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IBD is an inflammatory disease of the gastrointestinal tract that significantly impacts public health development. Monoclonal antibodies and other synthetic medications are currently used to treat IBD, but they are suspected of producing serious side effects and causing a number of other problems with long-term use. Numerous in vitro and in vivo studies have shown that organic macromolecules from plants and animals have an alleviating effect on IBD-related problems, and many of them are also capable of altering enzymatic function, reducing oxidative stress, and inhibiting the production of cytokines and release of proinflammatory transcriptional factors. Thus, in this paper, the natural products with potential anti-IBD activities and their mechanism of action were reviewed, with a focus on the protective effects of natural products on intestinal barrier integrity and the regulation of tight junction protein expression and remodeling. In conclusion, the insights provided in the present review will be useful for further exploration and development of natural products for the treatment of IBD.<\/jats:p>","DOI":"10.3390\/molecules28176293","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:59:05Z","timestamp":1693299545000},"page":"6293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Natural Products: A Dependable Source of Therapeutic Alternatives for Inflammatory Bowel Disease through Regulation of Tight Junctions"],"prefix":"10.3390","volume":"28","author":[{"given":"Jing","family":"Peng","sequence":"first","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-6619","authenticated-orcid":false,"given":"Oladejo Ayodele","family":"Olaolu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou 730050, China"},{"name":"Department of Animal Health Technology, Oyo State College of Agriculture and Technology Igboora Nigeria, Igboora 201003, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saber","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Packaging Materials Department, National Research Centre, Giza 12111, Egypt"},{"name":"Nanomaterials Investigation Laboratory, Central Laboratory Network, National Research Centre, Giza 12111, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction and AI, Veterinary Research Institute, National Research Centre, Dokki 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-5059","authenticated-orcid":false,"given":"Shengyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1603990","DOI":"10.3389\/phrs.2021.1603990","article-title":"A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration","volume":"42","author":"Tavakoli","year":"2021","journal-title":"Public Health Rev."},{"key":"ref_2","first-page":"CD012839","article-title":"Dietary interventions for induction and maintenance of remission in inflammatory bowel disease","volume":"10","author":"Limketkai","year":"2017","journal-title":"Cochrane Database Syst. 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