025265"],"award-info":[{"award-number":["S10 OD025265"]}]},{"DOI":"10.13039\/100000002","name":"NIH Cancer Center","doi-asserted-by":"publisher","award":["P30 CA14599"],"award-info":[{"award-number":["P30 CA14599"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH Cancer Center","doi-asserted-by":"publisher","award":["S10 OD025265"],"award-info":[{"award-number":["S10 OD025265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH Shared Instrumentation","doi-asserted-by":"publisher","award":["P30 CA14599"],"award-info":[{"award-number":["P30 CA14599"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH Shared Instrumentation","doi-asserted-by":"publisher","award":["S10 OD025265"],"award-info":[{"award-number":["S10 OD025265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the field of nuclear medicine, the \u03b2+ -emitting 43Sc and \u03b2\u2212 -emitting 47Sc are promising candidates in cancer diagnosis and targeted radionuclide therapy (TRT) due to their favorable decay schema and shared pharmacokinetics as a true theranostic pair. Additionally, scandium is a group-3 transition metal (like 177Lu) and exhibits affinity for DOTA-based chelators, which have been studied in depth, making the barrier to implementation lower for 43\/47Sc than for other proposed true theranostics. Before 43\/47Sc can see widespread pre-clinical evaluation, however, an accessible production methodology must be established and each isotope\u2019s radiolabeling and animal imaging capabilities studied with a widely utilized tracer. As such, a simple means of converting an 18 MeV biomedical cyclotron to support solid targets and produce 43Sc via the 42Ca(d,n)43Sc reaction has been devised, exhibiting reasonable yields. The NatTi(\u03b3,p)47Sc reaction is also investigated along with the successful implementation of chemical separation and purification methods for 43\/47Sc. The conjugation of 43\/47Sc with PSMA-617 at specific activities of up to 8.94 MBq\/nmol and the subsequent imaging of LNCaP-ENZaR tumor xenografts in mouse models with both 43\/47Sc-PSMA-617 are also presented.<\/jats:p>","DOI":"10.3390\/molecules28166041","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T11:07:10Z","timestamp":1692011230000},"page":"6041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Accelerator-Based Production of Scandium Radioisotopes for Applications in Prostate Cancer: Toward Building a Pipeline for Rapid Development of Novel Theranostics"],"prefix":"10.3390","volume":"28","author":[{"given":"Jason P.","family":"Meier","sequence":"first","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"},{"name":"Integrated Small Animal Imaging Research Resource, Office of Shared Research Facilities, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Freifelder","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"},{"name":"Cyclotron Facility, The University of Chicago, Chicago, IL 60637, USA"},{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI), Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Bhuiyan","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"},{"name":"Cyclotron Facility, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Selman","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavithra H. A.","family":"Kankanamalage","sequence":"additional","affiliation":[{"name":"Physics Division, Argonne National Laboratory, Lemont, IL 60439, USA"},{"name":"Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brossard","sequence":"additional","affiliation":[{"name":"Physics Division, Argonne National Laboratory, Lemont, IL 60439, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-3919","authenticated-orcid":false,"given":"Antonino","family":"Pusateri","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Ming","family":"Tsai","sequence":"additional","affiliation":[{"name":"Integrated Small Animal Imaging Research Resource, Office of Shared Research Facilities, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Leoni","sequence":"additional","affiliation":[{"name":"Integrated Small Animal Imaging Research Resource, Office of Shared Research Facilities, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-6899","authenticated-orcid":false,"given":"Sagada","family":"Penano","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaustab","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"},{"name":"Cyclotron Facility, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-5326","authenticated-orcid":false,"given":"Brittany A.","family":"Broder","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"},{"name":"National Institute of Standards and Technology, Gaithersburg, MD 20899, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Markiewicz","sequence":"additional","affiliation":[{"name":"Integrated Small Animal Imaging Research Resource, Office of Shared Research Facilities, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3092-1743","authenticated-orcid":false,"given":"Amy","family":"Renne","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"},{"name":"Physics Division, Argonne National Laboratory, Lemont, IL 60439, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Stadler","sequence":"additional","affiliation":[{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI), Chicago, IL 60637, USA"},{"name":"Department of Medicine, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Weichselbaum","sequence":"additional","affiliation":[{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI), Chicago, IL 60637, USA"},{"name":"Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Nolen","sequence":"additional","affiliation":[{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI), Chicago, IL 60637, USA"},{"name":"Physics Division, Argonne National Laboratory, Lemont, IL 60439, 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Division, Argonne National Laboratory, Lemont, IL 60439, USA"},{"name":"Medical Isotope Development Group, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell Z.","family":"Szmulewitz","sequence":"additional","affiliation":[{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI), Chicago, IL 60637, USA"},{"name":"Department of Medicine, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Tu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Chicago, Chicago, IL 60637, USA"},{"name":"Integrated Small Animal Imaging Research Resource, Office of Shared Research Facilities, The University of Chicago, Chicago, IL 60637, USA"},{"name":"Cyclotron Facility, The University of Chicago, Chicago, IL 60637, USA"},{"name":"UChicago\/Argonne Joint Radioisotope Initiative (JRI), Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1148\/rg.2020200021","article-title":"Theranostics in Nuclear Medicine: Emerging and Re-Emerging Integrated Imaging and Therapies in the Era of Precision Oncology","volume":"40","author":"Nunes","year":"2020","journal-title":"Radiographics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.2967\/jnumed.118.220566","article-title":"Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine","volume":"60","author":"Langbein","year":"2019","journal-title":"J. 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