{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:52:53Z","timestamp":1791841973867,"version":"4.3.4"},"reference-count":66,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study aimed to investigate the phenolic and antioxidant properties of Egyptian Sonchus oleraceus leaves extract (SOE) while comparing the antihyperglycemic efficacy of SOE with that of conventional medicines (glibenclamide) in vivo as a substitution for insulin-deficient patients. Total phenolic (TPC) and flavonoid contents (TFC) in SOE contributed around 127.66 \u00b1 0.56 mg GAE\/gm as gallic acid equivalent (GAE) and 74.80 \u00b1 0.55 mg QE\/gm as quercetin equivalent (QE). SOE also showed significant DPPH scavenging activity at 43.46%. The presence of five phenolic and six flavonoid compounds in SOE was discovered by HPLC analysis. For the in vivo assay, 42 rats were distributed into six groups (7 Wister albino rats each). The standard control group was fed a basal diet. While the 35 rats were induced with a single dose of 100 mg kg\u22121 body weight (b.w.) alloxan, then treated orally with glibenclamide (GLI) at 10 mg kg\u22121, 100, 200, and 300 mg kg\u22121 SOE (positive control group) for 56 days of routine gastric oral gavages and compared to the effects of GLI, the treatment of SOE 200 and 300 mg kg\u22121 in diabetic rats for two months dramatically decreased blood glucose, total lipid, total cholesterol, and low-density lipoprotein cholesterol (LDLC) while boosting high-density lipoprotein cholesterol (HDLC) levels and improving liver and kidney functions. The histological assay revealed that the SOE 300 mg kg\u22121 treatment significantly improved the pancreas tissues, implying the potential application of Egyptian SOE as a diabetes treatment.<\/jats:p>","DOI":"10.3390\/molecules28176389","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:12:22Z","timestamp":1693559542000},"page":"6389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Phenolic Profiles, Antihyperglycemic, Anti-Diabetic, and Antioxidant Properties of Egyptian Sonchus oleraceus Leaves Extract: An In Vivo Study"],"prefix":"10.3390","volume":"28","author":[{"given":"Nesrein S.","family":"Salim","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Agriculture, Benha University, Moshtohor 13736, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdel-Alim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Agriculture, Benha University, Moshtohor 13736, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-2127","authenticated-orcid":false,"given":"Huda E. M.","family":"Said","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2672-1370","authenticated-orcid":false,"given":"Mohamed F.","family":"Foda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Agriculture, Benha University, Moshtohor 13736, Egypt"},{"name":"College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1007\/s001250100023","article-title":"An economic model of the long-term health care burden of Type II diabetes","volume":"44","author":"Bagust","year":"2001","journal-title":"Diabetologia"},{"key":"ref_2","first-page":"753","article-title":"Comparison of hypoglycemic effects of Azadirachta indica seeds and leaves on alloxan induced diabetes in male albino rats","volume":"12","author":"Saleem","year":"2018","journal-title":"Pak. 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