{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:32:21Z","timestamp":1788229941015,"version":"build-2803163510"},"reference-count":101,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52250077"],"award-info":[{"award-number":["52250077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52272080"],"award-info":[{"award-number":["52272080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022E02130"],"award-info":[{"award-number":["2022E02130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xinjiang Uygur Autonomous Region Regional Collaborative Innovation Special Science and Technology Assistance Program","award":["52250077"],"award-info":[{"award-number":["52250077"]}]},{"name":"Xinjiang Uygur Autonomous Region Regional Collaborative Innovation Special Science and Technology Assistance Program","award":["52272080"],"award-info":[{"award-number":["52272080"]}]},{"name":"Xinjiang Uygur Autonomous Region Regional Collaborative Innovation Special Science and Technology Assistance Program","award":["2022E02130"],"award-info":[{"award-number":["2022E02130"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Indocyanine green (ICG) is an important kind of near infrared (NIR) photosensitive molecules for PTT\/PDT therapy as well as imaging. When exposed to NIR light, ICG can produce reactive oxygen species (ROS), which can kill cancer cells and pathogenic bacteria. Moreover, the absorbed light can also be converted into heat by ICG molecules to eliminate cancer cells. In addition, it performs exceptionally well in optical imaging-guided tumor therapy and antimicrobial therapy due to its deeper tissue penetration and low photobleaching properties in the near-infrared region compared to other dyes. In order to solve the problems of water and optical stability and multi-function problem of ICG molecules, composite nanomaterials based on ICG have been designed and widely used, especially in the fields of tumors and sterilization. So far, ICG molecules and their composite materials have become one of the most famous infrared sensitive materials. However, there have been no corresponding review articles focused on ICG molecules. In this review, the molecular structure and properties of ICG, composite material design, and near-infrared light- triggered anti-tumor, and antibacterial, and clinical applications are reviewed in detail, which of great significance for related research.<\/jats:p>","DOI":"10.3390\/molecules28166085","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T10:09:33Z","timestamp":1692180573000},"page":"6085","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Medical Applications and Advancement of Near Infrared Photosensitive Indocyanine Green Molecules"],"prefix":"10.3390","volume":"28","author":[{"given":"Zulpya","family":"Mahmut","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, College of Basic Medical Science, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, College of Basic Medical Science, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ruan","sequence":"additional","affiliation":[{"name":"State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, No. 964 Hospital of People\u2019s Liberation Army, 4799 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, College of Basic Medical Science, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuda","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, College of Basic Medical Science, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, College of Basic Medical Science, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operating Room, School and Hospital of Stomatology, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-368X","authenticated-orcid":false,"given":"Jiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, College of Basic Medical Science, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102717","DOI":"10.1016\/j.pdpdt.2022.102717","article-title":"Photodynamic therapy for the treatment of bacterial keratitis","volume":"37","year":"2022","journal-title":"Photodiagn. 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