{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:44:51Z","timestamp":1787453091676,"version":"build-2736575974"},"reference-count":34,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Program of the National Natural Science Foundation of China","award":["No. 82192915"],"award-info":[{"award-number":["No. 82192915"]}]},{"name":"Major Program of the National Natural Science Foundation of China","award":["No. 2018YFC1704500"],"award-info":[{"award-number":["No. 2018YFC1704500"]}]},{"name":"National Key Research and Development Program","award":["No. 82192915"],"award-info":[{"award-number":["No. 82192915"]}]},{"name":"National Key Research and Development Program","award":["No. 2018YFC1704500"],"award-info":[{"award-number":["No. 2018YFC1704500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>CAG is a burdensome and progressive disease. Numerous studies have shown the effectiveness of RUT in digestive system diseases. The therapeutic effects of RUT on MNNG-induced CAG and the potential mechanisms were probed. MNNG administration was employed to establish a CAG model. The HE and ELISA methods were applied to detect the treatment effects. WB, qRT-PCR, immunohistochemistry, TUNEL, and GES-1 cell flow cytometry approaches were employed to probe the mechanisms. The CAG model was successfully established. The ELISA and HE staining data showed that the RUT treatment effects on CAG rats were reflected by the amelioration of histological damage. The qRT-PCR and WB analyses indicated that the protective effect of RUT is related to the upregulation of the SHH pathway and downregulation of the downstream of apoptosis to improve gastric cellular survival. Our data suggest that RUT induces a gastroprotective effect by upregulating the SHH signaling pathway and stimulating anti-apoptosis downstream.<\/jats:p>","DOI":"10.3390\/molecules28176294","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:59:05Z","timestamp":1693299545000},"page":"6294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Rutaecarpine Ameliorates Murine N-Methyl-N\u2019-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway"],"prefix":"10.3390","volume":"28","author":[{"given":"Yong","family":"He","sequence":"first","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Zhang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Tian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3308-0898","authenticated-orcid":false,"given":"Li-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Yi","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chinese PLA General Hospital, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4149\/neo_2009_01_63","article-title":"Expression of retinoblastoma and cyclin D1 in gastric carcinoma","volume":"56","author":"Arici","year":"2009","journal-title":"Neoplasma"},{"key":"ref_2","first-page":"765","article-title":"Stomach cancer","volume":"15","author":"Bailey","year":"2006","journal-title":"Clin. 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