{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:48:03Z","timestamp":1791046083556,"version":"4.1.0"},"reference-count":106,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270989"],"award-info":[{"award-number":["82270989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800975"],"award-info":[{"award-number":["81800975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002886"],"award-info":[{"award-number":["82002886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dental caries is the most prevalent chronic disease globally, significantly impacting individuals\u2019 quality of life. A key reason behind the failure of implanted restorations is their biological inactivity, meaning they are unable to form crosslinks with the surrounding tooth structures, thus making patients susceptible to implant loss and recurrent tooth decay. For the treatment of caries, antibacterial medicine and remineralization are effective means of treating the recurrence of caries. Owing to the rapid progression in the biomaterials field, several biomaterials have been reported to display antimicrobial properties and aid in dentin remineralization. Bioactive materials hold considerable potential in diminishing biofilm accumulation, inhibiting the process of demineralization, enabling dentin remineralization, and combating bacteria related to caries. Bioactive materials, such as fluoride, amorphous calcium phosphate, bioactive glass, collagen, and resin-based materials, have demonstrated their effectiveness in promoting dentin remineralization and exerting antibacterial effects on dental caries. However, the concentration of fluoride needs to be strictly controlled. Although amorphous calcium phosphate can provide the necessary calcium and phosphorus ions for remineralization, it falls short in delivering the mechanical strength required for oral mastication. Resin-based materials also offer different advantages due to the complexity of their design. In this review, we delve into the application of advanced bioactive materials for enhancing dentin remineralization and antibacterial properties. We eagerly anticipate future developments in bioactive materials for the treatment of dental caries.<\/jats:p>","DOI":"10.3390\/molecules28176373","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:45:51Z","timestamp":1693482351000},"page":"6373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Engineered Biomaterials Trigger Remineralization and Antimicrobial Effects for Dental Caries Restoration"],"prefix":"10.3390","volume":"28","author":[{"given":"Yuexiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, China Medical University, Shenyang 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minda","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, China Medical University, Shenyang 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Xue","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, China Medical University, Shenyang 110002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Kang","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, China Medical University, Shenyang 110002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, China Medical University, Shenyang 110002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, China Medical University, Shenyang 110002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-9010","authenticated-orcid":false,"given":"Duoyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, China Medical University, Shenyang 110022, China"},{"name":"School and Hospital of Stomatology, China Medical University, Shenyang 110002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental Caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000345534","article-title":"Impact of early childhood caries on the oral health-related quality of life of preschool children and their parents","volume":"47","author":"Marques","year":"2013","journal-title":"Caries Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global Burden of Untreated Caries: A Systematic Review and Metaregression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J. 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