{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:47:39Z","timestamp":1791341259166,"version":"4.3.1"},"reference-count":117,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease transmission is related to the poor sanitation and hygiene habits that affect residents of impoverished regions in tropical and subtropical countries. The main species responsible for causing disease in humans are Schistosoma Mansoni, S. japonicum, and S. haematobium, each with different geographic distributions. Praziquantel is the drug predominantly used to treat this disease, which offers low effectiveness against immature and juvenile parasite forms. In addition, reports of drug resistance prompt the development of novel therapeutic approaches. Natural products represent an important source of new compounds, especially those obtained from plant sources. This review compiles data from several in vitro and in vivo studies evaluating various compounds and essential oils derived from plants with cercaricidal and molluscicidal activities against both juvenile and adult forms of the parasite. Finally, this review provides an important discussion on recent advances in molecular and computational tools deemed fundamental for more rapid and effective screening of new compounds, allowing for the optimization of time and resources.<\/jats:p>","DOI":"10.3390\/molecules28196807","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:58:17Z","timestamp":1695718697000},"page":"6807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis"],"prefix":"10.3390","volume":"28","author":[{"given":"Carine Machado","family":"Azevedo","sequence":"first","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ\/BA), Salvador 40296-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssio Santana","family":"Meira","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ\/BA), Salvador 40296-710, Brazil"},{"name":"SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI\/CIMATEC, Salvador 41650-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Wang","family":"da Silva","sequence":"additional","affiliation":[{"name":"SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI\/CIMATEC, Salvador 41650-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Maria Nascimento","family":"Moura","sequence":"additional","affiliation":[{"name":"Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (IAM-FIOCRUZ\/PE), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheilla Andrade","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (IAM-FIOCRUZ\/PE), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00edcero J\u00e1dson","family":"da Costa","sequence":"additional","affiliation":[{"name":"Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (IAM-FIOCRUZ\/PE), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuelle de Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI\/CIMATEC, Salvador 41650-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Botelho Pereira","family":"Soares","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ\/BA), Salvador 40296-710, Brazil"},{"name":"SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI\/CIMATEC, Salvador 41650-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1016\/S1473-3099(22)00221-3","article-title":"Review of 2022 WHO guidelines on the control and elimination of schistosomiasis","volume":"22","author":"Lo","year":"2022","journal-title":"Lancet Infect Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00281-020-00789-x","article-title":"Schistosomiasis\u2014From immunopathology to vacines","volume":"42","author":"McManus","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-030-18616-6_3","article-title":"Schistosomiasis","volume":"1154","author":"LoVerde","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3748\/wjg.v6.i1.12","article-title":"Schistosomiasis: Progress and problems","volume":"6","author":"Wu","year":"2000","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S0031182003003263","article-title":"Age-dependent survival and infectivity of Schistosoma mansoni cercariae","volume":"127","author":"Whitfield","year":"2003","journal-title":"Parasitology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3390\/molecules20021872","article-title":"Natural products as leads in schistosome drug discovery","volume":"20","author":"Neves","year":"2015","journal-title":"Molecules"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.actatropica.2017.08.002","article-title":"Schistosomiasis: Drugs used and treatment strategies","volume":"176","author":"Siqueira","year":"2017","journal-title":"Acta Trop."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1056\/NEJMra012396","article-title":"Schistosomiasis","volume":"346","author":"Ross","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1002\/anie.201208390","article-title":"Schistosomiasis chemotherapy","volume":"52","author":"Boissier","year":"2013","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_13","unstructured":"(2023, January 15). World Health Organization. Available online: http:\/\/www.who.int\/schistosomiasis\/strategy\/en\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.actatropica.2017.06.025","article-title":"Nanotechnology as a potential therapeutic alternative for schistosomiasis","volume":"174","author":"Machado","year":"2017","journal-title":"Acta Trop."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0169-4758(98)01323-4","article-title":"Chemotherapy of Schistosomiasis: An Update","volume":"14","author":"Cioli","year":"1998","journal-title":"Parasitol. Today"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4155\/fmc.15.27","article-title":"Schistosomiasis and its treatment","volume":"7","author":"Caffrey","year":"2015","journal-title":"Future Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1002\/cmdc.201800572","article-title":"Chemotherapy for Fighting Schistosomiasis: Past, Present and Future","volume":"13","author":"Rennar","year":"2018","journal-title":"Chem. Med. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e0034820","DOI":"10.1128\/CMR.00348-20","article-title":"Natural-Product-Based Solutions for Tropical Infectious Diseases","volume":"34","author":"Adegboye","year":"2021","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.4103\/njcp.njcp_1322_21","article-title":"Plant-Derived Compounds for the Treatment of Schistosomiasis: Improving Efficacy Via Nano-Drug Delivery","volume":"25","author":"Eze","year":"2022","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_20","first-page":"420","article-title":"Natural products as reservoirs of novel therapeutic agents","volume":"17","author":"Mushtaq","year":"2018","journal-title":"EXCLI J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"173614","DOI":"10.1155\/2012\/173614","article-title":"In vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds","volume":"2012","author":"Cunha","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.exppara.2012.07.004","article-title":"Schistosoma Mansoni: In vitro Schistosomicidal Activity and Tegumental Alterations Induced by Piplartine on Schistosomula","volume":"132","author":"Moraes","year":"2012","journal-title":"Exp. Parasitol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/ps.5631","article-title":"Molluscicidal and Cercaricidal Activities of Curcumin on Biomphalaria glabrata and Schistosoma mansoni Cercariae","volume":"76","author":"Matos","year":"2020","journal-title":"Pest. Manag. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/ptr.6643","article-title":"Anti-Schistosoma mansoni effects of essential oils and their components","volume":"34","author":"Islam","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.3390\/molecules19033793","article-title":"Antischistosomal Activity of the Terpene Nerolidol","volume":"19","author":"Silva","year":"2014","journal-title":"Molecules"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1055\/s-0032-1327832","article-title":"In vitro Schistosomicidal Activity of Balsaminol F and Karavilagenin, C","volume":"78","author":"Ramalhete","year":"2012","journal-title":"Planta Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11274-017-2228-3","article-title":"Bioactive Compounds of Aspergillus Terreus\u2014F7, an Endophytic Fungus from Hyptis suaveolens (L.) Poit","volume":"33","author":"Silva","year":"2017","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/cbdv.201000163","article-title":"Evaluation of the in vitro Activity of Dermaseptin 01, a Cationic Antimicrobial Peptide, against Schistosoma mansoni","volume":"8","author":"Moraes","year":"2011","journal-title":"Chem. Biodivers."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1055\/s-0032-1328173","article-title":"Anthelmintic Activity of the Natural Compound (+)-Limonene Epoxide against Schistosoma mansoni","volume":"79","author":"Moraes","year":"2013","journal-title":"Planta Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S0022149X13000205","article-title":"In vitro Schistosomicidal Effects of Aqueous and Dichloromethane Fractions from Leaves and Stems of Piper species and the Isolation of an Active Amide from P. Amalago L. (Piperaceae)","volume":"88","author":"Carrara","year":"2014","journal-title":"J. Helminthol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00436-013-3743-2","article-title":"A Penta-Substituted Pyridine Alkaloid from the Rhizome of Jatropha elliptica (Pohl) Muell. Arg. Is Active against Schistosoma mansoni and Biomphalaria glabrata","volume":"113","author":"Santos","year":"2014","journal-title":"Parasitol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.exppara.2015.09.015","article-title":"Schistosomicidal Activity and Docking of Schistosoma mansoni ATPDase 1 with Licoflavone B Isolated from Glycyrrhiza inflata (Fabaceae)","volume":"159","author":"Geraldo","year":"2015","journal-title":"Exp. Parasitol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8821","DOI":"10.1021\/acs.jafc.6b04200","article-title":"Schistosomicidal Activity of Alkyl-Phenols from the Cashew Anacardium occidentale against Schistosoma mansoni Adult Worms","volume":"64","author":"Alvarenga","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3347\/kjp.2016.54.4.477","article-title":"In vitro Schistosomicidal Activity of Phytol and Tegumental Alterations Induced in Juvenile and Adult Stages of Schistosoma haematobium","volume":"54","author":"Eraky","year":"2016","journal-title":"Korean J. Parasitol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1800398","DOI":"10.1002\/cbdv.201800398","article-title":"In vitro and in vivo Antischistosomal Activities of Chalcones","volume":"15","author":"Pereira","year":"2018","journal-title":"Chem. Biodivers."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1800305","DOI":"10.1002\/cbdv.201800305","article-title":"Evaluation of Lignans from Piper Cubeba against Schistosoma mansoni Adult Worms: A Combined Experimental and Theoretical Study","volume":"16","author":"Parreira","year":"2019","journal-title":"Chem. Biodivers."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Dube, M., Saoud, M., Rennert, R., Fotso, G.W., Andrae-Marobela, K., Imming, P., H\u00e4berli, C., Keiser, J., and Arnold, N. (2021). Anthelmintic Activity and Cytotoxic Effects of Compounds Isolated from the Fruits of Ozoroa insignis Del. (Anacardiaceae). Biomolecules, 11.","DOI":"10.3390\/biom11121893"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sirak, B., Asres, K., Hailu, A., Dube, M., Arnold, N., H\u00e4berli, C., Keiser, J., and Imming, P. (2021). In vitro Antileishmanial and Antischistosomal Activities of Anemonin Isolated from the Fresh Leaves of Ranunculus multifidus Forsk. Molecules, 26.","DOI":"10.3390\/molecules26247473"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"627837","DOI":"10.3389\/fphys.2021.627837","article-title":"Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression through Oxidative Stress","volume":"12","author":"Tirichen","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.04.001","article-title":"Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling","volume":"100","author":"Brand","year":"2016","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_42","first-page":"7955","article-title":"Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria","volume":"115","year":"2018","journal-title":"Biophys. Comput. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1017\/S0022149X13000278","article-title":"In vitro and in vivo Effects of Hesperidin Treatment on Adult Worms of Schistosoma mansoni","volume":"88","author":"Allam","year":"2014","journal-title":"J. Helminthol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Moraes, J., de Oliveira, R.N., Costa, J.P., Junior, A.L.G., de Sousa, D.P., Freitas, R.M., Allegretti, S.M., and Pinto, P.L.S. (2014). Phytol, a Diterpene Alcohol from Chlorophyll, as a Drug against Neglected Tropical Disease Schistosomiasis Mansoni. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002617"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ja.2015.54","article-title":"Inhibitory Activities of the Marine Streptomycete-Derived Compound SF2446A2 against Chlamydia Trachomatis and Schistosoma mansoni","volume":"68","author":"Reimer","year":"2015","journal-title":"J. Antibiot."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbi.2015.12.003","article-title":"Structural Parameters, Molecular Properties, and Biological Evaluation of Some Terpenes Targeting Schistosoma mansoni Parasite","volume":"244","author":"Mafud","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Martins, M.C.B., Silva, M.C., Silva, H.A.M.F., Silva, L.R.S., De Azevedo Albuquerque, M.C.P., Aires, A.L., Da Silva Falc\u00e3o, E.P., Pereira, E.C., De Melo, A.M.M.A., and De Silva, N.H. (2017). Barbatic Acid Offers a New Possibility for Control of Biomphalaria glabrata and Schistosomiasis. Molecules, 22.","DOI":"10.3390\/molecules22040568"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopha.2017.09.128","article-title":"Licochalcone A Induces Morphological and Biochemical Alterations in Schistosoma mansoni Adult Worms","volume":"96","author":"Souza","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4155\/fmc-2017-0112","article-title":"Antischistosomal Agents: State of art and perspectives","volume":"10","author":"Lago","year":"2018","journal-title":"Future Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.imbio.2008.11.017","article-title":"Immunomodulatory Effects of Curcumin Treatment on Murine Schistosomiasis Mansoni","volume":"214","author":"Allam","year":"2009","journal-title":"Immunobiology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10787-011-0092-6","article-title":"Prevention and Treatment of Schistosoma mansoni-Induced Liver Fibrosis in Mice","volume":"19","author":"Shebl","year":"2011","journal-title":"Inflammopharmacology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1016\/j.bmc.2014.07.014","article-title":"Synthesis and Activity of New Triphenylphosphonium Derivatives of Betulin and Betulinic Acid against Schistosoma mansoni in vitro and in vivo","volume":"22","author":"Spivak","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Guimar\u00e3es, M.A., de Oliveira, R.N., V\u00e9ras, L.M.C., Lima, D.F., Campelo, Y.D.M., Campos, S.A., Kuckelhaus, S.A.S., Pinto, P.L.S., Eaton, P., and Mafud, A.C. (2015). Anthelmintic Activity In vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003656"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ijantimicag.2017.06.005","article-title":"Antiparasitic Activity of Nerolidol in a Mouse Model of Schistosomiasis","volume":"50","author":"Silva","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exppara.2017.10.005","article-title":"Paeoniflorin Targets Apoptosis and Ameliorates Fibrosis in Murine Schistosomiasis Mansoni: A Novel Insight","volume":"183","author":"Hamza","year":"2017","journal-title":"Exp. Parasitol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.phymed.2017.11.001","article-title":"In vivo Schistosomicidal Activity of 7-Epiclusianone and Its Quantification in the Plasma of Healthy and Schistosoma mansoni Infected Mice Using UPLC-MS\/MS","volume":"38","author":"Castro","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Metwally, D.M., Al-Olayan, E.M., Alanazi, M., Alzahrany, S.B., and Semlali, A. (2018). Antischistosomal and Anti-Inflammatory Activity of Garlic and Allicin Compared with That of Praziquantel in vivo. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2191-z"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Guimar\u00e3es, M.A., de Oliveira, R.N., de Almeida, R.L., Mafud, A.C., Sarkis, A.L.V., Ganassin, R., da Silva, M.P., Roquini, D.B., Veras, L.M., and Sawada, T.C.H. (2018). Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity. PLoS ONE., 13.","DOI":"10.1371\/journal.pone.0196667"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105350","DOI":"10.1016\/j.actatropica.2020.105350","article-title":"Antiparasitic Activity of Piplartine (Piperlongumine) in a Mouse Model of Schistosomiasis","volume":"205","author":"Mengarda","year":"2020","journal-title":"Acta Trop."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1021\/acsinfecdis.0c00175","article-title":"Naturally Occurring Cardenolides Affecting Schistosoma mansoni","volume":"6","author":"Keiser","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1590\/1519-6984.216607","article-title":"In vivo effect of essential oil of Mentha x villosa and its active compound against Schistosoma mansoni (Sambon, 1907)","volume":"80","author":"Cavalcanti","year":"2020","journal-title":"Braz J. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.2217\/nnm-2021-0146","article-title":"Licochalcone A-Loaded Solid Lipid Nanoparticles Improve Antischistosomal Activity in vitro and in vivo","volume":"16","author":"Silva","year":"2021","journal-title":"Nanomedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1007\/s00436-021-07333-2","article-title":"Efficacy of Caracryl Acetate in vitro and Following Oral Administration to Mice Harboring either Prepatent or Patent Shistosoma mansoni Infections","volume":"120","author":"Silva","year":"2021","journal-title":"Parasitol. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e2100604","DOI":"10.1002\/cbdv.202100604","article-title":"Cardamonin Presents in vivo Activity against Schistosoma mansoni and Inhibits Potato Apyrase","volume":"18","author":"Carvalho","year":"2021","journal-title":"Chem. Biodivers."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"de Carvalho, L.S.A., de Souza, V.C., Rodrigues, V.C., Ribeiro, A.C., Nascimento, J.W.L., Capriles, P.V.S.Z., Pinto, P.F., de Moraes, J., and da Silva Filho, A.A. (2022). Identification of Asiaticoside from Centella erecta (Apiaceae) as Potential Apyrase Inhibitor by UF-UHPLC-MS and Its In vivo Antischistosomal Activity. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14051071"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e12945","DOI":"10.1111\/pim.12945","article-title":"Anti-inflammatory, Antioxidant, Anti-fibrotic and Schistosomicidal Properties of Plumbagin in Murine Schistosomiasis","volume":"44","author":"Bakery","year":"2022","journal-title":"Parasite Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"109415","DOI":"10.1016\/j.intimp.2022.109415","article-title":"Juglone: \u201cA Novel Immunomodulatory, Antifibrotic, and Schistosomicidal Agent to Ameliorate Liver Damage in Murine schistosomiasis Mansoni\u201d","volume":"113","author":"Khalil","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"155541","DOI":"10.1016\/j.cyto.2021.155541","article-title":"Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials","volume":"143","author":"Gorabi","year":"2021","journal-title":"Cytokine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.micinf.2010.06.001","article-title":"Th2 Immune Response against Schistosoma mansoni Infection","volume":"12","author":"Schramm","year":"2010","journal-title":"Microbes Infect."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6587150","DOI":"10.1155\/2019\/6587150","article-title":"Active essential oils and their components in use against neglected diseases and Arboviruses","volume":"2019","author":"Luna","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1590\/S0037-86821990000400002","article-title":"Molluscacide and cercariacide activity of different species of Eucalyptus","volume":"23","author":"Mendes","year":"1990","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s13071-020-04367-w","article-title":"Molluscicidal and parasiticidal activities of Eryngium triquetrum essential oil on Schistosoma mansoni and its intermediate snail host Biomphalaria Glabrata, a double impact","volume":"13","author":"Merad","year":"2020","journal-title":"Parasit. Vectors"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"106089","DOI":"10.1016\/j.actatropica.2021.106089","article-title":"Molluscicidal activity of monoterpenes and their effects on inhibition of acetylcholinesterase activity on Biomphalaria glabrata, an intermediate host of Schistosoma mansoni","volume":"223","author":"Ribeiro","year":"2021","journal-title":"Acta Trop."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e180489","DOI":"10.1590\/0074-02760180489","article-title":"Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)","volume":"114","author":"Albuquerque","year":"2019","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_75","first-page":"343","article-title":"Chemoprophylactic activity of soaps containing essential oil from the fruit of Pterodon pubescens in schistosomiasis mansoni","volume":"82","author":"Sarti","year":"1987","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01959202","article-title":"The essential oil of Apium graveolens var. secalinum and its cercaricidal activity","volume":"7","author":"Saleh","year":"1985","journal-title":"Pharm. Weekbl. Sci."},{"key":"ref_77","first-page":"390","article-title":"Schistosoma mansoni: Cercaricidal effects of Cedarwood oil and various of its components","volume":"95","author":"Naples","year":"1992","journal-title":"J. Trop. Med. Hyg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/cbdv.200900292","article-title":"Antiprotozoal, schistosomicidal, and antimicrobial activities of the essential oil from the leaves of Baccharis dracunculifolia","volume":"7","author":"Parreira","year":"2010","journal-title":"Chem. Biodivers."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/cbdv.201100167","article-title":"Chemical composition and in vitro schistosomicidal activity of the essential oil of Plectranthus neochilus grown in Southeast Brazil","volume":"8","author":"Caixeta","year":"2011","journal-title":"Chem. Biodivers."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/molecules16010762","article-title":"Schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae) against adult Schistosoma mansoni worms","volume":"16","author":"Magalhaes","year":"2011","journal-title":"Molecules"},{"key":"ref_81","first-page":"1627","article-title":"Antischistosomal and Cytotoxic Effects of the Essential Oil of Tetradenia riparia (Lamiaceae)","volume":"10","author":"Mantovani","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1055\/s-0033-1350732","article-title":"In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni","volume":"79","author":"Veras","year":"2013","journal-title":"Planta Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exppara.2012.06.005","article-title":"Schistosoma mansoni: In vitro schistosomicidal activity of essential oil of Baccharis trimera (less) DC","volume":"132","author":"Rehder","year":"2012","journal-title":"Exp. Parasitol."},{"key":"ref_84","first-page":"1","article-title":"Ultrastructural changes in Schistosoma mansoni male worms after in vitro incubation with the essential oil of Mentha x villosa Huds","volume":"58","author":"Cavalcanti","year":"2016","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/cbdv.201400293","article-title":"Anthelmintic effects of the essential oil of fennel (Foeniculum vulgare Mill., Apiaceae) against Schistosoma mansoni","volume":"12","author":"Wakabayashi","year":"2015","journal-title":"Chem. Biodivers."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e1600194","DOI":"10.1002\/cbdv.201600194","article-title":"Schistosomicidal Effects of the Essential Oils of Citrus limonia and Citrus reticulata against Schistosoma mansoni","volume":"14","author":"Martins","year":"2017","journal-title":"Chem. Biodivers."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e1700149","DOI":"10.1002\/cbdv.201700149","article-title":"Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)","volume":"14","author":"Soares","year":"2017","journal-title":"Chem. Biodivers."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3923\/pjbs.2012.971.978","article-title":"Comparative in vivo antioxidant levels in Schistosoma mansoni infected mice treated with praziquantel or the essential oil of Melaleuca armillaris leaves","volume":"15","author":"Rizk","year":"2012","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.pt.2016.08.002","article-title":"Discovery of novel antischistosomal agents by molecular modeling approaches","volume":"32","author":"Mafud","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"642383","DOI":"10.3389\/fimmu.2021.642383","article-title":"Schistosomiasis drug discovery in the era of automation and artificial intelligence","volume":"12","author":"Silva","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-0716-2855-3_7","article-title":"Computer-Aided Drug Design: An update","volume":"2601","author":"Yu","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Kwon, S., Bae, H., Jo, J., and Yoon, S. (2019). Comprehensive ensemble in QSAR prediction for drug discovery. BMC Bioinform., 20.","DOI":"10.1186\/s12859-019-3135-4"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"Berriman","year":"2009","journal-title":"Nature"},{"key":"ref_94","first-page":"456314","article-title":"Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system","volume":"13","author":"Buddenborg","year":"2021","journal-title":"BioRxiv"},{"key":"ref_95","first-page":"e79320","article-title":"Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination","volume":"11","author":"Lund","year":"2022","journal-title":"Elife"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Wangwiwatsin, A., Protasio, A.V., Wilson, S., Owusu, C., Holroyd, N.E., Sanders, M.J., Keane, J., Doenhoff, M.J., Rinaldi, G., and Berriman, M. (2020). Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0007743"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2174\/1568026621666210924101805","article-title":"Drug discovery and target identification against schistosomiasis: A reality check on progress and future prospects","volume":"22","author":"Cheuka","year":"2022","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ali, Z., Hayat, M.F., Shaukat, K., Alam, T.M., Hameed, I.A., Luo, S., Basheer, S., Ayadi, M., and Ksibi, A. (2022). A proposed framework for early prediction of schistosomiasis. Diagnostics, 12.","DOI":"10.3390\/diagnostics12123138"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1573409913666170119114859","article-title":"Structure-based study of natural products with anti-schistosoma activity","volume":"13","author":"Akachukwu","year":"2017","journal-title":"Curr. Comput. Aided Drug Des."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/cimb44010028","article-title":"Computer-assisted discovery of alkaloids with schistosomicidal activity","volume":"44","author":"Viana","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1021\/acs.jmedchem.5b02038","article-title":"Discovery of new anti-schistosomal hits by integration of QSAR- based virtual screening and high content screening","volume":"59","author":"Neves","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Gallinger, T.L., Aboagye, S.Y., Obermann, W., Weiss, M., Gr\u00fcnweller, A., Unverzagt, C., Williams, D.L., Schlitzer, M., and Haeberlein, S. (2022). First in silico screening of insect molecules for identification of novel anti-parasitic compounds. Pharmaceuticals, 15.","DOI":"10.3390\/ph15020119"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Moreira, B.P., Weber, M.H.W., Haeberlein, S., Mokosch, A.S., Spengler, B., Grevelding, C.G., and Falcone, F.H. (2022). Drug repurposing and de novo drug discovery of protein kinase inhibitors as new drugs against schistosomiasis. Molecules, 27.","DOI":"10.3390\/molecules27041414"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Marcellino, C., Gut, J., Lim, K.C., Singh, R., Mckerrow, J., and Sakanari, J. (2012). WormAssay: A novel computer application for whole-plate motion-based screening of macroscopic parasites. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001494"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1021\/acsmedchemlett.2c00248","article-title":"Identification of inhibitors of the Schistosoma mansoni VKR2 kinase domain","volume":"13","author":"Mathavan","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Simoben, C.V., Robaa, D., Chakrabarti, A., Schmidtkunz, K., Marek, M., Lancelot, J., Kannan, S., Melesina, J., Shaik, T.B., and Pierce, R.J. (2018). A novel class of Schistosoma mansoni histone deacetylase 8 (HDAC8) inhibitors identified by structure-based virtual screening and in vitro testing. Molecules, 23.","DOI":"10.3390\/molecules23030566"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1038\/s41467-021-24958-0","article-title":"Whole-Genome Sequencing of Schistosoma mansoni Reveals Extensive Diversity with Limited Selection despite Mass Drug Administration","volume":"12","author":"Berger","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Vianney, T.J., Berger, D.J., Doyle, S.R., Sankaranarayanan, G., Serubanja, J., Nakawungu, P.K., Besigye, F., Sanya, R.E., Holroyd, N., and Allan, F. (2022). Genome-Wide Analysis of Schistosoma mansoni Reveals Limited Population Structure and Possible Praziquantel Drug Selection Pressure within Ugandan Hot-Spot Communities. PLoS Negl. Trop. Dis., 16.","DOI":"10.1101\/2022.01.25.477652"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"950744","DOI":"10.3389\/fpara.2022.950744","article-title":"Differential Excretory\/Secretory Proteome of the Adult Female and Male Stages of the Human Blood Fluke, Schistosoma mansoni","volume":"1","author":"Kenney","year":"2022","journal-title":"Front. Parasitol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"101341","DOI":"10.1016\/j.cimid.2019.101341","article-title":"Biological and Proteomic Studies of Schistosoma mansoni with Decreased Sensitivity to Praziquantel","volume":"66","author":"Amer","year":"2019","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"664642","DOI":"10.3389\/fitd.2021.664642","article-title":"A Comparative Proteomic Analysis of Praziquantel-Susceptible and Praziquantel-Resistant Schistosoma mansoni Reveals Distinct Response between Male and Female Animals","volume":"2","author":"Mendes","year":"2021","journal-title":"Front. Trop. Dis."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Protasio, A.V., Tsai, I.J., Babbage, A., Nichol, S., Hunt, M., Aslett, M.A., De Silva, N., Velarde, G.S., Anderson, T.J.C., and Clark, R.C. (2012). A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001455"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.molbiopara.2018.12.005","article-title":"Transcriptomic Analysis of Reduced Sensitivity to Praziquantel in Schistosoma mansoni","volume":"228","author":"Sanchez","year":"2019","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.pt.2021.04.010","article-title":"SchistoCyte Atlas: A Single-Cell Transcriptome Resource for Adult Schistosomes","volume":"37","author":"Wendt","year":"2021","journal-title":"Trends Parasitol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Soria, C.L.D., Attenborough, T., Lu, Z., Graham, J., Hall, C., Thompson, S., Andrews, T.G.R., Rawlinson, K.A., Berriman, M., and Rinaldi, G. (2023). Single Cell Transcriptomics of the Human Parasite Schistosoma mansoni First Intra-Molluscan Stage Reveals Tentative Tegumental and Stem Cell Regulators. bioRxiv.","DOI":"10.1101\/2023.05.02.538881"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ijpddr.2018.10.005","article-title":"Combining Bioinformatics, Cheminformatics, Functional Genomics and Whole Organism Approaches for Identifying Epigenetic Drug Targets in Schistosoma mansoni","volume":"8","author":"Padalino","year":"2018","journal-title":"Int. J. Parasitol. Drugs Drug Resist."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/19\/6807\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:58:42Z","timestamp":1760129922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/19\/6807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":117,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["molecules28196807"],"URL":"https:\/\/doi.org\/10.3390\/molecules28196807","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,26]]}}}