{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:52:25Z","timestamp":1790589145357,"version":"4.1.0"},"reference-count":77,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Foundation","award":["22-77-10097"],"award-info":[{"award-number":["22-77-10097"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this article, the impact of an anthropogenically transformed environment on the content of pharmaceutically valuable biologically active compounds in medicinal plants is analyzed. The studied biologically active substances included phenolic compounds (flavonoids, anthocyanins, tannins, and phenolic acids). The number of transmissible forms of heavy metals (HMs), including cadmium, lead, and mercury, were discharged from factories that are present in the soil. Plants uptake these toxic metals from the soil. HM causes changes in the activity of the several enzymes such as phenylalanine ammonia lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI) and other enzymes. These enzymes play an important role in biosynthesis of phenolic compounds in medicinal plants. It has been demonstrated that plant materials possess high antioxidant potential due to their high phenolic content. As a result, the present review discusses a thorough investigation of anthropogenically transformed environment effects on the quantity of pharmaceutically valuable phenolic compounds in medicinal plants.<\/jats:p>","DOI":"10.3390\/molecules28176322","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:30:52Z","timestamp":1693391452000},"page":"6322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Phenolic Compounds of the Medicinal Plants in an Anthropogenically Transformed Environment"],"prefix":"10.3390","volume":"28","author":[{"given":"Natalya","family":"Vinogradova","sequence":"first","affiliation":[{"name":"Department of Management, Economics of Pharmacy, Pharmacognosy and Pharmaceutical Technology, Federal State Budgetary Educational Institution of Higher Professional Education, M. Gorky Donetsk State Medical University, 283003 Donetsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vinogradova","sequence":"additional","affiliation":[{"name":"Laboratory of Dendrology of the Federal State Budgetary Scientific Institution \u201cDonetsk Botanical Garden\u201d, 283001 Donetsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Chaplygin","sequence":"additional","affiliation":[{"name":"Academy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-2209","authenticated-orcid":false,"given":"Saglara","family":"Mandzhieva","sequence":"additional","affiliation":[{"name":"Academy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Botany, Banaras Hindu University, Varanasi 221005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-4805","authenticated-orcid":false,"given":"Vishnu D.","family":"Rajput","sequence":"additional","affiliation":[{"name":"Academy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-0883","authenticated-orcid":false,"given":"Tatiana","family":"Minkina","sequence":"additional","affiliation":[{"name":"Academy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-5109","authenticated-orcid":false,"given":"Chandra Shekhar","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Botany, University of Delhi, New Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0533-0418","authenticated-orcid":false,"given":"Marina","family":"Burachevskaya","sequence":"additional","affiliation":[{"name":"Academy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionise","family":"Lysenko","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Saint Petersburg State Chemical and Pharmaceutical University, 197022 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-1967","authenticated-orcid":false,"given":"Rupesh Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, 4704-553 Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref_1","first-page":"2167","article-title":"The expanding market for herbal, medicinal and aromatic plants in Nigeria and the international scene","volume":"144","author":"Mafimisebi","year":"2013","journal-title":"Med. 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