{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:00:57Z","timestamp":1770976857978,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004787","name":"TRC","doi-asserted-by":"publisher","award":["BFP\/GRG\/EBR\/21\/035"],"award-info":[{"award-number":["BFP\/GRG\/EBR\/21\/035"]}],"id":[{"id":"10.13039\/501100004787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004787","name":"TRC","doi-asserted-by":"publisher","award":["SR\/SCI\/CHEM\/01\/01"],"award-info":[{"award-number":["SR\/SCI\/CHEM\/01\/01"]}],"id":[{"id":"10.13039\/501100004787","id-type":"DOI","asserted-by":"publisher"}]},{"name":"His Majesty\u2019s Strategic Research Trust Fund","award":["BFP\/GRG\/EBR\/21\/035"],"award-info":[{"award-number":["BFP\/GRG\/EBR\/21\/035"]}]},{"name":"His Majesty\u2019s Strategic Research Trust Fund","award":["SR\/SCI\/CHEM\/01\/01"],"award-info":[{"award-number":["SR\/SCI\/CHEM\/01\/01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Maytenus dhofarensis Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of M. dhofarensis afforded dihydro-\u03b2-agarofuran-type sesquiterpene pyridine alkaloid (1), lupanyl myristoate (2) and lignanolactone (3). Compounds (1\u20133) are new isolates from M. dhofarensis. The structures of these compounds were assigned through comprehensive IR, NMR, and ESI-MS analyses, and the relative configurations of compounds 1 and 3 were deduced from density function theory (DFT) calculations and NMR experiments. Compound 1 was assayed against the kinase enzyme and showed no inhibition activity for p38 alpha and delta at a 10 \u00b5M test concentration. Compound 3 inhibited the 2,2\u2032-diphenyl-1-picrylhydrazyl radical (DPPH) by 69.5%, compared to 70.9% and 78.0% for gallic acid and butylated hydroxyanisole, respectively, which were used as positive controls.<\/jats:p>","DOI":"10.3390\/molecules28166077","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T11:15:08Z","timestamp":1692098108000},"page":"6077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Isolation and Identification of Phytocompounds from Maytenus dhofarensis and Their Biological Potentials"],"prefix":"10.3390","volume":"28","author":[{"given":"Fatma","family":"Al-Rubaiai","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakiya Zahran","family":"Al-Shariqi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalsa S.","family":"Al-Shabibi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1567-2999","authenticated-orcid":false,"given":"John","family":"Husband","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa M.","family":"Al-Hattali","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"Goettert","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universit\u00e4t T\u00fcbingen, D-72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-1486","authenticated-orcid":false,"given":"Stefan","family":"Laufer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universit\u00e4t T\u00fcbingen, D-72076 T\u00fcbingen, Germany"},{"name":"T\u00fcbingen Center for Academic Drug Discovery (T\u00fcCAD2), D-72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-8419","authenticated-orcid":false,"given":"Younis","family":"Baqi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-184X","authenticated-orcid":false,"given":"Syed Imran","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3289-112X","authenticated-orcid":false,"given":"Majekodunmi O.","family":"Fatope","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/mpev.2001.0937","article-title":"Phylogeny of the Celastraceae inferred from 26S nuclear ribosomal DNA, phytochrome B, rbcL, atpB, and morphology","volume":"19","author":"Simmons","year":"2001","journal-title":"Mol. Phylogenetics Evol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0378-8741(82)90022-8","article-title":"Chuchuhuasha\u2014A drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis","volume":"5","author":"Gonzalez","year":"1982","journal-title":"J. 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