{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:32:42Z","timestamp":1790253162659,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010265","name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control (Guizhou Medical University), Ministry of Education","doi-asserted-by":"publisher","award":["GMU-2022-HJZ-05"],"award-info":[{"award-number":["GMU-2022-HJZ-05"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control (Guizhou Medical University), Ministry of Education","doi-asserted-by":"publisher","award":["[2020]307"],"award-info":[{"award-number":["[2020]307"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control (Guizhou Medical University), Ministry of Education","doi-asserted-by":"publisher","award":["[2020]11"],"award-info":[{"award-number":["[2020]11"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Industry and Information of Guizhou Province, Rosa Roxburghii Special Project","award":["GMU-2022-HJZ-05"],"award-info":[{"award-number":["GMU-2022-HJZ-05"]}]},{"name":"Industry and Information of Guizhou Province, Rosa Roxburghii Special Project","award":["[2020]307"],"award-info":[{"award-number":["[2020]307"]}]},{"name":"Industry and Information of Guizhou Province, Rosa Roxburghii Special Project","award":["[2020]11"],"award-info":[{"award-number":["[2020]11"]}]},{"name":"Science and Technology Project of Forestry Bureau of Guizhou Province","award":["GMU-2022-HJZ-05"],"award-info":[{"award-number":["GMU-2022-HJZ-05"]}]},{"name":"Science and Technology Project of Forestry Bureau of Guizhou Province","award":["[2020]307"],"award-info":[{"award-number":["[2020]307"]}]},{"name":"Science and Technology Project of Forestry Bureau of Guizhou Province","award":["[2020]11"],"award-info":[{"award-number":["[2020]11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>As a native fruit of China, chestnut rose (Rosa roxburghii Tratt) juice is rich in bioactive ingredients. Oriental fruit moth (OFM), Grapholita molesta (Busck), attacks the fruits and shoots of Rosaceae plants, and its feeding affects the quality and yield of chestnut rose. To investigate the effects of OFM feeding on the quality of chestnut rose juice, the bioactive compounds in chestnut rose juice produced from fruits eaten by OFM were measured. The electronic tongue senses, amino acid profile, and untargeted metabolomics assessments were performed to explore changes in the flavour and metabolites. The results showed that OFM feeding reduced the levels of superoxide dismutase (SOD), tannin, vitamin C, flavonoid, and condensed tannin; increased those of polyphenols, soluble solids, total protein, bitterness, and amounts of bitter amino acids; and decreased the total amino acid and umami amino acid levels. Furthermore, untargeted metabolomics annotated a total of 426 differential metabolites (including 55 bitter metabolites), which were mainly enriched in 14 metabolic pathways, such as flavonoid biosynthesis, tryptophan metabolism, tyrosine metabolism, and diterpenoid biosynthesis. In conclusion, the quality of chestnut rose juice deteriorated under OFM feeding stress, the levels of bitter substances were significantly increased, and the bitter taste was subsequently enhanced.<\/jats:p>","DOI":"10.3390\/molecules28207170","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:15:36Z","timestamp":1697699736000},"page":"7170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Research on the Effect of Oriental Fruit Moth Feeding on the Quality Degradation of Chestnut Rose Juice Based on Metabolomics"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-268X","authenticated-orcid":false,"given":"Tingyuan","family":"Ren","sequence":"first","affiliation":[{"name":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mintao","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuming","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, J., Cai, Z., Huang, H., Zhang, S., Fu, L., Zhao, P., Yan, X., and Fu, Y. (2022). Improved physicochemical and functional properties of dietary fiber from Rosa roxburghii pomace fermented by bacillus natto. Food Biosci., 50.","DOI":"10.1016\/j.fbio.2022.102030"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Li, J., Luo, Y., Lu, M., Wu, X., and An, H. (2022). The pathogen of top rot disease in Rosa roxburghii and its effective control fungicides. Horticulturae, 8.","DOI":"10.3390\/horticulturae8111036"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.hpj.2021.01.002","article-title":"Chloroplast dna-based genetic variation of Rosa roxburghii in southwest china: Phylogeography and conservation implications","volume":"7","author":"Lu","year":"2021","journal-title":"Hortic. Plant J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijbiomac.2017.08.160","article-title":"Characterization of a novel polysaccharide isolated from Rosa roxburghii tratt fruit and assessment of its antioxidant in vitro and in vivo","volume":"107","author":"Chen","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14858","DOI":"10.1111\/jfpp.14858","article-title":"Physicochemical, functional and antioxidant properties of dietary fiber from Rosa roxburghii tratt fruit modified by physical, chemical and biological-enzyme treatments","volume":"44","author":"Wang","year":"2020","journal-title":"J. Food Process. Preserv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.2174\/1381612824666181010151849","article-title":"Phytochemistry, traditional uses and pharmacological profile of rose hip: A review","volume":"24","author":"Ayati","year":"2018","journal-title":"Curr. Pharm. Design"},{"key":"ref_7","first-page":"105","article-title":"Effects of different fermentation methods on the quality of Rosa roxburghii wine","volume":"45","author":"Wei","year":"2020","journal-title":"Food Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Marko, B., Sonja, B., Andreas, S., and Annick, S. (2014). Jasmonate-dependent induction of polyphenol oxidase activity in tomato foliage is important for defense against spodoptera exigua but not against manduca sexta. BMC Plant Biol., 14.","DOI":"10.1186\/s12870-014-0257-8"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.jksus.2019.04.008","article-title":"Activities of antioxidant enzymes in three species of Ludwigia weeds on feeding by Altica cyanea","volume":"31","author":"Mitra","year":"2019","journal-title":"J. King Saud Univ.\u2014Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11829-022-09914-z","article-title":"Oviposition preferences of the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae) to pear hipvs","volume":"16","author":"Ming","year":"2022","journal-title":"Arthropod-Plant Interact."},{"key":"ref_11","first-page":"24","article-title":"Research progress on occurrence and control of diseases and pests of Rosa roxburghii","volume":"40","author":"Huang","year":"2020","journal-title":"China Plant Prot."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Jiaohong, L., Zhenxiang, G., Yue, L., Xiaomao, W., and Huaming, A. (2021). Chitosan can induce Rosa roxburghii tratt. against Sphaerotheca sp. and enhance its resistance, photosynthesis, yield, and quality. Horticulturae, 7.","DOI":"10.3390\/horticulturae7090289"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00424-020-02464-4","article-title":"Taste transduction and channel synapses in taste buds","volume":"473","author":"Akiyuki","year":"2021","journal-title":"Pflug. Arch. Eur. J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3389\/fphys.2020.00431","article-title":"A bitter taste in your heart","volume":"11","author":"Bloxham","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.201003144","article-title":"The cell biology of taste","volume":"190","author":"Chaudhari","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.21099.1","article-title":"Recent advances in taste transduction and signaling","volume":"8","author":"Kinnamon","year":"2019","journal-title":"F1000Research"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/aob\/mcv054","article-title":"Mechanisms and ecological consequences of plant defence induction and suppression in herbivore communities","volume":"115","author":"Kant","year":"2015","journal-title":"Ann. Bot."},{"key":"ref_18","first-page":"1","article-title":"Research progress on influences of saline-alkali stress on plant morphology, physiology and biochemisttry and response of plants to saline-alkali stress","volume":"47","author":"Jiao","year":"2019","journal-title":"Jiangsu Agric. Sci."},{"key":"ref_19","unstructured":"Yokoi, S., Bressan, R.A., and Hasegawa, P.M. (2002). JIRCAS Working Report, Japan International Research Center for Agricultural Sciences. Available online: https:\/\/www.researchgate.net\/publication\/225040559."},{"key":"ref_20","first-page":"779","article-title":"Varying responses of insect herbivores to altered plant chemistry under organic and conventional treatments","volume":"1682","author":"Staley","year":"2009","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_21","unstructured":"Bo, L. (2004). Study on the chilling requirment and some physiological and biochemiscal changes of tree peony during dormancy release. [Master\u2019s Thesis, Shandong Agricultural University]."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0176-1617(00)80023-1","article-title":"Phenotypic plasticity and acclimation to water deficits in velvet-grass: A long-term greenhouse experiment. Changes in leaf morphology, photosynthesis and stress-induced metabolites","volume":"157","author":"Pedrol","year":"2000","journal-title":"J. Plant Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-arplant-042817-040047","article-title":"Modularity in jasmonate signaling for multistress resilience","volume":"69","author":"Howe","year":"2018","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1126\/science.1071547","article-title":"The jasmonate pathway","volume":"296","author":"Liechti","year":"2002","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1093\/jxb\/erz570","article-title":"Low temperature synergistically promotes wounding-induced indole accumulation by inducer of cbf expression-mediated alterations of jasmonic acid signaling in Camellia sinensis","volume":"71","author":"Zhou","year":"2020","journal-title":"J. Exp. Bot."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1038\/ncomms5851","article-title":"Species-specific defence responses facilitate conspecifics and inhibit heterospecifics in above-belowground herbivore interactions","volume":"5","author":"Huang","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_27","first-page":"125","article-title":"Plant defense responses induced by insect herbivory","volume":"58","author":"Qin","year":"2005","journal-title":"Acta Entomol. Sin."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Xiao, J., Sarker, S.D., and Asakawa, Y. (2021). Handbook of Dietary Phytochemicals, Springer.","DOI":"10.1007\/978-981-15-4148-3"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/10408690490886683","article-title":"Bioavailability of phenolic compounds","volume":"44","author":"Sibel","year":"2004","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tifs.2019.12.026","article-title":"Bitterness in alcoholic beverages: The profiles of perception, constituents, and contributors","volume":"96","author":"Luo","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1021\/jf100591c","article-title":"Sensory-guided identification of n-(1-methyl-4-oxoimidazolidin-2-ylidene)-\u03b1-amino acids as contributors to the thick-sour and mouth-drying orosensation of stewed beef juice","volume":"58","author":"Sonntag","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109071","DOI":"10.1016\/j.lwt.2020.109071","article-title":"Characterizing the effect of free amino acids and volatile compounds on excessive bitterness and sourness in defective dry-cured ham","volume":"123","author":"Zhou","year":"2020","journal-title":"LWT"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"12907","DOI":"10.1021\/acs.jafc.2c02867","article-title":"Characterization of bitter compounds in Shaoxing Huangjiu by quantitative measurements, taste recombination, and omission experiments","volume":"70","author":"Yu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12967-022-03320-y","article-title":"Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis","volume":"20","author":"Chen","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10389","DOI":"10.1021\/acs.jafc.1c06008","article-title":"Pathway-based metabolomics analysis reveals biosynthesis of key flavor compounds in mango","volume":"70","author":"Suh","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/pcp\/pcx084","article-title":"Synthesis and secretion of isoflavones by field-grown soybean","volume":"58","author":"Sugiyama","year":"2017","journal-title":"Plant Cell Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Hamamouch, N., Winkel, B.S.J., Li, C., and Davis, E.L. (2020). Modulation of arabidopsis flavonol biosynthesis genes by cyst and root-knot nematodes. Plants, 9.","DOI":"10.3390\/plants9020253"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1094\/MPMI.2004.17.8.909","article-title":"Cytological, genetic, and molecular analysis to characterize compatible and incompatible interactions between Medicago truncatula and Colletotrichum trifolii","volume":"17","author":"Torregrosa","year":"2004","journal-title":"Mol. Plant-Microbe Interact."},{"key":"ref_39","first-page":"289","article-title":"Humulus lupulus\u2014A story that begs to be told. A review","volume":"120","author":"Almaguer","year":"2014","journal-title":"J. Inst. Brew."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"134629","DOI":"10.1016\/j.foodchem.2022.134629","article-title":"Xanthohumol properties and strategies for extraction from hops and brewery residues: A review","volume":"404","author":"Ambrosi","year":"2023","journal-title":"Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1021\/acs.jafc.5b00239","article-title":"Sensomics analysis of key bitter compounds in the hard resin of hops (Humulus lupulus L.) and their contribution to the bitter profile of pilsner-type beer","volume":"63","author":"Dresel","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","unstructured":"Ndebele, K., Graham, B., and Tchounwou, P. (2012). Isoflavones: Chemistry, Analysis, Function and Effects, The Royal Society of Chemistry."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e4421","DOI":"10.1002\/poc.4421","article-title":"Computational analysis of peroxyl radical scavenging capacity of coumestrol: Insights into kinetics and reaction mechanisms","volume":"35","author":"Boulebd","year":"2022","journal-title":"J. Phys. Org. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ymben.2015.09.007","article-title":"Metabolic engineering of Escherichia coli for the production of phenylpyruvate derivatives","volume":"32","author":"Liu","year":"2015","journal-title":"Metab. Eng."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/mp\/ssq048","article-title":"New insights into the shikimate and aromatic amino acids biosynthesis pathways in plants","volume":"3","author":"Tzin","year":"2010","journal-title":"Mol. Plant"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.arplant.57.032905.105228","article-title":"Biology and biochemistry of glucosinolates","volume":"57","author":"Halkier","year":"2006","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.phytochem.2018.02.003","article-title":"Tyrosine biosynthesis, metabolism, and catabolism in plants","volume":"149","author":"Schenck","year":"2018","journal-title":"Phytochemistry"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hosokawa, S., Shukuya, K., Sogabe, K., Ejima, Y., and Tokuhara, Y. (2020). Novel absorbance peak of gentisic acid following the oxidation reaction. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232263"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1929732","DOI":"10.1080\/15592324.2021.1929732","article-title":"Influence of calcium channel modulators on the production of serotonin, gentisic acid, and a few other biosynthetically related phenolic metabolites in seedling leaves of salt tolerant rice variety nonabokra","volume":"16","author":"Poulami","year":"2021","journal-title":"Plant Signal. Behav."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ymben.2006.11.001","article-title":"Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi","volume":"9","author":"Vannelli","year":"2007","journal-title":"Metab. Eng."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Chen, Y., Wang, P.-C., Zhang, S.-S., Yang, J., Li, G.-C., Huang, L.-Q., and Wang, C.-Z. (2022). Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa armigera. PLoS Genet., 18.","DOI":"10.1371\/journal.pgen.1010455"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.plaphy.2007.12.009","article-title":"Structure and function of enzymes involved in the biosynthesis of phenylpropanoids","volume":"46","author":"Ferrer","year":"2008","journal-title":"Plant Physiol. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Xiao, J., Sarker, S.D., and Asakawa, Y. (2020). Handbook of Dietary Phytochemicals, Springer.","DOI":"10.1007\/978-981-13-1745-3"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"MAlfieri, M., Ambrosone, A., Vaccaro, M., De Tommasi, N., and Leone, A. (2022). Overcoming metabolic constraints in the mep-pathway enrich Salvia sclarea hairy roots in therapeutic abietane diterpenes. Appl. Sci., 12.","DOI":"10.3390\/app12147116"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.arplant.59.032607.092804","article-title":"Gibberellin metabolism and its regulation","volume":"59","author":"Yamaguchi","year":"2008","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-3040.2005.01441.x","article-title":"Gid1, a gibberellin-insensitive dwarf mutant, shows altered regulation of probenazole-inducible protein (pbz1) in response to cold stress and pathogen attack","volume":"29","author":"Tanaka","year":"2006","journal-title":"Plant Cell Environ."},{"key":"ref_57","first-page":"91","article-title":"Effects of foliar spraying gibberellin and brassicin on physiological characteristics of sugar beet","volume":"13","author":"Wei","year":"2022","journal-title":"J. Eng. Heilongjiang Univ."},{"key":"ref_58","first-page":"42","article-title":"Determination of reduced vitamin c by key blue colorimetry","volume":"21","author":"Li","year":"2000","journal-title":"Food Sci."},{"key":"ref_59","first-page":"243","article-title":"Determination of tannin in cotton plant","volume":"11","author":"Wu","year":"2000","journal-title":"Chin. J. Appl. Ecol."},{"key":"ref_60","first-page":"126","article-title":"On determination conditions for total polyphenols in fruits and its derived products by folin-phenol methods","volume":"25","author":"Li","year":"2008","journal-title":"J. Fruit Sci."},{"key":"ref_61","first-page":"87","article-title":"Ultrasound-assisted extraction process of total flavonoids from persimmon leaves","volume":"39","author":"Zhang","year":"2018","journal-title":"Food Res. Dev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11306-016-1050-5","article-title":"Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by uhplc-qtof\/ms","volume":"12","author":"Wang","year":"2016","journal-title":"Metabolomics"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/20\/7170\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:09:38Z","timestamp":1760130578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/20\/7170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":62,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["molecules28207170"],"URL":"https:\/\/doi.org\/10.3390\/molecules28207170","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]}}}