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In this study, we investigate the potential therapeutic efficacy of elaiophylin, a novel compound, in targeting BxPC-3 and PANC-1 pancreatic cancer cells. We comprehensively explore elaiophylin\u2019s impact on apoptosis induction, proliferation inhibition, migration suppression, invasion attenuation, and angiogenesis inhibition, key processes contributing to cancer progression and metastasis. The results demonstrate that elaiophylin exerts potent pro-apoptotic effects, inducing a substantial increase in apoptotic cells. Additionally, elaiophylin significantly inhibits proliferation, migration, and invasion of BxPC-3 and PANC-1 cells. Furthermore, elaiophylin exhibits remarkable anti-angiogenic activity, effectively disrupting tube formation in HUVECs. Moreover, elaiophylin significantly inhibits the Wnt\/\u03b2-Catenin signaling pathway. Our findings collectively demonstrate the multifaceted potential of elaiophylin as a promising therapeutic agent against pancreatic cancer via inhibition of the Wnt\/\u03b2-Catenin signaling pathway. By targeting diverse cellular processes crucial for cancer progression, elaiophylin emerges as a prospective candidate for future targeted therapies. Further investigation of the in vivo efficacy of elaiophylin is warranted, potentially paving the way for novel and effective treatment approaches in pancreatic cancer management.<\/jats:p>","DOI":"10.3390\/molecules28207205","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:59:48Z","timestamp":1697893188000},"page":"7205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elaiophylin Elicits Robust Anti-Tumor Responses via Apoptosis Induction and Attenuation of Proliferation, Migration, Invasion, and Angiogenesis in Pancreatic Cancer Cells"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-6095","authenticated-orcid":false,"given":"Lufen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiru","family":"Pan","sequence":"additional","affiliation":[{"name":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Key Laboratory of Medical Electrophysiology of Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jining Medical University, Rizhao 276500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anguo","family":"Wu","sequence":"additional","affiliation":[{"name":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Key Laboratory of Medical Electrophysiology of Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1053\/j.gastro.2022.03.056","article-title":"Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment","volume":"163","author":"Wood","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"The Lancet Gastroenterology Hepatology (2023). 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