{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:30:02Z","timestamp":1760149802741,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Key Research and Development Plan of Hainan Province","award":["ZDYF2022SHFZ285","220CXTD436"],"award-info":[{"award-number":["ZDYF2022SHFZ285","220CXTD436"]}]},{"name":"the Innovative Research Team Project of the Hainan Natural Science Foundation","award":["ZDYF2022SHFZ285","220CXTD436"],"award-info":[{"award-number":["ZDYF2022SHFZ285","220CXTD436"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Tumor hypoxia, which is mainly caused by the inefficient microvascular systems induced by rapid tumor growth, is a common characteristic of most solid tumors and has been found to hinder treatment outcomes for many types of cancer therapeutics. In this study, an amphiphilic block copolymer, poly (ethylene glycol) methyl ether acrylate-block-n-butyl acrylate (PEGA-BA), was prepared via the ATRP method and self-assembled into core-shell micelles as nano radiosensitizers. These micelles encapsulated a photosensitizer, Chlorin e6 (Ce6), and demonstrated well-defined morphology, a uniform size distribution, and high oxygen loading capacity. Cell experiments showed that PEGA-BA@Ce6@PFCE micelles could effectively enter cells. Further in vitro anticancer studies demonstrated that the PEGA-BA@Ce6@PFCE micelles significantly suppressed the tumor cell survival rate when exposed to a laser.<\/jats:p>","DOI":"10.3390\/molecules28186697","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T01:32:50Z","timestamp":1695173570000},"page":"6697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PEGA-BA@Ce6@PFCE Micelles as Oxygen Nanoshuttles for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-0898","authenticated-orcid":false,"given":"Junan","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyue","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-7801","authenticated-orcid":false,"given":"Yongjie","family":"Mo","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6401-9060","authenticated-orcid":false,"given":"Chunyan","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Haikou 571158, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Functional Organic Polymers of Haikou, Haikou 571158, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41590-020-00860-7","article-title":"Tumor hypoxia represses gammadelta T cell-mediated antitumor immunity against brain tumors","volume":"22","author":"Park","year":"2021","journal-title":"Nat. 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