{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:44:17Z","timestamp":1791499457560,"version":"4.3.4"},"reference-count":79,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Brown macroalgae are a rich source of fucoidans with many pharmacological uses. This research aimed to isolate and characterize fucoidan from Dictyota dichotoma var. dichotoma (Hudson) J.V. Lamouroux and evaluate in vitro its antioxidant and antitumor potential. The fucoidan yield was 0.057 g\/g algal dry wt with a molecular weight of about 48.6 kDa. In terms of fucoidan composition, the sulfate, uronic acid, and protein contents were 83.3 \u00b1 5.20 mg\/g fucoidan, 22.5 \u00b1 0.80 mg\/g fucoidan, and 26.1 \u00b1 1.70 mg\/g fucoidan, respectively. Fucose was the primary sugar component, as were glucose, galactose, mannose, xylose, and glucuronic acid. Fucoidan exhibited strong antioxidant potential that increased by more than 3 times with the increase in concentration from 0.1 to 5.0 mg\/mL. Moreover, different concentrations of fucoidan (0.05\u20131 mg\/mL) showed their ability to decrease the viability of Ehrlich ascites carcinoma cells in a time-dependent manner. These findings provided a fast method to obtain an appreciable amount of natural fucoidan with established structural characteristics as a promising compound with pronounced antioxidant and anticancer activity.<\/jats:p>","DOI":"10.3390\/molecules28207175","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T11:46:26Z","timestamp":1697715986000},"page":"7175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Chemical Composition, Antioxidant, and Antitumor Activity of Fucoidan from the Brown Alga Dictyota dichotoma"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-6312","authenticated-orcid":false,"given":"Mostafa M.","family":"El-Sheekh","sequence":"first","affiliation":[{"name":"Department of Botany, Faculty of Science, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, Faculty of Science, Damietta University, New Damietta City 34511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Deyab","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, Faculty of Science, Damietta University, New Damietta City 34511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-0121","authenticated-orcid":false,"given":"Majid","family":"Al-Zahrani","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Science and Arts at Rabigh, King Abdulaziz University, Rabigh 25732, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-2407","authenticated-orcid":false,"given":"Hussein E.","family":"Touliabah","sequence":"additional","affiliation":[{"name":"Faculty of Women for Ats, Science and Education, Ain Shams University, Cairo 11757, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4103\/1995-7645.244523","article-title":"In vitro anticancer activity of polysaccharide extracted from the red alga Jania rubens against breast and colon cancer cell lines","volume":"11","author":"Gheda","year":"2018","journal-title":"Asian Pac. 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