{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:46:22Z","timestamp":1790167582070,"version":"4.1.0"},"reference-count":138,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["22108103"],"award-info":[{"award-number":["22108103"]}]},{"name":"National Natural Science Foundation of China","award":["22078132"],"award-info":[{"award-number":["22078132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nucleoside analogs play a crucial role in the production of high-value antitumor and antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid degradation, chemical synthesis, and biotransformation. However, these methods face several challenges, such as low concentration of the main product, the presence of complex matrices, and the generation of numerous by-products that significantly limit the development of new drugs and their pharmacological studies. Therefore, this work aims to summarize the universal separation methods of nucleoside analogs, including crystallization, high-performance liquid chromatography (HPLC), column chromatography, solvent extraction, and adsorption. The review also explores the application of molecular imprinting techniques (MITs) in enhancing the identification of the separation process. It compares existing studies reported on adsorbents of molecularly imprinted polymers (MIPs) for the separation of nucleoside analogs. The development of new methods for selective separation and purification of nucleosides is vital to improving the efficiency and quality of nucleoside production. It enables us to obtain nucleoside products that are essential for the development of antitumor and antiviral drugs. Additionally, these methods possess immense potential in the prevention and control of serious diseases, offering significant economic, social, and scientific benefits to the fields of environment, biomedical research, and clinical therapeutics.<\/jats:p>","DOI":"10.3390\/molecules28207043","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:14:32Z","timestamp":1697080472000},"page":"7043","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Nucleoside Analogs: A Review of Its Source and Separation Processes"],"prefix":"10.3390","volume":"28","author":[{"given":"Pan","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nrd4010","article-title":"Advances in the Development of Nucleoside and Nucleotide Analogues for Cancer and Viral Diseases","volume":"12","author":"Jordheim","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1038\/s41467-019-10957-9","article-title":"Chemical Logic of MraY Inhibition by Antibacterial Nucleoside Natural Products","volume":"10","author":"Mashalidis","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1038\/sj.onc.1207229","article-title":"Mechanisms of Apoptosis Induction by Nucleoside Analogues","volume":"22","author":"Sampath","year":"2003","journal-title":"Oncogene"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15415","DOI":"10.1021\/acs.jpcc.6b02753","article-title":"Surface-Enhanced Hyper-Raman Spectra of Adenine, Guanine, Cytosine, Thymine, and Uracil","volume":"120","author":"Madzharova","year":"2016","journal-title":"J. Phys. Chem. C"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/jcc.20007","article-title":"TDDFT Investigation on Nucleic Acid Bases: Comparison with Experiments and Standard Approach","volume":"25","author":"Shukla","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.chroma.2014.06.065","article-title":"Simultaneous Quantification of Purine and Pyrimidine Bases, Nucleosides and Their Degradation Products in Bovine Blood Plasma by High Performance Liquid Chromatography Tandem Mass Spectrometry","volume":"1356","author":"Stentoft","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/cr900028p","article-title":"Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer","volume":"109","author":"Parker","year":"2009","journal-title":"Chem. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/febs.12143","article-title":"Recombinant Purine Nucleoside Phosphorylases from Thermophiles: Preparation, Properties and Activity towards Purine and Pyrimidine Nucleosides","volume":"280","author":"Zhou","year":"2013","journal-title":"FEBS J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41429-019-0236-2","article-title":"Recent Advances in the Biosynthesis of Nucleoside Antibiotics","volume":"72","author":"Shiraishi","year":"2019","journal-title":"J. Antibiot."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"213705","DOI":"10.1016\/j.ccr.2020.213705","article-title":"Organometallic nucleosides-Synthesis, Transformations, and Applications","volume":"432","author":"Kowalski","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ana.24922","article-title":"Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency","volume":"81","author":"Levy","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nature11181","article-title":"Watching DNA Polymerase \u03b7 Make a Phosphodiester Bond","volume":"487","author":"Nakamura","year":"2012","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1093\/nar\/gkt1405","article-title":"A Ribozyme That Triphosphorylates RNA 5\u2032-Hydroxyl Groups","volume":"42","author":"Moretti","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/sj.gt.3300806","article-title":"Bystander Effect of Purine Nucleoside Analogues in HSV-1tk Suicide Gene Therapy Is Superior to that of Pyrimidine Nucleoside Analogues","volume":"6","author":"Balzarini","year":"1999","journal-title":"Gene Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7524","DOI":"10.1038\/sj.onc.1206952","article-title":"Nucleoside Anticancer Drugs: The Role of Nucleoside Transporters in Resistance to Cancer Chemotherapy","volume":"22","author":"Damaraju","year":"2003","journal-title":"Oncogene"},{"key":"ref_16","first-page":"14243","article-title":"Simultaneous Determination of 16 Nucleosides and Nucleobases by Hydrophilic Interaction Chromatography and Its Application to the Quality Evaluation of Ganoderma","volume":"60","author":"Chen","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/sj.leu.2402114","article-title":"Nucleoside Analogues: Mechanisms of Drug Resistance and Reversal Strategies","volume":"15","author":"Galmarini","year":"2001","journal-title":"Leukemia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1021\/acsmedchemlett.0c00090","article-title":"Amidate Prodrugs of O-2-Alkylated Pyrimidine Acyclic Nucleosides Display Potent Anti-Herpesvirus Activity","volume":"11","author":"Luo","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.leu.2403271","article-title":"Nucleoside Transporters in Chronic Lymphocytic Leukaemia","volume":"18","author":"Casado","year":"2004","journal-title":"Leukemia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1021\/acsnano.0c04006","article-title":"Nanotechnology for COVID-19: Therapeutics and Vaccine Research","volume":"14","author":"Madou","year":"2020","journal-title":"ACS nano"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1002\/anie.201404832","article-title":"Synthesis of (carbo) nucleoside analogues by [3+2] annulation of aminocyclopropanes","volume":"53","author":"Racine","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1126\/science.abb3231","article-title":"A Short de Novo Synthesis of Nucleoside Analogues","volume":"369","author":"Meanwell","year":"2020","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1158\/1078-0432.CCR-04-2135","article-title":"Approval Summary: Azacitidine for Treatment of Myelodysplastic Syndrome Subtypes","volume":"11","author":"Kaminskas","year":"2005","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/cncr.22457","article-title":"Activity of Decitabine, a Hypomethylating Agent, in Chronic Myelomonocytic Leukemia","volume":"109","author":"Aribi","year":"2010","journal-title":"Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1021\/acs.orglett.9b02555","article-title":"Synthesis of 4\u2032\/5\u2032-Spirocyclopropanated Uridine and D-Xylouridine Derivatives and Their Activity against the Human Respiratory Syncytial Virus","volume":"21","author":"Koellmann","year":"2019","journal-title":"Org. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1021\/acs.joc.9b03425","article-title":"Protecting-Group-Mediated Diastereoselective Synthesis of C4\u2032-Methylated Uridine Analogs and Their Activity against the Human Respiratory Syncytial Virus","volume":"85","author":"Kollmann","year":"2020","journal-title":"J. Org. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jmv.1890410503","article-title":"Acyclovir: Discovery, Mechanism of Action, and Selectivity","volume":"41","author":"Elion","year":"1993","journal-title":"J. Med. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pa.33.040193.000245","article-title":"The Quest for a Cure","volume":"33","author":"Elion","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1021\/acs.jmedchem.0c00271","article-title":"Anti-HIV-Active Nucleoside Triphosphate Prodrugs","volume":"63","author":"Jia","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0899-9007(96)00376-0","article-title":"Role of Nucleosides and Nucleotides in the Immune System, Gut Reparation after Injury, and Brain Function","volume":"13","author":"Yamamoto","year":"1997","journal-title":"Nutrition"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the Microbiota, Immune and Nervous Systems in Health and Disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s41429-019-0230-8","article-title":"Engineering Nucleoside Antibiotics toward the Development of Novel Antimicrobial Agents","volume":"72","author":"Niu","year":"2019","journal-title":"J. Antibiot."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1021\/acs.bioconjchem.0c00191","article-title":"A Bifunctional Nucleoside Probe for the Inhibition of the Human Immunodeficiency Virus-Type 1 Reverse Transcriptase","volume":"31","author":"Shaw","year":"2020","journal-title":"Bioconjug. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Borbone, N., Piccialli, G., Roviello, G.N., and Oliviero, G. (2021). Nucleoside Analogues and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses. Molecules, 26.","DOI":"10.3390\/molecules26040986"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ejmech.2016.06.051","article-title":"New Imidazolidineiminothione Derivatives: Synthesis, Spectral Characterization and Evaluation of Antitumor, Antiviral, Antibacterial. and Antifungal Activities","volume":"122","author":"Moussa","year":"2016","journal-title":"Eur. J. Med. Chem. Chim. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10343","DOI":"10.1021\/acs.jmedchem.6b00325","article-title":"Nucleoside Derived Antibiotics to Fight Microbial Drug Resistance: New Utilities for an Established Class of Drugs?","volume":"59","author":"Serpi","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.1021\/acs.orglett.9b02833","article-title":"Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-Carboxamide, as Its Metabolites in Rice","volume":"21","author":"Choi","year":"2019","journal-title":"Org. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.1021\/acs.joc.6b02098","article-title":"Additions of Thiols to 7-Vinyl-7-Deazaadenine Nucleosides and Nucleotides. Synthesis of Hydrophobic Derivatives of 2\u2032-Deoxyadenosine, dATP and DNA","volume":"81","author":"Slavickova","year":"2016","journal-title":"J. Org. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1021\/acs.chemrev.5b00242","article-title":"Synthetic Polymers from Sugar-Based Monomers","volume":"116","author":"Galbis","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1021\/acs.jafc.5b05931","article-title":"Anti-Inflammatory Cerebrosides from Cultivated Cordyceps Militaris","volume":"64","author":"Chiu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1021\/acs.jnatprod.5b00573","article-title":"N6-(2-Hydroxyethyl) adenosine in the Medicinal Mushroom Cordyceps Cicadae Attenuates Lipopolysaccharide-Stimulated Pro-Inflammatory Responses by Suppressing TLR4-Mediated NF-KB Signaling Pathways","volume":"78","author":"Lu","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jsb.2005.02.010","article-title":"Crystal Structure of Nucleoside Diphosphate Kinase Required for Coleoptile Elongation in Rice (Oryza sativa L.)","volume":"150","author":"Huang","year":"2005","journal-title":"J. Struct. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1089\/hum.2017.133","article-title":"Long-Term Sustained Effect of Liver-Targeted Adeno-Associated Virus Gene Therapy for Mitochondrial Neurogastrointestinal Encephalomyopathy","volume":"29","author":"Viscomi","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1073\/pnas.73.4.1260","article-title":"Germ Line Integration and Mendelian Transmission of the Exogenous Moloney Leukemia Virus","volume":"73","author":"Jaenisch","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","first-page":"3","article-title":"Molecular Imaging of Lymphoid Organs and Immune Activation by Positron Emission Tomography with a New [18F]-Labeled 2\u2032-deoxycytidine Analog","volume":"14","author":"Radu","year":"2008","journal-title":"Infect. Dis. Aquac."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"100064","DOI":"10.1016\/j.talo.2021.100064","article-title":"Hydrophilic Interaction Liquid Chromatography Coupled to Quadrupole-Time-of-Flight Mass Spectrometry for Determination of Nuclear and Cytoplasmatic Contents of Nucleotides, Nucleosides and Their Nucleobases in Food Yeasts","volume":"4","author":"Campillo","year":"2021","journal-title":"Talanta Open."},{"key":"ref_47","first-page":"2320","article-title":"Isolation, Identification and Mass Multiplication of Trichodermaan Important Bio-Control Agent","volume":"4","author":"Babu","year":"2013","journal-title":"Int. J. Pharm. Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Correa, Y., Cabanillas, B., Jullian, V., Lvarez, D., and Castillo, D. (2019). Identification and Characterization of Compounds from Chrysosporium Multifidum, a Fungus with Moderate Antimicrobial Activity Isolated from Hermetia Illucens Gut Microbiota. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0218837"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1021\/acscentsci.1c00608","article-title":"Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19","volume":"12","author":"Mcintosh","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Westarp, S., Kaspar, F., Neubauer, P., and Kurreck, A. (2022). Industrial Potential of the Enzymatic Synthesis of Nucleoside Analogues: Existing Challenges and Perspectives. Curr. Opin. Biotechnol., 78.","DOI":"10.1016\/j.copbio.2022.102829"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8033","DOI":"10.1007\/s00253-021-11608-0","article-title":"Enzymatic Synthesis of Fluorinated Compounds","volume":"105","author":"Cheng","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/17460441.2022.2039620","article-title":"Advances in Biocatalytic and Chemoenzymatic Synthesis of Nucleoside Analogues","volume":"17","author":"Cosgrove","year":"2022","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1021\/ja501460j","article-title":"Total Synthesis of Nucleoside Antibiotic A201A","volume":"136","author":"Nie","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10199","DOI":"10.1021\/jacs.9b06050","article-title":"New Catalytic Asymmetric Formation of Oxygen Heterocycles Bearing Nucleoside Bases at the Anomeric Carbon","volume":"141","author":"Trost","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41557-019-0225-x","article-title":"Prebiotic Phosphorylation of 2-Thiouridine Provides Either Nucleotides or DNA Building Blocks via Photoreduction","volume":"11","author":"Xu","year":"2019","journal-title":"Nat. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1021\/cr1004138","article-title":"Chemoenzymatic Synthesis of Inositols, Conduritols, and Cyclitol Analogues","volume":"111","author":"Duchek","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.abd1283","article-title":"Unifying the Synthesis of Nucleoside Analogues","volume":"369","author":"Miller","year":"2020","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1021\/acsmedchemlett.0c00269","article-title":"Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides","volume":"11","author":"Li","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13227","DOI":"10.1021\/jacs.0c06354","article-title":"Convergent Total Synthesis of Hikizimycin Enabled by Intermolecular Radical Addition to Aldehyde","volume":"142","author":"Fujino","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1021\/acs.orglett.0c01846","article-title":"From Heterocycles to Carbacycles: Synthesis of Carbocyclic Nucleoside Analogues from Enals and Hydroxylamines","volume":"22","author":"Das","year":"2020","journal-title":"Org. Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12451","DOI":"10.1039\/C5CC04832J","article-title":"A Straightforward Entry to Chiral Carbocyclic Nucleoside Analogues via the Enantioselective [3+2] Cycloaddition of \u03b1-Nucleobase Substituted Acrylates","volume":"51","author":"Xie","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1002\/chem.201604955","article-title":"Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism","volume":"23","author":"Downey","year":"2017","journal-title":"Chem. Eur. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3762\/bjoc.13.123","article-title":"Strategies toward Protecting Group-Free Glycosylation through Selective Activation of the Anomeric Center","volume":"13","author":"Downey","year":"2017","journal-title":"Beilstein J. Org. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Merino, P. (2013). Chemical Synthesis of Nucleoside Analogues, John Wiley.","DOI":"10.1002\/9781118498088"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1021\/cr800464r","article-title":"Chemical Synthesis of Heterocyclic-Sugar Nucleoside Analogues","volume":"110","author":"Romeo","year":"2010","journal-title":"Chem. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/btpr.1602","article-title":"Biotransformation of 2,6-Diaminopurine Nucleosides by Immobilized Geobacillus Stearothermophilus","volume":"28","author":"Rivero","year":"2012","journal-title":"Biotechnol. Prog."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Hellendahl, K.F., Kamel, S., Wetterwald, A., Neubauer, P., and Wagner, A. (2019). Human Deoxycytidine Kinase Is a Valuable Biocatalyst for the Synthesis of Nucleotide Analogues. Catalysts, 9.","DOI":"10.3390\/catal9120997"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1381-1177(00)00121-1","article-title":"A Novel Enzymatic Method for the Production of Purine-2\u2032-Deoxyribonucleosides","volume":"10","author":"Yokozeki","year":"2000","journal-title":"J. Mol. Catal. B Enzym."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11814-010-0331-3","article-title":"Enhanced Adenosine Triphosphate Production by Saccharomyces Cerevisiae Using an Efficient Energy Regeneration System","volume":"28","author":"Yao","year":"2011","journal-title":"Korean J. Chem. Eng."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1039\/D2CY00751G","article-title":"A Novel Thymidine Phosphorylase to Synthesize (Halogenated) Anticancer and Antiviral Nucleoside Drugs in Continuous Flow","volume":"12","author":"Klein","year":"2022","journal-title":"Catal. Sci. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1002\/cctc.201701222","article-title":"Synthesis of Adenine Nucleosides by Transglycosylation Using Two Sequential Nucleoside Phosphorylase-Based Bioreactors with on-Line Reaction Monitoring by Using HPLC","volume":"9","author":"Cattaneo","year":"2017","journal-title":"ChemCatChem"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.procbio.2015.03.015","article-title":"Bioproduction of Ribavirin by Green Microbial Biotransformation","volume":"50","author":"Rivero","year":"2015","journal-title":"Process Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Pfeiffer, M., and Nidetzky, B. (2023). Biocatalytic Cascade Transformations for the Synthesis of C-Nucleosides and N-Nucleoside Analogues. Curr. Opin. Biotechnol., 79.","DOI":"10.1016\/j.copbio.2022.102873"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/acs.accounts.9b00420","article-title":"Chemoenzymatic Synthesis of Glycosaminoglycans","volume":"53","author":"Zhang","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Cohen, S., Jordheim, L.P., Megherbi, M., Dumontet, C., and Guitton, J. (2010). Liquid Chromatographic Methods for the Determination of Endogenous Nucleotides and Nucleotide Analogues Used in Cancer Therapy: A Review. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 878.","DOI":"10.1016\/j.jchromb.2010.05.016"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jconrel.2005.06.002","article-title":"V Polyplex Nanogel Formulations for Drug Delivery of Cytotoxic Nucleoside Analogues-ScienceDirect","volume":"107","author":"Vinogradov","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/bmc.980","article-title":"Simple HPLC-UV Determination of Nucleosides and Its Application to the Authentication of Cordyceps and Its Allies","volume":"22","author":"Ikeda","year":"2010","journal-title":"Biomed. Chromatogr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"11308","DOI":"10.1021\/jacs.8b05484","article-title":"Independent Generation of Reactive Intermediates Leads to an Alternative Mechanism for Strand Damage Induced by Hole Transfer in Poly (dA--T) Sequences","volume":"140","author":"Sun","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1038\/s41596-022-00705-7","article-title":"Practical and Concise Synthesis of Nucleoside Analogues","volume":"17","author":"Davison","year":"2022","journal-title":"Nat. Protoc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1002\/jctb.7212","article-title":"Extraction of Bioactive Compounds from Black-footed Abalone (Haliotis Iris) Using Subcritical Water Extraction","volume":"97","author":"Mohammadi","year":"2022","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1021\/acschembio.9b00367","article-title":"Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine","volume":"14","author":"Holzer","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0924-2244(01)00077-2","article-title":"Rapid Cooling of Porous and Moisture Foods by Using Vacuum Cooling Technology","volume":"12","author":"Wang","year":"2001","journal-title":"Trends Food Sci. Technol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Glasgow, S.M. (1996). Crystallization, William Andrew.","DOI":"10.1016\/B978-081551407-7.50014-3"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"(2020). Accelerating Crystallization of Open Organic Materials by Poly(ionic Liquid)s. Angew. Chem. Int. Ed., 59, 22109\u201322116.","DOI":"10.1002\/anie.202008415"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"16450","DOI":"10.1021\/jacs.9b08630","article-title":"Structural Elucidation of Bisulfite Adducts to Pseudouridine That Result in Deletion Signatures during Reverse Transcription of RNA","volume":"141","author":"Fleming","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.chemosphere.2012.01.029","article-title":"Characterization of Dissolved Organic Matter Using High-Performance Liquid Chromatography (HPLC)-Size Exclusion Chromatography (SEC) with a Multiple Wavelength Absorbance Detector","volume":"87","author":"Yan","year":"2012","journal-title":"Chemosphere"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.chemosphere.2006.01.064","article-title":"Polycyclic Aromatic Hydrocarbons (PAHs) in the Aerosol in Beijing, China, Measured by Aminopropylsilane Chemically-Bonded Stationary-Phase Column Chromatography and HPLC\/fluorescence Detection","volume":"65","author":"Okuda","year":"2006","journal-title":"Chemosphere"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1021\/acs.analchem.0c04466","article-title":"Advances and Innovations in Liquid Chromatography Stationary Phase Supports","volume":"93","author":"Broeckhoven","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1021\/acscentsci.1c00960","article-title":"Antagonistic Role of Aqueous Complexation in the Solvent Extraction and Separation of Rare Earth Ions","volume":"7","author":"Sun","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.seppur.2015.10.021","article-title":"Extraction and Separation of Indium and Copper from Zinc Residue Leach Liquor by Solvent Extraction","volume":"156","author":"Li","year":"2015","journal-title":"Sep. Purif. Technol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11831","DOI":"10.1038\/ncomms11831","article-title":"Metal-Organic Framework with Optimally Selective Xenon Adsorption and Separation","volume":"7","author":"Banerjee","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"129237","DOI":"10.1016\/j.cej.2021.129237","article-title":"Selective Adsorption and Separation of Organic Dyes Using Functionalized Cellulose Nanocrystals","volume":"417","author":"Mohammed","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1002\/ange.201602287","article-title":"Hybrid Ultra-Microporous Materials for Selective Xenon Adsorption and Separation","volume":"128","author":"Mohamed","year":"2016","journal-title":"Angew. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"10803","DOI":"10.1021\/ie501000k","article-title":"Determination of Solubility of cAMPNa in Water + (Ethanol, Methanol, and Acetone) within 293.15\u2013313.15 K","volume":"53","author":"Yang","year":"2014","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejmech.2013.12.055","article-title":"Synthesis and Biological Evaluation of 2-Oxonicotinonitriles and 2-Oxonicotinonitrile Based Nucleoside Analogues","volume":"74","author":"Moustafa","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1039\/b207207f","article-title":"The Stereospecific Synthesis of P-Chiral Biophosphates and Their Analogues by the Stec Reaction","volume":"32","author":"Wozniak","year":"2003","journal-title":"Chem. Soc. Rev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1021\/ja00862a022","article-title":"Studies on Polynucleotides. XIII.1 Stepwise Synthesis of Deoxyribo-Oligonucleotides. An Alternative General Approach and the Synthesis of Thymidine Di-, Tri- and Tetranucleotides Bearing 3\u201d-Phosphomonoester End Groups2","volume":"84","author":"Weimann","year":"1962","journal-title":"J. Am. Chem. Soc."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s42004-019-0130-7","article-title":"Integrated Synthesis of Nucleotide and Nucleosides Influenced by Amino Acids","volume":"2","author":"Gromski","year":"2019","journal-title":"Commun. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41596-018-0094-6","article-title":"Isotope-Dilution Mass Spectrometry for Exact Quantification of Noncanonical DNA Nucleosides","volume":"14","author":"Traube","year":"2018","journal-title":"Nat. Protoc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"8070","DOI":"10.1039\/C5CC00448A","article-title":"Diastereoselective Synthesis of P-Chirogenic Phosphoramidate Prodrugs of Nucleoside Analogues (ProTides) via Copper Catalysed Reaction","volume":"51","author":"Pertusati","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/acs.analchem.8b04281","article-title":"Method for Quantification of Ribonucleotides and Deoxyribonucleotides in Human Cells Using (Trimethylsilyl) Diazomethane Derivatization Followed by Liquid Chromatography--Tandem Mass Spectrometry","volume":"91","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/chromsci\/20.12.566","article-title":"Quantitative Analysis of the Pyrethrins by HPLC","volume":"20","author":"Otieno","year":"1982","journal-title":"J. Chromatogr. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.foodchem.2012.10.039","article-title":"Monitoring of Monosaccharides, Oligosaccharides, Ethanol and Glycerol during Wort Fermentation by Biosensors, HPLC and Spectrophotometry","volume":"138","author":"Monosik","year":"2013","journal-title":"Food Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1039\/D1GC00311A","article-title":"Sustainable Production of 5-Hydroxymethyl Furfural from Glucose for Process Integration with High Fructose Corn Syrup Infrastructure","volume":"23","author":"Chang","year":"2021","journal-title":"Green Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1021\/ie504718p","article-title":"Strategy of Combining Prefiltration and Chromatography Using Composite Cryogels for Large-Scale Separation of Biotransformation Compounds from Crude High-Cell-Density Broth","volume":"54","author":"Yun","year":"2015","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1021\/acs.joc.8b03178","article-title":"Synthesis and Conformation of Pentopyranoside Nucleoside Phosphonates","volume":"84","author":"Li","year":"2019","journal-title":"J. Org. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/acscombsci.8b00136","article-title":"Synthesis of Aza-Acyclic Nucleoside Libraries of Purine, Pyrimidine and 1,2,4-Triazole","volume":"21","author":"Pathak","year":"2019","journal-title":"ACS Comb. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1021\/acs.jnatprod.9b01231","article-title":"Kinase-Inhibitory Nucleoside Derivatives from the Pacific Bryozoan Nelliella Nelliiformis","volume":"83","author":"Bracegirdle","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1021\/acs.jnatprod.6b00954","article-title":"Neuroprotective Activity of Cerebrosides from Typhonium Giganteum by Regulating Caspase-3 and Bax\/Bcl-2 Signaling Pathways in PC12 Cells","volume":"80","author":"Jin","year":"2017","journal-title":"J. Nat. Prod."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/slct.201801261","article-title":"Preparation of a Boronate-Functionalized Affinity Silica Hybrid Monolith Column for the Specific Capture of Nucleosides","volume":"4","author":"Zheng","year":"2019","journal-title":"ChemistrySelect"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.chroma.2004.02.080","article-title":"Simultaneous Determination of Ergosterol, Nucleosides and Their Bases from Natural and Cultured Cordyceps by Pressurised Liquid Extraction and High-Performance Liquid Chromatography","volume":"1036","author":"Li","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jpba.2008.05.012","article-title":"Effects of Sample Preparation Methods on the Quantification of Nucleosides in Natural and Cultured Cordyceps","volume":"48","author":"Yang","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.foodchem.2016.11.119","article-title":"A Simple Extraction Method for the Detection and Quantification of Polyoxin D, a Nucleoside Antibiotic, in Butterbur Using UPLC-MS\/MS","volume":"221","author":"Rahman","year":"2017","journal-title":"Food Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1021\/la702852e","article-title":"Aggregation Behavior of NucleosideBoron Cluster Conjugates in Aqueous Solutions","volume":"24","author":"Olejniczak","year":"2008","journal-title":"Langmuir"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"129076","DOI":"10.1016\/j.foodchem.2021.129076","article-title":"LC-QqQ-MS\/MS Methodology for Determination of Purine and Pyrimidine Derivatives in Unifloral Honeys and Application of Chemometrics for Their Classification","volume":"348","author":"Rola","year":"2021","journal-title":"Food Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jchromb.2018.08.009","article-title":"A Rapid UHPLC-HILIC Method for Algal Guanosine 5\u2032-Diphosphate 3\u2032-Diphosphate (ppGpp) and the Potential Separation Mechanism","volume":"1096","author":"Jin","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1166\/jnn.2011.4138","article-title":"Base-Selective Adsorption of Nucleosides to Pore-Engineered Nanocarbon, Carbon Nanocage","volume":"11","author":"Datta","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3109\/21691401.2014.948550","article-title":"Boronate Affinity Nanoparticles for Nucleoside Separation","volume":"44","author":"Burcu","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/jssc.201900174","article-title":"Organized Cryogel Composites with 3D Hierarchical Porosity as an Extraction Adsorbent for Nucleosides","volume":"42","author":"Zhao","year":"2019","journal-title":"J. Sep. Sci."},{"key":"ref_120","first-page":"1779","article-title":"Boronic Acid-Functionalized Attapulgite with High Adsorption Capacity for Selective Capture of Nucleosides at Acidic pH Values","volume":"183","author":"Cheng","year":"2016","journal-title":"Mikrochim. Acta Int. J. Phys. Chem. Methods Anal."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.trac.2018.07.011","article-title":"Molecular Imprinting Technology for Microorganism Analysis","volume":"106","author":"Jia","year":"2018","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1039\/C6CS00061D","article-title":"Molecular Imprinting: Perspectives and Applications","volume":"45","author":"Chen","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"16161","DOI":"10.1039\/C9TA01116A","article-title":"Tailored Janus Silica Nanosheets Integrating Bispecific Artificial Receptors for Simultaneous Adsorption of 2, 6-Dichlorophenol and Pb (II)","volume":"7","author":"Liu","year":"2019","journal-title":"J. Mater. Chem. A"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"124931","DOI":"10.1016\/j.cej.2020.124931","article-title":"Mosaic-Inspired Magnetic Alginate Composite Sorbents Derived from Coalesce of Two Emulsion Droplets for Selective Recognition of 2\u2032-Deoxyadenosine","volume":"394","author":"Wang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1021\/acs.macromol.7b01782","article-title":"Dual-Oriented Solid-Phase Molecular Imprinting: Toward Selective Artificial Receptors for Recognition of Nucleotides in Water","volume":"50","author":"Mouro","year":"2017","journal-title":"Macromolecules"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"120472","DOI":"10.1016\/j.seppur.2022.120472","article-title":"Hybrid Hydrogel Microspheres Loading Single-Hole Hollow Imprinted Particles for Fast and Selective Uptake of 2\u2032-Deoxyadenosine","volume":"287","author":"Zhou","year":"2022","journal-title":"Sep. Purif. Technol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1002\/jssc.200900226","article-title":"Molecular Imprinting of AMP by an Ionic-Noncovalent Dual Approach","volume":"32","author":"Breton","year":"2009","journal-title":"J. Sep. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jenvman.2018.07.046","article-title":"A Review on Geopolymers as Emerging Materials for the Adsorption of Heavy Metals and Dyes","volume":"224","author":"Siyal","year":"2018","journal-title":"J. Environ. Manag."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1039\/C6TA09116D","article-title":"Enhanced Adsorption Capacity of Ultralong Hydrogen Titanate Nanobelts for Antibiotics","volume":"5","author":"Li","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"126863","DOI":"10.1016\/j.jhazmat.2021.126863","article-title":"Strong Adsorption Properties and Mechanism of Action with Regard to Tetracycline Adsorption of Double-Network Polyvinyl Alcohol-Copper Alginate Gel Beads","volume":"422","author":"Liao","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e00193","DOI":"10.1016\/j.teac.2022.e00193","article-title":"Molecularly Imprinted Polymers as Highly Selective Sorbents in Sample Preparation Techniques and Their Applications in Environmental Water Analysis","volume":"37","author":"Kaya","year":"2022","journal-title":"Trends Environ. Anal. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.trac.2017.02.002","article-title":"Novel Developments and Trends of Analytical Methods for Drug Analysis in Biological and Environmental Samples by Molecularly Imprinted Polymers","volume":"89","author":"Ansari","year":"2017","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.bios.2016.09.027","article-title":"Synthesis of Adenosine-Imprinted Microspheres for the Recognition of ADP-Ribosylated Proteins","volume":"87","author":"Gong","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1002\/jssc.201600132","article-title":"Selective Adsorption of Modified Nucleoside Cancer Biomarkers by Hybrid Molecularly Imprinted Adsorbents","volume":"39","author":"Iwanowska","year":"2016","journal-title":"J. Sep. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1021\/acsabm.9b00936","article-title":"Incorporation of Boronic Acid into Aptamer-Based Molecularly Imprinted Hydrogels for Highly Specific Recognition of Adenosine","volume":"3","author":"Li","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"134349","DOI":"10.1016\/j.cej.2021.134349","article-title":"Sequential Assembly Enabled Surface Precise Imprinting on Janus Nanosheets for Highly Specific Separation of Adenosine 5\u2032-Monophosphate","volume":"432","author":"Wang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cej.2019.03.175","article-title":"Janus Silica Nanosheets-Based MMIPs Platform for Synergetic Selective Capture and Fast Separation of 2\u2032-Deoxyadenosine: Two Different Components Segmented on the Surface of One Object","volume":"369","author":"Wang","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s00216-015-8550-4","article-title":"Synthesis of Boronic-Acid-Functionalized Magnetic Attapulgite for Selective Enrichment of Nucleosides","volume":"407","author":"Cheng","year":"2015","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/20\/7043\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:05:22Z","timestamp":1760130322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/20\/7043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":138,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["molecules28207043"],"URL":"https:\/\/doi.org\/10.3390\/molecules28207043","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]}}}