{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:52:08Z","timestamp":1789019528935,"version":"build-2803163510"},"reference-count":147,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ochratoxin A (OTA) is considered as the most toxic of the other ochratoxins synthesized by various fungal species belonging to the Aspergillus and Penicillium families. OTA commonly contaminates food and beverages, resulting in animal and human health issues. The toxicity of OTA is known to cause liver damage and is still being researched. However, current findings do not provide clear insights into the toxin mechanism of action. The current studies focusing on the use of potentially protective compounds against the effects of the toxin are insufficient as they are mainly conducted on animals. Further research is required to fill the existing gaps in both fields (namely the exact OTA molecular mechanism and the prevention of its toxicity in the human liver). This review article is a summary of the so far obtained results of studies focusing on the OTA hepatotoxicity, its mode of action, and the known approaches of liver cells protection, which may be the base for expanding other research in near future.<\/jats:p>","DOI":"10.3390\/molecules28186617","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:06:13Z","timestamp":1694750773000},"page":"6617","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Ochratoxin A\u2014The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention"],"prefix":"10.3390","volume":"28","author":[{"given":"Magdalena","family":"Wi\u0119ckowska","sequence":"first","affiliation":[{"name":"Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-2203","authenticated-orcid":false,"given":"Rafa\u0142","family":"Szelenberger","sequence":"additional","affiliation":[{"name":"Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Niemcewicz","sequence":"additional","affiliation":[{"name":"Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2318-6293","authenticated-orcid":false,"given":"Piotr","family":"Harmata","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Technologies and Chemistry, Military University of Technology, 2 gen. 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Kaliskiego St., 00-908 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2300-7339","authenticated-orcid":false,"given":"Tomasz","family":"Poplawski","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-4097","authenticated-orcid":false,"given":"Micha\u0142","family":"Bijak","sequence":"additional","affiliation":[{"name":"Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2005.10.106","article-title":"Toxicokinetics and toxicodynamics of ochratoxin A, an update","volume":"159","author":"Ringot","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/2051112a0","article-title":"Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh","volume":"205","author":"Steyn","year":"1965","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/19440049.2013.861933","article-title":"Ochratoxin A and citrinin production by Penicillium verrucosum on cereal solid substrates","volume":"31","author":"Wawrzyniak","year":"2014","journal-title":"Food Addit. Contam. Part A"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4141\/cjps74-003","article-title":"Some conditions favoring production of ochratoxin a and citrinin by penicillium viridicatum in wheat and barley","volume":"54","author":"Harwig","year":"1974","journal-title":"Can. J. Plant Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1590\/S1517-83822005000100005","article-title":"Growth of Aspergillus ochraceus, A. carbonarius and A. niger on culture media at different water activities and temperatures","volume":"36","author":"Taniwaki","year":"2005","journal-title":"Braz. J. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lwt.2018.12.032","article-title":"Influence of temperature and water activity on Ochratoxin A production by Aspergillus strain in coffee south of Minas Gerais\/Brazil","volume":"102","author":"Oliveira","year":"2019","journal-title":"LWT"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijfoodmicro.2011.03.005","article-title":"Effect of water activity, temperature and incubation time on growth and ochratoxin A production by Aspergillus niger and Aspergillus carbonarius on maize kernels","volume":"147","author":"Alborch","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/15569543.2018.1438472","article-title":"Occurrence of ochratoxin A in Algerian wheat and its milling derivatives","volume":"38","author":"Zebiri","year":"2019","journal-title":"Toxin Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/19393210.2017.1391335","article-title":"Aflatoxins and ochratoxin A in flour: A survey of the Serbian retail market","volume":"11","year":"2018","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kosicki, R., Twaru\u017cek, M., Dopiera\u0142a, P., Rudzki, B., and Grajewski, J. (2020). Occurrence of Mycotoxins in Winter Rye Varieties Cultivated in Poland (2017\u20132019). Toxins, 12.","DOI":"10.3390\/toxins12060423"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxicon.2020.05.008","article-title":"Unusual pattern of aflatoxins and ochratoxin in commercially grown maize varieties of Pakistan","volume":"182","author":"Sadef","year":"2020","journal-title":"Toxicon"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.foodchem.2016.04.104","article-title":"The presence of aflatoxins and ochratoxin A in rice and rice products; and evaluation of dietary intake","volume":"210","author":"Iqbal","year":"2016","journal-title":"Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.foodcont.2014.09.029","article-title":"Occurrence of aflatoxins and ochratoxin A in rice samples from six provinces in China","volume":"50","author":"Lai","year":"2015","journal-title":"Food Control"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/026520300420448","article-title":"Ochratoxin A in Brazilian roasted and instant coffees","volume":"17","author":"Leoni","year":"2000","journal-title":"Food Addit. Contam."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.foodcont.2014.05.014","article-title":"Occurrence of ochratoxin A in roasted and instant coffees in Chilean market","volume":"46","author":"Alvarado","year":"2014","journal-title":"Food Control"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.foodcont.2013.10.036","article-title":"Presence of mycotoxin in commercial infant formulas and baby foods from Italian market","volume":"39","author":"Juan","year":"2014","journal-title":"Food Control"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.foodcont.2015.10.018","article-title":"Investigation of ochratoxin A in Syrian consumed baby foods","volume":"62","author":"Darouj","year":"2016","journal-title":"Food Control"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.foodcont.2016.07.027","article-title":"Detection and quantitation of mycotoxins in infant cereals in the U.S. market by LC-MS\/MS using a stable isotope dilution assay","volume":"72","author":"Cappozzo","year":"2017","journal-title":"Food Control"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e12462","DOI":"10.1111\/jfs.12462","article-title":"Co-occurrence of aflatoxins and ochratoxin A in nuts, dry fruits, and nuty products","volume":"38","author":"Iqbal","year":"2018","journal-title":"J. Food Saf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110207","DOI":"10.1016\/j.foodres.2021.110207","article-title":"Ochratoxin A and related fungi in Brazilian black pepper (Piper nigrum L.)","volume":"142","author":"Silva","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.foodcont.2018.07.033","article-title":"Multimycotoxins occurrence in spices and herbs commercialized in Lebanon","volume":"95","author":"Gambacorta","year":"2019","journal-title":"Food Control"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40550-017-0063-9","article-title":"Ochratoxin A in black pepper, white pepper and clove sold in Yaound\u00e9 (Cameroon) markets: Contamination levels and consumers\u2019 practices increasing health risk","volume":"5","author":"Nguegwouo","year":"2018","journal-title":"Int. J. Food Contam."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.foodcont.2012.09.003","article-title":"Natural occurrence of aflatoxins and ochratoxin A in commercial chilli and chilli sauce samples","volume":"30","author":"Iqbal","year":"2013","journal-title":"Food Control"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"107621","DOI":"10.1016\/j.foodcont.2020.107621","article-title":"Assessment of aflatoxins and ochratoxin a in chili sauce samples and estimation of dietary intake","volume":"121","author":"Iqbal","year":"2021","journal-title":"Food Control"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.foodcont.2012.11.040","article-title":"Levels of ochratoxins in Mediterranean red wines","volume":"32","author":"Remiro","year":"2013","journal-title":"Food Control"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Silva, L.J.G., Teixeira, A.C., Pereira, A.M.P.T., Pena, A., and Lino, C.M. (2020). Ochratoxin A in Beers Marketed in Portugal: Occurrence and Human Risk Assessment. Toxins, 12.","DOI":"10.3390\/toxins12040249"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Fan, Z., Nie, D., Zhao, Z., and Han, Z. (2019). Analysis of the Carry-Over of Ochratoxin A from Feed to Milk, Blood, Urine, and Different Tissues of Dairy Cows Based on the Establishment of a Reliable LC-MS\/MS Method. Molecules, 24.","DOI":"10.3390\/molecules24152823"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/19393210.2015.1098735","article-title":"Ochratoxin A in artisan salami produced in Veneto (Italy)","volume":"9","author":"Armorini","year":"2016","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12550-018-0338-x","article-title":"Occurrence of ochratoxin A in typical salami produced in different regions of Italy","volume":"35","author":"Altafini","year":"2019","journal-title":"Mycotoxin Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3920\/WMJ2020.2568","article-title":"Ochratoxin A contamination of the casing and the edible portion of artisan salamis produced in two Italian regions","volume":"13","author":"Roncada","year":"2020","journal-title":"World Mycotoxin J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.foodcont.2014.02.046","article-title":"Natural incidence of aflatoxins, ochratoxin A and zearalenone in chicken meat and eggs","volume":"43","author":"Iqbal","year":"2014","journal-title":"Food Control"},{"key":"ref_32","first-page":"1626","article-title":"Determination of Aflatoxin M1 and Ochratoxin A in Raw, Pasteurized and UHT Milk in Turkey","volume":"47","author":"Turkoglu","year":"2019","journal-title":"Acta Sci. Vet."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Altafini, A., Roncada, P., Guerrini, A., Minkoumba Sonfack, G., Fedrizzi, G., and Caprai, E. (2021). Occurrence of Ochratoxin A in Different Types of Cheese Offered for Sale in Italy. Toxins, 13.","DOI":"10.3390\/toxins13080540"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/mnfr.201500220","article-title":"Biomonitoring using dried blood spots: Detection of ochratoxin A and its degradation product 2\u2019R-ochratoxin A in blood from coffee drinkers","volume":"59","author":"Cramer","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00394-010-0130-y","article-title":"The presence of ochratoxin A in cord serum and in human milk and its correspondence with maternal dietary habits","volume":"50","author":"Biasucci","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/toxins6020523","article-title":"Assessment of Multi-Mycotoxin Exposure in Southern Italy by Urinary Multi-Biomarker Determination","volume":"6","author":"Solfrizzo","year":"2014","journal-title":"Toxins"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.toxlet.2017.04.013","article-title":"Ochratoxin A and its metabolites in urines of German adults-An assessment of variables in biomarker analysis","volume":"275","author":"Ali","year":"2017","journal-title":"Toxicol. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12550-016-0261-y","article-title":"Evidence of ochratoxin A conjugates in urine samples from infants and adults","volume":"33","author":"Cramer","year":"2017","journal-title":"Mycotoxin Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3390\/toxins5111965","article-title":"Deleterious Effects of Mycotoxin Combinations Involving Ochratoxin A","volume":"5","author":"Peraica","year":"2013","journal-title":"Toxins"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12550-016-0265-7","article-title":"Mycotoxins as human carcinogens-the IARC Monographs classification","volume":"33","author":"Ostry","year":"2017","journal-title":"Mycotoxin Res."},{"key":"ref_41","unstructured":"EC (2023). Commission Regulation (EU) 2023\/915 of 25 April 2023 on maximum levels for certain contaminants in food and repealing Regulation (EC) No 1881\/2006. Off. J. Eur. Union, 119, 103\u2013157."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"K\u0151szegi, T., and Po\u00f3r, M. (2016). Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level. Toxins, 8.","DOI":"10.3390\/toxins8040111"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/toxins2040461","article-title":"Ochratoxin A: General Overview and Actual Molecular Status","volume":"2","author":"Atoui","year":"2010","journal-title":"Toxins"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1758-2946-1-20","article-title":"The PubChem chemical structure sketcher","volume":"1","author":"Ihlenfeldt","year":"2009","journal-title":"J. Cheminform."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/mpp.13013","article-title":"Functional roles of LaeA, polyketide synthase, and glucose oxidase in the regulation of ochratoxin A biosynthesis and virulence in Aspergillus carbonarius","volume":"22","author":"Maor","year":"2021","journal-title":"Mol. Plant Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1021\/acs.jafc.6b03907","article-title":"A Polyketide Synthase Encoded by the Gene An15g07920 Is Involved in the Biosynthesis of Ochratoxin A in Aspergillus niger","volume":"64","author":"Zhang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.fgb.2008.09.015","article-title":"Aspergillus westerdijkiae polyketide synthase gene \u201caoks1\u201d is involved in the biosynthesis of ochratoxin A","volume":"46","author":"Bacha","year":"2009","journal-title":"Fungal Genet. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1023\/B:EJPP.0000032405.21833.89","article-title":"Analysis of Differentially-Expressed Ochratoxin A Biosynthesis Genes of Penicillium Nordicum","volume":"110","author":"Geisen","year":"2004","journal-title":"Eur. J. Plant Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijfoodmicro.2014.03.007","article-title":"The influence of salt (NaCl) on ochratoxin A biosynthetic genes, growth and ochratoxin A production by three strains of Penicillium nordicum on a dry-cured ham-based medium","volume":"178","author":"Medina","year":"2014","journal-title":"Int. J. Food Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ferrara, M., Gallo, A., Cervini, C., Gambacorta, L., Solfrizzo, M., Baker, S.E., and Perrone, G. (2021). Evidence of the Involvement of a Cyclase Gene in the Biosynthesis of Ochratoxin A in Aspergillus carbonarius. Toxins, 13.","DOI":"10.3390\/toxins13120892"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1007\/s00253-023-12404-8","article-title":"AnAzf1 acts as a positive regulator of ochratoxin A biosynthesis in Aspergillus niger","volume":"107","author":"Wei","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gerin, D., Garrapa, F., Ballester, A.-R., Gonz\u00e1lez-Candelas, L., De Miccolis Angelini, R.M., Faretra, F., and Pollastro, S. (2021). Functional Role of Aspergillus carbonarius AcOTAbZIP Gene, a bZIP Transcription Factor within the OTA Gene Cluster. Toxins, 13.","DOI":"10.3390\/toxins13020111"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.1128\/AEM.02508-12","article-title":"New insight into the ochratoxin A biosynthetic pathway through deletion of a nonribosomal peptide synthetase gene in Aspergillus carbonarius","volume":"78","author":"Gallo","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijfoodmicro.2013.07.027","article-title":"VeA and LaeA transcriptional factors regulate ochratoxin A biosynthesis in Aspergillus carbonarius","volume":"166","author":"Sanchis","year":"2013","journal-title":"Int. J. Food Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13199","DOI":"10.1021\/acs.jafc.8b04523","article-title":"veA Gene Acts as a Positive Regulator of Conidia Production, Ochratoxin A Biosynthesis, and Oxidative Stress Tolerance in Aspergillus niger","volume":"66","author":"Zhang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jat.2550090204","article-title":"Toxicokinetics of ochratoxin A in several species and its plasma-binding properties","volume":"9","author":"Hagelberg","year":"1989","journal-title":"J. Appl. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s002040000157","article-title":"Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans","volume":"74","author":"Schlatter","year":"2000","journal-title":"Arch. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00297109","article-title":"Distribution of the [3H]-label from low doses of radioactive ochratoxin A ingested by rats, and evidence for DNA single-strand breaks caused in liver and kidneys","volume":"58","author":"Kane","year":"1986","journal-title":"Arch. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0378-4347(94)00569-Q","article-title":"Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: Methodology and Swiss data","volume":"666","author":"Zimmerli","year":"1995","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0024-3205(01)01296-6","article-title":"Characterization of ochratoxin A transport by human organic anion transporters","volume":"69","author":"Jung","year":"2001","journal-title":"Life Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0300-483X(97)03625-1","article-title":"Renal transepithelial secretion of ochratoxin A in the non-filtering toad kidney","volume":"120","author":"Bahnemann","year":"1997","journal-title":"Toxicology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1046\/j.1523-1755.2000.00007.x","article-title":"ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2","volume":"57","author":"Leier","year":"2000","journal-title":"Kidney Int."},{"key":"ref_63","first-page":"1507","article-title":"Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide","volume":"279","author":"Kontaxi","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"115072","DOI":"10.1016\/j.taap.2020.115072","article-title":"Human organic anion transporting polypeptide (OATP) 1B3 and mouse OATP1A\/1B affect liver accumulation of Ochratoxin A in mice","volume":"401","author":"Wang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1128\/aem.42.6.1051-1056.1981","article-title":"Formation of (4R)- and (4S)-4-hydroxyochratoxin A from ochratoxin A by liver microsomes from various species","volume":"42","author":"Hansen","year":"1981","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1128\/aem.45.4.1183-1187.1983","article-title":"Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes","volume":"45","author":"Hansen","year":"1983","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-2952(95)02194-9","article-title":"Effect of cytochrome P450 induction on the metabolism and toxicity of ochratoxin A","volume":"51","author":"Omar","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2520\/myco1975.1985.22_28","article-title":"Biotransformation of Mycotoxins in the Reconstituted Cytochrome P-450 System","volume":"1985","author":"Ueno","year":"1985","journal-title":"Mycotoxins"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1021\/jf0111817","article-title":"Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes","volume":"50","author":"Weymann","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1007\/s00216-015-8570-0","article-title":"In vitro and in vivo metabolism of ochratoxin A: A comparative study using ultra-performance liquid chromatography-quadrupole\/time-of-flight hybrid mass spectrometry","volume":"407","author":"Yang","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_71","unstructured":"Gupta, R.C. (2012). Veterinary Toxicology, Academic Press. [2nd ed.]."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/mnfr.200600137","article-title":"Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans","volume":"51","author":"Manderville","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.fct.2015.06.009","article-title":"Hepatotoxic effect of ochratoxin A and citrinin, alone and in combination, and protective effect of vitamin E: In vitro study in HepG2 cell","volume":"83","author":"Gayathri","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Shin, H.S., Lee, H.J., Pyo, M.C., Ryu, D., and Lee, K.-W. (2019). Ochratoxin A-Induced Hepatotoxicity through Phase I and Phase II Reactions Regulated by AhR in Liver Cells. Toxins, 11.","DOI":"10.3390\/toxins11070377"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1038\/srep05163","article-title":"Ochratoxin A induced early hepatotoxicity: New mechanistic insights from microRNA, mRNA and proteomic profiling studies","volume":"4","author":"Qi","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: A worldwide hub of protein knowledge","volume":"47","author":"Consortium","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s40168-019-0761-z","article-title":"Ochratoxin A induces liver inflammation: Involvement of intestinal microbiota","volume":"7","author":"Wang","year":"2019","journal-title":"Microbiome"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/dmrr.863","article-title":"Regulation of hepatic glucose production and the role of gluconeogenesis in humans: Is the rate of gluconeogenesis constant?","volume":"24","author":"Nuttall","year":"2008","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/MCB.20.17.6508-6517.2000","article-title":"Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism","volume":"20","author":"She","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0003-9861(81)90133-8","article-title":"Ochratoxin A, an in vivo inhibitor of renal phosphoenolpyruvate carboxykinase","volume":"208","author":"Meisner","year":"1981","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1021\/jp012314u","article-title":"Interaction of Ochratoxin A with Human Serum Albumin. Preferential Binding of the Dianion and pH Effects","volume":"106","author":"Perry","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0009-2797(02)00078-9","article-title":"Interaction of ochratoxin A with human serum albumin. Binding sites localized by competitive interactions with the native protein and its recombinant fragments","volume":"141","author":"Perry","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"ref_83","first-page":"319","article-title":"Ochratoxin a lowers mRNA levels of genes encoding for key proteins of liver cell metabolism","volume":"5","author":"Hundhausen","year":"2008","journal-title":"Cancer Genom. Proteom."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPAR\u03b3 signaling and metabolism: The good, the bad and the future","volume":"19","author":"Ahmadian","year":"2013","journal-title":"Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wang, Y., Nakajima, T., Gonzalez, F.J., and Tanaka, N. (2020). PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062061"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"166097","DOI":"10.1016\/j.bbadis.2021.166097","article-title":"PPARs in liver physiology","volume":"1867","author":"Berthier","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.livres.2018.12.001","article-title":"Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2","volume":"2","author":"Lee","year":"2018","journal-title":"Liver Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zheng, Q.W., Ding, X.F., Cao, H.J., Ni, Q.Z., Zhu, B., Ma, N., Zhang, F.K., Wang, Y.K., Xu, S., and Chen, T.W. (2021). Ochratoxin A Induces Steatosis via PPAR\u03b3-CD36 Axis. Toxins, 13.","DOI":"10.3390\/toxins13110802"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: Customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1016\/j.psj.2020.05.058","article-title":"Transcriptomic alterations induced by aflatoxin B1 and ochratoxin A in LMH cell line","volume":"99","author":"Choi","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0006-2952(90)90382-U","article-title":"Mechanism of ochratoxin a stimulated lipid peroxidation","volume":"40","author":"Omar","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1872-0854(06)01004-6","article-title":"Chapter 4 Genotoxicity of Chlorophenols and Ochratoxin A","volume":"1","author":"Manderville","year":"2006","journal-title":"Adv. Mol. Toxicol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0167-4889(97)00026-8","article-title":"Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs","volume":"1357","author":"Hoehler","year":"1997","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"ref_94","first-page":"281","article-title":"Significance of apoptosis and its relationship to antioxidants after ochratoxin A administration in mice","volume":"3","author":"Atroshi","year":"2000","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1079\/BJN20051425","article-title":"Cyanidin-3-O-\u03b2-glucopyranoside, a natural free-radical scavenger against aflatoxin B1- and ochratoxin A-induced cell damage in a human hepatoma cell line (Hep G2) and a human colonic adenocarcinoma cell line (CaCo-2)","volume":"94","author":"Guerra","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_96","first-page":"311","article-title":"The effect of ochratoxin A on the concentration of protein carbonyls in rats","volume":"56","author":"Domijan","year":"2005","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/toxsci\/kfj017","article-title":"A toxicogenomics approach to identify new plausible epigenetic mechanisms of ochratoxin a carcinogenicity in rat","volume":"89","author":"Nestler","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/toxsci\/kfl169","article-title":"Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity","volume":"96","author":"Cavin","year":"2007","journal-title":"Toxicol. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Xu, J., Zhang, X., Wang, J., Xie, H., Sun, Y., Zhang, Q., Chang, Z., and Liu, Y. (2022). Protective Effect of SeMet on Liver Injury Induced by Ochratoxin A in Rabbits. Toxins, 14.","DOI":"10.3390\/toxins14090628"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_103","first-page":"e7149","article-title":"N-acetyl Cysteine Use in the Treatment of Shock Liver","volume":"12","author":"Parvataneni","year":"2020","journal-title":"Cureus"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12550-019-00360-0","article-title":"Identification of ochratoxin-N-acetyl-L-cysteine as a new ochratoxin A metabolite and potential biomarker in human urine","volume":"36","author":"Sueck","year":"2020","journal-title":"Mycotoxin Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.fct.2014.04.039","article-title":"Protective effect of N-acetylcysteine against DNA damage and S-phase arrest induced by ochratoxin A in human embryonic kidney cells (HEK-293)","volume":"70","author":"Yang","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1021\/tx200430f","article-title":"An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity","volume":"25","author":"Manderville","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/bs.coac.2021.06.002","article-title":"Chapter Seven\u2014Progress in the applications of surface plasmon resonance for food safety","volume":"Volume 95","author":"Chen","year":"2021","journal-title":"Comprehensive Analytical Chemistry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1021\/tx950172n","article-title":"Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats","volume":"9","author":"Waidyanatha","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1021\/tx600359d","article-title":"Nucleobase-dependent reactivity of a quinone metabolite of pentachlorophenol","volume":"20","author":"Vaidyanathan","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1021\/tx700201z","article-title":"Phenol-induced in vivo oxidative stress in skin: Evidence for enhanced free radical generation, thiol oxidation, and antioxidant depletion","volume":"20","author":"Murray","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1021\/tx0255929","article-title":"Detection and characterization of a glutathione conjugate of ochratoxin A","volume":"15","author":"Dai","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1021\/tx9901074","article-title":"Oxidation of ochratoxin A by an Fe-porphyrin system: Model for enzymatic activation and DNA cleavage","volume":"12","author":"Gillman","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/mnfr.200500124","article-title":"Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats","volume":"49","author":"Kamp","year":"2005","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10565-009-9131-0","article-title":"Characterization of ochratoxin A-induced apoptosis in primary rat hepatocytes","volume":"26","author":"Chopra","year":"2010","journal-title":"Cell Biol. Toxicol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tox.2008.08.020","article-title":"Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells","volume":"254","author":"Bouaziz","year":"2008","journal-title":"Toxicology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/mnfr.200800110","article-title":"Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells","volume":"53","author":"Essid","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"Fso63","DOI":"10.4155\/fso.15.63","article-title":"Animal models are essential to biological research: Issues and perspectives","volume":"1","author":"Montagutelli","year":"2015","journal-title":"Future Sci. OA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1136\/bmj.328.7438.514","article-title":"Where is the evidence that animal research benefits humans?","volume":"328","author":"Pound","year":"2004","journal-title":"BMJ"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3382\/ps.0751508","article-title":"Influence of vitamins E and C on the toxic effects of ochratoxin A and T-2 toxin in chicks","volume":"75","author":"Hoehler","year":"1996","journal-title":"Poult. Sci."},{"key":"ref_120","unstructured":"Shalaby, A.M.E. (2004, January 12\u201316). The opposing effect of ascorbic acid (vitamin C) on ochratoxin toxicity in nile tilapia (Oreochromis niloticus). Proceedings of the 6th International Symposium on Tilapia in Aquaculture, Manila, Philippines."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Badriyah, B., and Hastuti, U.S. (2016, January 15). The effect of pomelo citrus (Citrus maxima var. Nambangan), vitamin C and lycopene towards the number reduction of mice (Mus musculus) apoptotic hepatocyte caused of ochratoxin A. Proceedings of the AIP Conference Proceedings, Surabaya, Indonesia.","DOI":"10.1063\/1.4985397"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bbagen.2013.10.024","article-title":"Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells\u2014Up regulation of Nrf2 expression and down regulation of NF-\u03baB and COX-2","volume":"1840","author":"Ramyaa","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1080\/09540105.2017.1313819","article-title":"Honey and quercetin reduce ochratoxin A-induced DNA damage in the liver and the kidney through the modulation of intestinal microflora","volume":"28","year":"2017","journal-title":"Food Agric. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/10915810601122893","article-title":"Protective role of melatonin and coenzyme Q10 in ochratoxin A toxicity in rat liver and kidney","volume":"26","author":"Sutken","year":"2007","journal-title":"Int. J. Toxicol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/B:CBTO.0000038459.98032.34","article-title":"The effects of ochratoxin A on lipid peroxidation and antioxidant enzymes: A protective role of melatonin","volume":"20","year":"2004","journal-title":"Cell Biol. Toxicol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1532-0456(01)00248-4","article-title":"Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney","volume":"130","author":"Meki","year":"2001","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-079X.2004.00184.x","article-title":"Melatonin counteracts oxidative stress in rats fed an ochratoxin A contaminated diet","volume":"38","year":"2005","journal-title":"J. Pineal Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"125239","DOI":"10.1016\/j.jhazmat.2021.125239","article-title":"Melatonin alleviates Ochratoxin A-induced liver inflammation involved intestinal microbiota homeostasis and microbiota-independent manner","volume":"413","author":"Xia","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.taap.2013.01.021","article-title":"Zinc protects HepG2 cells against the oxidative damage and DNA damage induced by ochratoxin A","volume":"268","author":"Zheng","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2478\/v10001-010-0009-4","article-title":"Ameliorative effect of Emblica officinalis aqueous extract on ochratoxin-induced lipid peroxidation in the kidney and liver of mice","volume":"23","author":"Chakraborty","year":"2010","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1570-0232(04)00720-2","article-title":"Hippophae rhamnoides L.: Chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects","volume":"812","author":"Guliyev","year":"2004","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"ref_132","first-page":"98","article-title":"Protective Effect of Sea buckthorn (Hippophae rhamnoides L.) Leaves on Ochratoxin-A Induced Hepatic Injury in Japanese Quail","volume":"3","author":"Patial","year":"2015","journal-title":"Vet. Res. Int."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2221-1691(13)60075-1","article-title":"A review on therapeutic potential of Nigella sativa: A miracle herb","volume":"3","author":"Ahmad","year":"2013","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_134","first-page":"59","article-title":"Protective Role of Nigella Sativa Oil on Ochratoxin A Toxicity in Liver and Kidney of Male Albino Rats: Histological and Histochemical Studies","volume":"21","author":"Alhussaini","year":"2014","journal-title":"Wulfenia"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Damiano, S., Longobardi, C., Andretta, E., Prisco, F., Piegari, G., Squillacioti, C., Montagnaro, S., Pagnini, F., Badino, P., and Florio, S. (2021). Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats. Antioxidants, 10.","DOI":"10.3390\/antiox10010125"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Longobardi, C., Damiano, S., Andretta, E., Prisco, F., Russo, V., Pagnini, F., Florio, S., and Ciarcia, R. (2021). Curcumin Modulates Nitrosative Stress, Inflammation, and DNA Damage and Protects against Ochratoxin A-Induced Hepatotoxicity and Nephrotoxicity in Rats. Antioxidants, 10.","DOI":"10.3390\/antiox10081239"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/toxins4050353","article-title":"Dimethylarginine Dimethylaminohydrolase\/Nitric Oxide Synthase Pathway in Liver and Kidney: Protective Effect of Cyanidin 3-O-\u03b2-D-Glucoside on Ochratoxin-A Toxicity","volume":"4","author":"Sorrenti","year":"2012","journal-title":"Toxins"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.toxrep.2019.11.015","article-title":"Protective effect of Yemeni green coffee powder against the oxidative stress induced by Ochratoxin A","volume":"7","author":"Nogaim","year":"2020","journal-title":"Toxicol. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1007\/s13204-021-02006-z","article-title":"Synthesis, characterization and protective effect of green tea-mediated zinc oxide nanoparticles against ochratoxin A induced hepatotoxicity and nephrotoxicity in albino rats","volume":"11","author":"Hassan","year":"2021","journal-title":"Appl. Nanosci."},{"key":"ref_140","first-page":"135","article-title":"Lycopene restores trace element levels in ochratoxin A-treated rats","volume":"68","author":"Palabiyik","year":"2017","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.toxicon.2013.07.004","article-title":"The carotenoid lycopene protects rats against DNA damage induced by Ochratoxin A","volume":"73","author":"Aydin","year":"2013","journal-title":"Toxicon"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/ptr.6171","article-title":"Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases","volume":"32","author":"Abenavoli","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_143","first-page":"1","article-title":"The Protective Effect of Silymarin against Ochratoxin A Induced Histopathological and Biochemical Changes in Chicks","volume":"11","author":"Stoev","year":"2021","journal-title":"J. Adv. Vet. Res."},{"key":"ref_144","first-page":"2551","article-title":"Protective effects of compound ammonium glycyrrhizin, L-arginine, silymarin and glucurolactone against liver damage induced by ochratoxin A in primary chicken hepatocytes","volume":"18","author":"Yu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3390\/toxins4111139","article-title":"Apoptosis Induction by OTA and TNF-\u03b1 in Cultured Primary Rat Hepatocytes and Prevention by Silibinin","volume":"4","author":"Essid","year":"2012","journal-title":"Toxins"},{"key":"ref_146","first-page":"382","article-title":"Comparison of drug binding sites on rat and human serum albumins using immobilized-protein stationary phases as a tool for the selection of suitable animal models in pharmacological studies","volume":"135","author":"Massolini","year":"1996","journal-title":"Boll. Chim. Farm."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s41232-022-00248-0","article-title":"State-of-the-art liver disease research using liver-on-a-chip","volume":"42","author":"Deguchi","year":"2022","journal-title":"Inflamm. Regen."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/18\/6617\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:50:51Z","timestamp":1760129451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/18\/6617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":147,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["molecules28186617"],"URL":"https:\/\/doi.org\/10.3390\/molecules28186617","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]}}}